Digital Commons Network^™

Validity Evaluation Of The Genetics And Genomics In Nursing Practice Survey, Alexandra Plavskin, William E. Samuels, Kathleen A. Calzone

Publications and Research

Aim: To psychometrically test the Genetics and Genomics Nursing Practice Survey (GGNPS) for evidence of content, face and construct validity.

Design:This study was a secondary data analysis.

Method: Data collected from the Method for Introducing a New Competency into Nursing Practice (MINC) study were used to evaluate the GGNPS for evidence of construct validity via structural equation modelling and confirmatory factor analysis. Face validity was evaluated via feedback from practicing RNs without specific experience with or knowledge of genetics/genomics. Content validity was evaluated via content expert feedback and assessment of a content validity index.

Results: The thresholds …

Endothelial Iqgap1 Regulates Leukocyte Transmigration By Directing The Lbrc To The Site Of Diapedesis, David P. Sullivan, Prarthana J. Dalal, Fanny Jaulin, David B. Sacks, Geri Kreitzer, William A. Muller

Publications and Research

Transendothelial migration (TEM) of leukocytes across the endothelium is critical for inflammation. In the endothelium, TEM requires the coordination of membrane movements and cytoskeletal interactions, including, prominently, recruitment of the lateral border recycling compartment (LBRC). The scaffold protein IQGAP1 was recently identified in a screen for LBRC-interacting proteins. Knockdown of endothelial IQGAP1 disrupted the directed movement of the LBRC and substantially reduced leukocyte TEM. Expression of truncated IQGAP1 constructs demonstrated that the calponin homology domain is required for IQGAP1 localization to endothelial borders and that the IQ domain, on the same IQGAP1 polypeptide, is required for its function in TEM. …

Choline: Exploring The Growing Science On Its Benefits For Moms And Babies, Hunter W. Korsmo, Xinyin Jiang, Marie A. Caudill

Publications and Research

The importance of ensuring adequate choline intakes during pregnancy is increasingly recognized. Choline is critical for a number of physiological processes during the prenatal period with roles in membrane biosynthesis and tissue expansion, neurotransmission and brain development, and methyl group donation and gene expression. Studies in animals and humans have shown that supplementing the maternal diet with additional choline improves several pregnancy outcomes and protects against certain neural and metabolic insults. Most pregnant women in the U.S. are not achieving choline intake recommendations of 450 mg/day and would likely benefit from boosting their choline intakes through dietary and/or supplemental approaches.

Synthesis And Evaluations Of “1,4-Triazolyl Combretacoumarins” And Desmethoxy Analogs, Tashrique A. Khandaker, Jessica D. Hess, Renato Aguilera, Graciela Andrei, Robert Snoeck, Dominique Schols, Padmanava Pradhan, Mahesh K. Lakshman

Publications and Research

1,4-Triazolyl combretacoumarins have been prepared by linking the trimethoxyarene unit of combretastatin A4 with coumarins, via a 1,2,3-triazole. For this, 4-azidocoumarins were accessed by a sequential two-step, one-pot reaction of 4-hydroxycoumarins with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), followed by reaction with NaN₃. In the reaction with BOP, a coumarin-derived phosphonium ion intermediate seems to form, leading to an O⁴-(benzotriazolyl)coumarin derivative. For the CuAAC reaction of azidocoumarins with 5-ethynyl-1,2,3-trimethoxybenzene, catalytic [(MeCN)₄Cu]PF₆ in CH₂Cl₂/MeOH with 2,6-lutidine, at 50 ^oC, was suitable. The 4-azidocoumarins were less reactive as compared to PhN₃ and …

Top-Quark Pair Hadroproduction In Association With A Heavy Boson At Nlo+Nnll Including Ew Corrections, Alessandro Broggio, Andrea Ferroglia, Rikkert Frederix, Davide Pagani, Benjamin D. Pecjak, Ioannis Tsinikos

