Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
-
- Humans (321)
- Animals (227)
- Female (168)
- Male (153)
- Mice (151)
-
- Middle Aged (67)
- Adult (64)
- Aged (60)
- Mice, Inbred C57BL (44)
- Disease Models, Animal (42)
- Signal Transduction (42)
- Mice, Knockout (40)
- COVID-19 (37)
- SARS-CoV-2 (32)
- Mutation (30)
- Brain (26)
- Young Adult (23)
- Adolescent (22)
- Aged, 80 and over (22)
- Child (22)
- Cells, Cultured (21)
- Neurons (21)
- Cell Line, Tumor (20)
- Mice, Transgenic (20)
- Child, Preschool (18)
- Protein Binding (17)
- Alzheimer Disease (16)
- Cell Line (16)
- Cell Proliferation (15)
- Gastrointestinal Microbiome (15)
Articles 4591 - 4620 of 5949
Full-Text Articles in Entire DC Network
Congenital Bone Marrow Failure In Dna-Pkcs Mutant Mice Associated With Deficiencies In Dna Repair, Shichuan Zhang, Hirohiko Yajima, Hoangdinh Huynh, Junke Zheng, Elsa Callen, Hua-Tang Chen, Nancy Wong, Samuel Bunting, Yu-Fen Lin, Mengxia Li, Kyung-Jone Lee, Michael Story, Eric Gapud, Barry P. Sleckman, André Nussenzweig, Cheng Cheng Zhang, David J. Chen, Benjamin P.C. Chen
Congenital Bone Marrow Failure In Dna-Pkcs Mutant Mice Associated With Deficiencies In Dna Repair, Shichuan Zhang, Hirohiko Yajima, Hoangdinh Huynh, Junke Zheng, Elsa Callen, Hua-Tang Chen, Nancy Wong, Samuel Bunting, Yu-Fen Lin, Mengxia Li, Kyung-Jone Lee, Michael Story, Eric Gapud, Barry P. Sleckman, André Nussenzweig, Cheng Cheng Zhang, David J. Chen, Benjamin P.C. Chen
Open Access Publications
No abstract provided.
Long-Term Calorie Restriction, But Not Endurance Exercise, Lowers Core Body Temperature In Humans, Andreea Soare, Roberto Cangemi, Daniela Omodei, John O. Holloszy, Luigi Fontana
Long-Term Calorie Restriction, But Not Endurance Exercise, Lowers Core Body Temperature In Humans, Andreea Soare, Roberto Cangemi, Daniela Omodei, John O. Holloszy, Luigi Fontana
Open Access Publications
Reduction of body temperature has been proposed to contribute to the increased lifespan in calorie restricted animals and mice overexpressing the uncoupling protein-2 in hypocretin neurons. However, nothing is known regarding the long-term effects of calorie restriction (CR) with adequate nutrition on body temperature in humans. In this study, 24-hour core body temperature was measured every minute by using ingested telemetric capsules in 24 men and women (mean age 53.7 ± 9.4 yrs) consuming a CR diet for an average of 6 years, 24 age- and sex-matched sedentary (WD) and 24 body fat-matched exercise-trained (EX) volunteers, who were eating Western …
The Cytoplasmic Adaptor Protein Caskin Mediates Lar Signal Transduction During Drosophila Motor Axon Guidance, Yi-Lan Weng, Nan Liu, Aaron Diantonio, Heather T. Broihier
The Cytoplasmic Adaptor Protein Caskin Mediates Lar Signal Transduction During Drosophila Motor Axon Guidance, Yi-Lan Weng, Nan Liu, Aaron Diantonio, Heather T. Broihier
Open Access Publications
The multiprotein complexes that receive and transmit axon pathfinding cues during development are essential to circuit generation. Here, we identify and characterize the Drosophila sterile α-motif (SAM) domain-containing protein Caskin, which shares homology with vertebrate Caskin, a CASK [calcium/calmodulin-(CaM)-activated serine-threonine kinase]-interacting protein. Drosophila caskin (ckn) is necessary for embryonic motor axon pathfinding and interacts genetically and physically with the leukocyte common antigen-related (Lar) receptor protein tyrosine phosphatase. In vivo and in vitro analyses of a panel of ckn loss-of-function alleles indicate that the N-terminal SAM domain of Ckn mediates its interaction with Lar. Like Caskin, Liprin-α is a neuronal adaptor …
Functional Analysis Of Novel Analogues Of E3330 That Block The Redox Signaling Activity Of The Multifunctional Ap Endonuclease/Redox Signaling Enzyme Ape1/Ref-1, Mark R. Kelley, Meihua Luo, April Reed, Dian Su, Sarah Delaplane, Richard F. Borch, Rodney L. Nyland Ii, Michael L. Gross, Millie M. Georgiadis
Functional Analysis Of Novel Analogues Of E3330 That Block The Redox Signaling Activity Of The Multifunctional Ap Endonuclease/Redox Signaling Enzyme Ape1/Ref-1, Mark R. Kelley, Meihua Luo, April Reed, Dian Su, Sarah Delaplane, Richard F. Borch, Rodney L. Nyland Ii, Michael L. Gross, Millie M. Georgiadis
Open Access Publications
No abstract provided.
