Digital Commons Network^™

Refining Environmental Satellite Data Using A Statistical Approach, Md Zahidur Rahman, Leonid Roytman, Abdelhamid Kadik

Publications and Research

The proposed approach in this article applies an efficient and novel statistical technique to accurately describe radiometric data measured by Advanced Very High Resolution Radiometers (AVHRR) onboard the National Oceanic and Atmospheric Administration’s (NOAA) Polar Orbiting Environmental Satellites (POES). The corrected data set will then be applied to improve the strength of NOAA Global Vegetation Index (GVI) data set for the 1982- 2003 period produced from AVHRR. The GVI is used extensively for studying and monitoring land surface, atmosphere and recently for analyzing climate and environmental changes. The POES AVHRR data, though useful, cannot be directly used in climate change …

A Phylogeny And Revised Classification Of Squamata, Including 4161 Species Of Lizards And Snakes, R. Alexander Pyron, Frank T. Burbrink, John J. Wiens

Publications and Research

Background: The extant squamates (>9400 known species of lizards and snakes) are one of the most diverse and conspicuous radiations of terrestrial vertebrates, but no studies have attempted to reconstruct a phylogeny for the group with large-scale taxon sampling. Such an estimate is invaluable for comparative evolutionary studies, and to address their classification. Here, we present the first large-scale phylogenetic estimate for Squamata.

Results: The estimated phylogeny contains 4161 species, representing all currently recognized families and subfamilies. The analysis is based on up to 12896 base pairs of sequence data per species (average = 2497 bp) from 12 genes, …

Restoring College Education To The Nation's Prisons, Jeremy Travis

Publications and Research

No abstract provided.

The Impact Of Medicare Prescription Drug Coverage On The Use Of Antidementia Drugs, Nicole R. Fowler, Yi-Fan Chen, Christiana A. Thurton, Aiju Men, Eric G. Rodriguez, Julie M. Donohue

Publications and Research

Background Cholinesterase inhibitors and memantine are prescribed to slow the progression dementia. Although the efficacy of these drugs has been demonstrated, their effectiveness, from the perspective of patients and caregivers, has been questioned. Little is known about whether the demand for cholinesterase inhibitors and memantine are sensitive to out-of-pocket cost. Using the 2006 implementation of Medicare Part D as a natural experiment, this study examines the impact of changes in drug coverage on use of cholinesterase inhibitors and memantine by comparing use before and after Medicare Part D implementation among older adults who did and did not experience a change …

Earliest Archaeological Evidence Of Persistent Hominin Carnivory, Joseph V. Ferraro, Thomas W. Plummer, Briana L. Pobiner, James S. Oliver, Laura C. Bishop, David R. Braun, Peter W. Ditchfield, John W. Seaman, Katie M. Binetti, John W. Seaman, Fritz Hertel, Richard Potts

Publications and Research

The emergence of lithic technology by ∼2.6 million years ago (Ma) is often interpreted as a correlate of increasingly recurrent hominin acquisition and consumption of animal remains. Associated faunal evidence, however, is poorly preserved prior to ∼1.8 Ma, limiting our understanding of early archaeological (Oldowan) hominin carnivory. Here, we detail three large well-preserved zooarchaeological assemblages from Kanjera South, Kenya. The assemblages date to ∼2.0 Ma, pre-dating all previously published archaeofaunas of appreciable size. At Kanjera, there is clear evidence that Oldowan hominins acquired and processed numerous, relatively complete, small ungulate carcasses. Moreover, they had at least occasional access to the …

Serine Proteolytic Pathway Activation Reveals An Expanded Ensemble Of Wound Response Genes In Drosophila, Rachel A. Patterson, Michelle T. Juarez, Anita Hermann, Roman Sasik, Gary Hardiman, William Mcginnis

Publications and Research

After injury to the animal epidermis, a variety of genes are transcriptionally activated in nearby cells to regenerate the missing cells and facilitate barrier repair. The range and types of diffusible wound signals that are produced by damaged epidermis and function to activate repair genes during epidermal regeneration remains a subject of very active study in many animals. In Drosophila embryos, we have discovered that serine protease function is locally activated around wound sites, and is also required for localized activation of epidermal repair genes. The serine protease trypsin is sufficient to induce a striking global epidermal wound response without …