Publications and Research

This work studies the associated production of a top-quark pair with a W, Z, or Higgs boson at the LHC. Predictions for the total cross sections as well as for several differential distributions of the massive particles in the final state are provided. These predictions, valid for the LHC operating at 13 TeV, include without any approximation all the NLO electroweak and QCD contributions of O (α^sα^j+1) with i + j = 2, 3. In addition, the predictions presented here improve upon the NLO QCD results by adding the effects of soft gluon emission corrections resummed …

Trump Ships Out--Without Seeing The Ship, Marleen S. Barr

Publications and Research

This is a short story written in response to efforts to hide the U.S.S. John McCain from Trump when he visited Japan.

Nyssma Manual Revisited, Di Su

Publications and Research

The New York State School Music Association’s NYSSMA Manual is revised every three years. A new edition, the 33^rd, is expected in July 2021. Back in 2008 this author wrote a review article of the 28^th edition (2006). Since then, four revisions have been released and some changes have been made. This article, as a follow-up, reviews the Violin Solos section of the current edition, the 32^nd (2018).

After The Supreme Court Decision Relative To The Citizen Question In The Census: What Are The Options?, Alfredo Morabia

Publications and Research

No abstract provided.

Intervention Principles In Pediatric Health Care: The Difference Between Physicians And The State., D. Robert Macdougall

Publications and Research

According to various accounts, intervention in pediatric decisions is justified either by the best interests standard or by the harm principle. While these principles have various nuances that distinguish them from each other, they are similar in the sense that both focus primarily on the features of parental decisions that justify intervention, rather than on the competency or authority of the parties that intervene. Accounts of these principles effectively suggest that intervention in pediatric decision making is warranted for both physicians and the state under precisely the same circumstances. This essay argues that there are substantial differences in the competencies …

Free Information, Not Free Labor, Edward Lehner, John R. Ziegler

Publications and Research

The increased institutional demand for all faculty to publish scholarly work, even for faculty in non-research institutions, has created a near perfect two-sided market effect for commercial entities to profit from the labor of already overburdened academics while offering little-to-no compensation to these individuals or their institutions. As significant, institutional-level pushback against the cost of access to scholarly materials has begun to coalesce, it seems prudent if not pressing to revisit once more the longstanding debates over labor, cost, and access in scholarly publishing and to argue for more ethical, equitable, and democratizing models. To that end, this essay 1) …

Modular Interconnected Processes, Fluid Partnering, And Innovation Speed: A Loosely Coupled Systems Perspective On B2b Service Supply Chain Management, Chandan Acharya, Divesh Ojha, Pankaj C. Patel, Rahul Gokhale

Publications and Research

In this paper, we examine whether and how loosely coupled systems in service supply chains influence the speed of innovation in service organizations. Drawing upon the nomological network of loosely coupled systems, we propose a way for supply chains in the business to business (B2B) market context to be conceptualized as loosely coupled systems and explain how the dialectical elements of modularity at the interface of standard process and content interfaces (SPCI) and structured data connectivity (SDC) enable the sharing of high-quality information through fluid partnership in service supply chains to improve innovation speed. Results that are based on a …

Similar Muscular Adaptations In Resistance Training Performed Two Versus Three Days Per Week, Thiago Lasevicius, Brad Jon Schoenfeld, Jozo Grgic, Gilberto Laurentino, Lucas Duarte Tavares, Valmor Tricoli

Publications and Research

The purpose of the present study was to compare changes in muscle strength and hypertrophy between volume-equated resistance training (RT) performed 2 versus 3 times per week in trained men. Thirty-six resistance-trained men were randomly assigned to one of the two experimental groups: a split-body training routine (SPLIT) with muscle groups trained twice per week (n = 18) over four weekly sessions, or a total-body routine (TOTAL), with muscle groups being trained three times per week (n = 18) over three weekly sessions. The training intervention lasted 10 weeks. Testing was carried out pre- and post-study to assess maximal muscular …

