Digital Commons Network^™

The Effectiveness Of Critical Time Intervention For Abused Women And Homeless People Leaving Dutch Shelters: Study Protocol Of Two Randomised Controlled Trials, Danielle Am Lako, Renée De Vet, Mariëlle D. Beijersbergen, Daniel B. Herman, Albert M. Van Hemert, Judith Rlm Wolf

Publications and Research

Background One of the main priorities of Dutch organisations providing shelter services is to develop evidence-based interventions in the care for abused women and homeless people. To date, most of these organisations have not used specific intervention models and the interventions which have been implemented rarely have an empirical and theoretical foundation. The present studies aim to examine the effectiveness of critical time intervention (CTI) for abused women and homeless people. Methods In two multi-centre randomised controlled trials we investigate whether CTI, a time-limited (nine month) outreach intervention, is more effective than care-as-usual for abused women and homeless people making …

Mutation Of Simple In Charcot–Marie–Tooth 1c Alters Production Of Exosomes, Hong Zhu, Sara Guariglia, Raymond Y. L. Yu, Wenjing Li, Deborah Brancho, Hector Peinado, David Lyden, James Salzer, Craig Bennett, Chi-Wing Chow

Publications and Research

Mutations in the protein SIMPLE account for the rare autosomal-dominant demyelination in type 1C CMT patients (CMT1C). SIMPLE plays a role in the production of exosomes. Dysregulated endosomal trafficking and changes in exosome-mediated intercellular communications might account for CMT1C molecular pathogenesis.

Library Facelift: Syncing Library Signage With A College’S New Brand, Mark Aaron Polger, Amy F. Stempler

Publications and Research

No abstract provided.

Dynamic Optimization Of Caregiver Schedules Based On Vital Sign Streams, Mohamed Saad, Bilal Khan

Publications and Research

Hospital facilities use a collection of heterogeneous devices, produced by many different vendors, to monitor the state of patient vital signs. The limited interoperability of current devices makes it difficult to synthesize multivariate moni- toring data into a unified array of real-time information regarding the patients state. Without an infrastructure for the integrated evaluation, display, and storage of vital sign data, one cannot adequately ensure that the assignment of care- givers to patients reflects the relative urgency of patient needs. This is an especially serious issue in critical care units (CCUs). We present a formal mathematical model of an operational …

Computational Modeling Of Transcranial Direct Current Stimulation (Tdcs) In Obesity: Impact Of Head Fat And Dose Guidelines☆, Dennis Q. Truong, Greta Magerowski, George L. Blackburn, Marom Bikson, Miguel Alonso-Alonso

Publications and Research

Recent studies show that acute neuromodulation of the prefrontal cortex with transcranial direct current stimulation (tDCS) can decrease food craving, attentional bias to food, and actual food intake. These data suggest potential clinical applications for tDCS in the field of obesity. However, optimal stimulation parameters in obese individuals are uncertain. One fundamental concern is whether a thick, low-conductivity layer of subcutaneous fat around the head can affect current density distribution and require dose adjustments during tDCS administration. The aim of this study was to investigate the role of head fat on the distribution of current during tDCS and evaluate whether …

Dominance Of Orientation Over Frequency In The Perception Of 3-D Slant And Shape, Danny M. Tam, Ji Shin, Andrea Li

Publications and Research

In images of textured three-dimensional surfaces, pattern changes can be characterized as changes in orientation and spatial frequency, features for which neurons in primary visual cortex are classically selective. Previously, we have demonstrated that correct 3-D shape perception is contingent on the visibility of orientation flows that run parallel to the surface curvature. We sought to determine the relative contributions of orientation modulations (OMs) and frequency modulations (FMs) for the detection of slant and shape from 3-D surfaces. Results show that 1) when OM and FM indicate inconsistent degrees of surface slant or curvature, observer responses were consistent with the …

Access To Hiv/Aids Care: A Systematic Review Of Socio-Cultural Determinants In Low And High Income Countries, Sara Gari, Camilo Doig-Acuña, Tino Smail, Jacob Rs Malungo, Adriane Martin-Hilber, Sonja Merten

