Digital Commons Network^™

Digital Preservation, Stephen Klein

Publications and Research

Despite the ease of creation, the web is ephemeral. The fleeting nature of websites present a challenge to repositories when a record needs to be preserved. The Graduate Center Library was recently presented with this challenge with the increase of submissions of online components to dissertations. This presentation focused on the need to capture a snapshot, the limitations of current normative practices and some alternative approaches.

A Proteomics Approach To Investigate Mir-153-3p And Mir-205-5p Targets In Neuroblastoma Cells, Ketan S. Patil, Indranil Basak, Ramavati Pal, Hsin-Pin Ho, Guido Alves, Emmanuel J. Chang, Jan Petter Larsen, Simon Geir Møller

Publications and Research

MicroRNAs are key regulators associated with numerous diseases. In HEK293 cells, miR-153-3p and miR-205-5p down-regulate alpha-synuclein (SNCA) and Leucine-rich repeat kinase 2 (LRRK2), two key proteins involved in Parkinson’s disease (PD). We have used two-dimensional gel electrophoresis (2D-PAGE) coupled to mass spectrometry (MS) to identify a spectrum of miR-153-3p and miR-205-5p targets in neuronal SH-SY5Y cells. We overexpressed and inhibited both microRNAs in SH-SY5Y cells and through comparative proteomics profiling we quantified ~240 protein spots from each analysis. Combined, thirty-three protein spots were identified showing significant (p-value < 0.05) changes in abundance. Modulation of miR-153-3p resulted in seven up-regulated proteins and eight down-regulated proteins. miR-205 modulation resulted in twelve up-regulated proteins and six down-regulated proteins. Several of the proteins are associated with neuronal processes, including peroxiredoxin-2 and -4, cofilin-1, prefoldin 2, alpha-enolase, human nucleoside diphosphate kinase B (Nm23) and 14-3-3 protein epsilon. Many of the differentially expressed proteins are involved in diverse pathways including metabolism, neurotrophin signaling, actin cytoskeletal regulation, HIF-1 signaling and the proteasome indicating that miR-153-3p and miR-205-5p are involved in the regulation of a wide variety of biological processes in neuroblastoma cells.

Prescription Drug Diversion: Predictors Of Illicit Acquisition And Redistribution In Three U.S. Metropolitan Areas, Shana Harris, Valentina Nikulina, Camila Gelpi-Acosta, Cory Morton, Valerie Newsome, Alana Gunn, Heidi Hoefinger, Ross Aikins, Vivian Smith, Victoria Barry, Martin J. Downing Jr.

Publications and Research

Objective: Prescription drug diversion, the transfer of prescription drugs from lawful to unlawful channels for distribution or use, is a problem in the United States. Despite the pervasiveness of diversion, there are gaps in the literature regarding characteristics of individuals who participate in the illicit trade of prescription drugs. This study examines a range of predictors (e.g., demographics, prescription insurance coverage, perceived risk associated with prescription drug diversion) of membership in three distinct diverter groups: individuals who illicitly acquire prescription drugs, those who redistribute them, and those who engage in both behaviors.

Methods: Data were drawn from a cross-sectional Internet …

Changes In Familiarity With And Willingness To Take Prep In A Longitudinal Study Of Highly Sexually Active Gay And Bisexual Men, Christian Grov, H. Jonathan Rendina, Thomas H.F. Whitfield, Ana Ventuneac, Jeffrey T. Parsons

Publications and Research

PURPOSE: For gay and bisexual men (GBM), research suggests that familiarity with Pre-Exposure Prophylaxis (PrEP) has been increasing since being approved by the U.S. FDA in 2012. However, it is less clear how willingness to start using PrEP has changed over time. Likewise, some have expressed concerns regarding the potential for risk compensation (i.e., reduced condom use) were one to start PrEP; however, again, it is unclear how these may have been changing over time.

