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R-Symmetries And Curvature Constraints In A-Twisted Heterotic Landau–Ginzburg Models, Richard S. Garavuso
R-Symmetries And Curvature Constraints In A-Twisted Heterotic Landau–Ginzburg Models, Richard S. Garavuso
Publications and Research
In this paper, we discuss various aspects of a class of A-twisted heterotic Landau–Ginzburg models on a Kähler variety X. We provide a classification of the R-symmetries in these models which allow the A-twist to be implemented, focusing on the case in which the gauge bundle is either a deformation of the tangent bundle of X or a deformation of a sub-bundle of the tangent bundle of X. Some anomaly-free examples are provided. The curvature constraint imposed by supersymmetry in these models when the superpotential is not holomorphic is reviewed. Constraints of this nature have been used to establish properties …
Pulling It All Together: Teaching Genre, Disciplinary And Career Literacies, And The Framework For Information Literacy In An Associate Degree Capstone Course, Linda Miles, Elisabeth Tappeiner
Pulling It All Together: Teaching Genre, Disciplinary And Career Literacies, And The Framework For Information Literacy In An Associate Degree Capstone Course, Linda Miles, Elisabeth Tappeiner
Publications and Research
We team teach a semester-long credit-bearing information literacy course for urban community college students in New York City’s South Bronx. It is a capstone course, designed to support students at the end of their first two years of college as they consider the next stage in their own development, be that transferring to a four-year institution or entering the workforce. For this course, we have constructed an approach to critical reading that combines explicit exploration of academic and disciplinary genres with an investigation into the processes of knowledge production and communication shared by the individuals who produce them. This chapter …
Art, Propaganda, And Truth, Melissa Dinsman
Art, Propaganda, And Truth, Melissa Dinsman
Publications and Research
This essay explores how British and American writers and theorists in the first half of the twentieth century thought about art, propaganda, and truth. Focusing largely on literature written during the First and the Second World Wars, this essay shows that very few authors defined their art as propaganda or truth and instead used words like “political,” “resistance,” “information,” and “anti-fascist” to describe their wartime writing. However, while authors might have eschewed the term propaganda, that does not mean that they avoided producing it. As this essay illustrates, what many authors wrote would now be considered “propaganda.” Moreover, even if …
Disturbing Development Through Drawing: Preservice Teachers’ Visual Representation Of Childhood And Their Links To Teaching ., Debbie Sonu
Publications and Research
No abstract provided.
Improving A Library Faq: Assessment And Reflection Of The First Year’S Use, Vanessa Arce, Michelle Ehrenpreis
Improving A Library Faq: Assessment And Reflection Of The First Year’S Use, Vanessa Arce, Michelle Ehrenpreis
Publications and Research
In 2020, the Leonard Lief Library created a searchable online knowledge base (FAQs) as a complement to virtual reference during the library’s pandemic-related closure. One year of search query data was used to assess the online knowledge base. This paper discusses the assessment’s findings and planned improvements to the FAQs.
A content analysis of user queries revealed what users are seeking in the knowledge base. The study examined the actions taken by users after conducting a search to determine the knowledge base’s success rate.
The knowledge base was successful in answering user questions almost half of the time. The top …
Cross-Language Generalization In Language Treatment Of Multilingual Aphasia: A Meta-Analysis, Mira Goral, Monica I. Norvik, Jan Antfolk, Ioulia Agrotou, Minna Lehtonen
Cross-Language Generalization In Language Treatment Of Multilingual Aphasia: A Meta-Analysis, Mira Goral, Monica I. Norvik, Jan Antfolk, Ioulia Agrotou, Minna Lehtonen
Publications and Research
Studies on the efficacy of language treatment for multilingual people with post-stroke aphasia and its generalization to untreated languages have produced mixed results. We conducted a systematic review and a meta- analysis to examine within- and cross-language treatment effects and the variables that affect them. We searched PubMed, PsycINFO, CINAHL, and Google Scholar (February 2020; January 2023), identifying 40 studies reporting on 1573 effect sizes from 85 individuals. We synthesized effect sizes for treatment outcomes using a multi-level model to correct for multiple observations from the same individuals. The results showed significant treatment effects, with robust within-language treatment effects and …
Toward A New Approach To Job-Related Distress: A Three-Sample Study Of The Occupational Depression Inventory, Renzo Bianchi, James Sowden, Jay Verkuilen, Irvin Sam Schonfeld
Toward A New Approach To Job-Related Distress: A Three-Sample Study Of The Occupational Depression Inventory, Renzo Bianchi, James Sowden, Jay Verkuilen, Irvin Sam Schonfeld
Publications and Research
