Digital Commons Network^™

Associations Between Family Weight-Based Teasing, Eating Pathology, And Psychosocial Functioning Among Adolescent Military Dependents, Arielle T Pearlman, Denise E Wilfley, Et Al

Open Access Publications

Weight-based teasing (WBT) by family members is commonly reported among youth and is associated with eating and mood-related psychopathology. Military dependents may be particularly vulnerable to family WBT and its sequelae due to factors associated with their parents' careers, such as weight and fitness standards and an emphasis on maintaining one's military appearance; however, no studies to date have examined family WBT and its associations within this population. Therefore, adolescent military dependents at-risk for adult obesity and binge-eating disorder were studied prior to entry in a weight gain prevention trial. Youth completed items from the Weight-Based Victimization Scale (to assess …

Nanotherapy Targeting Nf-Κb Attenuates Acute Pain After Joint Injury, Huimin Yan, Xin Duan, Kelsey H Collins, Luke E Springer, Farshid Guilak, Samuel A Wickline, M Farooq Rai, Hua Pan, Christine T N Pham

Open Access Publications

Inflammation after joint injury leads to joint responses that result in eventual osteoarthritis development. Blockade of inflammation, by suppressing NF-κB expression, has been shown to reduce joint injury-induced chondrocyte apoptosis and reactive synovitis

Glioblastoma Treated With Magnetic Resonance Imaging-Guided Laser Interstitial Thermal Therapy: Safety, Efficacy, And Outcomes, Ashwin A. Kamath, Daniel D. Friedman, S Hassan A. Akbari, Albert H. Kim, Yu Tao, Jinqin Luo, Eric C. Leuthardt

Open Access Publications

BACKGROUND: Despite the multitude of available treatments, glioblastoma (GBM) remains an aggressive and uniformly fatal tumor. Laser interstitial thermal therapy (LITT) is a novel, minimally invasive treatment that holds promise for treating patients with GBM who are not candidates for traditional open craniotomy. However, due to the recent introduction of LITT into clinical practice, large series that evaluate safety and long-term outcomes after LITT are lacking.

OBJECTIVE: To present our institution's series of over 50 GBM patients treated with LITT, with regard to safety, efficacy, and outcomes.

METHODS: We performed a retrospective descriptive study of patients with histologically proven GBM …

Ctcf Variants In 39 Individuals With A Variable Neurodevelopmental Disorder Broaden The Mutational And Clinical Spectrum, Enrico D. H. Konrad, Marwan Shinawi, Emily Fassi, Et Al.

Open Access Publications

No abstract provided.

Syndemic Effects Of Hiv Risk Behaviours: Results From The Nhanes Study, L Smith, C Cao, X Zong, D T Mcdermott, S Stefanac, S Haider, S E Jackson, N Veronese, G F López-Sánchez, A Koyanagi, L Yang, I Grabovac

Open Access Publications

The aim of the present study is to use the syndemic framework to investigate the risk of contracting HIV in the US population. Cross-sectional analyses are from The National Health and Nutrition Examination Survey. We extracted and aggregated data on HIV antibody test, socio-demographic characteristics, alcohol use, drug use, depression, sexual behaviours and sexually transmitted diseases from cycle 2009-2010 to 2015-2016. We carried out weighted regression among young adults (20-39 years) and adults (40-59 years) separately. In total, 5230 men and 5794 women aged 20-59 years were included in the present analyses. In total, 0.8% men and 0.2% women were …

Recommendations And Alerting For Delirium Alleviation In Real-Time (Radar): Protocol For A Pilot Randomized Controlled Trial, Phillip E Vlisides, Jacqueline W Ragheb, Aleda Leis, Amanda Schoettinger, Kim Hickey, Amy Mckinney, Joseph Brooks, Mackenzie Zierau, Alexandra Norcott, Shirley Yang, Michael S Avidan, Lillian Min

Open Access Publications

No abstract provided.

Top 10 Research Priorities In Spatial Lifecourse Epidemiology, Peng Jia, Ross C. Brownson, Et Al.

Open Access Publications

No abstract provided.

