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Effectiveness Of Long-Acting Reversible Contraception, Brooke Winner, Jeffrey F. Peipert, Quihong Zhao, Christina Buckel, Tessa Madden, Jenifer E. Allsworth, Gina M. Secura Jan 2012

Effectiveness Of Long-Acting Reversible Contraception, Brooke Winner, Jeffrey F. Peipert, Quihong Zhao, Christina Buckel, Tessa Madden, Jenifer E. Allsworth, Gina M. Secura

Open Access Publications

No abstract provided.


Two-Year Outcomes After Transcatheter Or Surgical Aortic-Valve Replacement, Alan Zajarias, Et Al Jan 2012

Two-Year Outcomes After Transcatheter Or Surgical Aortic-Valve Replacement, Alan Zajarias, Et Al

Open Access Publications

No abstract provided.


Ultrastructural Studies In App/Ps1 Mice Expressing Human Apoe Isoforms: Implications For Alzheimer’S Disease, Krikor Dirkranian, Jungsu Kim, Floy R. Stewart, Marilyn A. Levy, David M. Holtzman Jan 2012

Ultrastructural Studies In App/Ps1 Mice Expressing Human Apoe Isoforms: Implications For Alzheimer’S Disease, Krikor Dirkranian, Jungsu Kim, Floy R. Stewart, Marilyn A. Levy, David M. Holtzman

Open Access Publications

No abstract provided.


Medicaid Expenditures On Psychotropic Medications For Children In The Child Welfare System, Ramesh Raghavan, Derek S. Brown, Hope Thompson, Susan L. Ettner, Lisa M. Clements, Whitney Key Jan 2012

Medicaid Expenditures On Psychotropic Medications For Children In The Child Welfare System, Ramesh Raghavan, Derek S. Brown, Hope Thompson, Susan L. Ettner, Lisa M. Clements, Whitney Key

Open Access Publications

No abstract provided.


Differential Replication Of Pathogenic And Nonpathogenic Strains Of West Nile Virus Within Astrocytes, Katherine L. Hussmann, Melanie A. Samuel, Kwang S. Kim, Michael S. Diamond, Brenda L. Fredericksen Jan 2012

Differential Replication Of Pathogenic And Nonpathogenic Strains Of West Nile Virus Within Astrocytes, Katherine L. Hussmann, Melanie A. Samuel, Kwang S. Kim, Michael S. Diamond, Brenda L. Fredericksen

Open Access Publications

No abstract provided.


Aspirin But Not Ibuprofen Use Is Associated With Reduced Risk Of Prostate Cancer: A Plco Study, G. L. Andriole, Et Al. Jan 2012

Aspirin But Not Ibuprofen Use Is Associated With Reduced Risk Of Prostate Cancer: A Plco Study, G. L. Andriole, Et Al.

Open Access Publications

No abstract provided.


Health Outcomes In Patients Using No-Prescription Online Pharmacies To Purchase Prescription Drugs, Theodore J. Cicero, Matthew S. Ellis Jan 2012

Health Outcomes In Patients Using No-Prescription Online Pharmacies To Purchase Prescription Drugs, Theodore J. Cicero, Matthew S. Ellis

Open Access Publications

No abstract provided.


Diazoxide Maintains Human Myocyte Volume Homeostasis During Stress, Sara K. Maffit, Angela D. Sellitto, Ashraf S. Al-Dadah, Richard B. Schuessler, Ralph J. Damiano Jr., Jennifer S. Lawton Jan 2012

Diazoxide Maintains Human Myocyte Volume Homeostasis During Stress, Sara K. Maffit, Angela D. Sellitto, Ashraf S. Al-Dadah, Richard B. Schuessler, Ralph J. Damiano Jr., Jennifer S. Lawton

Open Access Publications

No abstract provided.


Cooperative Role Of Antibodies Against Heat-Labile Toxin And The Etpa Adhesin In Preventing Toxin Delivery And Intestinal Colonization By Enterotoxigenic Escherichia Coli, Koushik Roy, David J. Hamilton, James M. Fleckenstein Jan 2012

Cooperative Role Of Antibodies Against Heat-Labile Toxin And The Etpa Adhesin In Preventing Toxin Delivery And Intestinal Colonization By Enterotoxigenic Escherichia Coli, Koushik Roy, David J. Hamilton, James M. Fleckenstein

Open Access Publications

No abstract provided.


