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Sum Of Mobius Functions Over The Shifted Primes, Nelson Carella Apr 2022

Sum Of Mobius Functions Over The Shifted Primes, Nelson Carella

Publications and Research

This article provides an asymptotic result for the summatory Mobius function ∑ p≤x μ(p + a) = O (x log−c x) over the shifted primes, where a ̸ = 0 is a fixed parameter, and c > 1 is a constant.


A Feminist Scholar Explains Why Will Smith's Words Speak As Loudly As His Actions, Marleen S. Barr Apr 2022

A Feminist Scholar Explains Why Will Smith's Words Speak As Loudly As His Actions, Marleen S. Barr

Publications and Research

Marleen S. Barr's contribution to the American Association of University Professors Academe magazine blog links the Will Smith slap to literary criticism to explain why the words Ssmith shouted are as important as his actions. .


Sources And Types Of Social Supports And Their Association With Mental Health Symptoms And Life Satisfaction Among Young Adults With A History Of Out-Of-Home Care, Rhiannon Evans, Colleen C. Katz, Anthony Fulginiti, Heather Taussig Apr 2022

Sources And Types Of Social Supports And Their Association With Mental Health Symptoms And Life Satisfaction Among Young Adults With A History Of Out-Of-Home Care, Rhiannon Evans, Colleen C. Katz, Anthony Fulginiti, Heather Taussig

Publications and Research

Young adults with a history of out-of-home care report poorer mental health and life satisfaction compared to non-care-experienced peers. Social support is a known protective factor for mental health. There is limited evidence, however, on the relationship between sources (e.g., family members) and types (e.g., information) of social support and mental health symptoms and life satisfaction in this population. Reporting cross-sectional survey data from 215 young adults aged 18–22 years with a history of out-of-home care, the current study conducted descriptive, bivariate, and linear regression analysis to examine the different sources and types of support young adults receive and their …


Early Pleistocene Large Mammals From Maka’Amitalu, Hadar, Lower Awash Valley, Ethiopia, John Rowan, Ignacio A. Lazagabaster, Christopher J. Campisano, Faysal Bibi, René Bobe, Jean-Renaud Boisserie, Stephen R. Frost, Tomas Getachew, Christopher C. Gilbert, Margaret E. Lewis, Sahleselasie Melaku, Eric Scott, Antoine Souron, Lars Werdelin, William H. Kimbel, Kaye E. Reed Apr 2022

Early Pleistocene Large Mammals From Maka’Amitalu, Hadar, Lower Awash Valley, Ethiopia, John Rowan, Ignacio A. Lazagabaster, Christopher J. Campisano, Faysal Bibi, René Bobe, Jean-Renaud Boisserie, Stephen R. Frost, Tomas Getachew, Christopher C. Gilbert, Margaret E. Lewis, Sahleselasie Melaku, Eric Scott, Antoine Souron, Lars Werdelin, William H. Kimbel, Kaye E. Reed

Publications and Research

The Early Pleistocene was a critical time period in the evolution of eastern African mammal faunas, but fossil assemblages sampling this interval are poorly known from Ethiopia ’ s Afar Depression. Field work by the Hadar Research Project in the Busidima Formation exposures (~2.7 – 0.8 Ma) of Hadar in the lower Awash Valley, resulted in the recovery of an early Homo maxilla (A.L. 666-1) with associated stone tools and fauna from the Maka ’ amitalu basin in the 1990s. These assemblages are dated to ~2.35 Ma by the Bouroukie Tuff 3 (BKT-3). Continued work by the Hadar Research Project …


Managing Illegality On Campus: Undocumented Mismatch Between Students And Staff, Holly E. Reed, Sofya Aptekar, Amy Hsin Apr 2022

Managing Illegality On Campus: Undocumented Mismatch Between Students And Staff, Holly E. Reed, Sofya Aptekar, Amy Hsin

