Digital Commons Network^™

Contraception Provision In The Emergency Department: Are We Ready To Overcome The Obstacles?, Kayleigh Fischer, Lauren S. Chernick

Open Access Publications

No abstract provided.

Maternal Race/Ethnicity And Postpartum Diabetes Screening: A Systematic Review And Meta-Analysis, Cynthia J. Herrick, Ritika Puri, Rana Rahaman, Angela Hardi, Karyn Stewart, Graham A. Colditz

Open Access Publications

No abstract provided.

Lung Transplant Pulmonologists’ Views Of Specialty Palliative Care For Lung Transplant Recipients, Eric Nolley, Jessica Fleck, Dio Kavalieratos, Mary Amanda Dew, Daniel Dilling, Rebecca Colman, Maria M. Crespo, Hilary Goldberg, Steven Hays, Ramsey Hachem, Erika Lease, James Lee, John Reynolds, Matthew Morrell, Yael Schenker

Open Access Publications

No abstract provided.

Structural Basis For Effector Protein Recognition By The Dot/Icm Type Ivb Coupling Protein Complex, Hyunmin Kim, Tomoko Kubori, Kohei Yamazaki, Mi-Jeong Kwak, Suk-Youl Park, Hiroki Nagai, Joseph P. Vogel, Byung-Ha Oh

Open Access Publications

No abstract provided.

Prostate Cancer Theranostics - An Overview, Diane Abou, Nadia Benabdallah, Wen Jiang, Lu Peng, Hanwen Zhang, Alexandria Villmer, Mark S Longtine, Daniel L J Thorek

Open Access Publications

Metastatic prostate cancer is incurable, and novel methods to detect the disease earlier and to direct definitive treatment are needed. Molecularly specific tools to localize diagnostic and cytotoxic radionuclide payloads to cancer cells and the surrounding microenvironment are recognized as a critical component of new approaches to combat this disease. The implementation of theranostic approaches to characterize and personalize patient management is beginning to be realized for prostate cancer patients. This review article summarized clinically translated approaches to detect, characterize, and treat disease in this rapidly expanding field.

Gata2 Regulates Constitutive Pd-L1 And Pd-L2 Expression In Brain Tumors, Yujie Fu, Connor J. Liu, Dale K. Kobayashi, Tanner M. Johanns, Jay A. Bowman-Kirigin, Maximilian O. Schaettler, Diane D. Mao, Diane Bender, Diane G. Kelley, Ravindra Uppaluri, Wenya Linda Bi, Ian F. Dunn, Yu Tao, Jingqin Luo, Albert H. Kim, Gavin P. Dunn

Open Access Publications

No abstract provided.

The Current State Of Antifungal Stewardship Among Pediatric Antimicrobial Stewardship Programs, Lourdes Eguiguren, Jason G Newland, Matthew P Kronman, Adam L Hersh, Jeffrey S Gerber, Grace M Lee, Hayden T Schwenk

Open Access Publications

OBJECTIVE: To characterize the current state of antifungal stewardship practices and perceptions of antifungal use among pediatric antimicrobial stewardship programs (ASPs).

DESIGN: We developed and distributed an electronic survey, which included 17 closed-ended questions about institutional antifungal stewardship practices and perceptions, among pediatric ASPs.

PARTICIPANTS: ASP physicians and pharmacists of 74 hospitals participating in the multicenter Sharing Antimicrobial Reports for Pediatric Stewardship (SHARPS) Collaborative.

RESULTS: We sent surveys to 74 hospitals and received 68 unique responses, for a response rate of 92%. Overall, 63 of 68 the respondent ASPs (93%) reported that they conduct 1 or more antifungal stewardship activities. …

Residual Endotoxin Induces Primary Graft Dysfunction Through Ischemia/Reperfusion-Primed Alveolar Macrophages, Mahzad Akbarpour, Daniel Kreisel, Wenjun Li, Et Al

Open Access Publications

Despite the widespread use of antibiotics, bacterial pneumonias in donors strongly predispose to the fatal syndrome of primary graft dysfunction (PGD) following lung transplantation. We report that bacterial endotoxin persists in human donor lungs after pathogen is cleared with antibiotics and is associated with neutrophil infiltration and PGD. In mouse models, depletion of tissue-resident alveolar macrophages (TRAMs) attenuated neutrophil recruitment in response to endotoxin as shown by compartmental staining and intravital imaging. Bone marrow chimeric mice revealed that neutrophils were recruited by TRAM through activation of TLR4 in a MyD88-dependent manner. Intriguingly, low levels of endotoxin, insufficient to cause donor …

Reduced Intensity Conditioning For Acute Myeloid Leukemia Using Melphalan- Vs Busulfan-Based Regimens: A Cibmtr Report, Zheng Zhou, Geoffrey L. Uy, Et Al.

