Digital Commons Network^™

Pyronaridine Exerts Potent Cytotoxicity On Human Breast And Hematological Cancer Cells Through Induction Of Apoptosis, Paulina J. Villanueva, Alberto Martinez, Sarah T. Baca, Rebecca E. Dejesus, Manuel Larragoity, Lisett Contreras, Denisse A. Gutierrez, Armando Varela-Ramirez, Renato J. Aguilera

Publications and Research

The potent antimalarial drug pyronaridine (PND) was tested for its potential as an anticancer drug. After exposing cancerous (17) and non-cancerous (2) cells to PND for 72 hr, PND was found to exhibit consistent and potent cytotoxic activity at low micromolar (μM) concentrations that ranged from 1.6 μM to 9.4 μM. Moreover, PND exerted a significant selective cytotoxicity index (SCI) on five out of seven breast cancer cell lines tested, with favorable values of 2.5 to 4.4, as compared with the non-cancerous breast MCF-10A cell line. By using the same comparison, PND exhibited a significant SCI on three out of …

Microbial Diversity In Urban Environments: Concern For Antibiotic Resistance, Ality Aghedo, Mangala Tawde, Nazrul I. Khandaker

Publications and Research

We are almost oblivious to the presence of microorganisms in our daily lives, but they exist and come into contact with us all the time. While some bacteria are harmless, and even beneficial, other bacteria can cause infections. A common treatment to bacterial infections is antibiotics and the success of an antibiotic depends on the resistance of the bacteria to the antibiotic. We conducted experiments to identify the types of bacteria that can be found on surfaces or within soil environments that come into contact with a vast number of people on a daily basis and how this can affect …

An Overview Of Smartwater Management System: Strategic Potential In Bangladesh, Muhammad Qumrul Hassan, Mir F. Karim, Nazrul I. Khandaker, Jowaher Raza

Publications and Research

Water loss management is becoming an increasingly important as supplies are stressed by population growth or water scarcity. A SmartWater system ensures optimum consumption and prediction of future water use. Bangladesh is one of the most vulnerable countries due to global climate change considering its rapid urbanization, inequitable land use, low income and greater reliance on climate sensitive sectors, particularly agriculture. Agricultural lands used for cropping and livestock rearing are more susceptible to degradation than non-agricultural lands. Most farmers irrigate through flooding, losing up to 75% of water to evaporation and creating a substantial drawdown of much needed water for …

Water Flow Net Characterization By Using A Tank Model: Preliminary Outcome, Jasmin Budhan, Nazrul I. Khandaker, Stanley Schleifer

Publications and Research

A model study was conducted to observe and characterize the flow of water through sandy soil. One of the most relevant tools used for characterizing groundwater flow is the flow net. Assuming that water is incompressible and there is zero volume change in the soil mass, it is known that the total rate of inflow is to equal the total rate of outflow. Thus, following the principle of flow continuity, we use the Laplace equation of continuity, to observe the concept of the flow net. Computing the flow through a miniature channel, we observed the total head difference from the …

Nasa Maa (Murep Aerospace Academy) Stem Project At York College: Ensuring Future Stem Pipeline, Nazrul I. Khandaker, Shuayb Siddique, Matthew Khargie, Brandon Dhanraj, Zachary A. Sanichar, Mildred M. Selby, Chabenauth Ramnauth, Theresa Deepan, Yougeeta Singh, Krishna Mahabir, Sashi Singh, Omadevi Singh

Publications and Research

Our ongoing K1-12 NASA-supported STEM activities has served over 5000 children since 2015, largely from groups that are undeserved and underrepresented in the sciences. These STEM activities have been successfully delivered for several years and include earth science, meteorite geology, rocketry, aerodynamics, star gazing, EV3 Mindstorm robotics, basic coding exercises, wind tunnel, 3D-printing, etc., conducted largely through our present MAA (MUREP Aerospace Academy) Project. Corporate funding from the Con Edison and National Grid ensures additional STEM dissemination to the students during the summer operation. Significant positive component of the MAA program is the availability and willingness of the former student …

The Status Of Engineering Geology: Constraints On Infrastructure Development In Bangladesh, Mir Fazlul Karim, Muhammad Qumrul Hassan, Nazrul I. Khandaker, Masud Ahmed, Belal Ahmed Sayeed

