Digital Commons Network^™

Levoglucosan Indicates High Levels Of Biomass Burning Aerosols Over Oceans From The Arctic To Antarctic, Qi-Hou Hu, Zhou-Qing Xie, Xin-Ming Wang, Hui Kang, Pengfei Zhang

Publications and Research

Biomass burning is known to affect air quality, global carbon cycle, and climate. However, the extent to which biomass burning gases/aerosols are present on a global scale, especially in the marine atmosphere, is poorly understood. Here we report the molecular tracer levoglucosan concentrations in marine air from the Arctic Ocean through the North and South Pacific Ocean to Antarctica during burning season. Levoglucosan was found to be present in all regions at ng/m3 levels with the highest atmospheric loadings present in the mid-latitudes (30°–60° N and S), intermediate loadings in the Arctic, and lowest loadings in the Antarctic and equatorial …

Project Safe Flight: Making New York Safe For Migratory Birds, Kaitlyn L. Parkins, Susan B. Elbin Ph.D., Adriana Palmer, Darren Klein, Elle Barnes

Publications and Research

More than 100 species of migratory birds pass through New York City during spring and fall migrations. Located at the nexus of several migratory routes, New York City’s tall buildings and reflective glass pose a serious threat to over 100 species of migratory birds. Since 1997, NYC Audubon has led Project Safe Flight (PSF), a volunteer-based citizen-science project, with the goal of monitoring and mitigating bird collisions. We examined 16 years of PSF data, during which volunteers collected over 6,000 birds of 126 different species. The top two species, White-throated Sparrow and Common Yellowthroat, make up 23% of all collisions. …

Can Enlightenment Be Traced To Specific Neural Correlates, Cognition, Or Behavior? No, And (A Qualified) Yes, Jake H. Davis, David R. Vago

Publications and Research

The field of contemplative science is rapidly growing and integrating into the basic neurosciences, psychology, clinical sciences, and society-at-large. Yet the majority of current research in the contemplative sciences has been divorced from the soteriological context from which these meditative practices originate and has focused instead on clinical applications with goals of stress reduction and psychotherapeutic health. In the existing research on health outcomes of mindfulness-based clinical interventions, for example, there have been almost no attempts to scientifically investigate the goal of enlightenment. This is a serious oversight, given that such profound transformation across ethical, perceptual, emotional, and cognitive domains …

0112+1703_Nir_Gnirs, Michael C. Liu

Publications and Research

No abstract provided.

On The Gauge-Invariant Functional Measure For Gauge Fields On Cp^2, V. Parameswaran Nair

Publications and Research

We introduce a general parametrization for nonabelian gauge fields on the four-dimensional space CP^2. The volume element for the gauge-orbit space or the space of physical configurations is then investigated. The leading divergence in this volume element is obtained in terms of a higher dimensional Wess-Zumino-Witten action, which has previously been studied in the context of Kahler-Chern-Simons theories. This term, it is argued, implies that one needs to introduce a dimensional parameter to specify the integration measure, a step which is a nonperturbative version of the well-known dimensional transmutation in four-dimensional gauge theories.

Brooklyn's Waterfront As A Living Laboratory, Anne E. Leonard

Publications and Research

Fellows in the college’s Living Lab seminar develop general education learning outcomes using high-impact learning practices, especially place-based learning. Capitalizing on City Tech’s greatest asset, proximity to Brooklyn’s historic post-industrial waterfront, fellows participate in a walking tour, enhanced by a mobile website on the OpenLab. As this activity is integrated into coursework, students use the site to assess their learning.