Publications and Research

Contributing to the literature on the institutional experiences of undocumented youth, this essay by Holly E. Reed, Sofya Aptekar, and Amy Hsin explores undocumented and “DACAmented” students’ experiences managing their illegality on campus and how college staff and faculty manage that illegality while organizing programs and support. Their analysis of in-depth qualitative interviews conducted with more than a hundred undocumented college students and former students and thirty-five faculty and staff members at the City University of New York identifies multiple points of tension. The “undocumented mismatch” between campus management of illegality and student experiences was evident in the exclusion and …


Adapting Human-Based Transcutaneous Spinal Cord Stimulation To Develop A Clinically Relevant Animal Model, Dillon C. Malloy, Maria Knikou, Marie-Pascale Côté Apr 2022

Adapting Human-Based Transcutaneous Spinal Cord Stimulation To Develop A Clinically Relevant Animal Model, Dillon C. Malloy, Maria Knikou, Marie-Pascale Côté

Publications and Research

Transcutaneous spinal cord stimulation (tSCS) as a neuromodulatory strategy has received great attention as a method to promote functional recovery after spinal cord injury (SCI). However, due to the noninvasive nature of tSCS, investigations have primarily focused on human applications. This leaves a critical need for the development of a suitable animal model to further our understanding of this therapeutic intervention in terms of functional and neuroanatomical plasticity and to optimize stimulation protocols. The objective of this study is to establish a new animal model of thoracolumbar tSCS that (1) can accurately recapitulate studies in healthy humans and (2) can …


Occupational Depression In A Spanish-Speaking Sample: Associations With Cognitive Performance And Work-Life Characteristics, Bianchi Renzo, Guadalupe Manzano García, Maria Pilar Montanes, Emily A. Schonfeld, Irvin Sam Schonfeld Apr 2022

Occupational Depression In A Spanish-Speaking Sample: Associations With Cognitive Performance And Work-Life Characteristics, Bianchi Renzo, Guadalupe Manzano García, Maria Pilar Montanes, Emily A. Schonfeld, Irvin Sam Schonfeld

Publications and Research

This 386-participant study investigated the structural and psychometric properties of the Spanish version of the Occupational Depression Inventory (ODI). Exploratory structural equation modeling bifactor analysis revealed that the ODI meets the requirements for essential unidimensionality. Measurement invariance held across our sample and the English- and French-speaking samples used in the ODI’s initial validation study. Mokken scale analysis indicated that (a) the scalability of the instrument was strong, (b) no violations of monotonicity or local independence were present, and (c) invariant item ordering was sufficiently accurate. The ODI’s reliability was optimal. The ODI exhibited both convergent validity and discriminant validity vis-à-vis …


Clcd (Children's Literature Comprehensive Database) Enterprise, Sonali Sugrim Apr 2022

Clcd (Children's Literature Comprehensive Database) Enterprise, Sonali Sugrim

Publications and Research

CLCD Enterprise is one of three products offered by CLCD (Children’s Literature Comprehensive Database), LLC. CLCD Enterprise is an online database that provides access to book reviews, thematic lists, award winning content and curriculum tools of disparate collections for grade pre-K through 12 media of all types. The database allows for power search, advanced search, and award search options for browsing and locating content. CLCD Enterprise is available through a subscription and valuable for those in education, library and information science and literature fields looking for a tool to expand on collection and curriculum development, and reader advisory suggestions for …


"Courts And State-Building: The Welsh Marcher Lordships And The Somali Union Of Islamic Courts," Polity 54(2): 197--25., Zachary C. Shirkey Apr 2022

"Courts And State-Building: The Welsh Marcher Lordships And The Somali Union Of Islamic Courts," Polity 54(2): 197--25., Zachary C. Shirkey

Publications and Research

This article examines the roles of courts in state-building and aims to bring the state-building literature into deeper conversation with institutional approaches to the study of courts. Doing so highlights that courts can play important roles in state-building including extracting revenue, coercing subjects, and generating legitimacy for the state by justly adjudicating disputes. Of these, courts’ extractive role has been especially understudied. Yet, courts can raise significant sums through fees, fines, and confiscating property, particularly in less-developed states. These three roles of courts in state-building are explored in two highly disparate cases: the medieval Welsh Marcher lordships and the Union …