Killed But Metabolically Active Leishmania Infantum As A Novel Whole-Cell Vaccine For Visceral Leishmaniasis, Kevin W. Bruhn, Ron Birnbaum, Jacquelyn Haskell, Veena Vanchinathan, Stephanie Greger, Rupa Narayan, Pei-Lin Chang, Thu Anh Tran, Suzanne M. Hickerson, Stephen M. Beverley, Mary E. Wilson, Noah Craft Jan 2012

Killed But Metabolically Active Leishmania Infantum As A Novel Whole-Cell Vaccine For Visceral Leishmaniasis, Kevin W. Bruhn, Ron Birnbaum, Jacquelyn Haskell, Veena Vanchinathan, Stephanie Greger, Rupa Narayan, Pei-Lin Chang, Thu Anh Tran, Suzanne M. Hickerson, Stephen M. Beverley, Mary E. Wilson, Noah Craft

Open Access Publications

No abstract provided.


Five-Year Update On The Mouse Model Of Orthotopic Lung Transplantation: Scientific Uses, Tricks Of The Trade, And Tips For Success, Xue Lin, Wenjun Li, Jiaming Lai, Mikio Okazaki, Seiichiro Sugimoto, Sumiharu Yamamoto, Xingan Wang, Andrew E. Gelman, Daniel Kreisel, Alexander S. Krupnick Jan 2012

Five-Year Update On The Mouse Model Of Orthotopic Lung Transplantation: Scientific Uses, Tricks Of The Trade, And Tips For Success, Xue Lin, Wenjun Li, Jiaming Lai, Mikio Okazaki, Seiichiro Sugimoto, Sumiharu Yamamoto, Xingan Wang, Andrew E. Gelman, Daniel Kreisel, Alexander S. Krupnick

Open Access Publications

No abstract provided.


Zbtb46 Expression Distinguishes Classical Dendritic Cells And Their Committed Progenitors From Other Immune Lineages, Ansuman T. Satpathy, Wumesh Kc, Jörn C. Albring, Brian T. Edelson, Nicole M. Kretzer, Deepta Bhattacharya, Theresa L. Murphy, Kenneth M. Murphy Jan 2012

Zbtb46 Expression Distinguishes Classical Dendritic Cells And Their Committed Progenitors From Other Immune Lineages, Ansuman T. Satpathy, Wumesh Kc, Jörn C. Albring, Brian T. Edelson, Nicole M. Kretzer, Deepta Bhattacharya, Theresa L. Murphy, Kenneth M. Murphy

Open Access Publications

Distinguishing dendritic cells (DCs) from other cells of the mononuclear phagocyte system is complicated by the shared expression of cell surface markers such as CD11c. In this study, we identified Zbtb46 (BTBD4) as a transcription factor selectively expressed by classical DCs (cDCs) and their committed progenitors but not by plasmacytoid DCs (pDCs), monocytes, macrophages, or other lymphoid or myeloid lineages. Using homologous recombination, we replaced the first coding exon of Zbtb46 with GFP to inactivate the locus while allowing detection of Zbtb46 expression. GFP expression in Zbtb46(gfp/+) mice recapitulated the cDC-specific expression of the native locus, being restricted to cDC …


Dna2 And Exo1 In Replication-Coupled, Homology-Directed Repair And In The Interplay Between Hdr And The Fa/Brca Network, Kenneth K. Karanja, Stephanie W. Cox, Julien P. Duxin, Sheila A. Stewart, Judith L. Campbell Jan 2012

Dna2 And Exo1 In Replication-Coupled, Homology-Directed Repair And In The Interplay Between Hdr And The Fa/Brca Network, Kenneth K. Karanja, Stephanie W. Cox, Julien P. Duxin, Sheila A. Stewart, Judith L. Campbell

Open Access Publications

No abstract provided.


