Digital Commons Network^™

When The Pandemic Opts For The Lockdown: Secretion System Evolution In The Cholera Bacterium, Francis J. Santoriello, Stefan Pukatzki

Publications and Research

Vibrio cholerae, the causative agent of the diarrheal disease cholera, is a microbe capable of inhabiting two different ecosystems: chitinous surfaces in brackish, estuarine waters and the epithelial lining of the human gastrointestinal tract. V. cholerae defends against competitive microorganisms with a contact-dependent, contractile killing machine called the type VI secretion system (T6SS) in each of these niches. The T6SS resembles an inverted T4 bacteriophage tail and is used to deliver toxic effector proteins into neighboring cells. Pandemic strains of V. cholerae encode a unique set of T6SS effector proteins, which may play a role in pathogenesis or pandemic …

Should Covid-19 Patients >75 Years Be Ventilated? An Outcome Study, H. Raheja, N. Chukwuka, C. Agarwal, D. Sharma, A. Munoz-Martinez, Joshua Fogel, M. Khalid, A. T. Hashmi, S. Ehrlich, M. A. Waheed, S. Siddiqui, B. A. De Brito Gomes, A. Aslam, C. J. Merino Gualan, I. Aftab, A. Tiwari, S. Singh, K. Pouching, N. Somal, J Shani, G Rojas-Marte

Publications and Research

Background: Elderly patients with COVID-19 disease are at increased risk for adverse outcomes. Current data regarding disease characteristics and outcomes in this population are limited.

Aim: To delineate the adverse factors associated with outcomes of COVID-19 patients ≥ 75 years of age. Design: Retrospective cohort study.

Methods: Patients were classified into mild/moderate, severe/very severe and critical disease (intubated) based on oxygen requirements. The primary outcome was in-hospital mortality.

Results: A total of 355 patients aged ≥ 75 years hospitalized with COVID-19 between 19 March and 25 April 2020 were included.Mean age was 84.3 years. One-third of the patients developed critical …

Advocating For Social Justice And Diverse Voices In The Virtual World, Annie E. Tummino, Jo-Ann Wong

Publications and Research

Queens Memory is a local community archiving and oral history project, co-administered by Queens Public Library and Queens College, CUNY. Due to COVID-19 safety protocols, all projects and programs were required to move to a virtual setting. While under these restricted measures, members from both institutions found an opportunity to embark on a collaborative virtual event series for our respective library communities. The programs covered current events and their historical contexts, social justice, and creating positive social change. Key ingredients fueling the success of this initiative included building relationships with multiple co-sponsors; bringing together multigenerational, diverse panelists; and creative use …

The Neural Correlates Of Cued Reward Omission, Jessica A. Mollick, Luke J. Change, Anjali Krishnan, Thomas E. Hazy, Kai A. Krueger, Guido K. W. Frank, Tor D. Wager, Randall C. O'Reilly

Publications and Research

Compared to our understanding of positive prediction error signals occurring due to unexpected reward outcomes, less is known about the neural circuitry in humans that drives negative prediction errors during omission of expected rewards. While classical learning theories such as Rescorla–Wagner or temporal difference learning suggest that both types of prediction errors result from a simple subtraction, there has been recent evidence suggesting that different brain regions provide input to dopamine neurons which contributes to specific components of this prediction error computation. Here, we focus on the brain regions responding to negative prediction error signals, which has been well-established in …

A Bisphosphonate With A Low Hydroxyapatite Binding Affinity Prevents Bone Loss In Mice After Ovariectomy And Reverses Rapidly With Treatment Cessation, Abigail A. Coffman, Jelena Basta-Pljakic, Rosa M. Guerra, Frank H. Ebetino, Mark W. Lundy, Robert J. Majeska, Mitchell B. Schaffler

Publications and Research

Bisphosphonates (BPs) are a mainstay of osteoporosis treatment; however, concerns about bone health based on oversuppression of remodeling remain. Long-term bone remodeling suppression adversely affects bone material properties with microdamage accumulation and reduced fracture toughness in animals and increases in matrix mineralization and atypical femur fractures in patients. Although a “drug holiday” from BPs to restore remodeling and improve bone quality seems reasonable, clinical BPs have long functional half-lives because of their high hydroxyapatite (HAP) binding affinities. This places a practical limit on the reversibility and effectiveness of a drug holiday. BPs with low HAP affinity and strong osteoclast inhibition …

Beauty That Moves: Dance For Parkinson’S Effects On Affect, Self-Efficacy, Gait Symmetry, And Dual Task Performance, Cecilia Fontanesi, Joseph F. X. Desouza

Publications and Research

Background: Previous studies have investigated the effects of dance interventions on Parkinson’s motor and non-motor symptoms in an effort to develop an integrated view of dance as a therapeutic intervention. This within-subject study questions whether dance can be simply considered a form of exercise by comparing a Dance for Parkinson’s class with a matched-intensity exercise session lacking dance elements like music, metaphorical language, and social reality of art-partaking.