Publications and Research

Background The role of socio-cultural factors in influencing access to HIV/AIDS treatment, care and support is increasingly recognized by researchers, international donors and policy makers. Although many of them have been identified through qualitative studies, the evidence gathered by quantitative studies has not been systematically analysed. To fill this knowledge gap, we did a systematic review of quantitative studies comparing surveys done in high and low income countries to assess the extent to which socio-cultural determinants of access, identified through qualitative studies, have been addressed in epidemiological survey studies. Methods Ten electronic databases were searched (Cinahl, EMBASE, ISI Web of …

Multiscale Modeling Of The Causal Functional Roles Of Nssnps In A Genome-Wide Association Study: Application To Hypoxia, Li Xie, Clara Ng, Thahmina Ali, Raoul Valencia, Barbara L. Ferreira, Vincent Xue, Maliha Tanweer, Dan Zhou, Gabriel G. Haddad, Philip E. Bourne, Lei Xie

Publications and Research

Background It is a great challenge of modern biology to determine the functional roles of non-synonymous Single Nucleotide Polymorphisms (nsSNPs) on complex phenotypes. Statistical and machine learning techniques establish correlations between genotype and phenotype, but may fail to infer the biologically relevant mechanisms. The emerging paradigm of Network-based Association Studies aims to address this problem of statistical analysis. However, a mechanistic understanding of how individual molecular components work together in a system requires knowledge of molecular structures, and their interactions. Results To address the challenge of understanding the genetic, molecular, and cellular basis of complex phenotypes, we have, for the …

Lim Protein Ajuba Participates In The Repression Of The Atr-Mediated Dna Damage Response, Sampada Kalan, Anastasiya Matveyenko, Diego Loayza

Publications and Research

LIM proteins constitute a superfamily characterized by the presence of a LIM domain, known to be involved in protein–protein interactions. Our previous work has implicated members of the Zyxin family of LIM proteins, namely TRIP6 and LPP, in the repression of the DNA damage response (DDR) at telomeres. Here, we describe a role for Ajuba, a closely related LIM molecule, in repressing the ATR-mediated DDR. We found that depletion of Ajuba led to apparent delays in the cell cycle, accompanied with increased Rb phosphorylation, Chk1 phosphorylation, induction of p53, and cell death. Ajuba could be found in a complex with …

Cobweb Theorems With Production Lags And Price Forecasting, Daniel Dufresne, Felisa Vázquez-Abad

Publications and Research

The classical cobweb theorem is extended to include production lags and price forecasts. Price forecasting based on a longer period has a stabilizing effect on prices. Longer production lags do not necessarily lead to unstable prices; very long lags lead to cycles of constant amplitude. The classical cobweb requires elasticity of demand to be greater than that of supply; this is not necessarily the case in a more general setting. Random shocks are also considered.

Synergistic Inhibition Of Survival, Proliferation, And Migration Of U87 Cells With A Combination Of Ly341495 And Iressa, Zarina Yelskaya, Vangie Carrillo, Ewa Dubisz, Hira Gulzar, Devon Morgan, Shahana S. Mahajan

Publications and Research

Glioblastomas exploit various molecular pathways to promote glutamate-dependent growth by activating the AMPA (2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propanoic acid) receptor, the group II metabotropic glutamate receptor, mGluR, and the epidermal growth factor receptor, EGFR. We hypothesized that targeting more than one of these pathways would be more effective in inhibiting glutamate-dependent growth. Using a model of U87 cell line, we show that blocking glutamate release by Riluzole inhibits cell proliferation. Glutamate-dependent growth is effectively inhibited by a combination of Iressa, an inhibitor of EGFR activation and LY341495, a group II mGluR inhibitor. Treatment of U87 cells with a combination of Iressa and LY341495 …

The Era Of Open-Ended Dual Life, Hirosuke Hyodo

Publications and Research

Although missing in mainstream studies of American immigration in the post-1965 Act era, the volume of native Japanese living in the U.S. today (called the shin-issei) is three times that of the prewar Japanese-American community on the U.S. mainland. Their curious absence from the mainstream studies results from the traditionally entrenched frame, ‘immigrants’, that does not unfit their migrant patterns. This paper explores the shin-issei, portraying their characters in three parts: (1) akogare (‘longing or desire’) for the West grown in Japan in the late nineteenth century, (2) a statistical sketch of the shin-issei over the last several decades, and …

Impacts Of Soil-Acquifer Heat And Water Fluxes On Simulated Global Climate, Nir Krakauer, M. J. Puma, B. I. Cook