Igh Gene Rearrangements As Plasma Biomarkers In Non- Hodgkin's Lymphoma Patients, Jian He, Jian Wu, Yuchen Jiao, Nina Wagner-Johnston, Richard F. Ambinder, Luis A. Diaz, Kenneth W. Kinzler, Bert Vogelstein, Nickolas Papadopoulos
Igh Gene Rearrangements As Plasma Biomarkers In Non- Hodgkin's Lymphoma Patients, Jian He, Jian Wu, Yuchen Jiao, Nina Wagner-Johnston, Richard F. Ambinder, Luis A. Diaz, Kenneth W. Kinzler, Bert Vogelstein, Nickolas Papadopoulos
Open Access Publications
New biomarkers with improved accuracy could be helpful for monitoring disease in patients with Non-Hodgkin's lymphomas (NHL). Towards this end, we have explored the feasibility of identifying the sequence of rearranged IgH genes using next-generation sequencing, then using PCR to detect specific rearranged DNA fragments in patients' plasma. By capturing and sequencing the IgH genomic regions (IgCap), we were able to detect and precisely determine the sequence of rearranged IgH loci in the tumors of three NHL patients. Moreover, circulating rearranged DNA fragments could be identified in the plasma of all three patients. Even in cases wherein tumor biopsies were …
Effect Of Short-Duration Low-Magnitude Cyclic Loading Versus Immobilization On Tendon-Bone Healing After Acl Reconstruction In A Rat Model, Robert H. Brophy, David Kovacevic, Carl W. Imhauser, Mark Stasiak, Asheesh Bedi, Alice J.S. Fox, Xiang-Hua Deng, Scott A. Rodeo
Effect Of Short-Duration Low-Magnitude Cyclic Loading Versus Immobilization On Tendon-Bone Healing After Acl Reconstruction In A Rat Model, Robert H. Brophy, David Kovacevic, Carl W. Imhauser, Mark Stasiak, Asheesh Bedi, Alice J.S. Fox, Xiang-Hua Deng, Scott A. Rodeo
Open Access Publications
No abstract provided.
Calcium-Independent Inhibitory G-Protein Signaling Induces Persistent Presynaptic Muting Of Hippocampal Synapses, Devon C. Crawford, Chun Yun Chang, Krzysztof L. Hyrc, Steven Mennerick
Calcium-Independent Inhibitory G-Protein Signaling Induces Persistent Presynaptic Muting Of Hippocampal Synapses, Devon C. Crawford, Chun Yun Chang, Krzysztof L. Hyrc, Steven Mennerick
Open Access Publications
Adaptive forms of synaptic plasticity that reduce excitatory synaptic transmission in response to prolonged increases in neuronal activity may prevent runaway positive feedback in neuronal circuits. In hippocampal neurons, for example, glutamatergic presynaptic terminals are selectively silenced, creating "mute" synapses, after periods of increased neuronal activity or sustained depolarization. Previous work suggests that cAMP-dependent and proteasome-dependent mechanisms participate in silencing induction by depolarization, but upstream activators are unknown. We, therefore, tested the role of calcium and G-protein signaling in silencing induction in cultured hippocampal neurons. We found that silencing induction by depolarization was not dependent on rises in intracellular calcium, …
In Vitro And In Vivo Evaluation Of 64cu-Radiolabeled Kccysl Peptides For Targeting Epidermal Growth Factor Receptor-2 In Breast Carcinomas, Senthil R. Kumar, Fabio A. Gallazzi, Riccardo Ferdani, Carolyn J. Anderson, Thomas P. Quinn, Susan L. Deutscher
In Vitro And In Vivo Evaluation Of 64cu-Radiolabeled Kccysl Peptides For Targeting Epidermal Growth Factor Receptor-2 In Breast Carcinomas, Senthil R. Kumar, Fabio A. Gallazzi, Riccardo Ferdani, Carolyn J. Anderson, Thomas P. Quinn, Susan L. Deutscher
Open Access Publications
No abstract provided.