METHODS: We conducted baseline and 12 month assessments with 158 highly sexually active HIV-negative GBM in NYC who were assessed between 2011 and 2014. …

Hybrid Sol–Gel Glasses With Glass-Transition Temperatures Below Room Temperature, Andrei Jitianu, Guadalupe Gonzalez, Lisa C. Klein

Publications and Research

Melting gels are hybrid gels that have the ability to soften and flow at around 100 ° C for some combinations of mono- and di-substituted alkoxysiloxanes, where substitutions are either all aromatic or all aliphatic. In this study, melting gels were prepared using phenyltriethoxysilane (PhTES) and dimethyldiethoxysilane (DMDES), meaning both an aromatic and aliphatic substitution. Differential scanning calorimetry was performed to identify glass-transition temperatures, and thermal gravimetric analysis coupled with differential thermal analysis (TGA-DTA) was performed to measure weight loss. The glass-transition temperatures ( T g ) ranged from – 61 ° C to + 5.6 ° C, which are …

Becoming American: Constructing Mexican Immigrants In Local Newspapers, Zheng Zhu

Publications and Research

Media representation of Latino immigrants has been extensively studied by scholars across diverse academic disciplines. Particular to the U.S. context, preceding scholarships pertaining to the ways in which Latinos were represented centered on the media representation of Latino immigrants either as the exotic racial other or undesirable foreigners. In light of the important role that the Mexican immigrants played in understanding the current national debate on illegal immigration and the overall historical experiences of immigrants in Washington State (WA), this study critically investigated how news articles published in WA represented Mexican immigrants. As a crucial point of departure from prior …

Synchronizing Oral History Text And Speech: A Tools Overview, Robin Camille Davis

Publications and Research

This article explores three tools that synchronize sound and text for online oral history collections: the Oral History Metadata Synchronizer (OHMS), the Text Encoding Initiative (TEI), and YouTube. A detailed description and examples are given for each. Integrating audio/video recordings and transcripts enables searching and browsing, making oral histories more accessible and approachable.

Biomechanical Performances Of Networked Polyethylene Glycol Diacrylate: Effect Of Photoinitiator Concentration, Temperature, And Incubation Time, Morshed Khandaker, Albert Orock, Stefano Tarantini, Jeremiah White, Ozlem Yasar

Publications and Research

Nutrient conduit networks can be introduced within the Polyethylene Glycol Diacrylate (PEGDA) tissue construct to enable cells to survive in the scaffold. Nutrient conduit networks can be created on PEGDA by macrochannel to nanochannel fabrication techniques. Such networks can influence the mechanical and cell activities of PEGDA scaffold. There is no study conducted to evaluate the effect of nutrient conduit networks on the maximum tensile stress and cell activities of the tissue scaffold.The study aimed to explore the influence of the network architecture on the maximum tensile stress of PEGDA scaffold and compared with the nonnetworked PEGDA scaffold. Our study …

Cuny Libraries Faculty Collaboration For Information Literacy Project Survey 2014, Barbara Gray, Galina Letnikova

Publications and Research

CUNY, one of the largest urban universities in the United States, comprises eleven senior colleges, seven community colleges, five graduate and professional schools, and an honors college. The University’s system is a federation of 31 libraries, with more than 350 faculty and professional staff. As faculty members, CUNY librarians provide students and departmental faculty with a high level of professional library services, at the same time doing research, publishing, teaching, and leading information literacy programs. In the fall semester of 2013 the CUNY Office of Library Services decided to conduct a university-wide survey to explore and identify best practices for …

Anthology And Absence: The Post-9/11 Anthologizing Impulse, Anne Lovering Rounds

Publications and Research

The decade after the attacks of 9/11 and the fall of the World Trade Center saw a proliferation of New York-themed literary anthologies from a wide range of publishers. With titles like Poetry After 9/11, Manhattan Sonnet, Poems of New York, Writing New York, and I Speak of the City, these texts variously reflect upon their own post-9/11 plurivocality as preservative, regenerative, and reconstructive. However, the work of such anthologies is more complex than filling with plurivocality the physical and emotional hole of Ground Zero. These regional collections operate on the dilemma of all anthologies: that between collecting and editing. …

