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Genotypic And Phenotypic Characterization Of Antimicrobial Resistance In Neisseria Gonorrhoeae: A Cross-Sectional Study Of Isolates Recovered From Routine Urine Cultures In A High-Incidence Setting, Adam L. Bailey, Robert F. Potter, Meghan A. Wallace, Caitlin Johnson, Gautam Dantas, Carey-Ann D. Burnham Jan 2019

Genotypic And Phenotypic Characterization Of Antimicrobial Resistance In Neisseria Gonorrhoeae: A Cross-Sectional Study Of Isolates Recovered From Routine Urine Cultures In A High-Incidence Setting, Adam L. Bailey, Robert F. Potter, Meghan A. Wallace, Caitlin Johnson, Gautam Dantas, Carey-Ann D. Burnham

Open Access Publications

No abstract provided.


Separability Of Calcium Slow Waves And Functional Connectivity During Wake, Sleep, And Anesthesia, Lindsey M. Brier, Eric C. Landsness, Abraham Z. Snyder, Patrick W. Wright, Grant A. Baxter, Adam Q. Bauer, Jin-Moo Lee, Joseph P. Culver Jan 2019

Separability Of Calcium Slow Waves And Functional Connectivity During Wake, Sleep, And Anesthesia, Lindsey M. Brier, Eric C. Landsness, Abraham Z. Snyder, Patrick W. Wright, Grant A. Baxter, Adam Q. Bauer, Jin-Moo Lee, Joseph P. Culver

Open Access Publications

No abstract provided.


Omics Driven Understanding Of The Intestines Of Parasitic Nematodes, Douglas P. Jasmer, Bruce A. Rosa, Rahul Tyagi, Makedonka Mitreva Jan 2019

Omics Driven Understanding Of The Intestines Of Parasitic Nematodes, Douglas P. Jasmer, Bruce A. Rosa, Rahul Tyagi, Makedonka Mitreva

Open Access Publications

No abstract provided.


Monitoring Behaviorally Induced Biochemical Changes Using Fluorescence Lifetime Photometry, Suk Joon Lee, Yao Chen, Bart Lodder, Bernardo L. Sabatini Jan 2019

Monitoring Behaviorally Induced Biochemical Changes Using Fluorescence Lifetime Photometry, Suk Joon Lee, Yao Chen, Bart Lodder, Bernardo L. Sabatini

Open Access Publications

No abstract provided.


Comparison Of The Pharmacokinetic Properties Of Triamcinolone And Dexamethasone For Local Therapy Of The Inner Ear, Alec Nicholas Salt, Jared James Hartsock, Jennifer Hou, Fabrice Piu Jan 2019

Comparison Of The Pharmacokinetic Properties Of Triamcinolone And Dexamethasone For Local Therapy Of The Inner Ear, Alec Nicholas Salt, Jared James Hartsock, Jennifer Hou, Fabrice Piu

Open Access Publications

No abstract provided.


Chronic Ly49h Receptor Engagement In Vivo Decreases Nk Cell Response To Stimulation Through Itam-Dependent And Independent Pathways Both In Vitro And In Vivo, Phillip N. Key, Joe Germino, Liping Yang, Sytse J. Piersma, Sandeep K. Tripathy Jan 2019

Chronic Ly49h Receptor Engagement In Vivo Decreases Nk Cell Response To Stimulation Through Itam-Dependent And Independent Pathways Both In Vitro And In Vivo, Phillip N. Key, Joe Germino, Liping Yang, Sytse J. Piersma, Sandeep K. Tripathy

Open Access Publications

No abstract provided.


Treatment, Complications, And Outcomes Of Metastatic Disease Of The Spine: From Patchell To Promis, Alexander T. Yahanda, Jacob M. Buchowski, Adam M. Wegner Jan 2019

Treatment, Complications, And Outcomes Of Metastatic Disease Of The Spine: From Patchell To Promis, Alexander T. Yahanda, Jacob M. Buchowski, Adam M. Wegner

Open Access Publications

No abstract provided.