Factors Associated With Smoking Among Adolescent Males Prior To Incarceration And After Release From Jail: A Longitudinal Study, Megha Ramaswamy, Babalola Faseru, Karen L. Cropsey, Marvia Jones, Karisa Deculus, Nicholas Freudenberg

Publications and Research

Background The prevalence of cigarette smoking among incarcerated adult men and women is three-four times higher than in the general population, ranging from 70-80%. However, little is known about factors associated with smoking among incarcerated adolescents, especially upon their re-entry into communities after release from jail. The current study explores factors associated with smoking among adolescent males prior to incarceration and one year after their release from jail. Methods We conducted a secondary data analysis of the Returning Educated African-American and Latino Men to Enriched Neighborhoods (REAL MEN) study, which was designed to reduce HIV risk, substance use, and recidivism …

"'Jackin’ For Beats'": Djing For Citation Critique, Todd Craig

Publications and Research

A challenge in teaching English composition is helping students envision plagiarism as “borrowing” – showing love to author(s) and/or text(s) that further their argument(s), versus “stealing” – biting someone’s style and words. Alastair Pennycook (1996) and Sarah Wakefield (2006) have contributed pieces to the elaborate plagiarism/citation puzzle, while Houston Baker situated the hip-hop DJ in seminal text Black Studies, Rap and the Academy (1993). Merging these moments introduces critical questions: Did Diddy invent “the remix” or become the illest beat-biter ever? How did DJ/Producers Pete Rock and Large Professor pay homage to previous musical genres to further hip-hop remix production …

Structure–Activity Relationships And Molecular Modeling Of Sphingosine Kinase Inhibitors, Dong Jae Baek, Neil Macritchie, Nahoum G. Anthony, Simon P. Mackay, Susan Pyne, Nigel J. Pyne, Robert Bittman

Publications and Research

The design, synthesis, and evaluation of the potency of new isoform-selective inhibitors of sphingosine kinases 1 and 2 (SK1 and SK2), the enzyme that catalyzes the phosphorylation of d-erythro-sphingosine to produce the key signaling lipid, sphingosine 1-phosphate, are described. Recently, we reported that 1-(4-octylphenethyl)piperidin-4-ol (RB-005) is a selective inhibitor of SK1. Here we report the synthesis of 43 new analogues of RB-005, in which the lipophilic tail, polar headgroup, and linker region were modified to extend the structure–activity relationship profile for this lead compound, which we explain using modeling studies with the recently published crystal structure of SK1. We provide …

An Apparent Angular Unconformity In Western Connecticut, Stanley Schleifer, Nazrul I. Khandaker, Adisa Charles, Hernando Martinez, Shirley Jackson, Chiemeka Ihebom

Publications and Research

The recent extension, to the north, of the U. S. Route 7 ‘superhighway’ in the town of Brookfield, Connecticut has involved the excavation of crystalline bedrock of lower Paleozoic to upper Proterozoic age in the area. The road cuts produced by this excavation have exposed some interesting features of structure and lithology. An outcrop, observed by the authors off the east side of route 7, at grid coordinates 41.482444 N, 73.415307 W is of particular interest. It appears, to the casual observer to be an angular unconformity. Maps and publications regarding this area of Western Connecticut support the likelihood of …

Cardiovascular Disease Hospitalizations In Relation To Exposure To The September 11, 2001 World Trade Center Disaster And Posttraumatic Stress Disorder, Hannah T. Jordan, Steven D. Stellman, Alfredo Morabia, Sara A. Miller‐Archie, Howard Alper, Zoey Laskaris, Robert M. Brackbill, James E. Cone

Publications and Research

Background A cohort study found that 9/11‐related environmental exposures and posttraumatic stress disorder increased self‐reported cardiovascular disease risk. We attempted to replicate these findings using objectively defined cardiovascular disease hospitalizations in the same cohort. Methods and Results Data for adult World Trade Center Health Registry enrollees residing in New York State on enrollment and no cardiovascular disease history (n=46 346) were linked to a New York State hospital discharge–reporting system. Follow‐up began at Registry enrollment (2003–2004) and ended at the first cerebrovascular or heart disease (HD) hospitalization, death, or December 31, 2010, whichever was earliest. We used proportional hazards models …

Acute Physiological Stress Promotes Clustering Of Synaptic Markers And Alters Spine Morphology In The Hippocampus, Veronica Sebastian, Jim Brian Estil, Daniel Chen, Lisa M. Schrott, Peter A. Serrano

