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Metabolically Healthy Obesity: Facts And Fantasies, Gordon I Smith, Bettina Mittendorfer, Samuel Klein Jan 2019

Metabolically Healthy Obesity: Facts And Fantasies, Gordon I Smith, Bettina Mittendorfer, Samuel Klein

Open Access Publications

Although obesity is typically associated with metabolic dysfunction and cardiometabolic diseases, some people with obesity are protected from many of the adverse metabolic effects of excess body fat and are considered "metabolically healthy." However, there is no universally accepted definition of metabolically healthy obesity (MHO). Most studies define MHO as having either 0, 1, or 2 metabolic syndrome components, whereas many others define MHO using the homeostasis model assessment of insulin resistance (HOMA-IR). Therefore, numerous people reported as having MHO are not metabolically healthy, but simply have fewer metabolic abnormalities than those with metabolically unhealthy obesity (MUO). Nonetheless, a small …


Mechanism Of Microtubule Plus-End Tracking By The Plant-Specific Spr1 Protein And Its Development As A Versatile Plus-End Marker, Rachappa Balkunde, Layla Foroughi, Eric Ewan, Ryan Emenecker, Valeria Cavalli, Ram Dixit Jan 2019

Mechanism Of Microtubule Plus-End Tracking By The Plant-Specific Spr1 Protein And Its Development As A Versatile Plus-End Marker, Rachappa Balkunde, Layla Foroughi, Eric Ewan, Ryan Emenecker, Valeria Cavalli, Ram Dixit

Open Access Publications

No abstract provided.


Structural And Functional Evidence That Lipoprotein Lpqn Supports Cell Envelope Biogenesis In Mycobacterium Tuberculosis, Geoff C. Melly, Haley Stokas, Jennifer L. Dunaj, Fong Fu Hsu, Malligarjunan Rajavel, Chih-Chia Su, Edward W. Yu, Georgiana E. Purdy Jan 2019

Structural And Functional Evidence That Lipoprotein Lpqn Supports Cell Envelope Biogenesis In Mycobacterium Tuberculosis, Geoff C. Melly, Haley Stokas, Jennifer L. Dunaj, Fong Fu Hsu, Malligarjunan Rajavel, Chih-Chia Su, Edward W. Yu, Georgiana E. Purdy

Open Access Publications

No abstract provided.


Myeloid Acat1/Soat1 Ko Attenuates Pro-Inflammatory Responses In Macrophages And Protects Against Atherosclerosis In A Model Of Advanced Lesions, Elaina M. Melton, Haibo Li, Jalen Benson, Paul Sohn, Li-Hao Huang, Bao-Liang Song, Bo-Liang Li, Catherine C.Y. Chang, Ta-Yuan Chang Jan 2019

Myeloid Acat1/Soat1 Ko Attenuates Pro-Inflammatory Responses In Macrophages And Protects Against Atherosclerosis In A Model Of Advanced Lesions, Elaina M. Melton, Haibo Li, Jalen Benson, Paul Sohn, Li-Hao Huang, Bao-Liang Song, Bo-Liang Li, Catherine C.Y. Chang, Ta-Yuan Chang

Open Access Publications

No abstract provided.


Phosphorylation Of The Hcn Channel Auxiliary Subunit Trip8b Is Altered In An Animal Model Of Temporal Lobe Epilepsy And Modulates Channel Function, Kendall M. Foote, Kyle A. Lyman, Ye Han, Ioannis E. Michailidis, Robert J. Heuermann, Danielle Mandikian, James S. Trimmer, Geoffrey T. Swanson, Dane M. Chetkovich Jan 2019

Phosphorylation Of The Hcn Channel Auxiliary Subunit Trip8b Is Altered In An Animal Model Of Temporal Lobe Epilepsy And Modulates Channel Function, Kendall M. Foote, Kyle A. Lyman, Ye Han, Ioannis E. Michailidis, Robert J. Heuermann, Danielle Mandikian, James S. Trimmer, Geoffrey T. Swanson, Dane M. Chetkovich

Open Access Publications

No abstract provided.


Implementation Of The Uterine Fibroids Option Grid Patient Decision Aids Across Five Organizational Settings: A Randomized Stepped-Wedge Study Protocol, Peter Scalia, Mary C. Politi, Tessa Madden, Et Al Jan 2019

Implementation Of The Uterine Fibroids Option Grid Patient Decision Aids Across Five Organizational Settings: A Randomized Stepped-Wedge Study Protocol, Peter Scalia, Mary C. Politi, Tessa Madden, Et Al

Open Access Publications

No abstract provided.