Diffusion Tensor Model Links To Neurite Orientation Dispersion And Density Imaging At High B-Value In Cerebral Cortical Gray Matter, Hikaru Fukutomi, Matthew F. Glasser, Katsutoshi Murata, Thai Akasaka, Koji Fujimoto, Takayuki Yamamoto, Joonas A. Autio, Tomohisa Okada, Kaori Togashi, Hui Zhang, David C. Van Essen, Takuya Hayashi Jan 2019

Diffusion Tensor Model Links To Neurite Orientation Dispersion And Density Imaging At High B-Value In Cerebral Cortical Gray Matter, Hikaru Fukutomi, Matthew F. Glasser, Katsutoshi Murata, Thai Akasaka, Koji Fujimoto, Takayuki Yamamoto, Joonas A. Autio, Tomohisa Okada, Kaori Togashi, Hui Zhang, David C. Van Essen, Takuya Hayashi

Open Access Publications

No abstract provided.


Genetic Variation Across Rna Metabolism And Cell Death Gene Networks Is Implicated In The Semantic Variant Of Primary Progressive Aphasia, Celeste M. Karch, Natalie L. Wen, Et Al. Jan 2019

Genetic Variation Across Rna Metabolism And Cell Death Gene Networks Is Implicated In The Semantic Variant Of Primary Progressive Aphasia, Celeste M. Karch, Natalie L. Wen, Et Al.

Open Access Publications

No abstract provided.


A Meta-Analysis Of Genome-Wide Association Studies Identifies Multiple Longevity Genes, Mary K. Wojczynski, Michael A. Province, Et Al. Jan 2019

A Meta-Analysis Of Genome-Wide Association Studies Identifies Multiple Longevity Genes, Mary K. Wojczynski, Michael A. Province, Et Al.

Open Access Publications

No abstract provided.


Patients With Endometrial Cancer Continue To Lack Understanding Of Their Risks For Cancer, Subhjit Sekhon, L. Stewart Massad, Andrea R. Hagemann, Rebecca Dick, Andrea Leon, Abigail S. Zamorano, Premal H. Thaker, Carolyn K. Mccourt, David G. Mutch, Matthew A. Powell, Lindsay M. Kuroki Jan 2019

Patients With Endometrial Cancer Continue To Lack Understanding Of Their Risks For Cancer, Subhjit Sekhon, L. Stewart Massad, Andrea R. Hagemann, Rebecca Dick, Andrea Leon, Abigail S. Zamorano, Premal H. Thaker, Carolyn K. Mccourt, David G. Mutch, Matthew A. Powell, Lindsay M. Kuroki

Open Access Publications

No abstract provided.


Desmin Forms Toxic, Seeding-Competent Amyloid Aggregates That Persist In Muscle Fibers, Niraja Kedia, Khalid Arhzaouy, Sara K. Pittman, Yuanzi Sun, Mark Batchelor, Conrad C. Weihl, Jan Bieschke Jan 2019

Desmin Forms Toxic, Seeding-Competent Amyloid Aggregates That Persist In Muscle Fibers, Niraja Kedia, Khalid Arhzaouy, Sara K. Pittman, Yuanzi Sun, Mark Batchelor, Conrad C. Weihl, Jan Bieschke

Open Access Publications

No abstract provided.


Bogotá River Anthropogenic Contamination Alters Microbial Communities And Promotes Spread Of Antibiotic Resistance Genes, Carlos Eduardo Posada-Perlaza, Adán Ramírez-Rojas, Paola Porras, Boahemaa Adu-Oppong, Ana-María Botero-Coy, Félix Hernández, Juan M. Anzola, Lorena Díaz, Gautam Dantas, Alejandro Reyes, María Mercedes Zambrano Jan 2019

Bogotá River Anthropogenic Contamination Alters Microbial Communities And Promotes Spread Of Antibiotic Resistance Genes, Carlos Eduardo Posada-Perlaza, Adán Ramírez-Rojas, Paola Porras, Boahemaa Adu-Oppong, Ana-María Botero-Coy, Félix Hernández, Juan M. Anzola, Lorena Díaz, Gautam Dantas, Alejandro Reyes, María Mercedes Zambrano

Open Access Publications

No abstract provided.