Measuring Racial Microaggression In Medical Practice, Amanda Lee Almond

Publications and Research

The purpose of the present study was to validate the already existing Racial Microaggression in Counseling Scale (RMCS) when the term “therapist” was replaced with “physician”, thus constituting the modification as the Racial Microaggression in Medical Practice Scale (RMMPS). Racial microaggressions work at reinforcing inferior social status on a cognitive level. Unlike overt racism, messages behind microaggression are subtler and more every day. A lack of acceptance, respect, and regard emerges from interactions in medical contexts as there are layers of in-group and out-group statuses at play (e.g., physician-patient, Black-White, expert-lay, and Westernized-alternative). The layer focused on in the present …

An Optimized Encoding Algorithm For Systematic Polar Codes, Xiumin Wang, Zhihong Zhang, Jun Li, Yu Wang, Haiyan Cao, Zhengquan Li, Liang Shan

Publications and Research

Many different encoding algorithms for systematic polar codes (SPC) have been introduced since SPC was proposed in 2011. However, the number of the computing units of exclusive OR (XOR) has not been optimized yet. According to an iterative property of the generator matrix and particular lower triangular structure of the matrix, we propose an optimized encoding algorithm (OEA) of SPC that can reduce the number of XOR computing units compared with existing non-recursive algorithms. We also prove that this property of the generator matrix could extend to different code lengths and rates of the polar codes. Through the matrix segmentation …

Rocketry And Observability Predictions For Cubesat, Juliano A. Everett

Publications and Research

Estimating the visibility of Sunlight reflected by the holographic retro-reflector of Cubesat Alpha, and to convert this to star apparent magnitude to learn more about the visibility of these sails through reflected sunlight, to in turn determine if glints of these holograms are visible by terrestrial observers.

Usability Study For A Community College Library Website: A Methodology For Large-Scale Data Gathering, Mark E. Eaton, Carlos Arguelles

Publications and Research

Usability studies (UX) are increasingly common in libraries. A UX methodology is a useful tool to support librarians’ decision-making processes during a website (re)design. This article describes a UX process using a custom-built usability-testing environment and a data-collection tool, written in JavaScript and Python respectively. The resulting automated approach allowed us to collect usability data from a sample of 225 students. The methodology described in this study will be of interest to those considering or planning a UX study in their libraries.

Reduced Alphabet Of Prebiotic Amino Acids Optimally Encodes The Conformational Space Of Diverse Extant Protein Folds, Armando D. Solis

Publications and Research

Background

There is wide agreement that only a subset of the twenty standard amino acids existed prebiotically in sufficient concentrations to form functional polypeptides. We ask how this subset, postulated as {A,D,E,G,I,L,P,S,T,V}, could have formed structures stable enough to found metabolic pathways. Inspired by alphabet reduction experiments, we undertook a computational analysis to measure the structural coding behavior of sequences simplified by reduced alphabets. We sought to discern characteristics of the prebiotic set that would endow it with unique properties relevant to structure, stability, and folding.

Results

Drawing on a large dataset of single-domain proteins, we employed an information-theoretic measure …

Rape At Bergdorf's, Marleen S. Barr

Publications and Research

This article provides a feminist analysis of E. Jean Carroll's description of being raped by Trump in Bergdorf Goodman's lingerie department.

