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Direct Expansion Of Functional Cd25+ Cd4+ Regulatory T Cells By Antigen-Processing Dendritic Cells, Sayuri Yarmazaki, Sayuri Yamazaki, Tomonori Iyoda, Kristin V. Tarbell Jan 2003

Direct Expansion Of Functional Cd25+ Cd4+ Regulatory T Cells By Antigen-Processing Dendritic Cells, Sayuri Yarmazaki, Sayuri Yamazaki, Tomonori Iyoda, Kristin V. Tarbell

Publications

An important pathway for immune tolerance is provided by thymic-derived CD25+ CD4+ T cells that suppress other CD25- autoimmune disease-inducing T cells. The antigen-presenting cell (APC) requirements for the control of CD25+ CD4+ suppressor T cells remain to be identified, hampering their study in experimental and clinical situations. CD25+ CD4+ T cells are classically anergic, unable to proliferate in response to mitogenic antibodies to the T cell receptor complex. We now find that CD25+ CD4+ T cells can proliferate in the absence of added cytokines in culture and in vivo when …

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Dendritic Cells Initiate Immune Control Of Epstein-Barr Virus Transformation Of B Lymphocytes In Vitro, Kara L. Bickham, Kiera Goodman, Casper Paludan Jan 2003

Dendritic Cells Initiate Immune Control Of Epstein-Barr Virus Transformation Of B Lymphocytes In Vitro, Kara L. Bickham, Kiera Goodman, Casper Paludan

Publications

The initiation of cell-mediated immunity to Epstein-Barr virus (EBV) has been analyzed with cells from EBV-seronegative blood donors in culture. The addition of dendritic cells (DCs) is essential to prime naive T cells that recognize EBV-latent antigens in enzyme-linked immunospot assays for interferon γ secretion and eradicate transformed B cells in regression assays. In contrast, DCs are not required to control the outgrowth of EBV-transformed B lymphocytes from seropositive donors. Enriched CD4+ and CD8 + T cells mediate regression of EBV-transformed cells in seronegative and seropositive donors, but the kinetics of T-dependent regression occurs with much greater speed with …

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Dendritic Cells Charged With Apoptotic Tumor Cells Induce Long-Lived Protective Cd4+ And Cd8+ T Cell Immunity Against B16 Melanoma, Romina S. Goldszmid, Juliana Idoyaga, Alicia Inès Bravo Jan 2003

Dendritic Cells Charged With Apoptotic Tumor Cells Induce Long-Lived Protective Cd4+ And Cd8+ T Cell Immunity Against B16 Melanoma, Romina S. Goldszmid, Juliana Idoyaga, Alicia Inès Bravo

Publications

Dendritic cells (DCs) are potent APCs and attractive vectors for cancer immunotherapy. Using the B16 melanoma, a poorly immunogenic experimental tumor that expresses low levels of MHC class I products, we investigated whether DCs loaded ex vivo with apoptotic tumor cells could elicit combined CD4+ and CD8+ T cell dependent, long term immunity following injection into mice. The bone marrow-derived DCs underwent maturation during overnight coculture with apoptotic melanoma cells. Following injection, DCs migrated to the draining lymph nodes comparably to control DCs at a level corresponding to ∼0.5% of the injected inoculum. Mice vaccinated with tumor-loaded DCs …

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Snowmelt Research And Management: Ready For The Next Big Step [2003 Stormwater Management In Cold Climates Conference Keynote Address], Gary L. Oberts Jan 2003

Snowmelt Research And Management: Ready For The Next Big Step [2003 Stormwater Management In Cold Climates Conference Keynote Address], Gary L. Oberts

Publications

No abstract provided.

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Using A Professional Moderator In Library Focus Group Research, Eric C. Shoaf Jan 2003

Using A Professional Moderator In Library Focus Group Research, Eric C. Shoaf

Publications

Brown University Library hired a professional marketing and opinion research firm to conduct focus group meetings with library users and to provide data analysis. The discussion includes a review of the library literature on focus group use, practical aspects of focus group methodology, and the benefits of employing professionals where librarian expertise is low. Logistics of focus group preparation, meetings, and report are discussed. Findings and lessons learned are presented along with outcomes for the library.