Offspring Adhd As A Risk Factor For Parental Marital Problems: Controls For Genetic And Environmental Confounds, Alice C. Schermerhorn, Brian M. D'Onofrio, Wendy S. Slutske, Robert E. Emery, Eric Turkheimer, K. Paige Harden, Andrew C. Heath, Nicholas G. Martin Jan 2012

Offspring Adhd As A Risk Factor For Parental Marital Problems: Controls For Genetic And Environmental Confounds, Alice C. Schermerhorn, Brian M. D'Onofrio, Wendy S. Slutske, Robert E. Emery, Eric Turkheimer, K. Paige Harden, Andrew C. Heath, Nicholas G. Martin

Open Access Publications

No abstract provided.


Reply To Herigon And Newland, Stephanie A. Fritz, Bernard C. Camins, Jonathan Dukes, Gregory A. Storch Jan 2012

Reply To Herigon And Newland, Stephanie A. Fritz, Bernard C. Camins, Jonathan Dukes, Gregory A. Storch

Open Access Publications

No abstract provided.


Attempted Endoscopic Closure Of A Pancreaticocolonic Fistula With An Over-The-Scope Clip, Darrell M. Gray Ii, Daniel K. Mullady Jan 2012

Attempted Endoscopic Closure Of A Pancreaticocolonic Fistula With An Over-The-Scope Clip, Darrell M. Gray Ii, Daniel K. Mullady

Open Access Publications

No abstract provided.


Actin Cap Associated Focal Adhesions And Their Distinct Role In Cellular Mechanosensing, Dong-Hwee Kim, Shyam B. Khatau, Yunfeng Feng, Sam Walcott, Sean X. Sun, Gregory D. Longmore, Denis Wirtz Jan 2012

Actin Cap Associated Focal Adhesions And Their Distinct Role In Cellular Mechanosensing, Dong-Hwee Kim, Shyam B. Khatau, Yunfeng Feng, Sam Walcott, Sean X. Sun, Gregory D. Longmore, Denis Wirtz

Open Access Publications

No abstract provided.


Absence Of Ca2+-Stimulated Adenylyl Cyclases Leads To Reduced Synaptic Plasticity And Impaired Experience-Dependent Fear Memory, L. Wieczorek, D. Majumdar, T. A. Wills, L. Hu, D. G. Winder, D. J. Webb, L. J. Muglia Jan 2012

Absence Of Ca2+-Stimulated Adenylyl Cyclases Leads To Reduced Synaptic Plasticity And Impaired Experience-Dependent Fear Memory, L. Wieczorek, D. Majumdar, T. A. Wills, L. Hu, D. G. Winder, D. J. Webb, L. J. Muglia

Open Access Publications

No abstract provided.


Deciphering A Global Network Of Functionally Associated Post-Translational Modifications, Pablo Minguez, Luca Parca, Francesca Diella, Daniel R. Mende, Runjun Kumar, Manuela Helmer-Citterich, Anne-Claude Gavin, Vera Van Noort, Peer Bork Jan 2012

Deciphering A Global Network Of Functionally Associated Post-Translational Modifications, Pablo Minguez, Luca Parca, Francesca Diella, Daniel R. Mende, Runjun Kumar, Manuela Helmer-Citterich, Anne-Claude Gavin, Vera Van Noort, Peer Bork

Open Access Publications

No abstract provided.


The Distinct Roles Of The Nucleus And Nucleus-Cytoskeleton Connections In Three-Dimensional Cell Migration, Shyam B. Khatau, Ryan J. Bloom, Saumendra Bajpai, David Razafsky, Shu Zhang, Anjil Giri, Pei-Hsun Wu, Jorge Marchand, Alfredo Celedon, Christopher M. Hale, Sean X. Sun, Didier Hodzic, Denis Wirtz Jan 2012

The Distinct Roles Of The Nucleus And Nucleus-Cytoskeleton Connections In Three-Dimensional Cell Migration, Shyam B. Khatau, Ryan J. Bloom, Saumendra Bajpai, David Razafsky, Shu Zhang, Anjil Giri, Pei-Hsun Wu, Jorge Marchand, Alfredo Celedon, Christopher M. Hale, Sean X. Sun, Didier Hodzic, Denis Wirtz

Open Access Publications

No abstract provided.