Cancer Incidence In World Trade Center Rescue And Recovery Workers, 2001–2008, Samara Solan, Sylvan Wallenstein, Moshe Shapiro, Susan L. Teitelbaum, Lori Stevenson, Anne Kochman, Julia Kaplan, Cornelia Dellenbaugh, Amy Kahn, F. Noah Biro, Michael Crane, Laura Crowley, Janice Gabrilove, Lou Gonsalves, Denise Harrison, Robin Herbert, Benjamin Luft, Steven B. Markowitz, Jacqueline Moline, Xiaoling Niu

Publications and Research

Background: World Trade Center (WTC) rescue and recovery workers were exposed to a complex mix of pollutants and carcinogens. Objective: The purpose of this investigation was to evaluate cancer incidence in responders during the first 7 years after 11 September 2001. Methods: Cancers among 20,984 consented participants in the WTC Health Program were identified through linkage to state tumor registries in New York, New Jersey, Connecticut, and Pennsylvania. Standardized incidence ratios (SIRs) were calculated to compare cancers diagnosed in responders to predicted numbers for the general population. Multivariate regression models were used to estimate associations with degree of exposure. Results: …

A Plspm-Based Test Statistic For Detecting Gene-Gene Co-Association In Genome-Wide Association Study With Case-Control Design, Xiaoshuai Zhang, Xiaowei Yang, Zhongshang Yuan, Yanxun Liu, Fangyu Li, Bin Peng, Dianwen Zhu, Jinghua Zhao, Fuzhong Xue

Publications and Research

For genome-wide association data analysis, two genes in any pathway, two SNPs in the two linked gene regions respectively or in the two linked exons respectively within one gene are often correlated with each other. We therefore proposed the concept of gene-gene co-association, which refers to the effects not only due to the traditional interaction under nearly independent condition but the correlation between two genes. Furthermore, we constructed a novel statistic for detecting gene-gene co-association based on Partial Least Squares Path Modeling (PLSPM). Through simulation, the relationship between traditional interaction and co-association was highlighted under three different types of co-association. …

Educational Uses For The Ipad, Philip G. Swan Jr.

Publications and Research

These are bullet points of a talk regarding iPad apps suitable for use in higher education.

Horizontal Cooling Towers: Riverine Ecosystem Services And The Fate Of Thermoelectric Heat In The Contemporary Northeast Us, Robert J. Stewart, Wilfred M. Wollheim, Ariel Miara, Charles J. Vorosmarty, Balázs M. Fekete, Richard B. Lammers, Bernice Rosenzweig

Publications and Research

The electricity sector is dependent on rivers to provide ecosystem services that help regulate excess heat, either through provision of water for evaporative cooling or by conveying, diluting and attenuating waste heat inputs. Reliance on these ecosystem services alters flow and temperature regimes, which impact fish habitat and other aquatic ecosystem services. We demonstrate the contemporary (2000–2010) dependence of the electricity sector on riverine ecosystem services and associated aquatic impacts in the Northeast US, a region with a high density of thermoelectric power plants. We quantify these dynamics using a spatially distributed hydrology and water temperature model (the framework for …

Testosterone, Cardiovascular, Men, Trial, Lin Xu, Guy Freeman, Benjamin J. Cowling, Mary Schooling

Publications and Research

Background
Testosterone therapy is increasingly promoted. No randomized placebo-controlled trial has been implemented to assess the effect of testosterone therapy on cardiovascular events, although very high levels of androgens are thought to promote cardiovascular disease.

Methods
A systematic review and meta-analysis was conducted of placebo-controlled randomized trials of testosterone therapy among men lasting 12+ weeks reporting cardiovascular-related events. We searched PubMed through the end of 2012 using “(“testosterone” or “androgen”) and trial and (“random*”)” with the selection limited to studies of men in English, supplemented by a bibliographic search of the World Health Organization trial registry. Two reviewers independently searched, …

Testosterone Therapy And Cardiovascular Events Among Men: A Systematic Review And Meta-Analysis Of Placebo-Controlled Randomized Trials, Lin Xu, Guy Freeman, Benjamin J. Cowling, C Mary Schooling

Publications and Research

Background Testosterone therapy is increasingly promoted. No randomized placebo-controlled trial has been implemented to assess the effect of testosterone therapy on cardiovascular events, although very high levels of androgens are thought to promote cardiovascular disease. Methods A systematic review and meta-analysis was conducted of placebo-controlled randomized trials of testosterone therapy among men lasting 12+ weeks reporting cardiovascular-related events. We searched PubMed through the end of 2012 using “(“testosterone” or “androgen”) and trial and (“random*”)” with the selection limited to studies of men in English, supplemented by a bibliographic search of the World Health Organization trial registry. Two reviewers independently searched, …