Publications and Research

In recent years, megacity Dhaka is known to have one of the fastest urban population growths in Bangladesh. The population in Dhaka and other megacities has increased from 7 to 50 million during the last four decades. The rapid rate of urban population growth, along with the extreme paucity of real-estate for new infrastructure development or upgrading existing facilities, is already exacerbating the situation for the city planners and exerting tremendous pressure to come-up with viable solutions. Although practice of engineering geology, geotechnical exploration, and testing exists in Bangladesh; the system has still yet to adopt controlled quality standards with …

The Challenges Of Geotechnical Exploration In Bangladesh For Sustainable Urban Development And Risk Reductions In Engineering Geology, Mir Fazul Karim, Nazrul I. Khandaker, Muhammad Qumrul Hasson, A.T.M. Shakhawat Hossain

Publications and Research

Bangladesh is a unique example of rapid urbanization where the urban population increased from 5 to 58 million in last four decades. Due to complex geology and active tectonic setting, the urban ground is impacted by fluvio-deltaic processes and regional seismicity. The densely populated cities of the country are facing risks from many natural hazards like floods, tidal surge, riverbank and coastal erosion, scour, landslides, soil collapse and foundation failures. Geologists anticipate severe seismic threats from yet-undefined tectonic structures and seek to determine their consequential geo-structural responses and conformance to the national building code. With rapid growth, demands on infrastructure …

Recruiting And Retaining K9–16 Students Through Field- And Laboratory - Based Geoscience Experiences, Nazrul I. Khandaker, Stanley Schleifer, Arif M. Sikder, Krishna Mahabir, Ality Aghedo, Charren Cabaroy, Mildred M. Selby, Gugu Ginindza, Leonardo Sanchez

Publications and Research

Since 2004, we have been directly involved with the GSA to provide access and opportunities for K9-16 students, particularly those interested in the broader aspects of geoscience-related topics, to present their field-and- laboratory based research outcomes at professional conferences and to learn from each other. So far, well-over 400 students from the U. S. and abroad have taken advantage of this opportunity and participated our topical sessions. It is quite gratifying to report that many of these students, as a result of their attendance at the GSA conference, felt a continuing need for exposure to high-level professional venues with effective …

Lithologic Constraints On The Hydrological Parameters Of Regional Aquifers In The Ibb Province, West-Central Region Of Yemen (Middle East), Malek Shami, Zarine Ali, Wedad Abdurabu, Nazrul I. Khandaker, Stanley Schleifer

Publications and Research

The lithology of the Ibb Province Yemen (Middle East) consists of Precambrian gneissic bedrocks with post-tectonic intrusions of granite and granodiorite. The overall topography is dominated by extensive volcanic extrusions that randomly surround Ibb Province with minimal Mesozoic sedimentary outcrops. According to the Yemen Geological Survey and Mineral Resource Board (YGSMRB), the origin and age of such extrusive bodies that manifest on the surface as dikes, lava flows, and small (currently passive) cinder-cone volcanoes are of Cenozoic age associated with the rifting episode of the Arabian Peninsula and subsequent opening of the Red Sea. The overall aerial extension of the …

Writing To Learn: Embedding A Crucial Study Skill In A Gateway Science Course, Shylaja Akkaraju

Publications and Research

Handwriting is a multisensory process known to enhance memory, focus, engagement, and cognition in the learner, thereby making it a valuable study skill. In an attempt to embed handwriting as a study skill in a gateway science course, I used a combination of scaffolding and individual student consultations. Scaffolding emphasized the use of desirable difficulties and retrieval practice through the implementation of techniques such as the flipped learning approach and take home-in class hybrid essay exams. While the former helped to increase overall student success the latter technique was aimed at enhancing written fluency in the subject, curbing procrastination, and …

Effect Of Internet-Based Cognitive Behavioral Humanistic And Interpersonal Training Vs Internet-Based General Health Education On Adolescent Depression In Primary Care, Tracy R. G. Gladstone, Daniela A. Terrizzi, Allison Paulson, Jennifer Nidetz, Jason Canel, Eumene Ching, Anita D. Berry, James Cantorna, Joshua Fogel, Milton Eder, Megan Bolotin, Lauren O. Thomann, Kathy Griffiths, Patrick Ip, David A. Aaby, C. Hendricks Brown, William Beardslee, Carl Bell, Theodore J. Crawford, Marian Fitzgibbon, Linda Schiffer, Nina Liu, Monika Marko-Holguin, Benjamin W. Van Voorhees

Publications and Research

Importance: Although 13% to 20% of American adolescents experience a depressive episode annually, no scalable primary care model for adolescent depression prevention is currently available.