Topologically Protected Elastic Waves In Phononic Metamaterials, S. Hossein Mousavi, Alexander B. Khanikaev, Zheng Wang

Publications and Research

Surface waves in topological states of quantum matter exhibit unique protection from backscattering induced by disorders, making them ideal carriers for both classical and quantum information. Topological matters for electrons and photons are largely limited by the range of bulk properties, and the associated performance trade-offs. In contrast, phononic metamaterials provide access to a much wider range of material properties. Here we demonstrate numerically a phononic topological metamaterial in an elastic-wave analogue of the quantum spin Hall effect. A dual-scale phononic crystal slab is used to support two effective spins for phonons over a broad bandwidth, and strong spin–orbit coupling …

Using Relationship Marketing To Develop A Successful First Year Library Workshop Program, Mark Aaron Polger

Publications and Research

No abstract provided.

Case Studies And Pervasive Instruction: Using Journalism Education Techniques In The Information Literacy Classroom, Jennifer Noe

Publications and Research

The purpose of this paper is to explore whether journalism education techniques can be adapted for use in the information literacy classroom as a means of teaching the ethical use of information. The author uses personal experience as a journalist and graduate of journalism education programs to examine the similarities between journalism pedagogy and information literacy and whether any aspect of journalism pedagogy is transferrable to the information literacy classroom.

Organometallic Titanocene–Gold Compounds As Potential Chemotherapeutics In Renal Cancer. Study Of Their Protein Kinase Inhibitory Properties, Jacob Fernández-Gallardo, Benelita T. Elie, Florian J. Sulzmaier, Mercedes Sanaú, Joe W. Ramos, María Contel

Publications and Research

Early–late transition metal TiAu2 compounds [(η-C5H5)2Ti{OC(O)CH2PPh2AuCl}2] (3) and new [(η-C5H5)2Ti{OC(O)-4-C6H4PPh2AuCl}2] (5) were evaluated as potential anticancer agents in vitro against renal and prostate cancer cell lines. The compounds were significantly more effective than monometallic titanocene dichloride and gold(I) [{HOC(O)RPPh2}AuCl] (R = −CH2– 6, −4-C6H4– 7) derivatives in renal cancer cell lines, indicating a synergistic effect of the resulting heterometallic species. The activity on renal cancer cell lines (for 5 in the nanomolar range) was considerably higher than that of cisplatin and highly active titanocene Y. Initial mechanistic studies in Caki-1 cells in vitro coupled with studies of their inhibitory properties …

The State Of Evaluation Research On Food Policies To Reduce Obesity And Diabetes Among Adults In The United States, 2000–2011, Nicholas Freudenberg, Emily Franzosa, Nancy Sohler, Rui Li, Heather Devlin, Jeanine Albu

Publications and Research

Introduction Improvements in diet can prevent obesity and type 2 diabetes. Although policy changes provide a foundation for improvement at the population level, evidence for the effectiveness of such changes is slim. This study summarizes the literature on recent efforts in the United States to change food-related policies to prevent obesity and diabetes among adults. Methods We conducted a systematic review of evidence of the impact of food policies. Websites of government, academic, and nonprofit organizations were scanned to generate a typology of food-related policies, which we classified into 18 categories. A key-word search and a search of policy reports …

In Vitro Mutational And Bioinformatics Analysis Of The M71 Odorant Receptor And Its Superfamily, Jaclyn Bubnell, Sophie Jamet, Delia Tomoiaga, Charlotte D’Hulst, Konstantinos Krampis, Paul Feinstein