Publications and Research

GluA2-containing AMPA receptors and their association with protein kinase M zeta (PKMζ) and post-synaptic density-95 (PSD-95) are important for learning, memory and synaptic plasticity processes. Here we investigated these synaptic markers in the context of an acute 1h platform stress, which can disrupt spatial memory retrieval for a short-term memory on the object placement task and long-term memory retrieval on a well-learned radial arm maze task. Acute stress increased serum corticosterone and elevated the expression of synaptic PKMζ while decreasing synaptic GluA2. Using co-immunoprecipitation, we found that this stressor promotes the clustering of GluA2, PKMζ and PSD-95, which is consistent …

Effects Of Weak Transcranial Alternating Current Stimulation On Brain Activity—A Review Of Known Mechanisms From Animal Studies, Davide Reato, Asif Rahman, Marom Bikson, Lucas C. Parra

Publications and Research

Rhythmic neuronal activity is ubiquitous in the human brain. These rhythms originate from a variety of different network mechanisms, which give rise to a wide-ranging spectrum of oscillation frequencies. In the last few years an increasing number of clinical research studies have explored transcranial alternating current stimulation (tACS) with weak current as a tool for affecting brain function. The premise of these interventions is that tACS will interact with ongoing brain oscillations. However, the exact mechanisms by which weak currents could affect neuronal oscillations at different frequency bands are not well known and this, in turn, limits the rational optimization …

From Information Literacy To Mobile Literacy: Supporting Students’ Research And Information Needs In A Mobile World, Stefanie Havelka

Publications and Research

Presentation slides from a workshop at European Conference on Information Literacy, Istanbul, Turkey.

Ethical Issues In Knowledge Management: Conflict Of Knowledge Ownership, Isabel D. W. Rechberg, Jawad Syed

Publications and Research

Purpose: This paper reviews ethical issues inherent in the theorisation and practice of knowledge management (KM) with specific attention to the conflict of knowledge ownership between organisations and individual employees.

Design/methodology/approach: Relevant literature was identified and reviewed via EBSCO host and ISIWeb.

Findings: The paper notes that knowledge, although rooted in individuals, is often claimed or treated as owned by organisations, creating a conflict of knowledge ownership. The paper argues that such an approach to appropriation and management of knowledge leads to tension in knowledge processes between organisations and individuals, and also among individuals. This situation may, in turn, jeopardise …

Origins Of Specificity During Tdcs: Anatomical, Activity-Selective, And Input-Bias Mechanisms, Marom Bikson, Asif Rahman

Publications and Research

Transcranial Direct Current Stimulation (tDCS) is investigated for a broad range of neuropsychiatric indications, various rehabilitation applications, and to modulate cognitive performance in diverse tasks. Specificity of tDCS refers broadly to the ability of tDCS to produce precise, as opposed to diffuse, changes in brain function. Practically, specificity of tDCS implies application-specific customization of protocols to maximize desired outcomes and minimize undesired effects. Especially given the simplicity of tDCS and the complexity of brain function, understanding the mechanisms leading to specificity is fundamental to the rational advancement of tDCS. We define the origins of specificity based on anatomical and functional …

Ih Tunes Theta/Gamma Oscillations And Cross-Frequency Coupling In An In Silico Ca3 Model, Samuel A. Neymotin, Markus M. Hilscher, Thiago C. Moulin, Yosef Skolnick, Maciej T. Lazarewicz, William W. Lytton

Publications and Research

channels are uniquely positioned to act as neuromodulatory control points for tuning hippocampal theta (4–12 Hz) and gamma (25 Hz) oscillations, oscillations which are thought to have importance for organization of information flow. contributes to neuronal membrane resonance and resting membrane potential, and is modulated by second messengers. We investigated oscillatory control using a multiscale computer model of hippocampal CA3, where each cell class (pyramidal, basket, and oriens-lacunosum moleculare cells), contained type-appropriate isoforms of . Our model demonstrated that modulation of pyramidal and basket allows tuning theta and gamma oscillation frequency and amplitude. Pyramidal also controlled cross-frequency coupling (CFC) and …

A New Look At The Dynamic Similarity Hypothesis: The Importance Of Swing Phase, David A. Raichlen, Herman Pontzer, Liza J. Shapiro