The Occupational Depression Inventory (ODI) was recently developed to assess depressive symptoms that individuals specifically attribute to their work. One purpose of the ODI is to respond to limitations of current assessments of job-related distress, most notably, assessments relying on the burnout construct. In this study, we conducted a thorough examination of the psychometric and structural properties of the ODI using exploratory structural equation modelling bifactor analysis and Mokken scale analysis. The study involved three samples of employed individuals, recruited in France (N = 3454), Switzerland (N = 1971), and Australia (N = 1485). Results were consistent across the three …
Taking Advantage Of Opportunities For Informal Leadership, Linda Miles, Susanne Markgren
Taking Advantage Of Opportunities For Informal Leadership, Linda Miles, Susanne Markgren
Publications and Research
We contend that informal leadership (IL)—the type that does not come from an official title or decree—not only helps our organizations function, it can be vital in helping mid-career academic librarians grow and succeed, and such pursuits should be encouraged and supported no matter where they emerge within an organizational structure. We aim to define and explore IL and provide strategies for mid-career librarians who may want to identify, seek out, and step into IL opportunities. We begin our discussion by considering concepts emerging from the literature on leaders and leadership in general and what it means to lead when …
Beyond Demographic Identifiers And Classification: A Search For Alternative Approaches To Quantitatively Evaluating Educational Equity, Grace Pai
Publications and Research
In April 2022, United States Agency for International Development (USAID) released its first ever Equity Action Plan to advance equity across their policies, programs, and partner base. This action plan entails five priority areas, the fifth of which is to: “…incorporate racial and ethnic equity and diversity into policy, planning, and learning” (USAID, 2022, para. 3). This essay addresses the question of how USAID, along with other international development agencies and practitioners, can institutionalize equity, particularly in its evaluation and data collection processes. I argue that as interest in addressing diversity, equity, and inclusion (DEI)1 increases in the U.S. and …
Characteristics Of Effective Postsecondary Advising: How Often To Meet And What To Focus On, Grace Pai, Melissa De Feo
Characteristics Of Effective Postsecondary Advising: How Often To Meet And What To Focus On, Grace Pai, Melissa De Feo
Publications and Research
Using data from a senior exit survey administered at public high schools in New York City, this study explores the relationship between quantity and quality of postsecondary advisement, parental/guardian involvement in postsecondary planning, and students’ likelihood of exiting high school with a full-time college plan. Results show receiving help in completing college applications, along with talking to a counselor and parents/guardians at least 3 times in their senior year, to be salient predictors of college-going.
Gender Differences In High School Students’ Perceived Values And Costs Of Learning Chemistry, Xiaoyang Gong, Bradley W. Bergey, Ying Jin, Kexin Mao, Yan Cheng
Gender Differences In High School Students’ Perceived Values And Costs Of Learning Chemistry, Xiaoyang Gong, Bradley W. Bergey, Ying Jin, Kexin Mao, Yan Cheng
Publications and Research
Students’ perceived values and costs of learning chemistry influence their performance and intentions of choosing chemistry-related majors or careers. Based on Situated Expectancy-Value Theory, this study adopted a mixed method approach to examine the conceptualization of values and costs among Chinese high school students and identify their relations with chemistry test performance across gender. Qualitative content analyses revealed that students’ perceived values for chemistry could be categorized into five broad categories: utility value, epistemic value, intrinsic value, aesthetic value, and social value. Chi-square tests and multidimensional scaling revealed that boys and girls perceived values and costs in different ways: relational …
How A Community Engagement Model Of Near-Peer Counseling Impacts Student Mentors’ College Outcomes, Leigh Mccallen, Neshat Yazdani, Grace Pai, Janice Bloom, Lori Chajet, Michelle Fine
How A Community Engagement Model Of Near-Peer Counseling Impacts Student Mentors’ College Outcomes, Leigh Mccallen, Neshat Yazdani, Grace Pai, Janice Bloom, Lori Chajet, Michelle Fine
Publications and Research
This study examines how a community engagement model of near-peer counseling impacts counselors’ own college success as underrepresented students in higher education, here defined as one-year persistence in college. Near-peer mentors participated in a program provided by College Access: Research and Action (CARA), which trains young people to support peers in their home communities at New York City public high schools and City University of New York (CUNY) 2-year colleges through critical college application, enrollment, and retention milestones. Aggregated across 4 years of data, our results indicate CARA near-peer counselors are nearly twice as likely to persist in college (p < .001) as peers with similar demographic and academic characteristics not participating in CARA. Findings are replicated for students of color (2.09 times higher, p < .001) and economically disadvantaged students (1.78 times higher, p = .003). Implications for peer mentor program development through public university–community partnerships are discussed.