How Do Anticipated And Self Regulations And Information Sourcing Openness Drive Firms To Implement Eco-Innovation? Evidence From Korean Manufacturing Firms, Cheon Yu, Junghoon Park, Yun Seop Hwang

Publications and Research

Building upon institutional theory and the concept of openness to external sources in terms of breadth and depth, this study investigates the following three understudied drivers of eco-innovation in terms of external and internal factors: Anticipated regulation and self-regulation as external drivers, and information sourcing openness comprised of breadth and importance as internal drivers. Toward this end, this study employs a sample of 1824 Korean manufacturing firms collected from the Korean Innovation Survey 2010, which is compatible with the Oslo Manual and the Eurostat Community Innovation Survey (CIS). The current research adopts a multivariate probit model for the nine binary …

An Early Modern Human Outside Africa, Eric Delson

Publications and Research

Analysis of two fossils from a Greek cave has shed light on early hominins in Eurasia. One fossil is the earliest known specimen of Homo sapiens found outside Africa; the other is a Neanderthal who lived 40,000 years later.

Shifting The Balance Of Power: Asking Questions About The Comics-Questions Curriculum, Stephanie M. Margolin, Sarah Laleman Ward, Mason Brown

Publications and Research

We shift the balance of power in this paper by discussing a particular library lesson, the Comics-Questions Curriculum, with some of the students who participated in it, several years after they completed the workshop. By interviewing students and including them as co-authors of this paper, we re-center students in our analysis of this curriculum. In the process of reflecting on our work with the students and each other, we begin to see ways to engage in more meaningful, longer-term assessment of our classroom work while involving student voices in the process. We share our experiences here in order to take …

Safe Automated Refactoring For Intelligent Parallelization Of Java 8 Streams, Raffi Khatchadourian, Yiming Tang, Mehdi Bagherzadeh, Syed Ahmed

Publications and Research

Streaming APIs are becoming more pervasive in mainstream Object-Oriented programming languages and platforms. For example, the Stream API introduced in Java 8 allows for functional-like, MapReduce-style operations in processing both finite, e.g., collections, and infinite data structures. However, using this API efficiently involves subtle considerations such as determining when it is best for stream operations to run in parallel, when running operations in parallel can be less efficient, and when it is safe to run in parallel due to possible lambda expression side-effects. Also, streams may not run all operations in parallel depending on particular collectors used in reductions. In …

Non-Invasive Treatment Of Patients With Upper Extremity Spasticity Following Stroke Using Paired Trans-Spinal And Peripheral Direct Current Stimulation, Alexandra Paget-Blanc, Johanna L. Chang, Maira Saul, Regina Lin, Zaghloul Ahmed, Bruce T. Volpe

Publications and Research

Background: Muscle spasticity is a common impediment to motor recovery in patients with chronic stroke. Standard-of-care treatments such as botulinum toxin injections can temporarily relieve muscle stiffness and pain associated with spasticity, but often at the expense of increased muscle weakness. Recent preclinical investigations of a non-invasive treatment that pairs trans-spinal direct current stimulation and peripheral nerve direct current stimulation (tsDCS+pDCS) provided promising data for a novel approach based on bioelectronic medicine for the treatment of patients with post-stroke spasticity.

Methods: Twenty-six patients with upper limb hemiparesis and wrist spasticity at least 6 months after their initial stroke participated in …

Is Animal Suffering Really All That Matters? The Move From Suffering To Vegetarianism, Carlo Alvaro

Publications and Research

The animal liberation movement, among other goals, seeks an end to the use of animals for food. Philosophers who write against animal exploitation agree on the goal but differ in their approaches: Deontologists argue that rearing animals for food infringes animals’ inherent right to life. Utilitarians claim that discontinuing the use of animals for food will result in the maximization of utility. Virtue-oriented theorists argue that using animals for food is an unvirtuous practice. Despite their different approaches, arguments for vegetarianism or veganism have a common step. They move from the notion of suffering to the conclusion of vegetarianism or …

The Leaked Texts At The Heart Of Puerto Rico’S Massive Protests, Yarimar Bonilla

Publications and Research

With Governor Rosselló refusing to step down, Puerto Ricans are gathering today in what could be the island’s largest-ever protest.