Long-Term Prospective Clinical And Radiographic Outcomes After Minimally Invasive Lateral Transiliac Sacroiliac Joint Fusion Using Triangular Titanium Implants, Peter G Whang, Emily Darr, S Craig Meyer, Don Kovalsky, Clay Frank, Harry Lockstadt, Robert Limoni, Andy J Redmond, Philip Ploska, Michael Oh, Abhineet Chowdhary, Daniel Cher, Travis Hillen

Open Access Publications

Background: Accumulating evidence supports the long-term safety and effectiveness of minimally invasive sacroiliac joint fusion (SIJF) for sacroiliac joint dysfunction.

Objective: To report 5-year clinical and radiographic follow-up in patients undergoing SIJF using triangular titanium implants (TTI).

Methods: One hundred and three subjects at 12 centers treated with SIJF using TTI in two prospective clinical trials (NCT01640353 and NCT01681004) were enrolled and followed in the current study (NCT02270203) with clinic visits at 3, 4 and 5 years. CT scans performed at 5 years were compared to prior CT scans (at 1 or 2 years) by an independent radiologist.

Results: Compared …

Genomic Characterization Of Antibiotic Resistant Escherichia Coli Isolated From Domestic Chickens In Pakistan, Muhammad Rafique, Robert F Potter, Aura Ferreiro, Meghan A Wallace, Abdul Rahim, Akbar Ali Malik, Naila Siddique, Muhammad Athar Abbas, Alaric W D'Souza, Carey-Ann D Burnham, Naeem Ali, Gautam Dantas

Open Access Publications

Poultry husbandry is important for the economic health of Pakistan, but the Pakistani poultry industry is negatively impacted by infections from

Implementation And Sustainability Of A Pharmacy-Led, Hospital-Wide Bedside Medication Delivery Program: A Qualitative Process Evaluation Using Re-Aim, Beth Prusaczyk, Amanda S Mixon, Sunil Kripalani

Open Access Publications

No abstract provided.

The Interplay Between Viral-Derived Mirnas And Host Immunity During Infection, Richa Mishra, Ashish Kumar, Harshad Ingle, Himanshu Kumar

Open Access Publications

MicroRNAs are short non-coding RNAs that play a crucial role in the regulation of gene expression during cellular processes. The host-encoded miRNAs are known to modulate the antiviral defense during viral infection. In the last decade, multiple DNA and RNA viruses have been shown to produce miRNAs known as viral miRNAs (v-miRNAs) so as to evade the host immune response. In this review, we highlight the origin and biogenesis of viral miRNAs during the viral lifecycle. We also explore the role of viral miRNAs in immune evasion and hence in maintaining chronic infection and disease. Finally, we offer insights into …

Rrx-001 Followed By Platinum Plus Etoposide In Patients With Previously Treated Small-Cell Lung Cancer, Daniel Morgensztern, Michal Rose, Saiama N Waqar, John Morris, Patrick C Ma, Thomas Reid, Christina E Brzezniak, Karen G Zeman, Arvinda Padmanabhan, Joann Hirth, Alexander I Spira, Jane B Trepel, Sukhmani K Padda

Open Access Publications

BACKGROUND: This exploratory single-arm phase II study evaluated the efficacy and safety of RRx-001 followed by reintroduction of platinum plus etoposide in patients with previously treated small-cell lung cancer (SCLC).

METHODS: Patients were treated with RRx-001 4 mg IV on day 1 of each week of a 21-day cycle followed at progression by re-challenge with etoposide 80-100 IV mg/m

RESULTS: Twenty-six patients were enroled and received at least one dose of RRx-001. The median number of prior lines of therapy was 2 (range 1-9) and 19 (73.1%) patients had platinum-resistant disease. In the intention-to-treat population, one patient (3.8%) had complete …

Visualization Of Positive And Negative Sense Viral Rna For Probing The Mechanism Of Direct-Acting Antivirals Against Hepatitis C Virus, Dandan Liu, Philip R Tedbury, Shuiyun Lan, Andrew D Huber, Maritza N Puray-Chavez, Juan Ji, Eleftherios Michailidis, Mohsan Saeed, Tanyaradzwa P Ndongwe, Leda C Bassit, Raymond F Schinazi, Robert Ralston, Charles M Rice, Stefan G Sarafianos