How A Community Engagement Model Of Near-Peer Counseling Impacts Student Mentors’ College Outcomes, Leigh Mccallen, Neshat Yazdani, Grace Pai, Janice Bloom, Lori Chajet, Michelle Fine
How A Community Engagement Model Of Near-Peer Counseling Impacts Student Mentors’ College Outcomes, Leigh Mccallen, Neshat Yazdani, Grace Pai, Janice Bloom, Lori Chajet, Michelle Fine
Publications and Research
This study examines how a community engagement model of near-peer counseling impacts counselors’ own college success as underrepresented students in higher education, here defined as one-year persistence in college. Near-peer mentors participated in a program provided by College Access: Research and Action (CARA), which trains young people to support peers in their home communities at New York City public high schools and City University of New York (CUNY) 2-year colleges through critical college application, enrollment, and retention milestones. Aggregated across 4 years of data, our results indicate CARA near-peer counselors are nearly twice as likely to persist in college ( …
Social Workers And Case Managers Coping With Supports To Mitigate Workplace Stress, Franzeska Sampson-Bacchus
Social Workers And Case Managers Coping With Supports To Mitigate Workplace Stress, Franzeska Sampson-Bacchus
Publications and Research
The homelessness crisis has mandated increased social service employees to work with this population. Working in a homeless shelter entails consistent exposure to stress due to the frequency of serving a population with various traumatic pasts. The purpose of this qualitative descriptive study was to explore how social workers and case managers cope with internal and external supports to mitigate workplace stress in NYC family homeless shelters. This qualitative descriptive study utilized Lazarus and Folkman's Transactional Model of Stress and Coping. This study's purpose was to answer the following questions RQ1: How do social workers and case managers cope with …
C-Glycopyranosyl Aldehydes: Emerging Chiral Synthons In Organic Synthesis, Sandeep Kumar, Vinod Khatri, Priyanka Mangla, Rajni Johar Chhatwal, Virinder S. Parmar, Ashok K. Prasad
C-Glycopyranosyl Aldehydes: Emerging Chiral Synthons In Organic Synthesis, Sandeep Kumar, Vinod Khatri, Priyanka Mangla, Rajni Johar Chhatwal, Virinder S. Parmar, Ashok K. Prasad
Publications and Research
Herein, we have summarized the vast array of synthetic processes that have been developed for the synthesis of C-glycopyranosyl aldehydes and diverse C-glycoconjugates derived from them by covering the literature reported from 1979 to 2023. Notwithstanding its challenging chemistry, C-glycosides are considered stable pharmacophores and are used as important bioactive molecules. The discussed synthetic methodologies to access C-glycopyranosyl aldehydes take advantage of seven key intermediates, viz. allene, thiazole, dithiane, cyanide, alkene, and nitromethane. Furthermore, the integration of complex C-glycoconjugates derived from varied C-glycopyranosyl aldehydes involves nucleophilic addition/substitution, reduction, condensation, oxidation, cyclo condensation, coupling, and …
Adaptive Single Low-Light Image Enhancement By Fractional Stretching In Logarithmic Domain, Thaweesak Trongtirakul, Sos S. Agaian, Shiqian Wu
Adaptive Single Low-Light Image Enhancement By Fractional Stretching In Logarithmic Domain, Thaweesak Trongtirakul, Sos S. Agaian, Shiqian Wu
Publications and Research
Low-light image enhancement is a challenging task that aims to improve the visibility and quality of images captured in dark environments. However, existing methods often introduce undesirable artifacts such as color distortion, halo effects, blocking artifacts, and noise amplification. In this paper, we propose a novel method that overcomes these limitations by using the logarithmic domain fractional stretching approach to estimate the reflectance component of the image based on the improved Retinex theory. Moreover, we apply a simple adaptive gamma correction algorithm to the Lab color-space to adjust the brightness and saturation of the image. Our method effectively reduces the …
Transnational Dominican Activism: Documenting Grassroots Social Movements Through Esendom, Nelson Santana, Amaury Rodriguez, Emmanuel Espinal
Transnational Dominican Activism: Documenting Grassroots Social Movements Through Esendom, Nelson Santana, Amaury Rodriguez, Emmanuel Espinal
Publications and Research
