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Articles 5101 - 5130 of 6228
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Membrane Anchoring Subunits Specify Selective Regulation Of Rgs9·Gbeta5 Gap Complex In Photoreceptor Neurons, Yan Cao, Alexander V. Kolesnikov, Ikuo Masuho, Vladimir J. Kefalov, Kirill A. Martemyanov
Membrane Anchoring Subunits Specify Selective Regulation Of Rgs9·Gbeta5 Gap Complex In Photoreceptor Neurons, Yan Cao, Alexander V. Kolesnikov, Ikuo Masuho, Vladimir J. Kefalov, Kirill A. Martemyanov
Open Access Publications
The RGS9·Gβ5 complex is the key regulator of neuronal G-protein signaling and shows remarkable selectivity of subunit composition. In retinal photoreceptors, RGS9·Gβ5 is bound to the membrane anchor R9AP and the complex regulates visual signaling. In the basal ganglia neurons, RGS9·Gβ5 is instead associated with a homologous protein, R7BP, and regulates reward circuit. Switching this selective subunit composition of the complex in rod photoreceptors allowed us to study the molecular underpinning of signaling specificity in diverse G-protein pathways. We have found that both membrane anchoring subunits play a conserved role in regulating protein levels of RGS9·Gβ5 and enhancing the ability …
Report From The 2009 Aoa North American Traveling Fellowship, Ryan T. Bicknell, Gregory J. Della Rocca, Wellington K. Hsu, Amanda D. Marshall, Robert H. Brophy
Report From The 2009 Aoa North American Traveling Fellowship, Ryan T. Bicknell, Gregory J. Della Rocca, Wellington K. Hsu, Amanda D. Marshall, Robert H. Brophy
Open Access Publications
No abstract provided.
Protein Turnover Of The Wallenda/Dlk Kinase Regulates A Retrograde Response To Axonal Injury, Xin Xiong, Xin Wang, Ronny Ewanek, Pavan Bhat, Aaron Diantonio, Catherine A. Collins
Protein Turnover Of The Wallenda/Dlk Kinase Regulates A Retrograde Response To Axonal Injury, Xin Xiong, Xin Wang, Ronny Ewanek, Pavan Bhat, Aaron Diantonio, Catherine A. Collins
Open Access Publications
No abstract provided.
What's New In Spine Surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, Jeffrey C. Wang
What's New In Spine Surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, Jeffrey C. Wang
Open Access Publications
No abstract provided.
Age-Related Deterioration Of Rod Vision In Mice, Alexander V. Kolesnikov, Jie Fan, Rosalie K. Crouch, Vladimir J. Kefalov
Age-Related Deterioration Of Rod Vision In Mice, Alexander V. Kolesnikov, Jie Fan, Rosalie K. Crouch, Vladimir J. Kefalov
Open Access Publications
Even in healthy individuals, aging leads to deterioration in visual acuity, contrast sensitivity, visual field, and dark adaptation. Little is known about the neural mechanisms that drive the age-related changes of the retina and, more specifically, photoreceptors. According to one hypothesis, the age-related deterioration in rod function is due to the limited availability of 11-cis-retinal for rod pigment formation. To determine how aging affects rod photoreceptors and to test the retinoid-deficiency hypothesis, we compared the morphological and functional properties of rods of adult and aged B6D2F1/J mice. We found that the number of rods and the length of their outer …
Combined Hip Arthroscopy And Limited Open Osteochondroplasty For Anterior Femoroacetabular Impingement, John C. Clohisy, Lukas P. Zebala, Jeffrey J. Nepple, Gail Pashos
Combined Hip Arthroscopy And Limited Open Osteochondroplasty For Anterior Femoroacetabular Impingement, John C. Clohisy, Lukas P. Zebala, Jeffrey J. Nepple, Gail Pashos
Open Access Publications
No abstract provided.