Open Access Publications

RNA viruses are highly successful pathogens and are the causative agents for many important diseases. To fully understand the replication of these viruses it is necessary to address the roles of both positive-strand RNA ((+)RNA) and negative-strand RNA ((-)RNA), and their interplay with viral and host proteins. Here we used branched DNA (bDNA) fluorescence in situ hybridization (FISH) to stain both the abundant (+)RNA and the far less abundant (-)RNA in both hepatitis C virus (HCV)- and Zika virus-infected cells, and combined these analyses with visualization of viral proteins through confocal imaging. We were able to phenotypically examine HCV-infected cells …

Mobilized Peripheral Blood: An Updated Perspective, Darja Karpova, Michael P Rettig, John F Dipersio

Open Access Publications

Enforced egress of hematopoietic stem cells (HSCs) out of the bone marrow (BM) into the peripheral circulation, termed mobilization, has come a long way since its discovery over four decades ago. Mobilization research continues to be driven by the need to optimize the regimen currently available in the clinic with regard to pharmacokinetic and pharmacodynamic profile, costs, and donor convenience. In this review, we describe the most recent findings in the field and how we anticipate them to affect the development of mobilization strategies in the future. Furthermore, the significance of mobilization beyond HSC collection, i.e. for chemosensitization, conditioning, and …

Interpreting Neurologic Outcomes In A Changing Trial Design Landscape: An Analysis Of Heartware Left Ventricular Assist Device Using A Hybrid Intention To Treat Population, Claudius Mahr, Duc Thinh Pham, Nahush A. Mokadam, Scott C. Silvestry, Jennifer Cowger, Michael S. Kiernan, David A. D'Alessandro, Erin E. Coglianese, Muhammad Faraz Masood, Robert L. Kormos, Mary V. Jacoski, Jeffrey J. Teuteberg

Open Access Publications

No abstract provided.

Association Between Early Anatomic Response To Anti-Vascular Endothelial Growth Factor Therapy And Long-Term Outcome In Diabetic Macular Edema: An Independent Analysis Of Protocol I Study Data, Pravin U. Dugel, Joanna H. Campbell, Szilárd Kiss, Anat Loewenstein, Vanessa Shih, Xiaoshu Xu, Nancy Holekamp, Albert J. Augustin, Allen C. Ho, Victor H. Gonzalez, Scott M. Whitcup

Open Access Publications

No abstract provided.

Determining Population Stratification And Subgroup Effects In Association Studies Of Rare Genetic Variants For Nicotine Dependence, Ai-Ru Hsieh, Li-Shiun Chen, Ying-Ju Li, Cathy S. J. Fann

Open Access Publications

No abstract provided.

Challenges To Curing Primary Brain Tumours, Kenneth Aldape, David H. Gutmann, Et Al.

Open Access Publications

No abstract provided.

Clinical Performance Of A Novel Fully Synthetic Dura Substitute, Umang Khandpur, Wilson Ray, Matthew Macewan

Open Access Publications

No abstract provided.

A Strategy For Building And Using A Human Reference Pangenome, Bastien Llamas, Allison Regier, Et Al

Open Access Publications

In March 2019, 45 scientists and software engineers from around the world converged at the University of California, Santa Cruz for the first pangenomics codeathon. The purpose of the meeting was to propose technical specifications and standards for a usable human pangenome as well as to build relevant tools for genome graph infrastructures. During the meeting, the group held several intense and productive discussions covering a diverse set of topics, including advantages of graph genomes over a linear reference representation, design of new methods that can leverage graph-based data structures, and novel visualization and annotation approaches for pangenomes. Additionally, the …

Somatosensory Predictors Of Response To Pregabalin In Painful Chemotherapy-Induced Peripheral Neuropathy: A Randomized, Placebo-Controlled, Crossover Study, Alexander Hincker, Karen Frey, Lesley Rao, Nina Wagner-Johnston, Arbi Ben Abdallah, Benjamin Tan, Manik Amin, Tanya Wildes, Rajiv Shah, Pall Karlsson, Kristopher Bakos, Katarzyna Kosicka, Leonid Kagan, Simon Haroutounian

Open Access Publications

No abstract provided.

Working Memory Improves Developmentally As Neural Processes Stabilize, David Florentino Montez, Finnegan J. Calabro, Beatriz Luna

Open Access Publications

No abstract provided.