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Reviewed Work(S): Mexico City In Contemporary Mexican Cinema By David William Foster, Salvador Oropesa Jan 2003

Reviewed Work(S): Mexico City In Contemporary Mexican Cinema By David William Foster, Salvador Oropesa

Publications

No abstract provided.

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Motor Control Of Locomotor Hindlimb Posture In The American Alligator (Alligator Mississippiensis), Stephen M. Reilly, Richard W. Blob Jan 2003

Motor Control Of Locomotor Hindlimb Posture In The American Alligator (Alligator Mississippiensis), Stephen M. Reilly, Richard W. Blob

Publications

Crocodilians are unusual among quadrupedal tetrapods in their frequent use of a wide variety of hindlimb postures, ranging from sprawling to a more erect high walk. In this study, we use synchronized kinematic videos and electromyographic recordings to test how the activity patterns of hindlimb muscles in American alligators (Alligator mississippiensis Daudin) differ between sprawling and more upright postures. Previous force platform analyses suggested that upright posture in alligators would require greater activation by hindlimb extensors to counter increases in the flexor moments exerted about joints by the ground reaction force during upright stance. Consistent with these predictions, ankle extensors …

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Subtropical Dry Forest Trees With No Apparent Damage Sprout Following A Hurricane, Skip Van Bloem, Peter G. Murphy, Ariel E. Lugo Jan 2003

Subtropical Dry Forest Trees With No Apparent Damage Sprout Following A Hurricane, Skip Van Bloem, Peter G. Murphy, Ariel E. Lugo

Publications

Hurricane Georges passed over mature dry forest near Guánica, Puerto Rico in September, 1998. The trees of the dense, short-statured Guánica Forest have a multi-stemmed structure unique to the West Indies in the neo-tropics, a characteristic that has been difficult to explain. Following the hurricane, we measured sprout development below breast height on 1407 stems to assess how response to hurricane disturbance may influence dry forest structure. Basal sprouting increased 8-14 fold after Hurricane Georges. Basal sprouting was found on al- most 68% of damaged stems and, notably, on about 32% of undamaged stems. Basal sprouting was found in all …

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Beryllium Abundances In F And G Dwarfs In The Pleiades And A Persei Clusters From Keck High-Resolution Echelle Spectrometer Observations, Ann Merchant Boesgaard, Eric Aremngaud, Jeremy R. King Jan 2003

Beryllium Abundances In F And G Dwarfs In The Pleiades And A Persei Clusters From Keck High-Resolution Echelle Spectrometer Observations, Ann Merchant Boesgaard, Eric Aremngaud, Jeremy R. King

Publications

While there are many observations of Li in open clusters, there are very few of the companion light element Be. As we have seen in the study of Be in the Hyades by Boesgaard & King, the two elements together provide important and unique information on the extent and nature of interior mixing in solar-like stars. We have obtained high-resolution (45,000) spectra of the Be ii resonance lines in the 14 Pleiades and four Per dwarfs of spectral types F and G with the Keck I telescope and High-Resolution Echelle Spectrometer. The signal-to-noise ratio in the Be spectral region is …

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“Required Reading For Library Administrators Part 2”, Eric C. Shoaf, Tobeylynn Birch, Mark T. Day, William B. Edgar Jan 2003

“Required Reading For Library Administrators Part 2”, Eric C. Shoaf, Tobeylynn Birch, Mark T. Day, William B. Edgar

Publications

The library and information science literature is overflowing with how-to articles, particularly how to manage the library. Increasingly, library managers find that the time they have available to peruse such literature lessens as other professional demands intrude. With this trend in mind, members of the Comparative Library Organization Committee (CLOC), a LAMA/LOMS standing committee, decided that a list of required readings is in order. Not just another bibliography, the selection of titles was developed using citation analysis, or bibliometrics, to select highly cited authors and titles for works published outside of the professional library literature, and for works published within …