Methods: In this repeated-measure design, 7 adults with Parkinson’s were tested four times; (i) before and (ii) after a Dance for Parkinson’s class, as well as (iii) before and (iv) after a …

T-Moca: A Valid Phone Screen For Cognitive Impairment In Diverse Community Samples, Mindy J. Katz, Cuiling Wang, Caroline O. Nester, Carol A. Derby, Molly E. Zimmerman, Richard B. Lipton, Martin J. Sliwinski, Laura A. Rabin

Publications and Research

Introduction: There is an urgent need to validate telephone versions of widely used general cognitive measures, such as the Montreal Cognitive Assessment (T-MoCA), for remote assessments.

Methods: In the Einstein Aging Study, a diverse community cohort (n = 428; mean age = 78.1; 66% female; 54% non-White), equivalence testing was used to examine concordance between the T-MoCA and the corresponding in-person MoCA assess- ment. Receiver operating characteristic analyses examined the diagnostic ability to dis- criminate between mild cognitive impairment and normal cognition. Conversion meth- ods from T-MoCA to the MoCA are presented.

Results: Education, race/ethnicity, gender, age, self-reported cognitive concerns, …

Exploring The Silent Aspect Of Carbon Nanopores, Teresa J. Bandosz

Publications and Research

Recently, owing to the discovery of graphene, porous carbons experienced a revitalization in their explorations. However, nowadays, the focus is more on search for suitable energy advancing catalysts sensing, energy storage or thermal/light absorbing features than on separations. In many of these processes, adsorption, although not emphasized sufficiently, can be a significant step. It can just provide a surface accumulation of molecules used in other application-driving chemical or physical phenomena or can be even an additional mechanism adding to the efficiency of the overall performance. However, that aspect of confined molecules in pores and their involvement in the overall performance …

Using Verb Extension To Gauge Children’S Verb Meaning Construals: The Case Of Chinese, Weiyi Ma, Roberta Michnick Golinkoff, Lulu Song, Kathy Hirsh-Pasek

Publications and Research

Verb extension is a crucial gauge of the acquisition of verb meaning. In English, studies suggest that young children show conservative extension. An important test of whether an early conservative extension is a general phenomenon or a function of the input language is made possible by Chinese, a language in which verbs are more frequent and acquired earlier. This study tested whether 3-year-old Chinese children extended a group of familiar verbs that specify various ways to carry objects. Shown videos that portrayed typical, mid-typical, or atypical carrying actions (as verified by Chinese adults), children were asked to judge whether they …

Facilitating Healthier Eating At Restaurants: A Multidisciplinary Scoping Review Comparing Strategies, Barriers, Motivators, And Outcomes By Restaurant Type And Initiator, Melissa Fuster, Margaret A. Handley, Tamara Alam, Lee Ann Fullington, Brian Elbel, Krishnendu Ray, Terry T-K Huang

Publications and Research

Restaurants are understudied yet increasingly important food environment institutions for tackling diet-related diseases. This scoping review analyzes research and gray literature (n = 171 records) to assess which healthy eating promotion strategies have been implemented in restaurants and the associated motivations, barriers, and outcomes, compared by restaurant type (corporate/chain vs. independently owned restaurants) and initiator (restaurant-initiated vs. investigator-initiated). We found that the most commonly reported strategy was the increase of generally healthy offerings and the promotion of such offerings. Changes in food availability were more common among corporate restaurants and initiated by restaurants, while environmental facilitators were more commonly initiated …