Rad53 Homologue Forkhead-Associated Kinase A (Fhka) And Ca2+-Binding Protein 4a (Cbp4a) Are Nucleolar Proteins That Differentially Redistribute During Mitosis In Dictyostelium, Andrew Catalano, Danton H. O’Day

Publications and Research

Background During mitosis most nucleolar proteins redistribute to other locales providing an opportunity to study the relationship between nucleolar protein localization and function. Dictyostelium is a model organism for the study of several fundamental biological processes and human diseases but only two nucleolar proteins have been studied during mitosis: NumA1 and Snf12. Both of them are linked to the cell cycle. To acquire a better understanding of nucleolar protein localization and dynamics in Dictyostelium we studied the nucleolar localization of two additional proteins during mitosis: Snf12-linked forkhead-associated kinase A (FhkA), which is involved in the cell cycle, and Ca2+-binding protein …

Edges And Overlaps In Northwest Atlantic Phylogeography, Safra Altman, John D. Robinson, James M. Pringle, James E. Byers, John P. Wares

Publications and Research

As marine environments change, the greatest ecological shifts—including resource usage and species interactions—are likely to take place in or near regions of biogeographic and phylogeographic transition. However, our understanding of where these transitional regions exist depends on the defining criteria. Here we evaluate phylogeographic transitions using a bootstrapping procedure that allows us to focus on either the strongest genetic transitions between a pair of contiguous populations, versus evaluation of transitions inclusive of the entire overlap between two intraspecific genetic lineages. We compiled data for the Atlantic coast of the United States, and evaluate taxa with short- and long-dispersing larval phases …

Steered Molecular Dynamics Simulations Of A Type Iv Pilus Probe Initial Stages Of A Force-Induced Conformational Transition, Joseph L. Baker, Nicolas Biais, Florence Tama

Publications and Research

Type IV pili are long, protein filaments built from a repeating subunit that protrudes from the surface of a wide variety of infectious bacteria. They are implicated in a vast array of functions, ranging from bacterial motility to microcolony formation to infection. One of the most well-studied type IV filaments is the gonococcal type IV pilus (GC-T4P) from Neisseria gonorrhoeae, the causative agent of gonorrhea. Cryo-electron microscopy has been used to construct a model of this filament, offering insights into the structure of type IV pili. In addition, experiments have demonstrated that GC-T4P can withstand very large tension forces, and …

Effect Of Exercise On Appetite-Regulating Hormones In Overweight Women, G. Tiryaki-Sonmez, S. Ozen, G. Bugdayci, U. Karli, G. Ozen, S. Cogalgil, B. Schoenfeld, K. Sozbir, K. Aydin

Publications and Research

Over the past decade, our knowledge of how homeostatic systems regulate food intake and body weight has increased with the discovery of circulating peptides such as leptin, acyl ghrelin, des-acyl ghrelin and obestatin. These hormones regulate the appetite and food intake by sending signals to the brain regarding the body's nutritional status. The purpose of this study was to investigate the response of appetite-regulating hormones to exercise. Nine overweight women undertook two 2 h trials in a randomized crossover design. In the exercise trial, subjects ran for 60 min at 50% of maximal oxygen uptake followed by a 60 min …

Exploratory Bioinformatics Study Of Lncrnas In Alzheimer's Disease Mrna Sequences With Application To Drug Development, T. Holden, A. Nguyen, E. Lin, E. Cheung, S. Dehipawala, J. Ye, G. Tremberger, D. Lieberman, T. Cheung

Publications and Research

Long noncoding RNA (lncRNA) within mRNA sequences of Alzheimer's disease genes, namely, APP, APOE, PSEN1, and PSEN2, has been analyzed using fractal dimension (FD) computation and correlation analysis. We examined lncRNA by comparing mRNA FD to corresponding coding DNA sequences (CDSs) FD. APP, APOE, and PSEN1 CDSs select slightly higher FDs compared to the mRNA, while PSEN2 CDSs FDs are lower. The correlation coefficient for these sequences is 0.969. A comparative study of differentially expressed MAPK signaling pathway lncRNAs in pancreatic cancer cells shows a correlation of 0.771. Selection of higher FD CDSs could indicate interaction of Alzheimer's gene products …