Calculating Set-Volume For The Limb Muscles With The Performance Of Multi-Joint Exercises: Implications For Resistance Training Prescription, Brad J. Schoenfeld, Jozo Grgic, Cody Haun, Takahiro Itagaki, Eric R. Helms

Publications and Research

Resistance training volume, determined by the number of sets performed (set-volume) is considered one of the key variables in promoting muscle hypertrophy. To better guide resistance exercise prescription for weekly per-muscle training volume, the purpose of this paper is to provide evidence-based considerations for set-volume ratios between multi-joint (MJ) and single-joint (SJ) exercises so that practitioners can better manage prescription of training volume in program design. We analyzed this topic from three primary areas of focus: (1) biomechanical and physiological factors; (2) acute research; and (3) longitudinal research. From a biomechanical and physiological standpoint, when considering force production of different …

Cruzar Fronteras Em Espaços Acadêmicos: Transgressing “The Limits Of Translanguaging”, Brendan H. O’Connor, Katherine S. Mortimer, Lesley Bartlett, María Teresa De La Piedra, Ana Maria Rabelo Gomes, Ariana Mangual Figueroa, Gabriela Novaro, Marjorie Faulstich Orellana, Char Ullman

Publications and Research

Scholarship on translanguaging and related concepts has challenged traditional assumptions about how people use their multiple languages, urging us to move beyond the boundaries of named linguistic codes and toward conceptualizations of multilingual language use as flexible use of a speaker’s whole linguistic repertoire. Critiques of this theoretical shift have included assertions of translanguaging’s conceptual and practical limits—limits to its transformative potential as well as limits to its practical use. This paper takes up, in particular, the question of why we academics may assert the value of translanguaging in schools and communities while still largely failing to move beyond monoglossic …

Inadequate Data Limit The Analysis Of Health Disparities And Causes: A Call For Research On Youth Interpersonal Violence, Maria Isabel Roldós, Tilda Farhat

Publications and Research

Interpersonal violence among racial and ethnic minority youth is of great concern in health disparity research. Child maltreatment (CM), adolescent dating abuse (ADA), sexual abuse, and polyvictimization are key forms of interpersonal violence that require surveillance and national epidemiological data. However, national data systems and published evidence do not depict this health burden for all racial and ethnic populations. Prevalence and incidence rates for American Indians, Eskimo, and Asian youth are absent from most estimates. This commentary provides a brief overview of the gaps in the literature and offers suggestions for addressing these gaps.

Cc Chemokine Ccl1 Receptor Ccr8 Mediates Conversion Of Mesenchymal Stem Cells To Embryoid Bodies Expressing Foxp3+Ccr8+ Regulatory T Cells, Nasreen Haque, Tuteja Akaash, Niloufar Haque

Publications and Research

Embryoid bodies (EBs) are three dimensional aggregates of pluripotent stem cells primarily used to investigate morphogenesis and cell toxicity, are also attractive tools in regenerative medicine. While embryonic stem cells (ESCs) and induced pluripotent cells (IPSCs) have been shown to form EBs in mouse, primate and humans, EB formation have not been previously demonstrated in mesenchymal stem cells (MSCs). Here we show that rat MSCs form EBs; which express regulatory T cell (Treg) marker Foxp3 and CC chemokine CCL1 receptor CCR8. We show a novel method for formation of EBs from MSCs under stress and demonstrate that the induction of …

Developing Physician Educational Competencies For The Management Of Female Genital Cutting: A Call To Action, Holly G. Atkinson, Amaris Geisler

Publications and Research

Female genital cutting (FGC), also called female genital mutilation, is defined as “all procedures involving partial or total removal of the external female genitalia or other injury to the female genital organs whether for cultural, religious, or other nontherapeutic reasons.” FGC can have significant health consequences, including multiple physical and psychological complications, throughout the life course. Despite violating numerous human rights and existing legal prohibitions, the practice continues. In the United States, FGC is becoming increasingly prevalent, however, physicians are not routinely trained to care for these patients. Despite the evidence of the need, there is a woeful lack of …