Open Access Publications

No abstract provided.

Interleukin-15 Superagonist (N-803) Treatment Of Pml And Jcv In A Post–Allogeneic Hematopoietic Stem Cell Transplant Patient, Aabha Oza, Michael P. Rettig, Phil Powell, Kathryn O'Brien, David B. Clifford, Julie Ritchey, Leah Gehrs, Julia Hollaway, Eugene Major, Todd A. Fehniger, Christopher A. Miller, Patrick Soon-Shiong, Amy Rock, John F. Dipersio

Open Access Publications

No abstract provided.

Quantitative Cardiac Magnetic Resonance T2 Imaging Offers Ability To Non-Invasively Predict Acute Allograft Rejection In Children, Neeta Sethi, Ashish Doshi, Tina Doshi, Russell Cross, Ileen Cronin, Elena Amin, Joshua Kanter, Janet Scheel, Sairah Khan, Adrienne Campbell-Washburn, Laura Olivieri

Open Access Publications

BACKGROUND: Monitoring for acute allograft rejection improves outcomes after cardiac transplantation. Endomyocardial biopsy is the gold standard test defining rejection, but carries risk and has limitations. Cardiac magnetic resonance T2 mapping may be able to predict rejection in adults, but has not been studied in children. Our aim was to evaluate T2 mapping in identifying paediatric cardiac transplant patients with acute rejection.

METHODS: Eleven paediatric transplant patients presenting 18 times were prospectively enrolled for non-contrast cardiac magnetic resonance at 1.5 T followed by endomyocardial biopsy. Imaging included volumetry, flow, and T2 mapping. Regions of interest were manually selected on the …

Both Unmedicated And Medicated Individuals With Schizophrenia Show Impairments Across A Wide Array Of Cognitive And Reinforcement Learning Tasks, Erin K Moran, James M Gold, Cameron S Carter, Angus W Macdonald, J Daniel Ragland, Steven M Silverstein, Steven J Luck, Deanna M Barch

Open Access Publications

BACKGROUND: Schizophrenia is a disorder characterized by pervasive deficits in cognitive functioning. However, few well-powered studies have examined the degree to which cognitive performance is impaired even among individuals with schizophrenia not currently on antipsychotic medications using a wide range of cognitive and reinforcement learning measures derived from cognitive neuroscience. Such research is particularly needed in the domain of reinforcement learning, given the central role of dopamine in reinforcement learning, and the potential impact of antipsychotic medications on dopamine function.

METHODS: The present study sought to fill this gap by examining healthy controls (N = 75), unmedicated (N = 48) …

Risks Of Requiring A Dedicated Molecular Specimen For Hiv Diagnosis And A Potential Strategy For Mitigation, Adam L. Bailey, Neil Anderson

Open Access Publications

BACKGROUND: HIV screening (i.e. antigen/antibody) tests are followed by a supplemental (i.e. antibody-only) if the screen is positive. Discrepant results can result from two scenarios: a false-positive screening test or acute HIV infection. These scenarios can be distinguished by a molecular HIV test, but due to contamination concerns, our laboratory recently implemented a policy requiring a second specimen dedicated for molecular HIV testing. Our objective was to (1) characterize the effect of this policy on the time-to-diagnosis for patients with discrepant screening and supplemental test results, and (2) explore "strength of positivity" as an interim predictor of screening test accuracy …

Ancestral Roles Of Atypical Cadherins In Planar Cell Polarity, Maria Brooun, Alexander Klimovich, Mikhail Bashkurov, Bret J. Pearson, Robert E. Steele, Helen Mcneill

Open Access Publications

No abstract provided.

Exposure To Covid-19 Patients Increases Physician Trainee Stress And Burnout, Thomas G. Kannampallil, Charles W. Goss, Bradley A. Evanoff, Jaime R. Strickland, Rebecca P. Mcalister, Jennifer Duncan

Open Access Publications

The coronavirus disease 2019 (COVID-19) pandemic has put considerable physical and emotional strain on frontline healthcare workers. Among frontline healthcare workers, physician trainees represent a unique group-functioning simultaneously as both learners and caregivers and experiencing considerable challenges during the pandemic. However, we have a limited understanding regarding the emotional effects and vulnerability experienced by trainees during the pandemic. We investigated the effects of trainee exposure to patients being tested for COVID-19 on their depression, anxiety, stress, burnout and professional fulfillment. All physician trainees at an academic medical center (n = 1375) were invited to participate in an online survey. We …

2019 Pediatric Initiative Network: Progress, Proceedings, And Plans, Leena Nahata, Veronica Gomez-Lobo, Lillian Meacham, Leslie Appiah, Krista Childress, Holly Hoefgen, Maggie Dwiggins, Stacy Whiteside, Kari Bjornard, Julie Rios, Antoinette Anazodo, Courtney Finlayson, Olivia Frias, Teresa Woodruff, Molly Moravek

Open Access Publications

No abstract provided.