Medical Norm Of Psychiatric Misdiagnoses In Rare Disease Patients, Rachel Han Apr 2022

Medical Norm Of Psychiatric Misdiagnoses In Rare Disease Patients, Rachel Han

Publications and Research

Spring 2022 ENG 120 Student Final Research Paper on the medical norm of psychiatric misdiagnosis throughout the diagnostic journeys of rare disease patients. The idea of a norm was taken from Chimamanda Ngozi Adichie's Tedx Talk "The Danger of a Single Story". Paper discusses prevalence, harmful effects, and origin of this medical norm. Includes discussion of statistical data quoted relating to prevalence of rare diseases as well as anecdotal evidence of the severe ramifications of this norm. Discussion of how medically unexplained symptoms such as mysterious chronic pain often lead to the phenomenon of the psychogenic inference. Origins of this …


Parent Perspectives On Early Childhood Education Integration, Maria S. Mavrides Calderon, Gregory Brender Apr 2022

Parent Perspectives On Early Childhood Education Integration, Maria S. Mavrides Calderon, Gregory Brender

Publications and Research

Former Mayor De Blasio made the expansion of 3-K for All and Pre-K for All a top priority of his administration. In its re-procurement of contracts for community-based early childhood education providers, the De Blasio administration’s Department of Education made it a priority for programs to “foster socio-economic integration at the classroom level.” Mayor Eric L. Adams has spoken of his own experience being educated in segregated schools and has called for students to be exposed to more diverse environments (Shapiro, 2021). It is up to his administration to implement the changes that will foster desegregation in New York City’s …


Bigger Dreams, Majolyn N. Nunez Apr 2022

Bigger Dreams, Majolyn N. Nunez

Publications and Research

While at the day program, my new care manager came to me with an application for the Melissa Riggio Higher Education program, and it changed everything for me. Today, I’m 30 years old and a junior at Hostos Community College. I have classes two days a week in education and history and I still live with my sister. I think being an older student has helped me because I’m more mature and independent. I changed. I’m more understanding, and I’m learning to depend on myself.


A-Z Database List Review: Getting Started And Keeping The Momentum, Sonali Sugrim Apr 2022

A-Z Database List Review: Getting Started And Keeping The Momentum, Sonali Sugrim

Publications and Research

Libraries have multiple portals to access their electronic resources. At Queens College, the two access portals are the catalog, Ex-Libris’ Primo, and Springshare’s A-Z Database List. The most recent comprehensive review of the A-Z Database List was conducted five years ago by the previous electronic resources librarian. As such, the list had multiple formats for displaying information and lacked consistency. The supporting information for the overall layout of the list was not helpful to users nor library staff. Users should be able to search for the resources they want without getting bogged down by unnecessary jargon, inconsistencies, and fluff.

It …


Cosmogenic Ages Indicate No Mis 2 Refugia In The Alexander Archipelago, Alaska, Caleb K. Walcott, Jason P. Briner, James F. Baichtal, Alia J. Lesnek, Joseph M. Licciardi Apr 2022

Cosmogenic Ages Indicate No Mis 2 Refugia In The Alexander Archipelago, Alaska, Caleb K. Walcott, Jason P. Briner, James F. Baichtal, Alia J. Lesnek, Joseph M. Licciardi

Publications and Research

The late-Pleistocene history of the coastal Cordilleran Ice Sheet remains relatively unstudied compared to chronologies of the Laurentide Ice Sheet. Yet accurate reconstructions of Cordilleran Ice Sheet extent and the timing of ice retreat along the Pacific Coast are essential for paleoclimate modeling, assessing meltwater contribution to the North Pacific, and determining the availability of ice-free land along the coastal Cordilleran Ice Sheet margin for human migration from Beringia into the rest of the Americas. To improve the chronology of Cordilleran Ice Sheet history in the Alexander Archipelago, Alaska, we applied 10Be and 36Cl dating to boulders and glacially sculpted …