How Drawing To Distract Improves Mood In Children, Jennifer E. Drake

Publications and Research

Previous research has shown that drawing improves short-term mood in children when used to distract from rather than express negative thoughts and feelings. The current study sought to examine (a) how drawing might elevate mood in children ages 6–12 by examining the role played by absorption, enjoyment, and perceived competence as well as entering an imaginary world; and (b) whether children spontaneously use drawing to distract from a sad mood. Across three studies, children were asked to think of a disappointing event. After a sad mood induction, they drew for 5 min. Mood was measured before and after the mood …

Molecular Speciation Of Size Fractionated Particulate Water-Soluble Organic Carbon By Two-Dimensional Nuclear Magnetic Resonance (Nmr) Spectroscopy, Marie-Cecile Chalbot, Salma Siddiqui, Ilias G. Kavouras

Publications and Research

Particulate matter is associated with increased morbidity and mortality; its effects depend on particle size and chemical content. It is important to understand the composition and resultant toxicological profile of particulate organic compounds, the largest and most complex fraction of particulate matter. The objective of the study was to delineate the nuclear magnetic resonance (NMR) spectral fingerprint of the biologically relevant water-soluble organic carbon (WSOC) fraction of size fractionated urban aerosol. A combination of one and two-dimensional NMR spectroscopy methods was used. The size distribution of particle mass, water-soluble extract, non-exchangeable organic hydrogen functional types and specific biomarkers such as …

Psychiatrist Burnout, Irvin Sam Schonfeld, Renzo Bianchi

Publications and Research

We critique a paper published by Summers et al. (2020) and papers in general that, because of flawed methods, arrive at exceedingly high estimates of burnout in psychiatrists and other professionals.

Making Sense Of Researcher Positionality In Foundational Literacy Studies Research, Amy J. Wan

Publications and Research

This article is an examination of researcher positionality in literacy studies research through a historiographical study of Brian Street.

Education Faculty As Knowledge Brokers: Competing For Access To New York State Print Media And Policy Influence, Gary Anderson, Nakia Gray-Nicolas, Madison Payton

Publications and Research

In an environment in which new policy entrepreneurs and networks are influencing policy and public opinion, many university faculty are increasingly seeking ways to mobilize knowledge beyond academic conferences and journals. Using New York state as a case, we searched Access World News to compare the level of media access of academics with other knowledge brokering organizations (KBOs; e.g. think tanks, teachers’ unions, advocacy organizations, etc.). Our data shows relatively low levels of access for academics and provides profiles of those academics with high levels of access and what we might learn from them. We provide a discussion of the …

Consumer Likings Of Different Miracle Fruit Products On Different Sour Foods, Sung-Eun Choi, Jeff Garza

Publications and Research

Miracle fruit has a high potential as a healthy sweetening enhancer, due to its powerful antioxidant capacity and its unique ability to transform sour taste into sweet taste. The aim of this study was to analyze the effect of different miracle fruit products on the likings of different sour foods.In total, 200 healthy adults (women 55%, 18–65 years old) evaluated five sour foods (apple, goat cheese, lemonade, yogurt, pickle) before and after miracle fruit application. Four commercial miracle fruit products (pills-Y; G; M, powder-P) were randomly assigned to each panelist. The pre- and post-test likings for overall, flavor, texture, and …

Fine-Grained, Spatiotemporal Datasets Measuring 200 Years Of Land Development In The United States, Johannes H. Uhl, Stefan Leyk, Caitlin M. Mcshane, Anna E. Braswell, Dylan S. Connor, Deborah Balk

Publications and Research

The collection, processing, and analysis of remote sensing data since the early 1970s has rapidly improved our understanding of change on the Earth’s surface. While satellite-based Earth observation has proven to be of vast scientific value, these data are typically confined to recent decades of observation and often lack important thematic detail. Here, we advance in this arena by constructing new spatially explicit settlement data for the United States that extend back to the early 19th century and are consistently enumerated at fine spatial and temporal granularity (i.e. 250m spatial and 5-year temporal resolution). We create these time series using …

It Could Be So Much Worse, Alexandra Juhasz, Pato Hebert

Publications and Research

Conversation between longtime AIDS activists about longhauling with COVID-19, disclosure, shame, and the possibilities of COVID politics with photographs of the "COVID Body."