Publications and Research

Climate models have traditionally only represented heat and water fluxes within relatively shallow soil layers, but there is increasing interest in the possible role of heat and water exchanges with the deeper subsurface. Here, we integrate an idealized 50m deep aquifer into the land surface module of the GISS ModelE general circulation model to test the influence of aquifer-soil moisture and heat exchanges on climate variables. We evaluate the impact on the modeled climate of aquifer-soil heat and water fluxes separately, as well as in combination. The addition of the aquifer to ModelE has limited impact on annual-mean climate, with …

Crime Drop Ii – Young People Are Leading The Newest Violent Crime Decline, Jeffrey A. Butts

Publications and Research

FBI crime data show that young people contributed a large share to the declining rate of violent crime in the United States. By 2011, the youth violent crime rate had dropped 60 percent since its peak in 1994. The databit shows the rate of violent crime between 1994-2004 and 2006-2011 for youth under age 18, 18-24, and 25 and older.

Seroprevalence Of Epstein-Barr Virus Infection In U.S. Children Ages 6-19, 2003-2010, Jennifer Beam Dowd, Tia Palermo, Jennifer Brite, Thomas W. Mcdade, Allison Aiello

Publications and Research

Background Epstein-Barr virus (EBV) is a common herpesvirus linked to infectious mononucleosis and multiple cancers. There are no national estimates of EBV seroprevalence in the United States. Our objective was to estimate the overall prevalence and sociodemographic predictors of EBV among U.S. children and adolescents aged 6–19. Methods We calculated prevalence estimates and prevalence ratios for EBV seroprevalence using data from the 2003–2010 U.S. National Health and Nutrition Examination Survey (NHANES) for children aged 6–19 (n = 8417). Poisson regression was used to calculate multivariable-adjusted prevalence ratios across subgroup categories (sex, race/ethnicity, parental education, household income, household size, foreign-born, BMI, …

Effects Of Localized Trap-States And Corrugation On Charge Transport In Graphene Nanoribbons, Oleksiy Roslyak, Upali Aparajita, Godfrey Gumbs, Danhong Huang

Publications and Research

We investigate effects of the electron traps on adiabatic charge transport in graphene nanoribbons under a longitudinal surface acoustic wave (SAW) potential. Due to the weak SAW potential and strong transverse confinement of nanoribbons, minibands of sliding tunnel-coupled quantum dots are formed. Therefore, as the chemical potential passes through minigaps, quantized adiabatic charge transport is expected to occur. We analyze the condition for a closed minigap, thereby destroying the current quantization in a nanoribbon. We present numerical calculations showing the localized energy states within minigaps. Additionally, we compare the results with the minibands of corrugated nanoribbons.

Capital Accumulation With And Without Land Market Liberalization: Beyond The “Win-Win” Situation, George Vachadze

Publications and Research

This paper examines the effect of land market liberalization on the dynamics of capital accumulation. It is shown that the land market liberalization, which is accompanied with the transfer of agricultural technology, may not always offer a “win‐win” outcome for developed and developing countries. Improved agricultural productivity generates a growth enhancing externality. However, land market liberalization affects the balance between the equalizing force of the diminishing returns technology and the un‐equalizing force of the low income elasticity of the agricultural commodity demand. As a result, land market liberalization accompanied with the transfer of agricultural productivity, may not always guarantee a …

Energy Economics And Policy, Zhan-Ming Chen, Bin Chen, Han-Song Tang

Publications and Research

No abstract provided.

Flurbiprofen Benzyl Nitrate (Nbs-242) Inhibits The Growth Of A-431 Human Epidermoid Carcinoma Cells And Targets Β-Catenin, Niharika Nath, Xiaoping Liu, Lloydine Jacobs, Khosrow Kashfi

Publications and Research

Background: The Wnt/β-catenin/T cell factor (TCF) signaling pathway is important in the development of nonmelanoma skin cancers (NMSCs). Nitric-oxide-releasing nonsteroidal anti-inflammatory drugs (NO-NSAIDs) are chemopreventive agents consisting of a traditional NSAID attached to an NO-releasing moiety through a chemical spacer. Previously we showed that an aromatic spacer enhanced the potency of a particular NO-NSAID compared to an aliphatic spacer.