Publications and Research

Summary The Dynamic Similarity Hypothesis (DSH) suggests that when animals of different size walk at similar Froude numbers (equal ratios of inertial and gravitational forces) they will use similar size-corrected gaits. This application of similarity theory to animal biomechanics has contributed to fundamental insights in the mechanics and evolution of a diverse set of locomotor systems. However, despite its popularity, many mammals fail to walk with dynamically similar stride lengths, a key element of gait that determines spontaneous speed and energy costs. Here, we show that the applicability of the DSH is dependent on the inertial forces examined. In general, …

Endogenous Human Mdm2-C Is Highly Expressed In Human Cancers And Functions As A P53-Independent Growth Activator, Danielle R. Okoro, Nicoleta Arva, Chong Gao, Alla Polotskaia, Cindy Puente, Melissa Rosso, Jill Bargonetti

Publications and Research

Human cancers over-expressing mdm2, through a T to G variation at a single nucleotide polymorphism at position 309 (mdm2 SNP309), have functionally inactivated p53 that is not effectively degraded. They also have high expression of the alternatively spliced transcript, mdm2-C. Alternatively spliced mdm2 transcripts are expressed in many forms of human cancer and when they are exogenously expressed they transform human cells. However no study to date has detected endogenous MDM2 protein isoforms. Studies with exogenous expression of splice variants have been carried out with mdm2-A and mdm2-B, but the mdm2-C isoform has remained virtually unexplored. We addressed the cellular …

Antibacterial Mechanisms Identified Through Structural Systems Pharmacology, Roger L. Chang, Lei Xie, Philip E. Bourne, Bernhard O. Palsson

Publications and Research

Background The growing discipline of structural systems pharmacology is applied prospectively in this study to predict pharmacological outcomes of antibacterial compounds in Escherichia coli K12. This work builds upon previously established methods for structural prediction of ligand binding pockets on protein molecules and utilizes and expands upon the previously developed genome scale model of metabolism integrated with protein structures (GEM-PRO) for E. coli, structurally accounting for protein complexes. Carefully selected case studies are demonstrated to display the potential for this structural systems pharmacology framework in discovery and development of antibacterial compounds. Results The prediction framework for antibacterial activity of compounds …

Inter- And Intra-Specific Pan-Genomes Of Borrelia Burgdorferi Sensu Lato: Genome Stability And Adaptive Radiation, Emmanuel F. Mongodin, Sherwood R. Casjens, John F. Bruno, Yun Xu, Elliott Franco Drabek, David R. Riley, Brandi L. Cantarel, Pedro E. Pagan, Yozen A. Hernandez, Levy C. Vargas, John J. Dunn, Steven E. Schutzer, Claire M. Fraser, Wei-Gang Qiu, Benjamin J. Luft

Publications and Research

Background Lyme disease is caused by spirochete bacteria from the Borrelia burgdorferi sensu lato (B. burgdorferi s.l.) species complex. To reconstruct the evolution of B. burgdorferi s.l. and identify the genomic basis of its human virulence, we compared the genomes of 23 B. burgdorferi s.l. isolates from Europe and the United States, including B. burgdorferi sensu stricto (B. burgdorferi s.s., 14 isolates), B. afzelii (2), B. garinii (2), B. “bavariensis” (1), B. spielmanii (1), B. valaisiana (1), B. bissettii (1), and B. “finlandensis” (1). Results Robust B. burgdorferi s.s. and B. burgdorferi s.l. phylogenies were obtained using genome-wide single-nucleotide polymorphisms, …

Master Talk: Assessing The Crime Decline: Did Bids Play A Role?, Jeremy Travis

Publications and Research

No abstract provided.