Ubiquitination And Degradation Of The Hominoid- Specific Oncoprotein Tbc1d3 Is Mediated By Cul7 E3 Ligase, Chen Kong, Dmitri Samovski, Priya Srikanth, Marisa J. Wainszelbaum, Audra J. Charron, Jialiu Liu, Jeffrey J. Lange, Pin-I Chen, Zhen-Qiang Pan, Xiong Su, Philip D. Stahl Jan 2012

Ubiquitination And Degradation Of The Hominoid- Specific Oncoprotein Tbc1d3 Is Mediated By Cul7 E3 Ligase, Chen Kong, Dmitri Samovski, Priya Srikanth, Marisa J. Wainszelbaum, Audra J. Charron, Jialiu Liu, Jeffrey J. Lange, Pin-I Chen, Zhen-Qiang Pan, Xiong Su, Philip D. Stahl

Open Access Publications

No abstract provided.


Expression And Function Of Pml-Rara In The Hematopoietic Progenitor Cells Of Ctsg-Pml-Rara Mice, Lukas D. Wartman, John S. Welch, Geoffrey L. Uy, Jeffery M. Klco, Tamara Lamprecht, Nobish Varhese, Rakesh Nagarajan, Timothy J. Ley Jan 2012

Expression And Function Of Pml-Rara In The Hematopoietic Progenitor Cells Of Ctsg-Pml-Rara Mice, Lukas D. Wartman, John S. Welch, Geoffrey L. Uy, Jeffery M. Klco, Tamara Lamprecht, Nobish Varhese, Rakesh Nagarajan, Timothy J. Ley

Open Access Publications

No abstract provided.


Functional Assessment Of Human Coding Mutations Affecting Skin Pigmentation Using Zebrafish, Zurab R. Tsetskhladze, Victor A. Canfield, Khai C. Ang, Steven M. Wentzel, Katherine P. Reid, Arthur S. Berg, Stephen L. Johnson, Koichi Kawakami, Keith C. Cheng Jan 2012

Functional Assessment Of Human Coding Mutations Affecting Skin Pigmentation Using Zebrafish, Zurab R. Tsetskhladze, Victor A. Canfield, Khai C. Ang, Steven M. Wentzel, Katherine P. Reid, Arthur S. Berg, Stephen L. Johnson, Koichi Kawakami, Keith C. Cheng

Open Access Publications

No abstract provided.


Ajuba Is Required For Rac Activation And Maintenance Of E-Cadherin Adhesion, Sébastien Nola, Reiko Daigaku, Kasia Smolarczyk, Maryke Carstens, Belen Martin-Martin, Gregory Longmore, Maryse Bailly, Vania M.M. Braga Nov 2011

Ajuba Is Required For Rac Activation And Maintenance Of E-Cadherin Adhesion, Sébastien Nola, Reiko Daigaku, Kasia Smolarczyk, Maryke Carstens, Belen Martin-Martin, Gregory Longmore, Maryse Bailly, Vania M.M. Braga

Open Access Publications

No abstract provided.


Mycoplasma Pneumoniae Periprosthetic Joint Infection Identified By 16s Ribosomal Rna Gene Amplification And Sequencing: A Case Report, Zhuolin Han, Carey-Ann D. Burnham, John Clohisy, Hilary Babcock Sep 2011

Mycoplasma Pneumoniae Periprosthetic Joint Infection Identified By 16s Ribosomal Rna Gene Amplification And Sequencing: A Case Report, Zhuolin Han, Carey-Ann D. Burnham, John Clohisy, Hilary Babcock

Open Access Publications

No abstract provided.


What's New In Orthopaedic Trauma, William M. Ricci, Christopher Mcandrew, David Merriman, Michael J. Gardner Sep 2011

What's New In Orthopaedic Trauma, William M. Ricci, Christopher Mcandrew, David Merriman, Michael J. Gardner

Open Access Publications

No abstract provided.


