Digital Commons Network^™

A Mutation In Site-1 Protease Is Associated With A Complex Phenotype That Includes Episodic Hyperckemia And Focal Myoedema, George G. Schweitzer, Connie Gan, Robert C. Bucelli, Daniel Wegner, Robert E. Schmidt, Marwan Shinawi, Brian N. Finck, Rita T. Brookheart

Open Access Publications

No abstract provided.

Bone Marrow Dendritic Cells Regulate Hematopoietic Stem/Progenitor Cell Trafficking, Jingzhu Zhang, Teerawit Supakorndej, Joseph R. Krambs, Mahil Rao, Grazia Abou-Ezzi, Rachel Y. Ye, Sidan Li, Kathryn Trinkaus, Daniel C. Link

Open Access Publications

No abstract provided.

When All Else Fails, Listen To The Patient: A Viewpoint On The Use Of Ecological Momentary Assessment In Clinical Trials, Aaron M. Mofsen, Thomas L. Rodebaugh, Ginger E. Nicol, Colin A. Depp, J. P. Miller, Eric J. Lenze

Open Access Publications

No abstract provided.

Mitofusin 2 Is Essential For Ip3-Mediated Sr/Mitochondria Metabolic Feedback In Ventricular Myocytes, Lea K. Seidlmayer, Christine Mages, Annette Berbner, Petra Eder-Negrin, Paula Anahi Arias-Loza, Mathias Kaspar, Moshi Song, Gerald W. Dorn Ii, Michael Kohlhaas, Stefan Frantz, Christoph Maack, Brenda Gerull, Elena N. Dedkova

Open Access Publications

No abstract provided.

Insights Into The Microbiome Of Breast Implants And Periprosthetic Tissue In Breast Implant-Associated Anaplastic Large Cell Lymphoma, Jennifer N. Walker, Blake M. Hanson, Chloe L. Pinkner, Shelby R. Simar, Jerome S. Pinkner, Rajiv Parikh, Mark W. Clemens, Scott J. Hultgren, Terence M. Myckatyn

Open Access Publications

No abstract provided.

Role Of Topical Magnesium In Post-Operative Sore Throat: A Systematic Review And Meta-Analysis Of Randomised Controlled Trials, Narinder P. Singh, Jeetinder K. Makkar, Vincent Wourms, Andrés Zorrilla-Vaca, Ronald B. Cappellani, Preet M. Singh

Open Access Publications

No abstract provided.

Online Physician Reviews: Is There A Place For Them?, Gregory P. Murphy, Kushan D. Radadia, Benjamin N. Breyer

Open Access Publications

No abstract provided.

Predicting Tumor Response To Pd-1 Blockade, Li Ding, Feng Chen

Open Access Publications

No abstract provided.

Perioperative Serum Albumin And Its Influence On Clinical Outcomes In Neonates And Infants Undergoing Cardiac Surgery With Cardiopulmonary Bypass: A Multi-Centre Retrospective Study, Brandon M. Henry, Santiago Borasino, Laura Ortmann, Mayte Figueroa, A.K.M. F. Rahman, Kristal M. Hock, Mario Briceno-Medina, Jeffrey A. Alten

Open Access Publications

No abstract provided.

Phenotypic Characterization Of Bone Marrow Mononuclear Cells And Derived Stromal Cell Populations From Human Lliac Crest, Vertebral Body And Femoral Head, Marietta Herrmann, Maria Hildebrand, Ursula Menzel, Niamh Fahy, Mauro Alini, Siegmund Lang, Lorin Benneker, Sophie Verrier, Martin J. Stoddart, Jennifer J. Bara

Open Access Publications

No abstract provided.

Orally Bioavailable Glutamine Antagonist Prodrug Jhu-083 Penetrates Mouse Brain And Suppresses The Growth Of Myc-Driven Medulloblastoma, Allison R. Hanaford, Jesse Alt, Rana Rais, Sabrina Z. Wang, Harpreet Kaur, Daniel L.J. Thorek, Charles G. Eberhart, Barbara S. Slusher, Allison M. Martin, Eric H. Raabe

Open Access Publications

No abstract provided.

Expression Signatures Of Cisplatin- And Trametinib-Treated Early-Stage Medaka Melanomas, Barbara Klotz, Susanne Kneitz, Yuan Lu, William Boswell, John Postlethwait, Wesley Warren, Ronald B. Walter, Manfred Shartl

Open Access Publications

No abstract provided.