Objective: To study whether competent adulthood transition with cognitive behavioral humanistic and interpersonal training (CATCH-IT) lowers the hazard for depression in at-risk adolescents identified in primary care, as compared with a general health education (HE) attention control.

Design, Setting, and Participants: This multicenter, randomized clinical trial, a phase 3 single-blind study, compares CATCH-IT with HE. Participants were enrolled from 2012 to 2016 and assessed at 2, 6, 12, 18, and 24 months postrandomization in …

Visibly (Un)Just: The Optics Of Grand Jury Secrecy And Police Violence, Nicole Smith Futrell

Publications and Research

Police violence has become more visible to the public through racial justice activism and social justice advocates’ use of technology. Yet, the heightened visibility of policing has had limited impact on transparency and accountability in the legal process, particularly when a grand jury is empaneled to determine whether to issue an indictment in a case of police violence. When a grand jury decides not to indict, the requirement of grand jury secrecy prevents public disclosure of the testimony, witnesses, and evidence presented to the grand jury. Grand jury secrecy leaves those who have seen and experienced the act of police …

Politics, Eugenics, And Yeats’S Radio Broadcasts, Melissa Dinsman

Publications and Research

Much has been written about the right-wing politics and eugenicist sympathies of Yeats’s late-1930s poetry in general and about On the Boiler in particular. Yeats’s focus on Ireland’s degeneration and his calls for its regeneration through cultural (and even biological methods) coincided with his dalliance with the Irish Blueshirts and his frustrations with the transformations of the Irish Free State under Éamon de Valera. However, these years also proved to be Yeats’s most active in terms of radio broadcasting, with six of his nine broadcasts made between 1937 and 1938. In this essay, I read Yeats’s broadcasts, in particular “In …

Between Paralysis And Empowerment: Action In Mathematics For Social Justice Work, Lidia Gonzalez

Publications and Research

In this article, I focus on my experiences teaching a seminar in critical pedagogy and the math for social justice (MfSJ) work that grew from of my students’ reflections as to how they might promote change towards justice. The course was designed to acquaint students with the research literature in critical pedagogy as we explored the social, political, cultural, and economic realities around our system of public education. Yet there came a point where students questioned the value of such exploration as they genuinely considered what to do next. I, too, struggled both to support the students I was working …

The Ties That Bind: Cradling In Tajikistan, Lana B. Karasik, Catherine S. Tamis-Lemonda, Ori Ossmy, Karen E. Adolph

Publications and Research

A traditional childrearing practice—“gahvora” cradling—in Tajikistan and other parts of Central Asia purportedly restricts movement of infants’ body and limbs. However, the practice has been documented only informally in anecdotal reports. Thus, this study had two research questions: (1) To what extent are infants’ movements restricted in the gahvora? (2) How is time in the gahvora distributed over a 24-hour day in infants from 1–24 months of age? To answer these questions, we video-recorded 146 mothers cradling their infants and interviewed them using 24-hour time diaries to determine the distribution of time infants spent in the gahvora within a day …

How Songbirds Learn To Sing Provides Suggestions For Designing Team Projects For Computing Courses, Ashwin Satyanarayana, Radhika Natarajan, Lior Baron

Publications and Research

Understanding how our brain works and how we learn is perhaps one of the greatest challenges facing twenty-first computer science. Songbirds are good candidates for trying to unravel some of this mystery. Over the last decade, a large amount of research has been made to better understand how songbirds learn complex songs. The Canary (Serinus canaria) and the Zebra Finch (Taeniopygia guttata) have been widely used bird models to study these brain and behavior relationships. Like songbirds, we humans are vocal and social learners. In such learners, the development of communication is initially steered by social interactions with adult tutors. …

Responsible Use Of Materials For Oer: A Hands-On Workshop For Faculty, Madeline Cohen