Publications and Research

We performed an extensive mutational analysis of the canonical mouse odorant receptor (OR) M71 to determine the properties of ORs that inhibit plasma membrane trafficking in heterologous expression systems. We employed the use of the M71::GFP fusion protein to directly assess plasma membrane localization and functionality of M71 in heterologous cells in vitro or in olfactory sensory neurons (OSNs) in vivo. OSN expression of M71::GFP show only small differences in activity compared to untagged M71. However, M71::GFP could not traffic to the plasma membrane even in the presence of proposed accessory proteins RTP1S or mβ2AR. To ask if ORs contain …

Situational Prevention And Public Transport Crime In El Salvador, Mangai Natarajan, Ronald Clarke, Carlos Carcach, Carlos Ponce, Margarita Beneke De Sanfeliú, Dolores Escobar Polanco, Mario Chávez, Mauricio Shi

Publications and Research

By any standard, there is a serious problem of crime on the public transport system in El Salvador. Guided by crime opportunity theory, this study undertook a rapid assessment of the problem consisting of a systematic observation of public transport in El Salvador and focus group discussions with passengers, bus operators, police and bus company owners/managers. The purposes were (1) to describe the main forms of crime and disorder afflicting the system, (2) to identify features of the system that contribute to the high levels of crime and disorder, and (3) to identify preventive measures, consistent with international experience. A …

Supporting Teachers’ Learning About Mathematical Modeling, June L. Gastón, Barbara A. Lawrence

Publications and Research

In the United States, one of the Standards for Mathematical Practice of the Common Core Curriculum (Common Core State Standards Initiative, 2010) is Model with mathematics. This standard requires that students be taught in a manner that will enable them to ―apply the mathematics they know to solve problems arising in everyday life, society, and the workplace‖ (p. 7). However many prospective and practicing teachers acquire a pedagogical style that does not support this standard. To promote higher levels of student thinking associated with mathematical modeling, teachers must thus be taught not only what mathematical modeling is, but how it …

Antimicrobial Copper Alloy Surfaces Are Effective Against Vegetative But Not Sporulated Cells Of Gram-Positive Bacillus Subtilis, Kaungmyat San, Janet Long, Corinne A. Michels, Nidhi Gadura

Publications and Research

This study explores the role of membrane phospholipid peroxidation in the copper alloy mediated contact killing of Bacillus subtilis, a spore-forming gram-positive bacterial species. We found that B. subtilis endospores exhibited significant resistance to copper alloy surface killing but vegetative cells were highly sensitive to copper surface exposure. Cell death and lipid peroxidation occurred in B. subtilis upon copper alloy surface exposure. In a sporulation-defective strain carrying a deletion of almost the entire SpoIIA operon, lipid peroxidation directly correlated with cell death. Moreover, killing and lipid peroxidation initiated immediately and at a constant rate upon exposure to the copper surface …

Knight Innovation Awards: An Interview With Honoree Neil Degrasse Tyson, Jeff Jarvis, Neil Degrasse Tyson

Publications and Research

Jeff Jarvis (Tow-Knight Center for Entrepreneurial Journalism at CUNY Graduate School of Journalism) and Dr. Tyson explore the universe -- and have a lot of fun doing it -- in this in-depth and wide-ranging interview. This video was recorded on October 14, 2015 during the Knight Innovation Awards at the CUNY Graduate School of Journalism.

Two Distinct Modes Of Metal Ion Binding In The Nuclease Active Site Of A Viral Dna-Packaging Terminase: Insight Into The Two-Metal-Ion Catalytic Mechanism, Haiyan Zhao, Zihan Lin, Anna Y. Lynn, Brittany Varnado, John A. Beutler, Ryan P. Murelli, Stuart F.J. Le Grice, Liang Tang