Methods: We synthesized an NO-releasing NSAID with an aromatic spacer (flurbiprofen benzyl nitrate, NBS-242), and using the human skin cancer cell line A-431, we evaluated its effects on cell kinetics, Wnt/β-catenin, cyclin D1, and caspase-3.

Results: NBS-242 inhibited the growth of …

An Improved Clearing And Mounting Solution To Replace Chloral Hydrate In Microscopic Applications1, Thomas S. Villani, Adolfina R. Koroch, James E. Simon

Publications and Research

• Premise of the study: This study presents Visikol™, a new proprietary formulation that can be used as an efficient replacement for chloral hydrate as a clearing agent for microscopic examination. In the United States, chloral hydrate is regulated and therefore difficult to acquire. • Methods and Results: Fresh and dry samples of the following plants: ginger (Zingiber officinale), maté (Ilex paraguariensis), lime basil (Ocimum americanum), oregano (Origanum vulgare), and mouse-ear cress (Arabidopsis thaliana), were cleared using Visikol or chloral hydrate solution and compared using a light microscope. • Conclusions: This new method can be used successfully to clear specimens, …

Dating Human Cultural Capacity Using Phylogenetic Principles, J. Lind, P. Lindenfors, S. Ghirlanda, K. Lidén, M. Enquist

Publications and Research

Humans have genetically based unique abilities making complex culture possible; an assemblage of traits which we term “cultural capacity”. The age of this capacity has for long been subject to controversy. We apply phylogenetic principles to date this capacity, integrating evidence from archaeology, genetics, paleoanthropology, and linguistics. We show that cultural capacity is older than the first split in the modern human lineage, and at least 170,000 years old, based on data on hyoid bone morphology, FOXP2 alleles, agreement between genetic and language trees, fire use, burials, and the early appearance of tools comparable to those of modern hunter-gatherers. We …

Origins Of Power-Law Degree Distribution In The Heterogeneity Of Human Activity In Social Networks, Lev Muchnik, Sen Pei, Lucas C. Parra, Saulo D. S. Reis, José S. Andrade Jr, Shlomo Havlin, Hernán A. Makse

Publications and Research

The probability distribution of number of ties of an individual in a social network follows a scale-free power-law. However, how this distribution arises has not been conclusively demonstrated in direct analyses of people's actions in social networks. Here, we perform a causal inference analysis and find an underlying cause for this phenomenon. Our analysis indicates that heavy-tailed degree distribution is causally determined by similarly skewed distribution of human activity. Specifically, the degree of an individual is entirely random - following a “maximum entropy attachment” model - except for its mean value which depends deterministically on the volume of the users' …

Trends In Citations To Books On Epidemiological And Statistical Methods In The Biomedical Literature, Miquel Porta, Jan P. Vandenbroucke, John P. A. Ioannidis, Sergio Sanz, Esteve Fernandez, Raj Bhopal, Alfredo Morabia, Cesar Victora, Tomàs Lopez

Publications and Research

Background There are no analyses of citations to books on epidemiological and statistical methods in the biomedical literature. Such analyses may shed light on how concepts and methods changed while biomedical research evolved. Our aim was to analyze the number and time trends of citations received from biomedical articles by books on epidemiological and statistical methods, and related disciplines. Methods and Findings The data source was the Web of Science. The study books were published between 1957 and 2010. The first year of publication of the citing articles was 1945. We identified 125 books that received at least 25 citations. …

Habitat And Host Indicate Lineage Identity In Colletotrichum Gloeosporioides S.L. From Wild And Agricultural Landscapes In North America, Vinson P. Doyle, Peter V. Oudemans, Stephen A. Rehner, Amy Litt

Publications and Research

Understanding the factors that drive the evolution of pathogenic fungi is central to revealing the mechanisms of virulence and host preference, as well as developing effective disease control measures. Prerequisite to these pursuits is the accurate delimitation of species boundaries. Colletotrichum gloeosporioides s.l. is a species complex of plant pathogens and endophytic fungi for which reliable species recognition has only recently become possible through a multi-locus phylogenetic approach. By adopting an intensive regional sampling strategy encompassing multiple hosts within and beyond agricultural zones associated with cranberry (Vaccinium macrocarpon Aiton), we have integrated North America strains of Colletotrichum gloeosporioides s.l. from …

Burden Of Disease From Toxic Waste Sites In India, Indonesia, And The Philippines In 2010, Kevin Chatham-Stephens, Jack Caravanos, Bret Ericson, Jennifer Sunga-Amparo, Budi Susilorini, Promila Sharma, Philip J. Landrigan, Richard Fuller