A Qualitative Study Of Community Home-Based Care And Antiretroviral Adherence In Swaziland, Robin Root, Alan Whiteside

Publications and Research

Introduction Antiretroviral therapy (ART) has rendered HIV and AIDS a chronic condition for individuals in many parts of the world. Adherence, however, is integral to achieving chronicity. Studies have shown both relatively high ART adherence rates in sub-Saharan Africa and the importance of community home-based care (CHBC) to facilitating this process. In light of diminished HIV and AIDS funding globally and increased reliance on CHBC throughout Africa, a better understanding of how CHBC may strengthen ART adherence is essential to improving patients’ quality of life, tending to the needs of care supporters and achieving healthier populations. Methods This article reports …

Anxiety And Error Monitoring: The Importance Of Motivation And Emotion, Greg H. Proudfit, Michael Inzlicht, Douglas S. Mennin

Publications and Research

No abstract provided.

Are Characiform Fishes Gondwanan In Origin? Insights From A Time-Scaled Molecular Phylogeny Of The Citharinoidei (Ostariophysi: Characiformes), Jairo Arroyave, John S. S. Denton, Melanie L. J. Stiassny

Publications and Research

Fishes of the order Characiformes are a diverse and economically important teleost clade whose extant members are found exclusively in African and Neotropical freshwaters. Although their transatlantic distribution has been primarily attributed to the Early Cretaceous fragmentation of western Gondwana, vicariance has not been tested with temporal information beyond that contained in their fragmentary fossil record and a recent time-scaled phylogeny focused on the African family Alestidae. Because members of the suborder Citharinoidei constitute the sister lineage to the entire remaining Afro-Neotropical characiform radiation, we inferred a time-calibrated molecular phylogeny of citharinoids using a popular Bayesian approach to molecular dating …

Cervicothoracic Multisegmental Transpinal Evoked Potentials In Humans, Jonathan Einhorn, Alan Li, Royi Hazan, Maria Knikou

Publications and Research

The objectives of this study were to establish the neurophysiological properties of the transpinal evoked potentials (TEPs) following transcutaneous electric stimulation of the spine (tsESS) over the cervicothoracic region, changes in the amplitude of the TEPs preceded by median nerve stimulation at group I threshold, and the effects of tsESS on the flexor carpi radialis (FCR) H-reflex in thirteen healthy human subjects while seated. Two re-usable self-adhering electrodes, connected to function as one electrode (cathode), were placed bilaterally on the clavicles. A re-usable electrode (anode) was placed on the cervicothoracic region covering from Cervical 4 – Thoracic 2 and held …

How I Teach Gender In History (Of Technology), Geoff Zylstra

Publications and Research

No abstract provided.

Predicting The Behavioral Impact Of Transcranial Direct Current Stimulation: Issues And Limitations, Archy O. De Berker, Marom Bikson, Sven Bestmann

Publications and Research

The transcranial application of weak currents to the human brain has enjoyed a decade of widespread use, providing a simple and powerful tool for non-invasively altering human brain function. However, our understanding of current delivery and its impact upon neural circuitry leaves much to be desired. We argue that the credibility of conclusions drawn with transcranial direct current stimulation (tDCS) is contingent upon realistic explanations of how tDCS works, and that our present understanding of tDCS limits the technique’s use to localize function in the human brain. We outline two central issues where progress is required: the localization of currents, …

Violent Youth Crime In U.S. Falls To New 32-Year Low, Jeffrey A. Butts

Publications and Research

FBI crime data shows a decline in violent youth crimes between 2011 and 2012, reaching a new 32-year-low. Violent youth crimes reached a new low every year between 2009 and 2012. This databit shows the rate of violent youth crimes based on crime offense between 1980 and 2012.

Transposable Element Evolution In Heliconius Suggests Genome Diversity Within Lepidoptera, Christine A. Lavoie, Roy N. Platt, Peter A. Novick, Brian A. Counterman, David A. Ray

Publications and Research

Background Transposable elements (TEs) have the potential to impact genome structure, function and evolution in profound ways. In order to understand the contribution of transposable elements (TEs) to Heliconius melpomene, we queried the H. melpomene draft sequence to identify repetitive sequences. Results We determined that TEs comprise ~25% of the genome. The predominant class of TEs (~12% of the genome) was the non-long terminal repeat (non-LTR) retrotransposons, including a novel SINE family. However, this was only slightly higher than content derived from DNA transposons, which are diverse, with several families having mobilized in the recent past. Compared to the only …