A Regulatory Variant Of Chrm3 Is Associated With Cannabis-Induced Hallucinations In European Americans, Zhongshan Cheng, Chureerat Phokaew, Yi-Ling Chou, Dongbing Lai, Jacquelyn L. Meyers, Arpana Agrawal, Lindsay A. Farrer, Henry R. Kranzler, Joel Gelernter Jan 2019

A Regulatory Variant Of Chrm3 Is Associated With Cannabis-Induced Hallucinations In European Americans, Zhongshan Cheng, Chureerat Phokaew, Yi-Ling Chou, Dongbing Lai, Jacquelyn L. Meyers, Arpana Agrawal, Lindsay A. Farrer, Henry R. Kranzler, Joel Gelernter

Open Access Publications

No abstract provided.


Modelling Resilience In Adolescence And Adversity: A Novel Framework To Inform Research And Practice, Gin S. Malhi, Pritha Das, Erica Bell, Greg Mattingly, Zola Mannie Jan 2019

Modelling Resilience In Adolescence And Adversity: A Novel Framework To Inform Research And Practice, Gin S. Malhi, Pritha Das, Erica Bell, Greg Mattingly, Zola Mannie

Open Access Publications

No abstract provided.


Whole-Cortex Mapping Of Common Genetic Influences On Depression And A Social Deficits Dimension, Alexander S. Hatoum, Andrew E. Reineberg, Harry R. Smolker, John K. Hewitt, Naomi P. Friedman Jan 2019

Whole-Cortex Mapping Of Common Genetic Influences On Depression And A Social Deficits Dimension, Alexander S. Hatoum, Andrew E. Reineberg, Harry R. Smolker, John K. Hewitt, Naomi P. Friedman

Open Access Publications

No abstract provided.


Cisplatin Exposure Causes C-Myc-Dependent Resistance To Cdk4/6 Inhibition In Hpv-Negative Head And Neck Squamous Cell Carcinoma, Anthony M. Robinson, Richa Rathore, Nathan J. Redlich, Douglas R. Adkins, Todd Vanarsdale, Brian A. Van Tine, Loren S. Michel Jan 2019

Cisplatin Exposure Causes C-Myc-Dependent Resistance To Cdk4/6 Inhibition In Hpv-Negative Head And Neck Squamous Cell Carcinoma, Anthony M. Robinson, Richa Rathore, Nathan J. Redlich, Douglas R. Adkins, Todd Vanarsdale, Brian A. Van Tine, Loren S. Michel

Open Access Publications

No abstract provided.


Multi-Ancestry Sleep-By-Snp Interaction Analysis In 126,926 Individuals Reveals Lipid Loci Stratified By Sleep Duration, Raymond Noordam, Yun Ju Sung, Karen Schwander, Lisa De Las Fuentes, Treva K. Rice, Dabeeru C. Rao, Mary Feitosa, Aldi Kraja, Mike Province, Et Al. Jan 2019

Multi-Ancestry Sleep-By-Snp Interaction Analysis In 126,926 Individuals Reveals Lipid Loci Stratified By Sleep Duration, Raymond Noordam, Yun Ju Sung, Karen Schwander, Lisa De Las Fuentes, Treva K. Rice, Dabeeru C. Rao, Mary Feitosa, Aldi Kraja, Mike Province, Et Al.

Open Access Publications

No abstract provided.


Vertical Transmission In Caenorhabditis Nematodes Of Rna Molecules Encoding A Viral Rna-Dependent Rna Polymerase, Aurélien Richaud, Lise Frézal, Stephen Tahan, Hongbing Jiang, Joshua A. Blatter, Guoyan Zhao, Taniya Kaur, David Wang, Marie-Anne Félix Jan 2019

Vertical Transmission In Caenorhabditis Nematodes Of Rna Molecules Encoding A Viral Rna-Dependent Rna Polymerase, Aurélien Richaud, Lise Frézal, Stephen Tahan, Hongbing Jiang, Joshua A. Blatter, Guoyan Zhao, Taniya Kaur, David Wang, Marie-Anne Félix

Open Access Publications

No abstract provided.