Home Sweet Home? Examining Residential Instability And Preschoolers’ Early Mathematics Development, Marisha Kashyap Apr 2022

Home Sweet Home? Examining Residential Instability And Preschoolers’ Early Mathematics Development, Marisha Kashyap

Publications and Research

In 2020, approximately 13% of all children under five experienced residential instability. Residential instability, also known as housing instability, is known to compromise the socio-emotional and behavioral development of young children. However, there is limited evidence documenting the effect of housing instability on preschoolers' cognitive and academic abilities, in particular the development of mathematics skills. The present literature review argues that unstable residential conditions have important implications for preschoolers’ early mathematics development. First, the current literature review explores the implications of residential instability for the early childhood developmental period. Then this review examines current studies on promotive and risk factors …


Neighbors At Risk, Jeffrey A. Butts, Gina Moreno, Richard A. Espinobarros Apr 2022

Neighbors At Risk, Jeffrey A. Butts, Gina Moreno, Richard A. Espinobarros

Publications and Research

Most New York City neighborhoods did not experience high rates of shootings in recent years, but others clearly did. Comparing crime rates across these relatively small geographic areas is important for officials considering where to invest in resources that support public safety and community wellbeing.


The Contemporary American Juvenile Justice System: Revisiting Parens Patriae, Katarzyna Celinska, Amina Cheboubi Apr 2022

The Contemporary American Juvenile Justice System: Revisiting Parens Patriae, Katarzyna Celinska, Amina Cheboubi

Publications and Research

The American juvenile justice system has undergone significant transformations since its inception in the late 19th century. In this paper, the authors seek to analyze the historical context of and subsequent reforms to the juvenile system and process in order to determine whether they remain true to their origins of the legal doctrine of parens patriae. Specifically, the authors contrast rehabilitative notions of parens patriae with the “tough on crime” perspective that developed in the 1990s in response to rising crime rates. This debate is illustrated by landmark Supreme Court cases, waivers to the adult system, increases in the use …


“The Amount Of Labor We Do For Free” And Other Contradictions: A Collective Inquiry Into The Pedagogical Choices Of Cuny Adjunct And Graduate Student Instructors Who Taught With Free Of Charge Materials During The Year 2020, Sami Disu, Joanna Dressel, Jamila Hammami, Marianne Madoré, Conor Tomás Reed Apr 2022

“The Amount Of Labor We Do For Free” And Other Contradictions: A Collective Inquiry Into The Pedagogical Choices Of Cuny Adjunct And Graduate Student Instructors Who Taught With Free Of Charge Materials During The Year 2020, Sami Disu, Joanna Dressel, Jamila Hammami, Marianne Madoré, Conor Tomás Reed

Publications and Research

A collective of five CUNY researchers developed and conducted a survey-based study of how CUNY adjunct and graduate student faculty taught with free of charge materials during the year 2020. A total of 152 respondents filled out the survey. Four themes emerged from the analysis of their responses:

  1. Adjunct and graduate student faculty who taught with free of charge materials at CUNY in 2020 were motivated by economic, logistical, and pedagogical benefits. They invested considerable amounts of time in both creating and selecting material.
  2. Their pedagogical choices about learning materials were formed in the context of the COVID-19 pandemic, the …


Lessons To Build An Educational Model For Higher Education Institutions Defined As Anchor Institutions To Tackle Public Health Crises: A Pilot Study On Covid-19 Vaccine Hesitancy Among Faculty And Students In Herbert L. College In The Bronx, Ny, Maria-Isabel Roldos, Katherine Burt, Jacob Eubank Apr 2022

Lessons To Build An Educational Model For Higher Education Institutions Defined As Anchor Institutions To Tackle Public Health Crises: A Pilot Study On Covid-19 Vaccine Hesitancy Among Faculty And Students In Herbert L. College In The Bronx, Ny, Maria-Isabel Roldos, Katherine Burt, Jacob Eubank

Publications and Research

Coronavirus disease 2019 exacerbated health inequities in Bronx Communities. This study explored vaccine hesitancy among a random sample of faculty and students from Herbert Lehman College. Findings suggest faculty are largely vaccinated (87%), while 59% of students are unvaccinated. Significant gaps in information were found related to safety and complications. This suggests universities need to adopt an educational model with a multipronged social support strategy to gain students’ trust and a greater sense of belonging.