Dominican-descended people are one of the most dynamic Caribbean and Latin American ethnic and cultural communities in the United States. Whether in the Dominican Republic or as members of a transnational community, the Dominican population has a long and rich history of challenging the powers that be, confronting unjust acts, and opposing oppressive laws within the communities they inhabit through their civic engagement. This paper addresses one question: As Dominican society and the world have evolved, what has been the role of U.S.-based online media in sustaining, disseminating, and rescuing the long tradition of civic involvement and struggle exemplified by …
The Vertical Transfer Pipeline And Its Leaks: Tracking Students From Associate’S Programs To Bachelor’S Degrees, Kerstin Gentsch, Yoshiko Oka, Sarah Truelsch, A. W. Logue
The Vertical Transfer Pipeline And Its Leaks: Tracking Students From Associate’S Programs To Bachelor’S Degrees, Kerstin Gentsch, Yoshiko Oka, Sarah Truelsch, A. W. Logue
Publications and Research
This longitudinal study of 17,455 students, the majority from underrepresented groups, investigated leaks in the vertical transfer pipeline from associate’s-degree program entry to bachelor’s-degree receipt. Investigated were both the size of the leaks and some associated variables. Pipeline progress examinations included quantification of early persistence, plus application to, enrollment and persistence in, and graduation from, bachelor’s programs. The examined associated variables included student demographic characteristics and possible pipeline leak malleable factors: academic preparation and performance and financial need. Overall, only 23% of the original cohort received a bachelor’s after eight years. In addition, this study is the first to identify …
Challenges For Successful Transfer From Community To Bachelor’S Colleges: Views Of Staff And Faculty With Transfer Responsibilities, A. W. Logue, Kerstin Gentsch, Yoshiko Oka, David Wutchiett, Stephanie Abbeyquaye
Challenges For Successful Transfer From Community To Bachelor’S Colleges: Views Of Staff And Faculty With Transfer Responsibilities, A. W. Logue, Kerstin Gentsch, Yoshiko Oka, David Wutchiett, Stephanie Abbeyquaye
Publications and Research
Staff and faculty have influential roles in the success of students transferring from associate’s- to bachelor’s-degree programs (vertical transfer students). Our survey compared the reported views on transfer of 607 staff and faculty with transfer responsibilities in associate’s or bachelor’s programs at 19 City University of New York colleges. The findings included: (1) Staff reported feeling more confident in their responsibilities than did faculty. (2) Participants working with associate’s-degree students were more likely to report their colleges had sufficient transfer-service resources. (3) Associate’s-degree faculty were the least likely participant group to respond that the biggest barrier to the transfer process …
Local Power Outages, Heat, And Community Characteristics In New York City, Peter J. Marcotullio, Olta Braçe, Kathryn Lane, Carolyn E. Olson, Jenna Tipaldo, Jennifer Ventrella, Liv Yoon, Kim Knowlton, Gowri Anand, Tom Matte
Local Power Outages, Heat, And Community Characteristics In New York City, Peter J. Marcotullio, Olta Braçe, Kathryn Lane, Carolyn E. Olson, Jenna Tipaldo, Jennifer Ventrella, Liv Yoon, Kim Knowlton, Gowri Anand, Tom Matte
Publications and Research
Electrical power outages are of increasing interest to US urban scholars, government officials and stakeholders, as they have increased in number and duration with significant health and economic, among other, impacts. This analysis examines reports of power outages in New York City in relation to socioeconomic and health characteristics of neighborhoods. Using the city’s 311-call database we examine complaint calls for power outages from 2014 to 2022. While 311-calls for power outages occur all year long, volume trended higher during the warmer months (June, July and August), and as minimum daily temperatures exceeded 20 °C (68°F), the number of calls …
Intergenerational Transmission Of Occupation In The United States, Swapnil Landge
Intergenerational Transmission Of Occupation In The United States, Swapnil Landge
Publications and Research
This paper explores the persistence of inequality via intergenerational transmission of occupations using the Panel Study of Income Dynamics (PSID) data from 1968 to 2001 of 56,952 unique parent-child pairs. I find that having a father who is in the top and bottom strata† of the socioeconomic professional category has a positive and significant effect on the probability that a son will follow the same professional category as the father, which supports my main hypothesis of persistence of income inequality concerning the transmission of the occupations. The main concern that has been addressed in this paper is that the intangible …