End Points For Sickle Cell Disease Clinical Trials: Renal And Cardiopulmonary, Cure, And Low-Resource Settings, Ann T. Farrell, Shalini Shenoy, Et Al. Jan 2019

End Points For Sickle Cell Disease Clinical Trials: Renal And Cardiopulmonary, Cure, And Low-Resource Settings, Ann T. Farrell, Shalini Shenoy, Et Al.

Open Access Publications

No abstract provided.


End Points For Sickle Cell Disease Clinical Trials: Patient-Reported Outcomes, Pain, And The Brain, Ann T. Farrell, Allison A. King, Et Al. Jan 2019

End Points For Sickle Cell Disease Clinical Trials: Patient-Reported Outcomes, Pain, And The Brain, Ann T. Farrell, Allison A. King, Et Al.

Open Access Publications

No abstract provided.


Phase 1 Dose Escalation Study Of The Allosteric Akt Inhibitor Bay 1125976 In Advanced Solid Cancer-Lack Of Association Between Activating Akt Mutation And Akt Inhibition-Derived Efficacy, Andreas Schneeweiss, Dagmar Hess, Markus Joerger, Andrea Varga, Stacy Moulder, Apostolia M Tsimberidou, Cynthia Ma, Sara A Hurvitz, Christine Rentzsch, Marion Rudolph, Silke Thiele, Oliver Boix, Gary Wilkinson, Eleni Lagkadinou, Matthias Ocker Jan 2019

Phase 1 Dose Escalation Study Of The Allosteric Akt Inhibitor Bay 1125976 In Advanced Solid Cancer-Lack Of Association Between Activating Akt Mutation And Akt Inhibition-Derived Efficacy, Andreas Schneeweiss, Dagmar Hess, Markus Joerger, Andrea Varga, Stacy Moulder, Apostolia M Tsimberidou, Cynthia Ma, Sara A Hurvitz, Christine Rentzsch, Marion Rudolph, Silke Thiele, Oliver Boix, Gary Wilkinson, Eleni Lagkadinou, Matthias Ocker

Open Access Publications

This open-label, phase I first-in-human study (NCT01915576) of BAY 1125976, a highly specific and potent allosteric inhibitor of AKT1/2, aimed to evaluate the safety, pharmacokinetics, and maximum tolerated dose of BAY 1125976 in patients with advanced solid tumors. Oral dose escalation was investigated with a continuous once daily (QD) treatment (21 days/cycle) and a twice daily (BID) schedule. A dose expansion in 28 patients with hormone receptor-positive metastatic breast cancer, including nine patients harboring the


Mechanisms Underlying Bone Loss Associated With Gut Inflammation, Ke Ke, Manoj Arra, Yousef Abu-Amer Jan 2019

Mechanisms Underlying Bone Loss Associated With Gut Inflammation, Ke Ke, Manoj Arra, Yousef Abu-Amer

Open Access Publications

Patients with gastrointestinal diseases frequently suffer from skeletal abnormality, characterized by reduced bone mineral density, increased fracture risk, and/or joint inflammation. This pathological process is characterized by altered immune cell activity and elevated inflammatory cytokines in the bone marrow microenvironment due to disrupted gut immune response. Gastrointestinal disease is recognized as an immune malfunction driven by multiple factors, including cytokines and signaling molecules. However, the mechanism by which intestinal inflammation magnified by gut-residing actors stimulates bone loss remains to be elucidated. In this article, we discuss the main risk factors potentially contributing to intestinal disease-associated bone loss, and summarize current …


A Review Of The Immunomodulating Components Of Maternal Breast Milk And Protection Against Necrotizing Enterocolitis, Lila S Nolan, Olivia B Parks, Misty Good Jan 2019

A Review Of The Immunomodulating Components Of Maternal Breast Milk And Protection Against Necrotizing Enterocolitis, Lila S Nolan, Olivia B Parks, Misty Good