Publications and Research

This lightening talk will give an overview of an active-learning workshop at Lehman College for faculty developing OER. The goals of the 90 minute workshop are to provide practical exercises through which faculty learn how to identify, provide attribution for, and reuse materials that are under copyright, open access (public domain) or under Creative Commons licenses. Research Guides and tutorials on copyright and Creative Commons have been provided to faculty, but the content can be difficult for the novice to absorb. In fact, faculty often think of copyright and Creative Commons as more confusing than they are in practice.Therefore, the …

Opting Out Is Not An Option: Why All Academic Librarians Must Understand Open Access, Jill Cirasella

Publications and Research

This presentation challenges the still-too-prevalent notion that scholarly communication competencies are essential only for scholarly communication librarians and optional for other academic librarians. It focuses on one competency in particular: a robust understanding of open access.

Postmortem Toxicology Of New Synthetic Opiods, Marta Concheiro, Rachel Chesser, Justine Pardi, Gail Cooper

Publications and Research

One hundred fifteen Americans die every day from opioid overdose. These overdose fatalities have been augmented by the increased availability of potent synthetic opioids, such as fentanyl and its derivatives. The death rate of synthetic opioids, other than methadone, increased by 72.2% from 2014 to 2015, and doubled from 2015 to 2016, situating the USA in the midst of an opioid overdose epidemic. The analytical identification of these opioids in postmortem samples and the correct toxicological data interpretation is critical to identify and implement preventive strategies. This article reviews the current knowledge of postmortem toxicology of synthetic opioids and the …

Impoved Hardware Design Of Iot Prosthetic Device, Yu Wang, Warren Hunter, Xiaolin Chen, Housney Ahmed, Haneefah Safo

Publications and Research

Our previous IoT based prosthetic arm prototype used servo motors to control finger movement through an Arduino Mega, which is connected to the muscle, pulse, and temperature sensors. The Arduino Mega was also connected to a Raspberry Pi 3 model B to transfer data from/to an online web application. One major limitation encountered during testing this prosthetic device was the space occupied by these components, which makes the device bulky. In addition, these servo motors cannot control the movement of the prosthetic device precisely. In this paper, we propose to improve on the existing prosthetic limb prototype by transitioning the …

Metacognition As A Tool For Engineering Technology Students, Melanie L. Villatoro, Claudia E. Hernandez Feiks, Chen Xu, Navid Allahverdi, Serdar Ozlek

Publications and Research

New York City College of Technology, “City Tech,” is the designated senior college of technology within the 24-unit City University of New York (CUNY). The college plays an important role nationally in the education of future scientists, engineers, technologists and mathematicians by offering a broad range of engineering technology majors. These majors have high enrollment annually; However, the one–year retention rates of freshman in the engineering technology associates degrees are typically 10-20% lower as compared to college wide one-year retention rates. One common reason for students changing majors or discontinuing their education after their first year is poor performance in …

Dreamers And Values: An Urban And Suburban Community College Comparison, David A. Caicedo

Publications and Research

Although previous research on the role of post-secondary education in the lives of undocumented youth has offered insight regarding demographics, educational achievement, measures of well-being, and generational trajectories, less is known about these young immigrants’ values and beliefs regarding themselves, their relation to others, their futures, and the potential influence of their social surroundings on these values. The intersecting perceptual beliefs between self and higher education were investigated among 7 Deferred Action for Childhood Arrivals (DACA) participants in 2 U.S. community colleges and were hypothesized to reflect two social environments: an urban (New York) and a suburban (New Jersey) setting. …

Engle-Friedman Studies Sleep And Sleep Deprivation, Aldemaro Romero Jr.

Publications and Research

“Clinical psychology is about helping people with specific issues. I have worked on insomnia. Probably the most effective treatments for insomnia are non-drug related. I have worked with behavioral methods, and they have now become a standard clinical practice.” That is how Dr. Mindy Engle-Friedman explains what her work is all about.