Vestibular Heading Discrimination And Sensitivity To Linear Acceleration In Head And World Coordinates, Paul R. Macneilage, Martin S. Banks, Gregory C. Deangelis, Dora E. Angelaki
Vestibular Heading Discrimination And Sensitivity To Linear Acceleration In Head And World Coordinates, Paul R. Macneilage, Martin S. Banks, Gregory C. Deangelis, Dora E. Angelaki
Open Access Publications
Effective navigation and locomotion depend critically on an observer's ability to judge direction of linear self-motion, i.e., heading. The vestibular cue to heading is the direction of inertial acceleration that accompanies transient linear movements. This cue is transduced by the otolith organs. The otoliths also respond to gravitational acceleration, so vestibular heading discrimination could depend on (1) the direction of movement in head coordinates (i.e., relative to the otoliths), (2) the direction of movement in world coordinates (i.e., relative to gravity), or (3) body orientation (i.e., the direction of gravity relative to the otoliths). To quantify these effects, we measured …
Dynamic Contact Mechanics Of The Medial Meniscus As A Function Of Radial Tear, Repair, And Partial Meniscectomy, Asheesh Bedi, Natalie H. Kelly, Michael Baad, Alice J.S. Fox, Robert H. Brophy, Russell F. Warren, Suzanne A. Maher
Dynamic Contact Mechanics Of The Medial Meniscus As A Function Of Radial Tear, Repair, And Partial Meniscectomy, Asheesh Bedi, Natalie H. Kelly, Michael Baad, Alice J.S. Fox, Robert H. Brophy, Russell F. Warren, Suzanne A. Maher
Open Access Publications
No abstract provided.
Identifying Basal Ganglia Divisions In Individuals Using Resting-State Functional Connectivity Mri, Kelly Anne Barnes, Alexander L. Cohen, Jonathan D. Power, Steven M. Nelson, Yannic B.L. Dosenbach, Francis M. Miezin, Steven E. Petersen, Bradley L. Schlaggar
Identifying Basal Ganglia Divisions In Individuals Using Resting-State Functional Connectivity Mri, Kelly Anne Barnes, Alexander L. Cohen, Jonathan D. Power, Steven M. Nelson, Yannic B.L. Dosenbach, Francis M. Miezin, Steven E. Petersen, Bradley L. Schlaggar
Open Access Publications
No abstract provided.
Location And Initiation Of Degenerative Rotator Cuff Tears: An Analysis Of Three Hundred And Sixty Shoulders, H. Mike Kim, Nirvikar Dahiya, Sharlene A. Teefey, William D. Middleton, Georgia Stobbs, Karen Steger-May, Ken Yamaguchi, Jay D. Keener
Location And Initiation Of Degenerative Rotator Cuff Tears: An Analysis Of Three Hundred And Sixty Shoulders, H. Mike Kim, Nirvikar Dahiya, Sharlene A. Teefey, William D. Middleton, Georgia Stobbs, Karen Steger-May, Ken Yamaguchi, Jay D. Keener
Open Access Publications
No abstract provided.
Molecular Dissection Of I(A) In Cortical Pyramidal Neurons Reveals Three Distinct Components Encoded By Kv4.2, Kv4.3, And Kv1.4 Alpha-Subunits, Aaron J. Norris, Jeanne M. Nerbonne
Molecular Dissection Of I(A) In Cortical Pyramidal Neurons Reveals Three Distinct Components Encoded By Kv4.2, Kv4.3, And Kv1.4 Alpha-Subunits, Aaron J. Norris, Jeanne M. Nerbonne
Open Access Publications
The rapidly activating and inactivating voltage-gated K(+) (Kv) current, I(A), is broadly expressed in neurons and is a key regulator of action potential repolarization, repetitive firing, backpropagation (into dendrites) of action potentials, and responses to synaptic inputs. Interestingly, results from previous studies on a number of neuronal cell types, including hippocampal, cortical, and spinal neurons, suggest that macroscopic I(A) is composed of multiple components and that each component is likely encoded by distinct Kv channel alpha-subunits. The goals of the experiments presented here were to test this hypothesis and to determine the molecular identities of the Kv channel alpha-subunits that …
Relationship Of Tear Size And Location To Fatty Degeneration Of The Rotator Cuff, H. Mike Kim, Nirvikar Dahiya, Sharlene A. Teefey, Jay D. Keener, Leesa M. Galatz, Ken Yamaguchi
Relationship Of Tear Size And Location To Fatty Degeneration Of The Rotator Cuff, H. Mike Kim, Nirvikar Dahiya, Sharlene A. Teefey, Jay D. Keener, Leesa M. Galatz, Ken Yamaguchi
Open Access Publications
No abstract provided.