Misogynistic Extremism: A Scoping Review, Robin O'Hanlon, Frederick L. Altice, Roy Ka-Wei Lee, Jack Laviolette, Gloria Mark, Orestis Papakyriakopoulos, Koustuv Saha, Munmun De Choudhury, Navin Kumar
Misogynistic Extremism: A Scoping Review, Robin O'Hanlon, Frederick L. Altice, Roy Ka-Wei Lee, Jack Laviolette, Gloria Mark, Orestis Papakyriakopoulos, Koustuv Saha, Munmun De Choudhury, Navin Kumar
Publications and Research
In recent years, the concept of “misogynistic extremism” has emerged as a subject of interest among scholars, governments, law enforcement personnel, and the media. Yet a consistent understanding of how misogynistic extremism is defined and conceptualized has not yet emerged. Varying epistemological orientations may contribute to the current conceptual muddle of this topic, reflecting long-standing and on-going challenges with the conceptualization of its individual components. To address the potential impact of misogynistic extremism (i.e., violent attacks), a more precise understanding of what this phenomenon entails is needed. To summarize the existing knowledge base on the nature of misogynistic extremism, this …
Lear’S Daughters? Unenumerated Fundamental Rights And The Constitution, Thomas Halper
Lear’S Daughters? Unenumerated Fundamental Rights And The Constitution, Thomas Halper
Publications and Research
How to determine whether fundamental unenumerated constitutional rights exist, and if so, what they are? The questions are of obvious enormous importance—witness the current controversy over abortion—and yet courts have generally been content to address the issues superficially, sometimes, cavalierly. Their treatment of the most common rationale, an historical/traditional consensus, exemplifies this shallow approach. The underdeveloped character of the argumentation on this topic stubbornly remains one of the most glaring shortfalls of modern constitutional law.
Futures On Dry Ground: Anthropology And Coastal Planning, Theodore Hilton, Sheehan Moore
Futures On Dry Ground: Anthropology And Coastal Planning, Theodore Hilton, Sheehan Moore
Publications and Research
Around the world, governments, industry, and other actors are creating plans to save coasts from environmental crisis. Louisiana is one prominent example: levees and other measures protect oil and gas infrastructure from inundation as the wetlands buffer rapidly erodes—in large part due to that same industry. The state’s primary answer to land loss is a $50 billion Coastal Master Plan. To illuminate such responses in Louisiana and globally, this article reviews emerging literature and frames an anthropology of coastal planning around three themes: (1) novel orientations toward time and space, (2) the reproduction of power and capital in the name …
Molecular Mechanism Behind The Safe Immunostimulatory Effect Of Withania Somnifera, Kriti Kalpana, Shen Yap, Moriya Tsuji, Akira Kawamura
Molecular Mechanism Behind The Safe Immunostimulatory Effect Of Withania Somnifera, Kriti Kalpana, Shen Yap, Moriya Tsuji, Akira Kawamura
Publications and Research
Withania somnifera (L.) Dunal (family Solanaceae) is a medicinal plant known for, among many pharmacological properties, an immune boosting effect. Our recent study revealed that its key immunostimulatory factor is lipopolysaccharide of plant-associated bacteria. This is peculiar, because, although LPS can elicit protective immunity, it is an extremely potent pro-inflammatory toxin (endotoxin). However, W. somnifera is not associated with such toxicity. In fact, despite the presence of LPS, it does not trigger massive inflammatory responses in macrophages. To gain insights into the safe immunostimulatory effect of W. somnifera, we conducted a mechanistic study on its major phytochemical constituent, …
Changes To Sea Surface Temperatures And Vertical Wind Shear And Their Influence On Tropical Cyclone Activity In The Caribbean And The Main Developing Region, Keneshia Hibbert, Equisha Glenn, Thomas M. Smith, Jorge E. González-Cruz
Changes To Sea Surface Temperatures And Vertical Wind Shear And Their Influence On Tropical Cyclone Activity In The Caribbean And The Main Developing Region, Keneshia Hibbert, Equisha Glenn, Thomas M. Smith, Jorge E. González-Cruz
Publications and Research
Sea surface temperatures and vertical wind shear are essential to tropical cyclone formation. TCs need warm SSTs and low shear for genesis. Increasing SSTs and decreasing VWS influences storm development. This work analyzes SST and VWS trends for the Caribbean, surrounding region, and the Atlantic hurricane main developing region from 1982–2020. Storm intensity increases significantly during this period. Annual and seasonal trends show that regional SSTs in the MDR are warming annually at 0.0219 °C yr−1 and, per season, 0.0280 °C yr−1. Simultaneously, VWS decreases during the late rainfall season, at 0.056 m/s yr−1 in the …