Parcel-Guided Rtms For Depression, M. Moreno Ortega, A. Kangarlu, S. Lee, T. Perera, J. Kangarlu, T. Palomo, M.F. Glasser, D.C. Javitt

Open Access Publications

No abstract provided.

Surgical Technique For Below-Knee Amputation With Concurrent Targeted Muscle Reinnervation, Timothy H.F. Daugherty, Rajiv Parikh, Brian A. Mailey, John M. Felder, Reuben A. Bueno Jr.

Open Access Publications

No abstract provided.

Reconstruction Of Severe Palm Injury With Sensate Medial Plantar Artery Flap And Nerve Grafting, William M. Padovano, Elspeth J.R. Hill, John M. Felder Iii

Open Access Publications

No abstract provided.

Sirt1 Mediates Hypoxic Preconditioning Induced Attenuation Of Neurovascular Dysfunction Following Subarachnoid Hemorrhage, Ananth K. Vellimana, Diane J. Aum, Deepti Diwan, Julian V. Clarke, James W. Nelson, Molly Lawrence, Byung Hee Han, Jeffrey M. Gidday, Gregory J. Zipfel

Open Access Publications

No abstract provided.

A Recommended "Minimum Data Set" Framework For Sd-Oct Retinal Image Acquisition And Analysis From The Atlas Of Retinal Imaging In Alzheimer's Study (Arias), Jessica Alber, Gregory Van Stavern, Et Al

Open Access Publications

Introduction: We propose a minimum data set framework for the acquisition and analysis of retinal images for the development of retinal Alzheimer's disease (AD) biomarkers. Our goal is to describe methodology that will increase concordance across laboratories, so that the broader research community is able to cross-validate findings in parallel, accumulate large databases with normative data across the cognitive aging spectrum, and progress the application of this technology from the discovery stage to the validation stage in the search for sensitive and specific retinal biomarkers in AD.

Methods: The proposed minimum data set framework is based on the Atlas of …

Challenges And Solutions For The Implementation Of Shared Decision-Making In Breast Reconstruction, Terence M. Myckatyn, Rajiv P. Parikh, Clara Lee, Mary C. Politi

Open Access Publications

No abstract provided.

Foot Salvage With Selective Arterialization Of Pedal Venosomes, Maleeh Effendi, Austin Y. Ha, John M. Felder Iii

Open Access Publications

No abstract provided.

Genetic Architecture Of Circulating Very-Long-Chain (C24:0 And C22:0) Ceramide Concentrations, Sharon Cresci, Ruibo Zhang, Qiong Yang, Meredith S Duncan, Vanessa Xanthakis, Xuntian Jiang, Ramachandran S Vasan, Jean E Schaffer, Linda R Peterson

Open Access Publications

OBJECTIVE: Total ceramide concentrations are linked with increased insulin resistance and cardiac dysfunction. However, recent studies have demonstrated that plasma concentrations of specific very-long-chain fatty ceramides (C24:0 and C22:0) are associated with a reduced incidence of coronary heart disease and all-cause mortality. We hypothesized that specific genetic loci are associated with plasma C22:0 and C24:0 concentrations.

METHODS: Heritability and genome-wide association studies of plasma C24:0 and C22:0 ceramide concentrations were performed among 2,217 participants in the Framingham Heart Study Offspring Cohort, adjusting for cardiovascular risk factor covariates and cardiovascular drug treatment.

RESULTS: The multivariable-adjusted heritability for C22:0 and C24:0 ceramides …

Practitioner Perspectives On Building Capacity For Evidence-Based Public Health In State Health Departments In The United States: A Qualitative Case Study, Stephanie Mazzucca, Cheryl A Valko, Amy A Eyler, Marti Macchi, Andrew Lau, Jeanne Alongi, John Robitscher, Ross C Brownson

Open Access Publications

BACKGROUND: Public health agencies are responsible for implementing effective, evidence-based public health programs and policies to reduce the burden of chronic diseases. Evidence-based public health can be facilitated by modifiable administrative evidence-based practices (A-EBPs) (e.g., workforce development, organizational climate), yet little is known about how practitioners view A-EBPs. Thus, the purpose of this qualitative study was to understand state health department practitioners' perceptions about how A-EBPs are implemented and what facilitators and barriers exist to using A-EBPs.