Association Between Self-Reported Body Mass Index And Active Life Expectancy In A Large Community-Dwelling Sample Of Older U.S. Adults, Haomiao Jia, Erica I. Lubetkin Apr 2022

Association Between Self-Reported Body Mass Index And Active Life Expectancy In A Large Community-Dwelling Sample Of Older U.S. Adults, Haomiao Jia, Erica I. Lubetkin

Publications and Research

Background: Obesity may have a protective effect (greater survival) in older adults, a finding known as the "obesity paradox." This study examined the association between self-reported body mass index (BMI) and active life expectancy (ALE) among older U.S. adults.

Methods: Using the Medicare Health Outcomes Survey Cohort 15 (2012 baseline, 2014 follow-up), we estimated life expectancy and ALE by participants' baseline BMI and age using multi-state models. A participant was classified as in an active state if this person reported having no difficulty for any of these six activities of daily living (ADLs).

Results: Small differences in life expectancy were …


An Evaluation Of The Effect Of The Oxycontin® Reformulation On Unintentional Fatal And Non-Fatal Overdose, Daniel C. Beachler, Kelsey Hall, Renu Garg, Geetanjoli Banerjee, Ling Li, Luke Boulanger, Huseyin Yuce, Alexander M. Walker Mar 2022

An Evaluation Of The Effect Of The Oxycontin® Reformulation On Unintentional Fatal And Non-Fatal Overdose, Daniel C. Beachler, Kelsey Hall, Renu Garg, Geetanjoli Banerjee, Ling Li, Luke Boulanger, Huseyin Yuce, Alexander M. Walker

Publications and Research

Objectives: OxyContin® was reformulated with a polyethylene oxide matrix in August 2010 to reduce the potential for intravenous abuse and for abuse by insufflation. The objective of this study was to evaluate the impact of OxyContin’s reformulation on overdose risk for individuals dispensed OxyContin in comparison to those dispensed other opioids under regular care. Methods: Three national insurance databases with National Death Index linkage identified OD in individuals with any dispensing of OxyContin or a primary comparator opioid (ER morphine, transdermal fentanyl, or methadone) between July 2008 through September 2015. A difference-in-differences design was used to compare the pre-post reformulation …


Variación Lingüística De La Cortesía Verbal En El Discurso Académico Escrito: Atenuación E Intensificación De La Voz Del Autor En La Evaluación De Las Fuentes, David Sánchez-Jiménez Mar 2022

Variación Lingüística De La Cortesía Verbal En El Discurso Académico Escrito: Atenuación E Intensificación De La Voz Del Autor En La Evaluación De Las Fuentes, David Sánchez-Jiménez

Publications and Research

Resumen

Como ocurre con la mayor parte de los elementos pragmáticos, la cortesía verbal cumple una función esencial en la elusión de los efectos no deseados de los actos amenazadores de la imagen, lo cual permite que se establezca una comunicación eficaz en la interpretación de los textos. Con el fin de facilitar esta labor, el escritor emplea una serie de recursos retóricos interpersonales −asociados con la expresión de la voz del autor− que se utilizan para proyectar una imagen social determinada del emisor del escrito y, al mismo tiempo, establecer un diálogo eficaz con su audiencia. En el análisis …


Adapting A Conceptual Framework To Engage Diverse Stakeholders In Genomic/Precision Medicine Research, Karriem S. Watson, Elizabeth G. Cohn, Alecia Fair, Usha Menon, Laura A. Szalacha, Selena M. Carpenter, Consuelo H. Wilkins Mar 2022