Publications and Research

Many dsDNA viruses encode DNA-packaging terminases, each containing a nuclease domain that resolves concatemeric DNA into genome-length units. Terminase nucleases resemble the RNase H-superfamily nucleotidyltransferases in folds, and share a two-metal-ion catalytic mechanism. Here we show that residue K428 of a bacteriophage terminase gp2 nuclease domain mediates binding of the metal cofactor Mg2+. A K428A mutation allows visualization, at high resolution, of a metal ion binding mode with a coupled-octahedral configuration at the active site, exhibiting an unusually short metal-metal distance of 2.42 A° . Such proximity of the two metal ions may play an essential role in catalysis by …

Topologically Robust Sound Propagation In An Angular-Momentum-Biased Graphene-Like Resonator Lattice, Alexander B. Khanikaev, Romain Fleury, S. Hossein Mousavi, Andrea Alù

Publications and Research

Topological insulators do not allow conduction in the bulk, yet they support edge modes that travel along the boundary only in one direction, determined by the carried electron spin, with inherent robustness to defects and disorder. Topological insulators have inspired analogues in photonics and optics, in which one-way edge propagation in topologically protected two-dimensional materials is achieved breaking time-reversal symmetry with a magnetic bias. Here, we introduce the concept of topological order in classical acoustics, realizing robust topological protection and one-way edge propagation of sound in a suitably designed resonator lattice biased with angular momentum, forming the acoustic analogue of …

Stargate Theatre Company: Engaging Justice-Involved Youth In Creativity And Growth, Jeffrey A. Butts, Martha Wade Steketee

Publications and Research

This report provides a possible starting point for an evaluation of The Stargate Theater company. The Stargate Theater Company, embedded in the resources, expertise, and artistry of the Manhattan Theatre Club Education Program, recruits its members, 10-15 males, from youth services agencies for a seven-week summer arts program. Members of the program write raw materials which become performable text and perform the work with the help of professional theater artists. The writer-performers work for pay and ultimately perform their own words about their life experiences. The program aims to be a paid job and a work readiness training program, a …

Introduction: The 1970s, Shelly J. Eversley, Michelle Habell-Pallán

Publications and Research

Introduction to special issue, "The 1970s," of WSQ (Women's Studies Quarterly), edited by Shelly Eversley and Michelle Habell-Pallán.

The Alteration Of The Image – Women And Japanese Society (1600-2000), Frank Jacob

Publications and Research

A survey paper on the development of the female image in Japan's society from the Tokugawa period until the 2000s.

Heroic Depiction Vs. Modern Slaughtering -The Great War In The Middle East As A Semi-Modern War, Frank Jacob, Riccardo Altieri

Publications and Research

The paper discusses the reception of the Middle East during the First World War comparing different areas of campaigns and battles in the region.

An Environmental Clinical Experience In A Rn-Bs Program, Michelle Gellar

Publications and Research

No abstract provided.

"Happily Ever After": The Tragic Queer And Delany's Comic Book Fairy Tale, Ann Matsuuchi

Publications and Research

Discusses the formulations of queer futurity and normativity in Samuel R. Delany’s autobiographical graphic novel Bread & Wine: An Erotic Tale of New York, drawn by artist Mia Wolff. This love story that is depicted via an interplay of text and imagery resists clichéd homonormative recasting of existing familial templates and questions how expectations queer happiness are bounded by a persistent set of social norms (race, class, education, and income) and their intersections. Also suggests how happy endings can function as a renegotiation of the utopian impulse into something more complex and realistic.

Blood, Tits And The Modern Depiction Of Antiquity – Sparatcus: Blood And Sand And The Display Of A Historical Myth, Frank Jacob

Publications and Research

The article is dealing with the depiction of antiquity in the TV series Spartacus: Blood and Sand.

Hollywood’S Image Of The Second World War - David Ayer’S Fury (2014) And The Depiction Of Violence In War, Frank Jacob

Publications and Research

The article describes the way in which violence is depicted in David Ayer’s World War II movie Fury (2014). It also deals with the general question how violence is visualized in current Hollywood movies.