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Lipopolysaccharide Or Whole Bacteria Block The Conversion Of Inflammatory Monocytes Into Dendritic Cells In Vivo, Gianluca Rotta, Emmerson W. Edwards, Sabina Sangaletti Jan 2003

Lipopolysaccharide Or Whole Bacteria Block The Conversion Of Inflammatory Monocytes Into Dendritic Cells In Vivo, Gianluca Rotta, Emmerson W. Edwards, Sabina Sangaletti

Publications

Monocytes can develop into dendritic cells (DCs) that migrate to lymph nodes (LNs) and present antigens to T cells. However, we find that this differentiation is blocked when monocytes accumulate subcutaneously in response to bacteria or lipopolysaccharide (LPS). The inhibition of DC differentiation is mediated by the bacteria and in conjunction with inflammatory cells recruited at the site of injection. Inhibition of migratory DC development was reversed in Toll-like receptor (TLR)4-mutated mice when LPS, but not whole bacteria, was injected, suggesting that TLR4 is one but not the only mediator of the inhibition. The block imposed by bacteria was partly …

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Dc-Sign (Cd209) Mediates Dengue Virus Infection Of Human Dendritic Cells, Boonrat Tassaneetrithep, Timothy H. Burgess, Angela Granelli-Piperno Jan 2003

Dc-Sign (Cd209) Mediates Dengue Virus Infection Of Human Dendritic Cells, Boonrat Tassaneetrithep, Timothy H. Burgess, Angela Granelli-Piperno

Publications

Dengue virus is a single-stranded, enveloped RNA virus that productively infects human dendritic cells (DCs) primarily at the immature stage of their differentiation. We now find that all four serotypes of dengue use DC-SIGN (CD209), a C-type lectin, to infect dendritic cells. THP-1 cells become susceptible to dengue infection after transfection of DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN), or its homologue L-SIGN, whereas the infection of dendritic cells is blocked by anti-DC-SIGN antibodies and not by antibodies to other molecules on these cells. Viruses produced by dendritic cells are infectious for DC-SIGN- and L-SIGN-bearing THP-1 cells and other permissive cell lines. …

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Marine Invaders In The Northeast: Rapid Assessment Survey Of Non-Native And Native Marine Species Of Floating Dock Communities, August 2003, Judith Pederson, Robert Bullock, James Carlton, Jennifer Dijkstra, Nicole Dobroski, Peter Dyrynda, Ryan Fisher, Larry Harris, Niels Hobbs, Gretchen Lambert, Eric Lazo-Wasem, Arthur Mathieson, Maria-Pia Miglietta, Jan Smith, Julian Smith Iii, Megan Tyrrell Jan 2003

Marine Invaders In The Northeast: Rapid Assessment Survey Of Non-Native And Native Marine Species Of Floating Dock Communities, August 2003, Judith Pederson, Robert Bullock, James Carlton, Jennifer Dijkstra, Nicole Dobroski, Peter Dyrynda, Ryan Fisher, Larry Harris, Niels Hobbs, Gretchen Lambert, Eric Lazo-Wasem, Arthur Mathieson, Maria-Pia Miglietta, Jan Smith, Julian Smith Iii, Megan Tyrrell

Publications

No abstract provided.

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Distribution, Habitat Use, And Morphotypes Of Feral Hogs (Sus Scrofa) In Illinois, Blake Mccann, Daniel K. Davie, George A. Feldhamer Jan 2003

Distribution, Habitat Use, And Morphotypes Of Feral Hogs (Sus Scrofa) In Illinois, Blake Mccann, Daniel K. Davie, George A. Feldhamer

Publications

Feral hogs (Sus scrofa) recently have been introduced to Illinois. They are important to resource managers because of their potentially negative ecological and economic impacts. We assessed the distribution, habitat use, and body morphology of feral hogs in Illinois. We confirmed the occurrence of feral hogs in Fulton, Hardin, Johnson, Lawrence, Massac, Pope, Randolph, and Union counties. Forest and croplands probably are the most important habitats for feral hogs in Illinois. We found free-ranging hogs in Illinois included four previously described morphotypes with distinguishable physical/cranial characteristics: domestic hogs, feral hogs, hybrids, and Eurasian wild hogs. However, 32.6% of …