Monthly Extended-Release Risperidone (Rbp-7000) In The Treatment Of Schizophrenia, Anne Andorn, Jay Graham, John Csernansky, John W. Newcomer, Sunita Shinde, Gilbert Muma, Christian Heidbreder, Maurizio Fava

Open Access Publications

No abstract provided.

Ether-A-Go-Go Related Gene-1a Potassium Channel Abundance Varies Within Specific Skeletal Muscle Fiber Type, Luke B. Anderson, Chase D. Latour, Omar Khader, Bryce H. Massey, Brittan Cobb, Amber L. Pond

Open Access Publications

No abstract provided.

Potential Role Of Gut Microbiota In Induction And Regulation Of Innate Immune Memory, Shikha Negi, Deepjyoti Kumar Das, Susanta Pahari, Sajid Nadeem, Javed N Agrewala

Open Access Publications

The gut microbiota significantly regulates the development and function of the innate and adaptive immune system. The attribute of immunological memory has long been linked only with adaptive immunity. Recent evidence indicates that memory is also present in the innate immune cells such as monocytes/macrophages and natural killer cells. These cells exhibit pattern recognition receptors (PRRs) that recognize microbe- or pathogen-associated molecular patterns (MAMPs or PAMPs) expressed by the microbes. Interaction between PRRs and MAMPs is quite crucial since it triggers the sequence of signaling events and epigenetic rewiring that not only play a cardinal role in modulating the activation …

The Upper-Airway Microbiota And Loss Of Asthma Control Among Asthmatic Children, Yanjiao Zhou, Leonard B. Bacharier, Mario Castro, Gregory A. Storch, Kristine Wylie, Avraham Beigelman, Et Al.

Open Access Publications

No abstract provided.

Epigenetic Dysregulation Of Enhancers In Neurons Is Associated With Alzheimer’S Disease Pathology And Cognitive Symptoms, Peipei Li, Lee Marshall, Gabriel Oh, Jennifer L. Jakubowski, Daniel Groot, Yu He, Ting Wang, Arturas Petronis, Viviane Labrie

Open Access Publications

No abstract provided.

A Fully Magnetically Levitated Left Ventricular Assist Device — Final Report, G.A. Ewald, A. Itoh

Open Access Publications

No abstract provided.

Dupilumab Improves Symptoms, Quality Of Life, And Productivity In Uncontrolled Persistent Asthma, Jonathan Corren, Mario Castro, Pascal Chanez, Leonardo Fabbri, Vijay N Joish, Nikhil Amin, Neil M H Graham, Vera Mastey, Adeline Abbé, Christine Taniou, Puneet Mahajan, Ariel Teper, Gianluca Pirozzi, Laurent Eckert

Open Access Publications

BACKGROUND: In a pivotal, phase 2b study (NCT01854047) in patients with uncontrolled persistent asthma, despite using medium-to-high-dose inhaled corticosteroids plus long-acting β2 agonists, dupilumab improved lung function, reduced severe exacerbations, and showed an acceptable safety profile.

OBJECTIVE: To assess the impact of dupilumab on asthma control, symptoms, quality of life (QoL), and productivity.

METHODS: Data are shown for the intention-to-treat population receiving dupilumab 200/300 mg every 2 weeks (doses being assessed in phase 3; NCT02414854), or placebo. Predefined analyses of total scores were conducted at week 24 for the 5-item Asthma Control Questionnaire (ACQ-5), patient-reported morning/evening (AM/PM) asthma symptoms, Asthma …

Impact Of An Electronic Hard-Stop Clinical Decision Support Tool To Limit Repeat Clostridioides Difficile Toxin Enzyme Immunoassay Testing On Test Utilization, Jennie H Kwon, Kimberly A Reske, Tiffany Hink, Ronald Jackups, Carey-Ann D Burnham, Erik R Dubberke

Open Access Publications

We performed an intervention evaluating the impact of an electronic hard-stop clinical decision support tool on repeat Clostridioides difficile (CD) toxin enzyme immunoassay (T-EIA) testing. The CD testing rate and number of admissions with repeat tests decreased significantly postintervention (P < .01 for both); the percentage of positive tests was unchanged (P = .27).