In Vivo Microdialysis Reveals Age-Dependent Decrease Of Brain Interstitial Fluid Tau Levels In P301s Human Tau Transgenic Mice, Kaoru Yamada, John R. Cirrito, Floy R. Stewart, Hong Jiang, Mary Beth Finn, Brandon B. Holmes, Lester I. Binder, Eva-Maria Mandelkow, Marc I. Diamond, Virginia M.-Y. Lee, David M. Holtzman Sep 2011

In Vivo Microdialysis Reveals Age-Dependent Decrease Of Brain Interstitial Fluid Tau Levels In P301s Human Tau Transgenic Mice, Kaoru Yamada, John R. Cirrito, Floy R. Stewart, Hong Jiang, Mary Beth Finn, Brandon B. Holmes, Lester I. Binder, Eva-Maria Mandelkow, Marc I. Diamond, Virginia M.-Y. Lee, David M. Holtzman

Open Access Publications

Although tau is a cytoplasmic protein, it is also found in brain extracellular fluids, e.g., CSF. Recent findings suggest that aggregated tau can be transferred between cells and extracellular tau aggregates might mediate spread of tau pathology. Despite these data, details of whether tau is normally released into the brain interstitial fluid (ISF), its concentration in ISF in relation to CSF, and whether ISF tau is influenced by its aggregation are unknown. To address these issues, we developed a microdialysis technique to analyze monomeric ISF tau levels within the hippocampus of awake, freely moving mice. We detected tau in ISF …


Spinal Reconstruction With Pedicle Screw-Based Instrumentation And Rhbmp-2 In Patients With Neurofibromatosis And Severe Dural Ectasia And Spinal Deformity: Report Of Two Cases And A Review Of The Literature, Samuel K. Cho, Geoffrey E. Stoker, Keith H. Bridwell Aug 2011

Spinal Reconstruction With Pedicle Screw-Based Instrumentation And Rhbmp-2 In Patients With Neurofibromatosis And Severe Dural Ectasia And Spinal Deformity: Report Of Two Cases And A Review Of The Literature, Samuel K. Cho, Geoffrey E. Stoker, Keith H. Bridwell

Open Access Publications

No abstract provided.


Ethanol Enhances Neurosteroidogenesis In Hippocampal Pyramidal Neurons By Paradoxical Nmda Receptor Activation, Kazuhiro Tokuda, Yukitoshi Izumi, Charles F. Zorumski Jul 2011

Ethanol Enhances Neurosteroidogenesis In Hippocampal Pyramidal Neurons By Paradoxical Nmda Receptor Activation, Kazuhiro Tokuda, Yukitoshi Izumi, Charles F. Zorumski

Open Access Publications

Using an antibody against 5α-reduced neurosteroids, predominantly allopregnanolone, we found that immunostaining in the CA1 region of rat hippocampal slices was confined to pyramidal neurons. This neurosteroid staining was increased following 15 min administration of 60 mm but not 20 mm ethanol, and the enhancement was blocked by finasteride and dutasteride, selective inhibitors of 5α-reductase, a key enzyme required for allopregnanolone synthesis. Consistent with a prior report indicating that N-methyl-D-aspartate (NMDA) receptor (NMDAR) activation can promote steroid production, we observed that D-2-amino-5-phosphonovalerate (APV), a competitive NMDAR antagonist, blocked the effects of 60 mm ethanol on staining. We previously reported that …


Controlled Cortical Impact Traumatic Brain Injury In 3xtg-Ad Mice Causes Acute Intra-Axonal Amyloid-Β Accumulation And Independently Accelerates The Development Of Tau Abnormalities, Hien T. Tran, Frank M. Laferla, David M. Holtzman, David L. Brody Jun 2011

Controlled Cortical Impact Traumatic Brain Injury In 3xtg-Ad Mice Causes Acute Intra-Axonal Amyloid-Β Accumulation And Independently Accelerates The Development Of Tau Abnormalities, Hien T. Tran, Frank M. Laferla, David M. Holtzman, David L. Brody

Open Access Publications

Alzheimer's disease (AD) is a neurodegenerative disorder characterized pathologically by progressive neuronal loss, extracellular plaques containing the amyloid-β (Aβ) peptides, and neurofibrillary tangles composed of hyperphosphorylated tau proteins. Aβ is thought to act upstream of tau, affecting its phosphorylation and therefore aggregation state. One of the major risk factors for AD is traumatic brain injury (TBI). Acute intra-axonal Aβ and diffuse extracellular plaques occur in ∼30% of human subjects after severe TBI. Intra-axonal accumulations of tau but not tangle-like pathologies have also been found in these patients. Whether and how these acute accumulations contribute to subsequent AD development is not …