Adapting A Conceptual Framework To Engage Diverse Stakeholders In Genomic/Precision Medicine Research, Karriem S. Watson, Elizabeth G. Cohn, Alecia Fair, Usha Menon, Laura A. Szalacha, Selena M. Carpenter, Consuelo H. Wilkins

Publications and Research

Introduction: Genomic/precision medicine offers a remarkable opportunity to improve health and address health disparities. Genomic medicine is the study of genes and their interaction with health. Precision medicine is an approach to disease prevention and treatment that considers individual variability in genes, environ- ment and lifestyle. Conclusions from studies lacking diversity may hinder general- izability as genomic variation occurs within and between populations. Historical factors, such as medical mistrust, ethical issues related to decision making, and data sharing pose complex challenges that may further widen inequities in genomic/ precision medicine if not appropriately addressed. Although few biomedical studies integrate priorities …


“I Can Math, Too!”: Reducing Math Anxiety In Stem-Related Courses Using A Combined Mindfulness And Growth Mindset Approach (Magma) In The Classroom, Tashana S. Samuel, Sebastien Buttet, Jared Warner Mar 2022

“I Can Math, Too!”: Reducing Math Anxiety In Stem-Related Courses Using A Combined Mindfulness And Growth Mindset Approach (Magma) In The Classroom, Tashana S. Samuel, Sebastien Buttet, Jared Warner

Publications and Research

Math anxiety has become an alarming social justice concern, as it results in negative academic consequences, contributes to disinterest and lack of persistence in STEM programs for underrepresented students, and limits their opportunities in STEM careers. According to research, this fear of math occurs long before students begin working on math problems. When high-math anxious students encounter math situations, anticipation anxiety consumes working memory capacity, inhibits learning, and causes them to severely underperform on mathematical tasks. However, very few studies have been conducted to embed psychological interventions in the classroom in an effort to mitigate both anticipation and execution anxiety. …


Linking Authentic Leadership With Employee Initiative Behavior And Task Performance: The Mediating Role Of Emotional Sharing And Communication Satisfaction, Jeong Sik Kim, Jong Gyu Park, Hyun Jung Park Mar 2022

Linking Authentic Leadership With Employee Initiative Behavior And Task Performance: The Mediating Role Of Emotional Sharing And Communication Satisfaction, Jeong Sik Kim, Jong Gyu Park, Hyun Jung Park

Publications and Research

Our study aims to explore the process through which authentic leadership leads to employees’ initiative behavior and task performance. In particular, we focused on the mediating roles of emotional sharing and communication satisfaction. Based on data collected from 242 employee-supervisor dyads, we found that authentic leadership was significantly related to emotional sharing, which was sequentially significantly related to communication satisfaction. Communication satisfaction was significantly associated with initiative behavior and task performance. In addition, emotional sharing and communication satisfaction played significant mediating roles not only in the relationship between authentic leadership and initiative behavior, but also in the relationship between authentic …


Monitoring Sars-Cov-2 In Wastewater During New York City's Second Wave Of Covid-19: Sewershed-Level Trends And Relationships To Publicly Available Clinical Testing Data, Catherine Hoar, Francoise Chauvin, Alexander Clare, Hope Mcgibbon, Esmeraldo Castro, Samantha Patinella, Dimitrios Katehis, John J. Dennehy, Monica Trujillo, Davida S. Smyth, Andrea I. Silverman Mar 2022

Monitoring Sars-Cov-2 In Wastewater During New York City's Second Wave Of Covid-19: Sewershed-Level Trends And Relationships To Publicly Available Clinical Testing Data, Catherine Hoar, Francoise Chauvin, Alexander Clare, Hope Mcgibbon, Esmeraldo Castro, Samantha Patinella, Dimitrios Katehis, John J. Dennehy, Monica Trujillo, Davida S. Smyth, Andrea I. Silverman