Sex-Specific Brain Deficits In Auditory Processing In An Animal Model Of Cocaine-Related Schizophrenic Disorders, Patricia A. Broderick, Taylor Rosenbaum

Publications and Research

Cocaine is a psychostimulant in the pharmacological class of drugs called Local Anesthetics. Interestingly, cocaine is the only drug in this class that has a chemical formula comprised of a tropane ring and is, moreover, addictive. The correlation between tropane and addiction is well-studied. Another well-studied correlation is that between psychosis induced by cocaine and that psychosis endogenously present in the schizophrenic patient. Indeed, both of these psychoses exhibit much the same behavioral as well as neurochemical properties across species. Therefore, in order to study the link between schizophrenia and cocaine addiction, we used a behavioral paradigm called Acoustic Startle. …

Conservation Genetics Of Extremely Isolated Urban Populations Of The Northern Dusky Salamander (Desmognathus Fuscus) In New York City, Jason Munshi-South, Yana Zak, Ellen Pehek

Publications and Research

Urbanization is a major cause of amphibian decline. Stream-dwelling plethodontid salamanders are particularly susceptible to urbanization due to declining water quality and hydrological changes, but few studies have examined these taxa in cities. The northern dusky salamander (Desmognathus fuscus) was once common in the New York City metropolitan area, but has substantially declined throughout the region in recent decades. We used five tetranucleotide microsatellite loci to examine population differentiation, genetic variation, and bottlenecks among five remnant urban populations of dusky salamanders in NYC. These genetic measures provide information on isolation, prevalence of inbreeding, long-term prospects for population persistence, and potential …

Neural Processing Of Facial Identity And Emotion In Infants At High-Risk For Autism Spectrum Disorders, Sharon E. Fox, Jennifer B. Wagner, Christine L. Shrock, Helen Tager-Flusberg, Charles A. Nelson

Publications and Research

Deficits in face processing and social impairment are core characteristics of autism spectrum disorder. The present work examined 7-month-old infants at high-risk for developing autism and typically developing controls at low-risk, using a face perception task designed to differentiate between the effects of face identity and facial emotions on neural response using functional Near-Infrared Spectroscopy. In addition, we employed independent component analysis, as well as a novel method of condition-related component selection and classification to identify group differences in hemodynamic wave forms and response distributions associated with face and emotion processing.The results indicate similarities of waveforms, but differences in the …

Overexpression Of Full-Length Centrobin Rescues Limb Malformation But Not Male Fertility Of The Hypodactylous (Hd) Rats, František Liška, Claudia Gosele, Elena Popova, Blanka Chylíková, Drahomíra Křenová, Vladimír Křen, Michael Bader, Laura L. Tres, Norbert Hubner, Abraham L. Kierszenbaum

Publications and Research

Rat hypodactyly (hd) mutation is characterized by abnormal spermatogenesis and sperm decapitation, limb malformation (missing digits II and III) and growth retardation. We have previously reported centrobin (centrosome BRCA2-interacting protein) truncation at the C-terminus in the hd mutant. Here, we report data from a transgenic rescue experiment carried out to determine a role of centrobin in pathogenesis of hd. The transgenic construct, consisting of full-length-coding cDNA linked to a ubiquitous strong promoter/enhancer combination, was inserted to chromosome 16 into a LINE repeat. No known gene is present in the vicinity of the insertion site. Transgenic centrobin was expressed in all …

Synthesis, Biological Activity And Molecular Modelling Studies Of Tricyclic Alkylimidazo-, Pyrimido- And Diazepinopurinediones, Anna Drabczyńska, Tadeusz Karcz, Ewa Szymańska, Meryem Köse, Christa E. Müller, Minka Paskaleva, Janina Karolak-Wojciechowska, Jadwiga Handzlik, Olga Yuzlenko, Katarzyna Kieć-Kononowicz

Publications and Research

Syntheses and biological activities of imidazo-, pyrimido- and diazepino[2,1-f]purinediones containing N-alkyl substituents (with straight, branched or unsaturated chains) are described. Tricyclic derivatives were synthesized by the cyclization of 8-bromo-substituted 7-(2-bromoethyl)-, 7-(3-chloropropyl)- or 7-(4-bromobutyl)-theophylline with primary amines under various conditions. Compound 22 with an ethenyl substituent was synthesized by dehydrohalogenation of 9-(2-bromoethyl)-1,3-dimethyltetrahydropyrimido[2,1-f]purinedione. The obtained derivatives (5–35) were initially evaluated for their affinity at rat A1 and A2A adenosine receptors (AR), showing moderate affinity for both adenosine receptor subtypes. The best ligands were diazepinopurinedione 28 (Ki = 0.28 μM) with fivefold A2A selectivity and the non-selective A1/A2A AR ligand pyrimidopurinedione 35 (Ki …