Single-Molecule Trapping And Spectroscopy Reveals Photophysical Heterogeneity Of Phycobilisomes Quenched By Orange Carotenoid Protein, Allison H. Squires, Peter D. Dahlberg, Haijun Liu, Nikki Cecil M. Magdaong, Robert E. Blankenship, W.E. Moerner

Open Access Publications

No abstract provided.

Histopathological Features Of Drug-Induced Liver Injury Secondary To Osimertinib, Ivan Gonzalez, Deyali Chatterjee

Open Access Publications

No abstract provided.

Comparison Of The Pharmacokinetic Properties Of Triamcinolone And Dexamethasone For Local Therapy Of The Inner Ear, Alec Nicholas Salt, Jared James Hartsock, Jennifer Hou, Fabrice Piu

Open Access Publications

No abstract provided.

Modelling Resilience In Adolescence And Adversity: A Novel Framework To Inform Research And Practice, Gin S. Malhi, Pritha Das, Erica Bell, Greg Mattingly, Zola Mannie

Open Access Publications

No abstract provided.

Whole-Cortex Mapping Of Common Genetic Influences On Depression And A Social Deficits Dimension, Alexander S. Hatoum, Andrew E. Reineberg, Harry R. Smolker, John K. Hewitt, Naomi P. Friedman

Open Access Publications

No abstract provided.

End Points For Sickle Cell Disease Clinical Trials: Renal And Cardiopulmonary, Cure, And Low-Resource Settings, Ann T. Farrell, Shalini Shenoy, Et Al.

Open Access Publications

No abstract provided.

The Zebrafish Xenograft Platform-A Novel Tool For Modeling Kshv-Associated Diseases, Eric S Pringle, Jaime Wertman, Nicole Melong, Andrew J Coombs, Andrew L Young, David O'Leary, Chansey Veinotte, Carolyn-Ann Robinson, Michael N Ha, Graham Dellaire, Todd E Druley, Craig Mccormick, Jason N Berman

Open Access Publications

Kaposi's sarcoma associated-herpesvirus (KSHV, also known as human herpesvirus-8) is a gammaherpesvirus that establishes life-long infection in human B lymphocytes. KSHV infection is typically asymptomatic, but immunosuppression can predispose KSHV-infected individuals to primary effusion lymphoma (PEL); a malignancy driven by aberrant proliferation of latently infected B lymphocytes, and supported by pro-inflammatory cytokines and angiogenic factors produced by cells that succumb to lytic viral replication. Here, we report the development of the first

Gna11 Brain Somatic Pathogenic Variant In An Individual With Phacomatosis Pigmentovascularis, Joseph M. Sliepka, Yi-Shan Lee, Et Al.

Open Access Publications

No abstract provided.

Selective Small Molecule Parg Inhibitor Causes Replication Fork Stalling And Cancer Cell Death, Jerry H. Houl, Roderick A. Stegeman, Tom Ellenberger, In-Kwon Kim, Et Al.

Open Access Publications

No abstract provided.

Diffusion Basis Spectrum Imaging Provides Insights Into Ms Pathology, Peng Sun, Ajit George, Dana C. Perantie, Kathryn Trinkaus, Zezhong Ye, Robert T. Naismith, Sheng-Kwei Song, Anne H. Cross

Open Access Publications

No abstract provided.

New Statistical Method Identifes Cytokines That Distinguish Stool Microbiomes, Dake Yang, Jethro Johnson, Xin Zhou, Elena Deych, Berkley Shands, Blake Hanson, Erica Sodergren, George Weinstock, William D. Shannon

Open Access Publications

No abstract provided.

The Epigenomic Landscape Of Transposable Elements Across Normal Human Development And Anatomy, Erica C. Pehrsson, Mayank N.K. Choudhary, Vasavi Sundaram, Ting Wang

Open Access Publications

No abstract provided.

Evaluating Glial And Neuronal Blood Biomarkers Gfap And Uch-L1 As Gradients Of Brain Injury In Concussive, Subconcussive And Non-Concussive Trauma: A Prospective Cohort Study, Linda Papa, Mark R Zonfrillo, Robert D Welch, Lawrence M Lewis, Carolina F Braga, Ciara N Tan, Neema J Ameli, Marco A Lopez, Crystal A Haeussler, Diego Mendez Giordano, Philip A Giordano, Jose Ramirez, Manoj K Mittal

Open Access Publications

Objectives: To evaluate the ability of glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase (UCH-L1) to detect concussion in children and adult trauma patients with a normal mental status and assess biomarker concentrations over time as gradients of injury in concussive and non-concussive head and body trauma.