Publications and Research

New York City's wastewater monitoring program tracked trends in sewershed-level SARS-CoV-2 loads starting in the fall of 2020, just before the start of the city's second wave of the COVID-19 outbreak. During a five-month study period, from November 8, 2020 to April 11, 2021, viral loads in influent wastewater from each of New York City's 14 wastewater treatment plants were measured and compared to new laboratory-confirmed COVID-19 cases for the populations in each corresponding sewershed, estimated from publicly available clinical testing data. We found significant positive correlations between viral loads in wastewater and new COVID-19 cases. The strength of the …


Divergent Water Requirements Partition Exposure Risk To Parasites In Wild Equids, Kaia J. Tombak, Laurel A. Easterling, Lindsay Martinez, Monica S. Seng, Liana F. Wait, Daniel I. Rubenstein Mar 2022

Divergent Water Requirements Partition Exposure Risk To Parasites In Wild Equids, Kaia J. Tombak, Laurel A. Easterling, Lindsay Martinez, Monica S. Seng, Liana F. Wait, Daniel I. Rubenstein

Publications and Research

For grazing herbivores, dung density in feeding areas is an important determinant of exposure risk to fecal- orally transmitted parasites. When host species share the same parasite species, a nonrandom distribution of their cumulative dung density and/or nonrandom ranging and feeding behavior may skew exposure risk and the relative selection pressure parasites impose on each host. The arid-adapted Grevy's zebra ( Equus grevyi ) can range more widely than the water-dependent plains zebra ( Equus quagga ), with which it shares the same species of gastrointestinal nematodes. We studied how the spatial distribution of zebra dung relates to ranging and …


Deepreal: A Deep Learning Powered Multi-Scalemodeling Framework For Predicting Out-Of-Distributionligand-Induced Gpcr Activity, Tian Cai, Kyra Alyssa Abbu, Yang Liu, Lei Xie Mar 2022

Deepreal: A Deep Learning Powered Multi-Scalemodeling Framework For Predicting Out-Of-Distributionligand-Induced Gpcr Activity, Tian Cai, Kyra Alyssa Abbu, Yang Liu, Lei Xie

Publications and Research

Motivation Drug discovery has witnessed intensive exploration of predictive modeling of drug–target physical interactions over two decades. However, a critical knowledge gap needs to be filled for correlating drug–target interactions with clinical outcomes: predicting genome-wide receptor activities or function selectivity, especially agonist versus antagonist, induced by novel chemicals. Two major obstacles compound the difficulty on this task: known data of receptor activity is far too scarce to train a robust model in light of genome-scale applications, and real-world applications need to deploy a model on data from various shifted distributions.

Results To address these challenges, we have developed an end-to-end …


Spin-Orbit Gravitational Locking - An Effective Potential Approach, Christopher Clouse, Andrea Ferroglia, Miguel C. N. Fiolhais Mar 2022

Spin-Orbit Gravitational Locking - An Effective Potential Approach, Christopher Clouse, Andrea Ferroglia, Miguel C. N. Fiolhais

Publications and Research

The objective of this paper is to study the tidally locked 3:2 spin–orbit resonance of Mercury around the Sun. In order to achieve this goal, the effective potential energy that determines the spinning motion of an ellipsoidal planet around its axis is considered. By studying the rotational potential energy of an ellipsoidal planet orbiting a spherical star on an elliptic orbit with fixed eccentricity and semi-major axis, it is shown that the system presents an infinite number of metastable equilibrium configurations. These states correspond to local minima of the rotational potential energy averaged over an orbit, where the ratio between …


A Hot Retired Woman Is Finally On Feminist Science Fiction's Radar: Review Of Cat Rambo's You Sexy Thing, Marleen S. Barr Mar 2022

A Hot Retired Woman Is Finally On Feminist Science Fiction's Radar: Review Of Cat Rambo's You Sexy Thing, Marleen S. Barr

Publications and Research

In her review of Cat Rambo's novel YOU SEXY THING Marleen S. Barr argues that Rambo brilliantly expands the definition of feminist science fiction when she brings a retired female hero to bear upon the subgenre.