Manipulation Of Human Verticality Using High-Definition Transcranial Direct Current Stimulation, Taiza E. G. Santos, Diandra B. Favoretto, Iman Ghodratti Toostani, Diego C. Nascimento, Brunna P. Rimoli, Eduardo Bergonzoni, Tenysson Will Lemos, Dennis Quangvinh Truong, Alexandre C. B. Delbem, Bahador Makkiabadi, Renato Moraes, Francisco Louzada, Marom Bikson, Joao P. Leite, Dylan J. Edwards

Publications and Research

Background: Using conventional tDCS over the temporo-parietal junction (TPJ) we previously reported that it is possible to manipulate subjective visual vertical (SVV) and postural control. We also demonstrated that high-definition tDCS (HD-tDCS) can achieve substantially greater cortical stimulation focality than conventional tDCS. However, it is critical to establish dose-response effects using well-defined protocols with relevance to clinically meaningful applications.

Objective: To conduct three pilot studies investigating polarity and intensity-dependent effects of HD-tDCS over the right TPJ on behavioral and physiological outcome measures in healthy subjects. We additionally aimed to establish the feasibility, safety, and tolerability of this stimulation protocol.

Methods: …

Hominoid Intraspecific Cranial Variation Mirrors Neutral Genetic Diversity, Julia M. Zichello, Karen L. Baab, Kieran P. Mcnulty, Christopher J. Raxworthy, Michael E. Steiper

Publications and Research

Natural selection, developmental constraint, and plasticity have all been invoked as explanations for intraspecific cranial variation in humans and apes. However, global patterns of human cranial variation are congruent with patterns of genetic variation, demonstrating that population history has influenced cranial variation in humans. Here we show that this finding is not unique to Homo sapiens but is also broadly evident across extant ape species. Specifically, taxa that exhibit greater intraspecific cranial shape variation also exhibit greater genetic diversity at neutral autosomal loci. Thus, cranial shape variation within hominoid taxa reflects the population history of each species. Our results suggest …

The Intentional De-Cohesion In Deportability, Talha Issevenler

Publications and Research

A critical exploration of loss or decohesion of political agency in deportability.

Dual Inhibition Of Bcl-2/Bcl-Xl And Xpo1 Is Synthetically Lethal In Glioblastoma Model Systems, Enyuan Shang, Yiru Zhang, Chang Shu, Chiaki Tsuge Ishida, Elena Bianchetti, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin

Publications and Research

XPO1 has recently emerged as a viable treatment target for solid malignancies, including glioblastoma (GBM), the most common primary malignant brain tumor in adults. However, given that tumors become commonly resistant to single treatments, the identification of combination therapies is critical. Therefore, we tested the hypothesis that inhibition of anti-apoptotic Bcl-2 family members and XPO1 are synthetically lethal. To this purpose, two clinically validated drug compounds, the BH3-mimetic, ABT263, and the XPO1 inhibitor, Selinexor, were used in preclinical GBM model systems. Our results show that inhibition of XPO1 reduces cellular viability in glioblastoma cell cultures. Moreover, addition of ABT263 significantly …

Use Of And Disparities In Access To Adaptive Devices Among U.S. Adults With Age-Related Eye Diseases, Diane M. Gibson

Publications and Research

This paper examines adaptive device use among two samples of U.S. adults aged 40 years and older with agerelated macular degeneration, diabetic retinopathy, glaucoma or cataracts from the 2008 and 2016 waves of the nationally-representative cross-sectional National Health Interview Survey (n=2875 and n=6233 respectively). Individuals who replied affirmatively to the question, “do you use any adaptive devices such as telescopic or other prescriptive lenses, magnifiers, large print or talking materials, CCTV, white cane or guide dogs?” were defined as adaptive device users. Descriptive statistics and logistic regression models of adaptive device use were estimated. The main regression models used 2008 …

The Role Of Metrics In Food Policy: Lessons From A Decade Of Experience In New York City, Nicholas Freudenberg, Craig Willingham, Nevin Cohen

Publications and Research

In the last decade, New York City developed food policies designed to improve access to healthy food, reduce food insecurity, support community development, promote sustainable food systems, and improve conditions for food workers. Since 2012, the New York City Council has mandated the Mayor’s Office to prepare annual Food Metrics Reports to present data on selected food system indicators. This article uses these reports to assess how the metrics describe the city’s progress in implementing municipal food policies set in the last decade. Our analysis examines: (1) changes in the indicators that the city reports; (2) strengths and weaknesses of …

Republican Senators Believe A Little Green Extraterrestrial Woman, Not Dr. Christine Blasey Ford, Marleen S. Barr

Publications and Research

This is a humorous science fiction story about the Brett Kavanaugh Supreme Court nomination.