Create Cornerstone: Introduction To Scientific Thinking, A New Course For Stem-Interested Freshmen, Demystifies Scientific Thinking Through Analysis Of Scientific Literature, Alan J. Gottesman, Sally G. Hoskins

Publications and Research

The Consider, Read, Elucidate hypotheses, Analyze and interpret data, Think of the next Experiment (CREATE) strategy for teaching and learning uses intensive analysis of primary literature to improve students’ critical-thinking and content integration abilities, as well as their self-rated science attitudes, understanding, and confidence. CREATE also supports maturation of undergraduates’ epistemological beliefs about science. This approach, originally tested with upper-level students, has been adapted in Introduction to Scientific Thinking, a new course for freshmen. Results fromthis course’s initial semesters indicate that freshmen in a one-semester introductory course that uses a narrowly focused set of readings to promote development of analytical …

Citizenship Status And Patterns Of Inequality In The United States And Canada, Sofya Aptekar

Publications and Research

Objective: This study investigates inequalities in the distribution of citizenship status among immigrants in Canada and the US between 1970 and 2001. It is motivated by a desire to probe deeper into the gap in citizenship rates between the two countries.

Methods: Logistic regression analysis of Census data is used to predict the odds of citizenship among the foreign-born, controlling for a range of factors.

Results: There has been a growing inequality in the distribution of citizenship in the US, but not in Canada. Low rates of citizenship hide the appearance of a large disparity in citizenship …

The Choral Works Of Hamish Maccunn (1868–1916), Jennifer Oates

Publications and Research

This article provides an overview of the partsongs of Hamish MacCunn and places them within the context of British choral music in the nineteenth century. A complete list of MacCunn's partsongs are included. To access the embedded sound files, access the article via the American Choral Review homepage.

The Use Of Statistics In Experimental Physics, Thomas J. Pfaff, Maksim Sipos, M. C. Sullivan, B. G. Thompson, Max Tran

Publications and Research

Most mathematicians are aware of the importance of statistics in biological sciences, business, and economics, but are less aware that statistics is used every day in experimental physics. This paper gives three interesting examples of how statistics plays a vital role in physics. These examples use the basic statistical tools of residuals analysis and goodness of fit.

Cuny Librarians And Faculty Status, John A. Drobnicki

Publications and Research

Although the libraries in what were then known as the City Colleges of New York were made academic departments in 1938, all of the librarians did not have faculty status until 1946, and faculty rank did not come until 1965.

Women, Leadership, And Transformation In Africa: A Study Of Social And Structural Factors Affecting Women’S Participation, Decision-Making Processes And Leadership Capabilities In Nigeria, Remi Alapo

Publications and Research

No abstract provided.

Between Harm Reduction, Loss And Wellness: On The Occupational Hazards Of Work, Benjamin C. Shepard

Publications and Research

Those working in the fields of harm reduction, healthcare, and human services must cope with a range of stresses, including post traumatic stress and vicarious trauma. Pain and loss are just a part of the job. So is dealing with premature death as a result of HIV, hypertension, and even overdose. Faced with a range of challenges, some workers in the field even turn to self-medication. For some, it is about pleasure; for others it is about alleviating suffering. In recent years, several leaders in the AIDS and harm reduction fields have died ahead of their time. Some stopped taking …

The Battle Of Brooklyn: World City And Space Of Neighborhoods., Benjamin C. Shepard

Publications and Research

Throughout Brooklyn, regular people are fighting off the negative dynamics of urban experience, including uneven development, speculative gentrification, displacement, and police brutality long seen in global cities. Yet, little of the global cities literature considers the ways local actors impact global forces shaping world cities. Instead, observers of globalization suggest local actors have been relegated the sidelines as passive spectators of larger social and economic forces. Many wonder, is there a space for agency in global cities? Can regular people shape the dynamics of life in cities? For many, the answer is clearly affirmative. Throughout the borough of Brooklyn, people …