Accurate Quantification Of Lipid Species By Electrospray Ionization Mass Spectrometry - Meet A Key Challenge In Lipidomics, Kui Yang, Xianlin Han
Accurate Quantification Of Lipid Species By Electrospray Ionization Mass Spectrometry - Meet A Key Challenge In Lipidomics, Kui Yang, Xianlin Han
Open Access Publications
No abstract provided.
Changes In Events Alter How People Remember Recent Information, Khena M. Swallow, Deanna M. Barch, Denise Head, Corey J. Maley, Derek Holder, Jeffrey M. Zacks
Changes In Events Alter How People Remember Recent Information, Khena M. Swallow, Deanna M. Barch, Denise Head, Corey J. Maley, Derek Holder, Jeffrey M. Zacks
Open Access Publications
No abstract provided.
Improving Salmonella Vector With Rec Mutation To Stabilize The Dna Cargoes, Xiangmin Zhang, Soo-Young Wanda, Karen Brenneman, Wei Kong, Xin Zhang, Kenneth Roland, Roy Curtiss Iii
Improving Salmonella Vector With Rec Mutation To Stabilize The Dna Cargoes, Xiangmin Zhang, Soo-Young Wanda, Karen Brenneman, Wei Kong, Xin Zhang, Kenneth Roland, Roy Curtiss Iii
Open Access Publications
No abstract provided.
Pcr-Based Genotyping Of Helicobacter Pylori Of Gambian Children And Adults Directly From Biopsy Specimens And Bacterial Cultures, Ousman Secka, Martin Antonio, Mary Tapgun, Douglas E. Berg, Christian Bottomley, Vivat Thomas, Robert Walton, Tumani Corrah, Richard A. Adegbola, Julian E. Thomas
Pcr-Based Genotyping Of Helicobacter Pylori Of Gambian Children And Adults Directly From Biopsy Specimens And Bacterial Cultures, Ousman Secka, Martin Antonio, Mary Tapgun, Douglas E. Berg, Christian Bottomley, Vivat Thomas, Robert Walton, Tumani Corrah, Richard A. Adegbola, Julian E. Thomas
Open Access Publications
No abstract provided.
Vacuolization Of Mucolipidosis Type Ii Mouse Exocrine Gland Cells Represents Accumulation Of Autolysosomes, Marielle Boonen, Eline Van Meel, Viola Oorschot, Judith Klumperman, Stuart Kornfeld
Vacuolization Of Mucolipidosis Type Ii Mouse Exocrine Gland Cells Represents Accumulation Of Autolysosomes, Marielle Boonen, Eline Van Meel, Viola Oorschot, Judith Klumperman, Stuart Kornfeld
Open Access Publications
No abstract provided.
Differential Regional And Subtype-Specific Vulnerability Of Enteric Neurons To Mitochondrial Dysfunction, Andreu Viader, Elizabeth C. Wright-Jin, Bhupinder P.S Vohra, Robert O. Heuckeroth, Jeffrey Milbrandt
Differential Regional And Subtype-Specific Vulnerability Of Enteric Neurons To Mitochondrial Dysfunction, Andreu Viader, Elizabeth C. Wright-Jin, Bhupinder P.S Vohra, Robert O. Heuckeroth, Jeffrey Milbrandt
Open Access Publications
No abstract provided.
Fatty-Acid Binding Proteins Modulate Sleep And Enhance Long-Term Memory Consolidation In Drosophila, Jason R. Gerstner, William M. Vanderheyden, Paul J. Shaw, Charles F. Landry, Jerry C. P. Yin
Fatty-Acid Binding Proteins Modulate Sleep And Enhance Long-Term Memory Consolidation In Drosophila, Jason R. Gerstner, William M. Vanderheyden, Paul J. Shaw, Charles F. Landry, Jerry C. P. Yin
Open Access Publications
No abstract provided.
Transcriptome Analysis Of Female And Male Xiphophorus Maculatus Jp 163 A, Ziping Zhang, Yilei Wang, Shuhong Wang, Jingtao Liu, Wesley Warren, Makedonka Mitreva, Ronald B. Walter
Transcriptome Analysis Of Female And Male Xiphophorus Maculatus Jp 163 A, Ziping Zhang, Yilei Wang, Shuhong Wang, Jingtao Liu, Wesley Warren, Makedonka Mitreva, Ronald B. Walter
Open Access Publications
No abstract provided.