Publications and Research

Background: Prior calculations of the burden of disease from toxic exposures have not included estimates of the burden from toxic waste sites due to the absence of exposure data. Objective: We developed a disability-adjusted life year (DALY)-based estimate of the disease burden attributable to toxic waste sites. We focused on three low- and middle-income countries (LMICs): India, Indonesia, and the Philippines. Methods: Sites were identified through the Blacksmith Institute’s Toxic Sites Identification Program, a global effort to identify waste sites in LMICs. At least one of eight toxic chemicals was sampled in environmental media at each site, and the population …

Flying Off The Shelf: E-Books Go Mobile, Madeline Cohen, Stefanie Havelka, Jennifer Poggiali, Kate Lyons, Elisabeth Tappeiner

Publications and Research

On May 3, 2013, the two Hostos librarians teamed up with two librarians of Lehman College’s Leonard Lief Library at the Bronx EdTech Showcase to address the challenges and joys of e-books. Their hour-long presentation, focused on trends in ebooks, technical issues such as DRM and formats, CUNY’s eBook collections, and the challenges of informing students and faculty about e-books.

Stepwise Acquisition Of Vocal Combinatorial Capacity In Songbirds And Human Infants, Dina Lipkind, Gary F. Marcus, Douglas Bemis, Kazutoshi Sasahara, Nori Jacoby, Miki Takahashi, Kenta Suzuki, Olga Feher, Primoz Ravbar, Kazuo Okanoya, Ofer Tchernichovski

Publications and Research

Human language, as well as birdsong, relies on the ability to arrange vocal elements in novel sequences. However, little is known about the ontogenetic origin of this capacity. We tracked the development of vocal combinatorial capacity in three species of vocal learners, combining an experimental approach in zebra finches with an analysis of natural development of vocal transitions in Bengalese finches and pre-lingual human infants and found a common, stepwise pattern of acquiring vocal transitions across species. In our first study, juvenile zebra finches were trained to perform one song and then the training target was altered, prompting the birds …

Robust Training Attenuates Tbi-Induced Deficits In Reference And Working Memory On The Radial 8-Arm Maze, Veronica Sebastian, Aissatou Diallo, Douglas S. F. Ling, Peter A. Serrano

Publications and Research

Globally, it is estimated that nearly 10 million people sustain severe brain injuries leading to hospitalization and/or death every year. Amongst survivors, traumatic brain injury (TBI) results in a wide variety of physical, emotional and cognitive deficits. The most common cognitive deficit associated with TBI is memory loss, involving impairments in spatial reference and working memory. However, the majority of research thus far has characterized the deficits associated with TBI on either reference or working memory systems separately, without investigating how they interact within a single task. Thus, we examined the effects of TBI on short-term working and long-term reference …

Massacre In Central Burma: Muslim Students Terrorized And Killed In Meiktila, Richard Sollom, Holly G. Atkinson

Publications and Research

This report details the results of a Physicians for Human Rights (PHR) investigation into the March 20 and 21, 2013, attacks on Muslim students, teachers, and residents in the Mingalar Zayyone quarter of Meiktila, a small town in central Burma.

A two-person team, the authors of the report, from PHR conducted 33 interviews about the attacks, which resulted in the deaths of at least 20 children and four teachers. The report details the attacks by the Buddhist mobs, provides evidence that local police officers were complicit in the crimes, and lists policy recommendations for the Burmese government and the international …

Comparison Of Sugar Content For Ionic Liquid Pretreated Douglas-Fir Woodchips And Forestry Residues, Aaron M. Socha, Samuel P. Plummer, Vitalie Stavila, Blake A. Simmons, Seema Singh

Publications and Research

Background The development of affordable woody biomass feedstocks represents a significant opportunity in the development of cellulosic biofuels. Primary woodchips produced by forest mills are considered an ideal feedstock, but the prices they command on the market are currently too expensive for biorefineries. In comparison, forestry residues represent a potential low-cost input but are considered a more challenging feedstock for sugar production due to complexities in composition and potential contamination arising from soil that may be present. We compare the sugar yields, changes in composition in Douglas-fir woodchips and forestry residues after pretreatment using ionic liquids and enzymatic saccharification in …