Open Access Publications

Breast milk contains immunomodulating components that are beneficial to newborns during maturation of their immune system. Human breast milk composition is influenced by an infant's gestational and chronological age, lactation stage, and the mother and infant's health status. Major immunologic components in human milk, such as secretory immunoglobulin A (IgA) and growth factors, have a known role in regulating gut barrier integrity and microbial colonization, which therefore protect against the development of a life-threatening gastrointestinal illness affecting newborn infants called necrotizing enterocolitis (NEC). Breast milk is a known protective factor in the prevention of NEC when compared with feeding with …


Changes In Food Cravings And Eating Behavior After A Dietary Carbohydrate Restriction Intervention Trial, Katherene O-B Anguah, Majid M Syed-Abdul, Qiong Hu, Miriam Jacome-Sosa, Colette Heimowitz, Vicki Cox, Elizabeth J Parks Jan 2019

Changes In Food Cravings And Eating Behavior After A Dietary Carbohydrate Restriction Intervention Trial, Katherene O-B Anguah, Majid M Syed-Abdul, Qiong Hu, Miriam Jacome-Sosa, Colette Heimowitz, Vicki Cox, Elizabeth J Parks

Open Access Publications

Compared to low-fat diets, low-carbohydrate (CHO) diets cause weight loss (WL) over a faster time frame; however, it is unknown how changes in food cravings and eating behavior contribute to this more rapid WL in the early phases of dieting. We hypothesized that reductions in food cravings and improved eating behaviors would be evident even after a relatively short (4-week) duration of CHO-restriction, and that these changes would be associated with WL. Adult participants (


Selective Small Molecule Parg Inhibitor Causes Replication Fork Stalling And Cancer Cell Death, Jerry H. Houl, Roderick A. Stegeman, Tom Ellenberger, In-Kwon Kim, Et Al. Jan 2019

Selective Small Molecule Parg Inhibitor Causes Replication Fork Stalling And Cancer Cell Death, Jerry H. Houl, Roderick A. Stegeman, Tom Ellenberger, In-Kwon Kim, Et Al.

Open Access Publications

No abstract provided.


New Statistical Method Identifes Cytokines That Distinguish Stool Microbiomes, Dake Yang, Jethro Johnson, Xin Zhou, Elena Deych, Berkley Shands, Blake Hanson, Erica Sodergren, George Weinstock, William D. Shannon Jan 2019

New Statistical Method Identifes Cytokines That Distinguish Stool Microbiomes, Dake Yang, Jethro Johnson, Xin Zhou, Elena Deych, Berkley Shands, Blake Hanson, Erica Sodergren, George Weinstock, William D. Shannon

Open Access Publications

No abstract provided.


De Novo Assembly Of The Brugia Malayi Genome Using Long Reads From A Single Minion Flowcell, Joseph R. Fauver, John Martin, Gary J. Weil, Makedonka Mitreva, Peter U. Fischer Jan 2019

De Novo Assembly Of The Brugia Malayi Genome Using Long Reads From A Single Minion Flowcell, Joseph R. Fauver, John Martin, Gary J. Weil, Makedonka Mitreva, Peter U. Fischer

Open Access Publications

No abstract provided.


The Epigenomic Landscape Of Transposable Elements Across Normal Human Development And Anatomy, Erica C. Pehrsson, Mayank N.K. Choudhary, Vasavi Sundaram, Ting Wang Jan 2019

The Epigenomic Landscape Of Transposable Elements Across Normal Human Development And Anatomy, Erica C. Pehrsson, Mayank N.K. Choudhary, Vasavi Sundaram, Ting Wang

Open Access Publications

No abstract provided.


Report From A Multidisciplinary Meeting On Anxiety As A Non-Motor Manifestation Of Parkinson’S Disease, Gregory M. Pontone, Eric J. Lenze, Et Al. Jan 2019

Report From A Multidisciplinary Meeting On Anxiety As A Non-Motor Manifestation Of Parkinson’S Disease, Gregory M. Pontone, Eric J. Lenze, Et Al.

Open Access Publications

No abstract provided.