Bioluminescent Imaging Reveals Divergent Viral Pathogenesis In Two Strains Of Stat1-Deficient Mice, And In Αßγ Interferon Receptor-Deficient Mice, Tracy Jo Pasieka, Lynne Collins, Megan A. O'Connor, Yufei Chen, Zachary M. Parker, Brent L. Berwin, David R. Piwnica-Worms, David A. Leib
Bioluminescent Imaging Reveals Divergent Viral Pathogenesis In Two Strains Of Stat1-Deficient Mice, And In Αßγ Interferon Receptor-Deficient Mice, Tracy Jo Pasieka, Lynne Collins, Megan A. O'Connor, Yufei Chen, Zachary M. Parker, Brent L. Berwin, David R. Piwnica-Worms, David A. Leib
Open Access Publications
No abstract provided.
Diffusion Of Mmps On The Surface Of Collagen Fibrils: The Mobile Cell Surface - Collagen Substratum Interface, Ivan E. Collier, Wesley Legant, Barry Marmer, Olga Lubman, Saveez Saffarian, Tetsuro Wakatsuki, Elliot Elson, Gregory I. Goldberg
Diffusion Of Mmps On The Surface Of Collagen Fibrils: The Mobile Cell Surface - Collagen Substratum Interface, Ivan E. Collier, Wesley Legant, Barry Marmer, Olga Lubman, Saveez Saffarian, Tetsuro Wakatsuki, Elliot Elson, Gregory I. Goldberg
Open Access Publications
No abstract provided.
A Clustering Analysis Of Lipoprotein Diameters In The Metabolic Syndrome, Alexis C. Frazier-Wood, Stephen Glasser, W Timothy Garvey, Edmond K. Kabagambe, Ingrid B. Borecki, Hemant K. Tiwari, Michael Y. Tsai, Paul N. Hopkins, Jose M. Ordovas, Donna K. Arnett
A Clustering Analysis Of Lipoprotein Diameters In The Metabolic Syndrome, Alexis C. Frazier-Wood, Stephen Glasser, W Timothy Garvey, Edmond K. Kabagambe, Ingrid B. Borecki, Hemant K. Tiwari, Michael Y. Tsai, Paul N. Hopkins, Jose M. Ordovas, Donna K. Arnett
Open Access Publications
No abstract provided.
Integrase Inhibitors Effective Against Human T-Cell Leukemia Virus Type 1, Muhammad Esa Seegulam, Lee Ratner
Integrase Inhibitors Effective Against Human T-Cell Leukemia Virus Type 1, Muhammad Esa Seegulam, Lee Ratner
Open Access Publications
No abstract provided.
Statistical Analysis And Interpretation Of Prenatal Diagnostic Imaging Studies, Part 3: Approach To Study Design, Katherine R. Goetzinger, Methodius G. Tuuli, Anthony O. Odibo
Statistical Analysis And Interpretation Of Prenatal Diagnostic Imaging Studies, Part 3: Approach To Study Design, Katherine R. Goetzinger, Methodius G. Tuuli, Anthony O. Odibo
Open Access Publications
No abstract provided.
Fig1 Facilitates Calcium Influx And Localizes To Membranes Destined To Undergo Fusion During Mating In Candida Albicans, Meng Yang, Alexandra Brand, Thyagarajan Srikantha, Karla J. Daniels, David R. Soll, Neil A.R. Gow
Fig1 Facilitates Calcium Influx And Localizes To Membranes Destined To Undergo Fusion During Mating In Candida Albicans, Meng Yang, Alexandra Brand, Thyagarajan Srikantha, Karla J. Daniels, David R. Soll, Neil A.R. Gow
Open Access Publications
No abstract provided.
Engraftment Of Cells From Porcine Islets Of Langerhans Following Transplantation Of Pig Pancreatic Primordia In Non-Immunosuppressed Diabetic Rhesus Macaques, Sharon A. Rogers, Piyush Tripathi, Thalachallour Mohanakumar, Helen Liapis, Feng Chen, Michael R. Talcott, Chad Faulkner, Marc R. Hammerman
Engraftment Of Cells From Porcine Islets Of Langerhans Following Transplantation Of Pig Pancreatic Primordia In Non-Immunosuppressed Diabetic Rhesus Macaques, Sharon A. Rogers, Piyush Tripathi, Thalachallour Mohanakumar, Helen Liapis, Feng Chen, Michael R. Talcott, Chad Faulkner, Marc R. Hammerman
Open Access Publications
No abstract provided.
6-Ohda Generated Ros Induces Dna Damage And P53- And Puma-Dependent Cell Death, Alison I. Bernstein, Sean P. Garrison, Gerard P. Zambetti, Karen L. O'Malley
6-Ohda Generated Ros Induces Dna Damage And P53- And Puma-Dependent Cell Death, Alison I. Bernstein, Sean P. Garrison, Gerard P. Zambetti, Karen L. O'Malley
Open Access Publications
No abstract provided.