Developmental Pathology Of Congenital Kidney And Urinary Tract Anomalies, Sanjay Jain, Feng Chen Jan 2019

Developmental Pathology Of Congenital Kidney And Urinary Tract Anomalies, Sanjay Jain, Feng Chen

Open Access Publications

No abstract provided.


Card And Rbpa Modify The Kinetics Of Initial Transcription And Slow Promoter Escape Of The Mycobacterium Tuberculosis Rna Polymerase, Drake Jensen, Ana R. Manzano, Christina L. Stallings, Eric A. Galburt Jan 2019

Card And Rbpa Modify The Kinetics Of Initial Transcription And Slow Promoter Escape Of The Mycobacterium Tuberculosis Rna Polymerase, Drake Jensen, Ana R. Manzano, Christina L. Stallings, Eric A. Galburt

Open Access Publications

No abstract provided.


Are The Intrinsically Disordered Linkers Involved In Ssb Binding To Accessory Proteins?, Min Kyung Shinn, Alexander G. Kozlov, Bihn Nguyen, Wlodek M. Bujalowski, Timothy M. Lohman Jan 2019

Are The Intrinsically Disordered Linkers Involved In Ssb Binding To Accessory Proteins?, Min Kyung Shinn, Alexander G. Kozlov, Bihn Nguyen, Wlodek M. Bujalowski, Timothy M. Lohman

Open Access Publications

No abstract provided.


Npy2r Signaling Gates Spontaneous And Mechanical, But Not Thermal, Pain Transmission, Sihan Chen, Xian-Yu Liu, Yingfu Jiao, Zhou-Feng Chen, Weifeng Yu Jan 2019

Npy2r Signaling Gates Spontaneous And Mechanical, But Not Thermal, Pain Transmission, Sihan Chen, Xian-Yu Liu, Yingfu Jiao, Zhou-Feng Chen, Weifeng Yu

Open Access Publications

No abstract provided.


Comparative Genomic Analysis Of Six Glossina Genomes, Vectors Of African Trypanosomes, Geoffrey M. Attardo, Patrick Minx, Chad Tomlinson, Wesley C. Warren, Richard K. Wilson, Et Al Jan 2019

Comparative Genomic Analysis Of Six Glossina Genomes, Vectors Of African Trypanosomes, Geoffrey M. Attardo, Patrick Minx, Chad Tomlinson, Wesley C. Warren, Richard K. Wilson, Et Al

Open Access Publications

No abstract provided.


Multiple Changes Underlie Allelic Divergence Of Cup2 Between Saccharomyces Species, Xueing C. Li, Justin C. Fay Jan 2019

Multiple Changes Underlie Allelic Divergence Of Cup2 Between Saccharomyces Species, Xueing C. Li, Justin C. Fay

Open Access Publications

No abstract provided.


Microglia Drive Apoe-Dependent Neurodegeneration In A Tauopathy Mouse Model, Yang Shi, Melissa Manis, Justin Long, Kairuo Wang, Patrick M. Sullivan, Javier Remolina Serrano, Rosa Hoyle, David M. Holtzman Jan 2019

Microglia Drive Apoe-Dependent Neurodegeneration In A Tauopathy Mouse Model, Yang Shi, Melissa Manis, Justin Long, Kairuo Wang, Patrick M. Sullivan, Javier Remolina Serrano, Rosa Hoyle, David M. Holtzman

Open Access Publications

No abstract provided.


Rory Regulates The Nlrp3 Inflammasome, Cyrielle Billon, Meghan H. Murray, Amer Avdagic, Thomas P. Burris Jan 2019

Rory Regulates The Nlrp3 Inflammasome, Cyrielle Billon, Meghan H. Murray, Amer Avdagic, Thomas P. Burris

Open Access Publications

No abstract provided.


Thiol Isomerase Erp57 Targets And Modulates The Lectin Pathway Of Complement Activation, Oskar Eriksson, Joyce Chiu, Philip J. Hogg, John P. Atkinson, M. Kathryn Liszewski, Robert Flaumenhaft, Bruce Furie Jan 2019

Thiol Isomerase Erp57 Targets And Modulates The Lectin Pathway Of Complement Activation, Oskar Eriksson, Joyce Chiu, Philip J. Hogg, John P. Atkinson, M. Kathryn Liszewski, Robert Flaumenhaft, Bruce Furie

Open Access Publications

No abstract provided.


Photoreceptors In A Mouse Model Of Leigh Syndrome Are Capable Of Normal Light-Evoked Signaling, Sidney M. Gospe Iii, Amanda M. Travis, Alexander V. Kolesnikov, Mikael Klingeborn, Luyu Wang, Vladimir J. Kefalov, Vadim Y. Arshavsky Jan 2019

Photoreceptors In A Mouse Model Of Leigh Syndrome Are Capable Of Normal Light-Evoked Signaling, Sidney M. Gospe Iii, Amanda M. Travis, Alexander V. Kolesnikov, Mikael Klingeborn, Luyu Wang, Vladimir J. Kefalov, Vadim Y. Arshavsky

Open Access Publications

No abstract provided.