Recruitment Of International Students Through A Synthesis Of English As A Second Language Instruction, Social Justice, And Service Learning, Daisuke Akiba

Publications and Research

Universities across the U.S. have increasingly emphasized internationalization, leading to rising numbers of international students attending U.S. institutions of higher education. However, these students tend to gravitate toward larger research-intensive universities with many other institutions seeing no increase in international student enrollments. Little is known concerning how to attract international students to regional institutions lacking name recognition. To address the above and promote internationalization through increasing the presence of students from abroad, an academic department at a regional public U.S. college used needs analysis to develop a pilot program for Japanese university students (N = 13). The program involved a …

Flavor Fatigue: Cognitive Depletion Influences Consumer Enjoyment Of Complex Flavors, Diogo Hildebrand, Dan Rubin, Rhonda Hadi, Thomas Kramer

Publications and Research

Surprisingly, little research has examined how consumer responses to specific flavor characteristics of food are formed or how they may fluctuate situationally. We address this lacuna in the literature on the hedonic appreciation of food by demonstrating that enjoyment along one important gustatory dimension, flavor complexity, varies with the degree to which consumers are mentally depleted. Specifically, showing that gustatory sensations are more cognitively demanding than previously thought, findings from three studies evince that cognitive depletion reduces consumer enjoyment of complex-flavored (but not simple-flavored) foods via a reduction in pleasure that otherwise can be derived from complex flavors. We establish …

Age And Sex Differences In Load-Induced Tibial Cortical Bone Surface Strain Maps, Alessandra Carriero, Behzad Javaheri, Neda Bassir Kazeruni, Andrew A. Pitsillides, Sandra J. Shefelbine

Publications and Research

Bone adapts its architecture to the applied load; however, it is still unclear how bone mechano-adaptation is coordinated and why potential for adaptation adjusts during the life course. Previous animal models have suggested strain as the mechanical stimulus for bone adaptation, but yet it is unknown how mouse cortical bone load-related strains vary with age and sex. In this study, full-field strain maps (at 1 N increments up to 12 N) on the bone surface were measured in young, adult, and old (aged 10, 22 weeks, and 20 months, respectively), male and female C57BL/6J mice with load applied using a …

A Peek Inside The Machines Of Bacterial Nucleotide Excision Repair, Thanyalak Kraithong, Silas Hartley, David Jeruzalmi, Danaya Pakotiprapha

Publications and Research

Double stranded DNA (dsDNA), the repository of genetic information in bacteria, archaea and eukaryotes, exhibits a surprising instability in the intracellular environment; this fragility is exacerbated by exogenous agents, such as ultraviolet radiation. To protect themselves against the severe consequences of DNA damage, cells have evolved at least six distinct DNA repair pathways. Here, we review recent key findings of studies aimed at understanding one of these pathways: bacterial nucleotide excision repair (NER). This pathway operates in two modes: a global genome repair (GGR) pathway and a pathway that closely interfaces with transcription by RNA polymerase called transcription-coupled repair (TCR). …

Neoliberalism And Public Library Policy In Ireland, 1998–2011: From The First Government Policy Document To The First General Election After The Great Recession, Maureen Garvey

Publications and Research

This article discusses the influence of neoliberal ideology on public libraries in Ireland, from the first government policy document published in 1998 to the first election after the recession in 2011. The context of the rise in importance of the idea of information and the parallel acceptance of the principles of the free market for providing public services are examined. The Irish government policy documents from the period are analyzed. A critical awareness of these changes is needed in the library and information science field to recognize and oppose policies that are detrimental to the public provision of a library …

Working Remotely, Working Effectively: Improving Collection Access During A Global Pandemic, Colleen Bradley-Sanders

Publications and Research

This article looks at how one college archive responded to the shutdown of its campus in response to the COVID-19 pandemic. The Archivist and Associate Archivist worked together to develop work assignments that could be done from home. While collection processing was halted, the tasks assigned to staff all aimed to improve informational access to the collections, through an expanded effort to convert PDF finding aids to EAD for placement in an ArchivesSpace site, a project to create a searchable listing of collections that includes a brief description of content and links to finding aids, and planning for digitization of …

Impacts Of Hurricane Maria On Land And Convection Modification Over Puerto Rico, Nathan Hosannah, Prathap Ramamurthy, J. Marti, Jonathan Munoz, Jorge E. González