Design: Large prospective cohort study.

Setting: Three level I trauma centres in the USA.

Participants: Paediatric and adult trauma patients of all ages, with and without head trauma, presenting with a normal mental status (Glasgow Coma Scale score of 15) within 4 hours of injury. Rigorous screening for concussive symptoms was conducted. …

The Effect Of Gut Microbiome Composition On Human Immune Responses: An Exploration Of Interference By Helminth Infections, Ivonne Martin, Maria M M Kaisar, Aprilianto E Wiria, Firdaus Hamid, Yenny Djuardi, Erliyani Sartono, Bruce A Rosa, Makedonka Mitreva, Taniawati Supali, Jeanine J Houwing-Duistermaat, Maria Yazdanbakhsh, Linda J Wammes

Open Access Publications

No abstract provided.

Attribution Of Ghrelin To Cancer; Attempts To Unravel An Apparent Controversy, Saeed Soleyman-Jahi, Fatemeh Sadeghi, Amin Pastaki Khoshbin, Leila Khani, Venus Roosta, Kazem Zendehdel

Open Access Publications

Ghrelin is an endogenous peptide hormone mainly produced in the stomach. It has been known to regulate energy homeostasis, stimulate secretion of growth hormone, and mediate many other physiologic effects. Various effects attributed to ghrelin contribute to many aspects of cancer development and progression. Accordingly, a large body of evidence has emerged about the association of ghrelin with several types of cancer in scales of cell-line, animal, and human studies. However, existing data are controversial. This controversy occurs in two main domains: one is the controversial results in local effects of ghrelin on different types of human cancer cell-lines; the …

The Telomere-Binding Protein Rif2 And Atp-Bound Rad50 Have Opposing Roles In The Activation Of Yeast Tel1atm Kinase, Sarem Hailemariam, Paolo De Bona, Roberto Galletto, Marcel Hohl, John H. Petrini, Peter M. Burgers

Open Access Publications

No abstract provided.

Structural And Functional Abnormities Of Amygdala And Prefrontal Cortex In Major Depressive Disorder With Suicide Attempts, Lifei Wang, Yimeng Zhao, Elliot K Edmiston, Fay Y Womer, Ran Zhang, Pengfei Zhao, Xiaowei Jiang, Feng Wu, Lingtao Kong, Yifang Zhou, Yanqing Tang, Shengnan Wei

Open Access Publications

Finding neural features of suicide attempts (SA) in major depressive disorder (MDD) may be helpful in preventing suicidal behavior. The ventral and medial prefrontal cortex (PFC), as well as the amygdala form a circuit implicated in emotion regulation and the pathogenesis of MDD. The aim of this study was to identify whether patients with MDD who had a history of SA show structural and functional connectivity abnormalities in the amygdala and PFC relative to MDD patients without a history of SA. We measured gray matter volume in the amygdala and PFC and amygdala-PFC functional connectivity using structural and functional magnetic …

Antibiotic Stewardship Teams And Clostridioides Difficile Practices In United States Hospitals: A National Survey In The Joint Commission Antibiotic Stewardship Standard Era, Valerie M Vaughn, M Todd Greene, David Ratz, Karen E Fowler, Sarah L Krein, Scott A Flanders, Erik R Dubberke, Sanjay Saint, Payal K Patel

Open Access Publications

OBJECTIVE: Clostridioides difficile infection (CDI) can be prevented through infection prevention practices and antibiotic stewardship. Diagnostic stewardship (ie, strategies to improve use of microbiological testing) can also improve antibiotic use. However, little is known about the use of such practices in US hospitals, especially after multidisciplinary stewardship programs became a requirement for US hospital accreditation in 2017. Thus, we surveyed US hospitals to assess antibiotic stewardship program composition, practices related to CDI, and diagnostic stewardship.

METHODS: Surveys were mailed to infection preventionists at 900 randomly sampled US hospitals between May and October 2017. Hospitals were surveyed on antibiotic stewardship programs; …