Nfat5 Up-Regulates Expression Of The Kidney-Specific Ubiquitin Ligase Gene Rnf183 Under Hypertonic Conditions In Inner-Medullary Collecting Duct Cells, Yujiro Maeoka, Yan Wu, Takumi Okamoto, Soshi Kanemoto, Xiao Peng Guo, Atsushi Saito, Rie Asada, Koji Matsuhisa, Takao Masaki, Kazunori Imaizumi, Masayuki Kaneko Jan 2019

Nfat5 Up-Regulates Expression Of The Kidney-Specific Ubiquitin Ligase Gene Rnf183 Under Hypertonic Conditions In Inner-Medullary Collecting Duct Cells, Yujiro Maeoka, Yan Wu, Takumi Okamoto, Soshi Kanemoto, Xiao Peng Guo, Atsushi Saito, Rie Asada, Koji Matsuhisa, Takao Masaki, Kazunori Imaizumi, Masayuki Kaneko

Open Access Publications

No abstract provided.


Identification And Characterization Of Nanh2 And Nanh3, Enzymes Responsible For Sialidase Activity In The Vaginal Bacterium Gardnerella Vaginalis, Lloyd S. Robinson, Jane Schwebke, Warren G. Lewis, Amanda L. Lewis Jan 2019

Identification And Characterization Of Nanh2 And Nanh3, Enzymes Responsible For Sialidase Activity In The Vaginal Bacterium Gardnerella Vaginalis, Lloyd S. Robinson, Jane Schwebke, Warren G. Lewis, Amanda L. Lewis

Open Access Publications

No abstract provided.


A Stable Tetramer Is Not The Only Oligomeric State That Mitochondrial Single-Stranded Dna Binding Proteins Can Adopt, Saurabh P. Singh, Vandna Kukshal, Roberto Galletto Jan 2019

A Stable Tetramer Is Not The Only Oligomeric State That Mitochondrial Single-Stranded Dna Binding Proteins Can Adopt, Saurabh P. Singh, Vandna Kukshal, Roberto Galletto

Open Access Publications

No abstract provided.


Activation Of Tel1atm Kinase Requires Rad50 Atpase And Long Nucleosome-Free Dna But No Dna Ends, Sarem Hailemariam, Sandeep Kumar, Peter M. Burgers Jan 2019

Activation Of Tel1atm Kinase Requires Rad50 Atpase And Long Nucleosome-Free Dna But No Dna Ends, Sarem Hailemariam, Sandeep Kumar, Peter M. Burgers

Open Access Publications

No abstract provided.


Detection Of Tar Dna-Binding Protein 43 (Tdp-43) Oligomers As Initial Intermediate Species During Aggregate Formation, Rachel L. French, Zachary R. Grese, Himani Aligireddy, Dhruva D. Dhavale, Ashley N. Reeb, Niraja Kedia, Paul T. Kotzbauer, Jan Bieschke, Yuna M. Ayala Jan 2019

Detection Of Tar Dna-Binding Protein 43 (Tdp-43) Oligomers As Initial Intermediate Species During Aggregate Formation, Rachel L. French, Zachary R. Grese, Himani Aligireddy, Dhruva D. Dhavale, Ashley N. Reeb, Niraja Kedia, Paul T. Kotzbauer, Jan Bieschke, Yuna M. Ayala

Open Access Publications

No abstract provided.


The Structure Of Acinetobacter-Secreted Protease Cpaa Complexed With Its Chaperone Cpab Reveals A Novel Mode Of A T2ss Chaperone–Substrate Interaction, Darya V. Urusova, Rachel L. Kinsella, Nichole D. Salinas, M. Florencia Haurat, Mario F. Feldman, Niraj H. Tolia Jan 2019

The Structure Of Acinetobacter-Secreted Protease Cpaa Complexed With Its Chaperone Cpab Reveals A Novel Mode Of A T2ss Chaperone–Substrate Interaction, Darya V. Urusova, Rachel L. Kinsella, Nichole D. Salinas, M. Florencia Haurat, Mario F. Feldman, Niraj H. Tolia

Open Access Publications

No abstract provided.


Regulation Of Lipophagy In Nafld By Cellular Metabolism And Cd36, Dmitri Samovski, Nada A. Abumrad Jan 2019

Regulation Of Lipophagy In Nafld By Cellular Metabolism And Cd36, Dmitri Samovski, Nada A. Abumrad

Open Access Publications

No abstract provided.