Structure–Activity Relationship Studies On 6-Chloro-1-Phenylbenzazepines Leads To The Identification Of A New Dopamine D1 Receptor Antagonist, Rajan Giri, Hari K. Namballa, Vishwashiv Emogaje, Wayne W. Harding
Structure–Activity Relationship Studies On 6-Chloro-1-Phenylbenzazepines Leads To The Identification Of A New Dopamine D1 Receptor Antagonist, Rajan Giri, Hari K. Namballa, Vishwashiv Emogaje, Wayne W. Harding
Publications and Research
The 1-phenylbenzazepine template has yielded a number of D1R-like ligands, which, though useful as pharmacological tools, have significant drawbacks in terms of selectivity versus D5R as well as pharmacokinetic behavior. A number of 1-phenylbenzazepines contain a 6-chloro functional group, but extensive SAR studies around the 6-chloro-1-phenylbenzazepine framework have not been reported in the literature. To further understand the tolerance of the 6-chloro-1-phenylbenzazepine template for various substituent groups towards affinity and selectivity at D1R, we synthesized two series of analogs with structural variations at the C-7, C-8, N-3, C-3′ and C-4′ positions. The series 2 analogs differed from …
Ecological Niche Comparison Among Closely Related Tree Species Of Lauraceae Using Climatic And Edaphic Data, Laura J. Giraldo-Kalil, Gonzalo E. Pinilla Buitrago, Andrés Lira-Noriega, Francisco Lorea-Hernández, Juan Núñez-Farfán
Ecological Niche Comparison Among Closely Related Tree Species Of Lauraceae Using Climatic And Edaphic Data, Laura J. Giraldo-Kalil, Gonzalo E. Pinilla Buitrago, Andrés Lira-Noriega, Francisco Lorea-Hernández, Juan Núñez-Farfán
Publications and Research
ABSTRACT:
Edaphic specialization is considered to promote ecological differentiation among closely related species of Damburneya (Lauraceae) occurring in sympatry. However, little is known about the effects of soil and other key environmental factors like climate on the ecological niche and distribution of these tree species. Here, we assessed the role of climate and soil on niche divergence and potential distribution of four Damburneya species whose distributions span Central America and Mexico. We performed ecological niche modeling with MaxEnt using three sets of environmental data: climatic-only, edaphic-only, and a combination of both, to characterize species niches and suitable distribution areas. Niche …
The Routes Of Introspection, Adriana Renero
The Routes Of Introspection, Adriana Renero
Publications and Research
In “What forms could introspective systems take? A research programme”, François Kammerer and Keith Frankish aim to map the space of “possible forms of introspection” while lending themselves to questions about how different kinds of minds represent themselves. This paper aligns with Kammerer and Frankish’s research programme in embracing other possible forms of introspection; it provides an outline of how, in representing its mental states, an introspective system could take a selective, cumulative, and/or predictive route while underscoring the importance of considering routes of introspection. Although this work only explores human minds, it contributes to Kammerer and Frankish’s research programme …
Radiation-Induced Gastrointestinal (Gi) Syndrome As A Function Of Age, Hongyan Li, Herman C. Kucharavy, Carla Hajj, Liyang Zhao, Guoqiang Hua, Ryan Glass, Phillip B. Paty, Zvi Fuks, Richard Kolesnick, Karen Hubbard, Adriana Haimovitz-Friedman
Radiation-Induced Gastrointestinal (Gi) Syndrome As A Function Of Age, Hongyan Li, Herman C. Kucharavy, Carla Hajj, Liyang Zhao, Guoqiang Hua, Ryan Glass, Phillip B. Paty, Zvi Fuks, Richard Kolesnick, Karen Hubbard, Adriana Haimovitz-Friedman
Publications and Research
Previous studies show increased sensitivity of older mice (28–29 months) compared with young adult mice (3 months, possessing a mature immune system) to radiation-induced GI lethality. Age-dependent lethality was associated with higher levels of apoptotic stem cells in small intestinal crypts that correlated with sphingomyelinase activity, a source of pro-apoptotic ceramide. The objective of this study is to determine whether the cycling crypt base columnar cells (CBCs) in aging animals are specifically more sensitive to radiation effects than the CBCs in young adult mice, and to identify factors that contribute to increased radiosensitivity. Mortality induced by subtotal body radiation was …