Publications and Research

Hurricane Maria drastically altered the landscape across the island of Puerto Rico. This article investigates modifications to surface-atmospheric interactions due to Hurricane Maria induced land damage and the associated impacts on local convective dynamics. Herein, we employed LANDSAT-8 image mosaics to quantify the hurricane induced land modification. Results of the analysis indicate that the island suffered significant forest damage—much of which registered as a 28.35% increase in barren land and a 10.85% increase in pasture. Smaller changes included a decrease in cultivated agricultural land cover by 0.76%, along with wetland and water increases of 0.62% and 0.25%, respectively. Pre and …

A New Vine Snake (Reptilia, Colubridae, Oxybelis) From Peru And Redescription Of O. Acuminatus, Robert C. Jadin, Michael J. Jowers, Sarah A. Orlofske, William E. Duellman, Christopher Blair, John C. Murphy

Publications and Research

The Brown Vine Snake, Oxybelis aeneus, was until recently considered a single species, distributed from southern Arizona through the Neotropics into southeastern Brazil. However, newly conducted research restructured the species with a substantial taxonomic revision, recognizing five additional taxa (i.e. O. koehleri, O. microphthalmus, O. potosiensis, O. rutherfordi, O. vittatus) in this species complex. This revision focused on populations in North America, Central America, and northern South America while neglecting the southern portion of its distribution. Here, we examine the taxonomic history of the complex and use it along with specimen data to resurrect O. acuminatus from southeastern Brazil. Finally, …

Outcomes In Patients With Covid-19 Disease And High Oxygen Requirements, Geurys Rojas-Marte, Arsalan Talib Hashmi, Mazin Khalid, Nnamdi Chukwuka, Joshua Fogel, Alejandro Munoz-Martinez, Samantha Ehrlich, Maham Akbar Waheed, Dikshya Sharma, Shaurya Sharma, Awais Aslam, Sabah Siddiqui, Chirag Agarwal, Yuri Malyshev, Carlos Henriquez-Felipe, Jacob Shani

Publications and Research

Background: Approximately 19% of people infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) progress to severe or critical stages of the coronavirus disease 2019 (COVID-19) with a mortality rate exceeding 50%. We aimed to examine the char- acteristics, mortality rates, intubation rate, and length of stay (LOS) of patients hospitalized with COVID-19 disease with high oxygen re- quirements (critically ill).

Methods: We conducted a retrospective analysis in a single center in Brooklyn, New York. Adult hospitalized patients with confirmed COVID-19 disease and high oxygen requirements were included. We performed multivariate logistic regression analyses for statistically significant variables to …

Single-Locus Species Delimitation And Ecological Niche Modeling Provide Insights Into The Evolution, Historical Distribution, And Taxonomy Of The Pacific Chorus Frogs, Robert C. Jadin, Sarah A. Orlofske, Tereza Jezkova, Christopher Blair

Publications and Research

The Pacific chorus frogs are a complex of three wide-ranging species (i.e. Hyliola hypochondriaca, Hyliola regilla, Hyliola sierra) whose current taxonomy remains unresolved. We conducted species delimitation analyses of these taxa using fragments of the cytochrome b and 12S–16S mtDNA genes to assess the species diversity. Importantly, we included samples from new locations throughout the range to better understand species distributions and identify potential contact zones among clades. Our analyses revealed three slightly parapatric but distinct species-level clades. Molecular dating revealed that these species began diverging in the Pleistocene c. 1.4 Mya with H. hypochondriaca and …

Special Issue On Professor John M. Tarbell’S Contribution To Cardiovascular Engineering, Hanjoong Jo, Keefe Manning, John M. Tarbell

Publications and Research

No abstract provided.

Single-Cell Fluidic Force Microscopy Reveals Stress- Dependent Molecular Interactions In Yeast Mating, Marion Mathelié-Guinlet, Felipe Viela, JéRôMe Dehullu, Sviatlana Filimonava, Jason M. Rauceo, Peter N. Lipke, Yves F. DufrêNe

Publications and Research

Sexual agglutinins of the budding yeast Saccharomyces cerevisiae are proteins mediating cell aggregation during mating. Complementary agglutinins expressed by cells of opposite mating types “a” and “α” bind together to promote agglutination and facilitate fusion of haploid cells. By means of an innovative single-cell manipulation assay combining fluidic force microscopy with force spectroscopy, we unravel the strength of single specific bonds between a- and α-agglutinins (~100 pN) which require pheromone induction. Prolonged cell–cell contact strongly increases adhesion between mating cells, likely resulting from an increased expression of agglutinins. In addition, we highlight the critical role of disulfide bonds of the …