Synthesis And Characterization Of Diazirine Alkyne Probes For The Study Of Intracellular Cholesterol Trafficking, Mckenna Feltes, Samantha Moores, Sarah E. Gale, Kathiresan Krishnan, Laurel Mydock-Mcgrane, Douglas F. Covey, Daniel S. Ory, Jean E. Schaffer Jan 2019

Synthesis And Characterization Of Diazirine Alkyne Probes For The Study Of Intracellular Cholesterol Trafficking, Mckenna Feltes, Samantha Moores, Sarah E. Gale, Kathiresan Krishnan, Laurel Mydock-Mcgrane, Douglas F. Covey, Daniel S. Ory, Jean E. Schaffer

Open Access Publications

No abstract provided.


Building Bridges: Pcsk7 As A Nafld Candidate Gene Connecting Hepatic Inflammation With Hypertriglyceridemia, Rotonya M. Carr, Nicholas O. Davidson Jan 2019

Building Bridges: Pcsk7 As A Nafld Candidate Gene Connecting Hepatic Inflammation With Hypertriglyceridemia, Rotonya M. Carr, Nicholas O. Davidson

Open Access Publications

No abstract provided.


The Complex Genetics And Biology Of Human Temperament: A Review Of Traditional Concepts In Relation To New Molecular Findings, C. Robert Cloninger, Kevin M. Cloninger, Igor Zwir, Lisa Keltikangas-Järvinen Jan 2019

The Complex Genetics And Biology Of Human Temperament: A Review Of Traditional Concepts In Relation To New Molecular Findings, C. Robert Cloninger, Kevin M. Cloninger, Igor Zwir, Lisa Keltikangas-Järvinen

Open Access Publications

No abstract provided.


Oxytocin And Oxytocinase In The Obese And Nonobese Parturients During Induction And Augmentation Of Labor, Annemaria De Tina, Jeremy Juang, Thomas F Mcelrath, Jack D Baty, Arvind Palanisamy Jan 2019

Oxytocin And Oxytocinase In The Obese And Nonobese Parturients During Induction And Augmentation Of Labor, Annemaria De Tina, Jeremy Juang, Thomas F Mcelrath, Jack D Baty, Arvind Palanisamy

Open Access Publications

No abstract provided.


Regulated Phosphosignaling Associated With Breast Cancer Subtypes And Druggability, Kuan-Lin Huang, Yige Wu, Tina Primeau, Joshua F. Mcmichael, Adam D. Scott, Song Cao, Michael C. Wendl, Kimberly J. Johnson, Jason Held, Sherri Davies, R. Reid Townsend, Feng Chen, David Fenyö, Shunqiang Li, Tao Liu, Li Ding, Et Al. Jan 2019

Regulated Phosphosignaling Associated With Breast Cancer Subtypes And Druggability, Kuan-Lin Huang, Yige Wu, Tina Primeau, Joshua F. Mcmichael, Adam D. Scott, Song Cao, Michael C. Wendl, Kimberly J. Johnson, Jason Held, Sherri Davies, R. Reid Townsend, Feng Chen, David Fenyö, Shunqiang Li, Tao Liu, Li Ding, Et Al.

Open Access Publications

No abstract provided.


Hepatic Monoacylglycerol Acyltransferase 1 Is Induced By Prolonged Food Deprivation To Modulate The Hepatic Fasting Response, Andrew J. Lutkewitte, Kyle S. Mccommis, George G. Schweitzer, Kari T. Chambers, Mark J. Graham, Lingjue Wang, Gary J. Patti, Angela M. Hall, Brian N. Finck Jan 2019

Hepatic Monoacylglycerol Acyltransferase 1 Is Induced By Prolonged Food Deprivation To Modulate The Hepatic Fasting Response, Andrew J. Lutkewitte, Kyle S. Mccommis, George G. Schweitzer, Kari T. Chambers, Mark J. Graham, Lingjue Wang, Gary J. Patti, Angela M. Hall, Brian N. Finck

Open Access Publications

No abstract provided.


Synthesis Of Oxidized Phospholipids By Sn-1 Acyltransferase Using 2–15-Hete Lysophospholipids, Gao-Yuan Liu, Sung Ho Moon, Christopher M. Jenkins, Harold F. Sims, Shaoping Guan, Richard W. Gross Jan 2019

Synthesis Of Oxidized Phospholipids By Sn-1 Acyltransferase Using 2–15-Hete Lysophospholipids, Gao-Yuan Liu, Sung Ho Moon, Christopher M. Jenkins, Harold F. Sims, Shaoping Guan, Richard W. Gross

Open Access Publications

No abstract provided.