Orthopaedic Surgeons And The Medical Device Industry: The Threat To Scientific Integrity And The Public Trust, Richard H. Gelberman, David Samson, Sohail K. Mirza, John J. Callaghan, Vincent D. Pellegrini
Orthopaedic Surgeons And The Medical Device Industry: The Threat To Scientific Integrity And The Public Trust, Richard H. Gelberman, David Samson, Sohail K. Mirza, John J. Callaghan, Vincent D. Pellegrini
Open Access Publications
No abstract provided.
A Genome-Wide Association Study Of Self-Rated Health, Miriam A. Mosing, Karin J.H. Verweij, Sarah E. Medland, Jodie Painter, Scott D. Gordon, Andrew C. Heath, Pamela A. Madden, Grant W. Montgomery, Nicholas G. Martin
A Genome-Wide Association Study Of Self-Rated Health, Miriam A. Mosing, Karin J.H. Verweij, Sarah E. Medland, Jodie Painter, Scott D. Gordon, Andrew C. Heath, Pamela A. Madden, Grant W. Montgomery, Nicholas G. Martin
Open Access Publications
No abstract provided.
A Grid To Facilitate Physics Staffing Justification, Eric E. Klein
A Grid To Facilitate Physics Staffing Justification, Eric E. Klein
Open Access Publications
No abstract provided.
Direction Discrimination Thresholds Of Vestibular And Cerebellar Nuclei Neurons, Sheng Liu, Tatyana Yakusheva, Gregory C. Deangelis, Dora E. Angelaki
Direction Discrimination Thresholds Of Vestibular And Cerebellar Nuclei Neurons, Sheng Liu, Tatyana Yakusheva, Gregory C. Deangelis, Dora E. Angelaki
Open Access Publications
No abstract provided.
Cd46 Engagement On Human Cd4+ T Cells Produces T Regulatory Type 1-Like Regulation Of Antimycobacterial T Cell Responses, Steven M. Truscott, Getahun Abate, Jeffrey D. Price, Claudia Kemper, John P. Atkinson, Daniel F. Hoft
Cd46 Engagement On Human Cd4+ T Cells Produces T Regulatory Type 1-Like Regulation Of Antimycobacterial T Cell Responses, Steven M. Truscott, Getahun Abate, Jeffrey D. Price, Claudia Kemper, John P. Atkinson, Daniel F. Hoft
Open Access Publications
No abstract provided.
Ccpa And Lacd.1 Affect Temporal Regulation Of Streptococcus Pyogenes Virulence Genes, Colin C. Kietzman, Michael G. Caparon
Ccpa And Lacd.1 Affect Temporal Regulation Of Streptococcus Pyogenes Virulence Genes, Colin C. Kietzman, Michael G. Caparon
Open Access Publications
No abstract provided.
Mof And Histone H4 Acetylation At Lysine 16 Are Critical For Dna Damage Response And Double-Strand Break Repair, Girdhar G. Sharma, Sairei So, Arun Gupta, Rakesh Kumar, Christelle Cayrou, Nikita Avvakumov, Utpal Bhadra, Raj K. Pandita, Matthew H. Porteus, David J. Chen, Jacques Cote, Tej K. Pandita
Mof And Histone H4 Acetylation At Lysine 16 Are Critical For Dna Damage Response And Double-Strand Break Repair, Girdhar G. Sharma, Sairei So, Arun Gupta, Rakesh Kumar, Christelle Cayrou, Nikita Avvakumov, Utpal Bhadra, Raj K. Pandita, Matthew H. Porteus, David J. Chen, Jacques Cote, Tej K. Pandita
Open Access Publications
No abstract provided.
Mechanisms Of Non-Apoptotic Programmed Cell Death In Diabetes And Heart Failure, Gerald W. Dorn Ii
Mechanisms Of Non-Apoptotic Programmed Cell Death In Diabetes And Heart Failure, Gerald W. Dorn Ii
Open Access Publications
No abstract provided.
Quantitation Of "Autophagic Flux" In Mature Skeletal Muscle, Jeong-Sun Ju, Arun S. Varadhachary, Sara E. Miller, Conrad C. Weihl
Quantitation Of "Autophagic Flux" In Mature Skeletal Muscle, Jeong-Sun Ju, Arun S. Varadhachary, Sara E. Miller, Conrad C. Weihl
Open Access Publications
No abstract provided.