METHODS: Chronic disease prevention and health promotion program staff who were members of the National Association of Chronic Disease Directors were recruited to …

The De-Implementation And Persistence Of Low-Value Hiv Prevention Interventions In The United States: A Cross-Sectional Study, Virginia R Mckay, Todd B Combs, M Margaret Dolcini, Ross C Brownson

Open Access Publications

BACKGROUND: As more effective or efficient interventions emerge out of scientific advancement to address a particular public health issue, it may be appropriate to de-implement low-value interventions, or interventions that are less effective or efficient. Furthermore, factors that contribute to appropriate de-implementation are not well identified. We examined the extent to which low-value interventions were de-implemented among public health organizations providing HIV prevention services, as well as explored socio-economic, organizational, and intervention characteristics associated with de-implementation.

METHODS: We conducted an online cross-sectional survey from the fall of 2017 to the spring of 2019 with organizations (

RESULTS: Organizations reported 359 …

Identifying Barriers, Facilitators, And Implementation Strategies For A Faith-Based Physical Activity Program, Jessica Haughton, Michelle L Takemoto, Jennifer Schneider, Steven P Hooker, Borsika Rabin, Ross C Brownson, Elva M Arredondo

Open Access Publications

BACKGROUND: Community engagement is critical to the acceleration of evidence-based interventions into community settings. Harnessing the knowledge and opinions of community leaders increases the likelihood of successful implementation, scale-up, and sustainment of evidence-based interventions.

METHODS: We conducted in-depth interviews using a semi-structured interview guide based on the Consolidated Framework for Implementation Research (CFIR) at various Catholic and Protestant churches with large Latino membership in San Diego County, California to explore barriers and facilitators to implementation of

RESULTS: Pastors and church staff described barriers and facilitators to implementation within three domains of CFIR: characteristics of individuals (lack of self-efficacy for and …

Defining And Conceptualizing Outcomes For De-Implementation: Key Distinctions From Implementation Outcomes, Beth Prusaczyk, Taren Swindle, Geoffrey Curran

Open Access Publications

BACKGROUND: Increasingly, scholars argue that de-implementation is a distinct concept from implementation; factors contributing to stopping a current practice might be distinct from those that encourage adoption of a new one. One such distinction is related to de-implementation

CONCEPTUALIZATION OF OUTCOMES: We conceptualize each of the outcomes from Proctor and colleagues' taxonomy of implementation outcomes for de-implementation research. First, we suggest key considerations for researchers assessing de-implementation outcomes, such as considering how the cultural or historical significance to the practice may impact de-implementation success and, as others have stated, the importance of the patient in driving healthcare overuse. Second, we …

Integrating A Multidisciplinary Pain Team And Chiropractic Care In A Community Health Center: An Observational Study Of Managing Chronic Spinal Pain, Christopher Prater, Melissa Tepe, Patrick Battaglia

Open Access Publications

BACKGROUND: Chronic spinal pain is one of the most common diseases in the United States. Underserved patients are most affected, and disproportionately may use opioid medications as they lack access to other therapies. It is therefore important to develop systems to treat spinal pain within the primary medical home.

METHODS: We designed a prospective observational pilot study at a community health center to measure the effectiveness of two interventions among an underserved population: a multidisciplinary pain team and chiropractic care. Study outcomes were pain and functional disability measured by the Pain Disability Questionnaire (PDQ), and reduction of opioid dose at …

Direct Tumor Visual Feedback During Free Breathing In 0.35t Mrgrt, Taeho Kim, Benjamin C Lewis, Alex Price, Thomas Mazur, H Michael Gach, Justin C Park, Bin Cai, Erin Wittland, Lauren Henke, Hyun Kim, Sasa Mutic, Olga Green

Open Access Publications

To present a tumor motion control system during free breathing using direct tumor visual feedback to patients in 0.35 T magnetic resonance-guided radiotherapy (MRgRT). We present direct tumor visualization to patients by projecting real-time cine MR images on an MR-compatible display system inside a 0.35 T MRgRT bore. The direct tumor visualization included anatomical images with a target contour and an auto-segmented gating contour. In addition, a beam-status sign was added for patient guidance. The feasibility was investigated with a six-patient clinical evaluation of the system in terms of tumor motion range and beam-on time. Seven patients without visual guidance …