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Chronic Wasting Disease In Deer And Elk: A Critique Of Current Models And Their Application, Eric M. Schauber, Alan Woolf Jan 2003

Chronic Wasting Disease In Deer And Elk: A Critique Of Current Models And Their Application, Eric M. Schauber, Alan Woolf

Publications

Chronic wasting disease (CWD), a fatal transmissible spongiform encephalopathy of deer (Odocoileus spp.) and elk (Cervus elaphus), presents a challenge to wildlife managers because little is known about its transmission, yet it could severely threaten wildlife populations if action is not taken rapidly. Published mathematical models predict that CWD could devastate populations of free-living deer and elk, prompting wildlife managers to attempt large-scale eradication of deer in hopes of containing CWD outbreaks. Our objective is to critically examine the theoretical and empirical support for current models of CWD epizootiology, in light of herd health-management actions. We identify …

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Evaluation Of The Ncep/Ncar Reanalysis In Terms Of Synoptic Scale Phenomea: A Case Study From The Midwestern Usa, Justin T. Schoof, S C. Pryor Jan 2003

Evaluation Of The Ncep/Ncar Reanalysis In Terms Of Synoptic Scale Phenomea: A Case Study From The Midwestern Usa, Justin T. Schoof, S C. Pryor

Publications

We evaluate the ability of the National Centers for Environmental Prediction (NCEP)–National Center for Atmosphere Research (NCAR) reanalysis to represent the synoptic-scale climate of the Midwestern USA relative to radiosonde data. Independent, automated synoptic classifications, based on rotated principal component analysis (PCA) of 500 hPa geopotential heights, 850 hPa air temperatures, and 200 hPa wind speeds and a two-step clustering algorithm, result in a 15-type NCEP–NCAR synoptic classification and a 14-type radiosonde classification. The classifications are examined in terms of similarities and differences in the modes of variance manifest in the PCA solutions, the spatial patterns and variability of input …

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Socia Networks And Political Participation: The Role Of Social Interaction In Explaining Political Participation, Scott D. Mcclurg Jan 2003

Socia Networks And Political Participation: The Role Of Social Interaction In Explaining Political Participation, Scott D. Mcclurg

Publications

The argument advanced in this paper is that interaction in social networks has a strong, though often overlooked, influence on the individual propensity to participate in politics. Specifically, I argue that social interaction creates opportunities for individuals to gather information about politics that allow them to live beyond personal resource constraints, thereby supporting the political activity of many people. Using relational data from the South Bend election survey, this paper provides evidence that the effect of social interaction on participation is contingent on the amount of political discussion that occurs in social networks. Additional analysis shows the substantive and theoretical …

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A Bad Subject, Daria Roithmayr Jan 2003

A Bad Subject, Daria Roithmayr

Publications

No abstract provided.

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You Can't Ask (Or Say) That: The First Amendment And Civil Rights Restrictions On Decisionmaker Speech, Helen Norton Jan 2003

You Can't Ask (Or Say) That: The First Amendment And Civil Rights Restrictions On Decisionmaker Speech, Helen Norton

Publications

Federal, state, and local civil rights laws regulate private decisionmaking about whom an employer may hire or fire, to whom a landlord may rent an apartment, or to whom a creditor may extend credit. In prohibiting discriminatory conduct, however, these laws also limit the speech of those making these decisions. In this Article, Professor Norton explores how we might think about these civil rights laws in the context of the First Amendment, and their place within the Supreme Court's commercial speech jurisprudence. She concludes that the speech restricted by these laws may be characterized as falling outside the protection of …

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Evidence Of Acclimatization In Persons With Severe-To-Profound Hearing Loss, Francis K. Kuk, Lisa G. Potts, Lidia Lee, Michael Valente, Jay Picirrillo Jan 2003

Evidence Of Acclimatization In Persons With Severe-To-Profound Hearing Loss, Francis K. Kuk, Lisa G. Potts, Lidia Lee, Michael Valente, Jay Picirrillo

Publications

No abstract provided.