Fluorescence Manipulation By Gold Nanoparticles: From Complete Quenching To Extensive Enhancement, Kyung A. Kang, Jianting Wang, Jacek B. Jasinski, Samuel Achilefu
Fluorescence Manipulation By Gold Nanoparticles: From Complete Quenching To Extensive Enhancement, Kyung A. Kang, Jianting Wang, Jacek B. Jasinski, Samuel Achilefu
Open Access Publications
No abstract provided.
Flyfactorsurvey: A Database Of Drosophila Transcription Factor Binding Specificities Determined Using The Bacterial One-Hybrid System, Lihua J. Zhu, Ryan G. Christensen, Majid Kazemian, Christopher J. Hull, Metewo S. Enuameh, Matthew D. Basciotta, Jessie A. Brasefield, Cong Zhu, Yuna Asriyan, David S. Lapointe, Saurabh Sinha, Scot A. Wolfe, Michael H. Brodsky
Flyfactorsurvey: A Database Of Drosophila Transcription Factor Binding Specificities Determined Using The Bacterial One-Hybrid System, Lihua J. Zhu, Ryan G. Christensen, Majid Kazemian, Christopher J. Hull, Metewo S. Enuameh, Matthew D. Basciotta, Jessie A. Brasefield, Cong Zhu, Yuna Asriyan, David S. Lapointe, Saurabh Sinha, Scot A. Wolfe, Michael H. Brodsky
Open Access Publications
No abstract provided.
Heparan Sulphate Proteoglycan And The Low-Density Lipoprotein Receptor-Related Protein 1, Takahisa Kanekiyo, Juan Zhang, Qiang Liu, Chia-Chen Liu, Lijuan Zhang, Guojun Bu
Heparan Sulphate Proteoglycan And The Low-Density Lipoprotein Receptor-Related Protein 1, Takahisa Kanekiyo, Juan Zhang, Qiang Liu, Chia-Chen Liu, Lijuan Zhang, Guojun Bu
Open Access Publications
No abstract provided.
Regulation Of Alr1 Mg Transporter Activity By Intracellular Magnesium, Phaik Har Lim, Nilambari P. Pisat, Nidhi Gadhia, Abhinav Pandey, Frank X. Donovan, Lauren Stein, David E. Salt, David J. Eide, Colin W. Macdiarmid
Regulation Of Alr1 Mg Transporter Activity By Intracellular Magnesium, Phaik Har Lim, Nilambari P. Pisat, Nidhi Gadhia, Abhinav Pandey, Frank X. Donovan, Lauren Stein, David E. Salt, David J. Eide, Colin W. Macdiarmid
Open Access Publications
No abstract provided.
Caenorhabditis Briggsae Recombinant Inbred Line Genotypes Reveal Inter-Strain Incompatibility And The Rvolution Of Recombination, Joseph A. Ross, Daniel C. Koboldt, Julia E. Staisch, Helen M. Chamberlin, Bhagwati P. Gupta, Raymond D. Miller, Scott E. Baird, Eric S. Haag
Caenorhabditis Briggsae Recombinant Inbred Line Genotypes Reveal Inter-Strain Incompatibility And The Rvolution Of Recombination, Joseph A. Ross, Daniel C. Koboldt, Julia E. Staisch, Helen M. Chamberlin, Bhagwati P. Gupta, Raymond D. Miller, Scott E. Baird, Eric S. Haag
Open Access Publications
No abstract provided.
Register Shifting Of An Insulin Peptide-Mhc Complex Allows Diabetogenic T Cells To Escape Thymic Deletion, James F. Mohan, Shirley J. Petzold, Emil R. Unanue
Register Shifting Of An Insulin Peptide-Mhc Complex Allows Diabetogenic T Cells To Escape Thymic Deletion, James F. Mohan, Shirley J. Petzold, Emil R. Unanue
Open Access Publications
In nonobese diabetic (NOD) mice, two sets of autoreactive CD4(+) T cells recognize the B:9-23 segment of the insulin B chain. One set, type A, recognizes insulin presented by antigen-presenting cells (APCs). These T cells are highly deleted in the thymus. The second set, type B, does not recognize insulin protein but reacts with soluble B chain peptide. This set is not deleted in the thymus but is activated in the islets of Langerhans. In this study, we examine the specificity of these two types of T cells. The protein-reactive set recognizes the stretch of residues 13-21 of the insulin …