P38Δ Mitogen-Activated Protein Kinase Regulates Skin Homeostasis And Tumorigenesis, Tatiana Efimova
P38Δ Mitogen-Activated Protein Kinase Regulates Skin Homeostasis And Tumorigenesis, Tatiana Efimova
Open Access Publications
No abstract provided.
Sliding-Clip Renorrhaphy Provides Superior Closing Tension During Robot-Assisted Partial Nephrectomy, Brian M. Benway, Jose M. Cabello, Robert S. Figenshau, Sam B. Bhayani
Sliding-Clip Renorrhaphy Provides Superior Closing Tension During Robot-Assisted Partial Nephrectomy, Brian M. Benway, Jose M. Cabello, Robert S. Figenshau, Sam B. Bhayani
Open Access Publications
No abstract provided.
Perceptions Of Hiv Risk Among Monogamous Wives Of Alcoholic Men In South India: A Qualitative Study, Deepthi S. Varma, Prabha S. Chandra, Catina Callahan, Wendy Reich, Linda B. Cottler
Perceptions Of Hiv Risk Among Monogamous Wives Of Alcoholic Men In South India: A Qualitative Study, Deepthi S. Varma, Prabha S. Chandra, Catina Callahan, Wendy Reich, Linda B. Cottler
Open Access Publications
No abstract provided.
Ventricular Tachycardia In Infants With Structurally Normal Heart: A Benign Disorder, Mark D. Levin, Paul Stephens, Ronn E. Tanel, Victoria L. Vetter, Larry A. Rhodes
Ventricular Tachycardia In Infants With Structurally Normal Heart: A Benign Disorder, Mark D. Levin, Paul Stephens, Ronn E. Tanel, Victoria L. Vetter, Larry A. Rhodes
Open Access Publications
No abstract provided.
Multiple Pathways Of Inhibition Shape Bipolar Cell Responses In The Retina, Erika D. Eggers, Peter D. Lukasiewicz
Multiple Pathways Of Inhibition Shape Bipolar Cell Responses In The Retina, Erika D. Eggers, Peter D. Lukasiewicz
Open Access Publications
No abstract provided.
The Role Of Presynaptic Dynamics In Processing Of Natural Spike Trains In Hippocampal Synapses, Umasankar Kandaswamy, Pan-Yue Deng, Charles F. Stevens, Vitaly A. Klyachko
The Role Of Presynaptic Dynamics In Processing Of Natural Spike Trains In Hippocampal Synapses, Umasankar Kandaswamy, Pan-Yue Deng, Charles F. Stevens, Vitaly A. Klyachko
Open Access Publications
No abstract provided.
A Novel Auxiliary Subunit Critical To Bk Channel Function In Caenorhabditis Elegans, Bojun Chen, Qian Ge, Xiao-Ming Xia, Ping Liu, Sijie J. Wang, Haiying Zhan, Betty A. Eipper, Zhao-Wen Wang
A Novel Auxiliary Subunit Critical To Bk Channel Function In Caenorhabditis Elegans, Bojun Chen, Qian Ge, Xiao-Ming Xia, Ping Liu, Sijie J. Wang, Haiying Zhan, Betty A. Eipper, Zhao-Wen Wang
Open Access Publications
No abstract provided.
Genetic Targeting Of Erk1 Suggests A Predominant Role For Erk2 In Murine Pain Models, Benedict J. Alter, Chengshui Zhao, Farzana Karim, Gary E. Landreth, Robert W. Gereau Iv
Genetic Targeting Of Erk1 Suggests A Predominant Role For Erk2 In Murine Pain Models, Benedict J. Alter, Chengshui Zhao, Farzana Karim, Gary E. Landreth, Robert W. Gereau Iv
Open Access Publications
No abstract provided.
Interdependent Roles For Accessory Kchip2, Kchip3, And Kchip4 Subunits In The Generation Of Kv4-Encoded Ia Channels In Cortical Pyramidal Neurons, Aaron J. Norris, Nicholas C. Foeger, Jeanne M. Nerbonne
Interdependent Roles For Accessory Kchip2, Kchip3, And Kchip4 Subunits In The Generation Of Kv4-Encoded Ia Channels In Cortical Pyramidal Neurons, Aaron J. Norris, Nicholas C. Foeger, Jeanne M. Nerbonne
Open Access Publications
No abstract provided.