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Fuel Consumption Modeling Of A Transport Category Aircraft: A Flight Operations Quality Assurance (Foqa) Analysis, Alan J. Stolzer Jan 2003

Fuel Consumption Modeling Of A Transport Category Aircraft: A Flight Operations Quality Assurance (Foqa) Analysis, Alan J. Stolzer

Publications

"Flight Operations Quality Assurance (FOQA)-derived data was used to develop parsimonious model(s) for fuel consumption on a Boeing 757 airplane using regression analysis. Using the model(s), it should be possible to identify outliers (specific flights) with respect to fuel consumption, which will enable the air carrier to investigate the cause of excessive fuel consumption and remedy the problem A major air carrier provided the database used for the study. Fuel flow was predicted by calibrated airspeed, gross weight, and n2 (ENG[1 or 2]n2). The models containing these three variables explained approximately 85% of the variation in fuel flow. A reporting …

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Mitigating The Negative Effects Of Stress In Space Flight: A Transactional Approach, Haydee Maria Cuevas Jan 2003

Mitigating The Negative Effects Of Stress In Space Flight: A Transactional Approach, Haydee Maria Cuevas

Publications

The primary goal of this theoretical paper is to highlight how a transactional approach to investigating stressor effects during space flight can lead to a greater understanding of the complex processes by which humans adapt psychologically and physically to the adverse conditions encountered in this extreme environment.Transactional approaches conceptualize stress as occurring in the nature of the "transaction" (Le., interaction) between the individual and the stimulus environment, emphasizing the role of cognitive appraisal (Le., perceived ability to cope with the situation). Interventions that positively influence this cognitive appraisal process may, therefore, lessen the experience of stress and optimize human performance …

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The Right To Receive Information, Susan Nevelow Mart Jan 2003

The Right To Receive Information, Susan Nevelow Mart

Publications

Ms. Mart examines the legal evolution of the right to receive information, particularly focusing on its application to libraries, beginning with the Supreme Court holding in Board of Education v. Pico, and followed by cases that have considered the meaning of Pico in a variety of library-related contexts.

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Western Justice, Richard B. Collins Jan 2003

Western Justice, Richard B. Collins

Publications

No abstract provided.

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Sacred Sites And Religious Freedom On Government Land, Richard B. Collins Jan 2003

Sacred Sites And Religious Freedom On Government Land, Richard B. Collins

Publications

No abstract provided.

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Litigation Narratives: Why Jensen V. Ellerth Didn't Change Sexual Harassment Law, But Still Has A Story Worth Telling, Melissa Hart Jan 2003

Litigation Narratives: Why Jensen V. Ellerth Didn't Change Sexual Harassment Law, But Still Has A Story Worth Telling, Melissa Hart

Publications

No abstract provided.

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Daubert Asks The Right Questions: Now Appellate Courts Should Help Find The Right Answers, Christopher B. Mueller Jan 2003

Daubert Asks The Right Questions: Now Appellate Courts Should Help Find The Right Answers, Christopher B. Mueller

Publications

No abstract provided.

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Regulatory Challenges And Models Of Regulation, Philip J. Weiser Jan 2003

Regulatory Challenges And Models Of Regulation, Philip J. Weiser

Publications

No abstract provided.

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Contractarian Economics And Mediation Ethics: The Case For Customizing Neutrality Through Contingent Fee Mediation, Scott R. Peppet Jan 2003

Contractarian Economics And Mediation Ethics: The Case For Customizing Neutrality Through Contingent Fee Mediation, Scott R. Peppet

Publications

No abstract provided.

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Water Management In The United States And The Fate Of The Colorado River Delta In Mexico, David H. Getches Jan 2003

Water Management In The United States And The Fate Of The Colorado River Delta In Mexico, David H. Getches

Publications

No abstract provided.

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