Digital Commons Network^™

The Genetic Architecture Of Sporadic And Multiple Consecutive Miscarriage, Triin Laisk, Avinash Ramu, Donald F. Conrad, Et Al.

Open Access Publications

No abstract provided.

Investigating The Ferric Ion Binding Site Of Magnetite Biomineralisation Protein Mms6, Andrea E. Rawlings, Panah Liravi, Sybilla Corbett, Alex S. Holehouse, Sarah S. Staniland

Open Access Publications

The biomineralization protein Mms6 has been shown to be a major player in the formation of magnetic nanoparticles both within the magnetosomes of magnetotactic bacteria and as an additive in synthetic magnetite precipitation assays. Previous studies have highlighted the ferric iron binding capability of the protein and this activity is thought to be crucial to its mineralizing properties. To understand how this protein binds ferric ions we have prepared a series of single amino acid substitutions within the C-terminal binding region of Mms6 and have used a ferric binding assay to probe the binding site at the level of individual …

High Prevalence Of Radiographic Outliers And Revisions With Unicompartmental Knee Arthroplasty, Gregory S Kazarian, Toby N Barrack, Louis Okafor, Robert L Barrack, Ryan M Nunley, Charles M Lawrie

Open Access Publications

BACKGROUND: Alignment outcomes and their impact on implant survival following unicompartmental knee arthroplasty (UKA) are unclear. The purpose of this study was to assess the implant survival and radiographic outcomes after UKA as well as the impact of component alignment and overhang on implant survival.

METHODS: We performed a retrospective analysis of 253 primary fixed-bearing and mobile-bearing medial UKAs from a single academic center. All UKAs were performed by 2 high-volume fellowship-trained arthroplasty surgeons. UKAs comprised <10% of their knee arthroplasty practices, with an average of 14.2 medial UKAs per surgeon per year. Implant survival was assessed. Femoral coronal (FCA), femoral sagittal (FSA), tibial coronal (TCA), and tibial sagittal (TSA) angles as well as implant overhang were radiographically measured. Outliers were defined for FCA (>±10° deviation from neutral), FSA (>15° of flexion), TCA (>±5° deviation from neutral), and TSA (>±5° deviation from 7°). "Far outliers" …

Stable Readout Of Observed Actions From Format-Dependent Activity Of Monkey’S Anterior Intraparietal Neurons, Marco Lanzilotto, Monica Maranesi, Alessandro Livi, Carolina Giulia Ferroni, Guy A. Orban, Luca Bonini

Open Access Publications

No abstract provided.

Orbitofrontal-Striatal Potentiation Underlies Cocaine-Induced Hyperactivity, Sebastiano Bariselli, Nanami L. Miyazaki, Meaghan C. Creed, Alexxai V. Kravitz

Open Access Publications

No abstract provided.

Contribution Of Aberrant Toll Like Receptor Signaling To The Pathogenesis Of Myelodysplastic Syndromes, Luana Chiquetto Paracatu, Laura G Schuettpelz

Open Access Publications

Toll like receptors (TLRs) are a family of pattern recognition receptors that play a central role in the innate immune response. These receptors are expressed on a wide variety of immune and non-immune cells, and they help shape the immune response to infection and injury through the recognition of pathogen-associated molecular patterns (PAMPs) as well as endogenous damage-associated molecular patterns (DAMPs). Accumulating evidence suggests that, in addition to regulating mature effector immune cells, TLRs can influence the immune response from the level of the hematopoietic stem cell (HSC). HSCs express TLRs, and exposure to TLR ligands influences the cycling, differentiation, …

The Road To Recovery: A Pilot Study Of Driving Behaviors Following Antibody-Mediated Encephalitis, Gregory S. Day, Ganesh M. Babulal, Ganesh Rajasekar, Sarah Stout, Catherine M. Roe

Open Access Publications

No abstract provided.

Outcome Of Everolimus-Based Therapy In Hormone-Receptor-Positive Metastatic Breast Cancer Patients After Progression On Palbociclib, Ajay Dhakal, Roby Antony Thomas, Ellis G. Levine, Adam Brufsky, Kazuaki Takabe, Matthew G. Hanna, Kristopher Attwood, Austin Miller, Thaer Khoury, Amy P. Early, Saif Soniwala, Tracy O'Connor, Matuesz Opyrchal

Open Access Publications

No abstract provided.

Global Proteomics Analysis Of Circulating Extracellular Vesicles Isolated From Lung Transplant Recipients, Sandhya Bansal, Marissa Mcgilvrey, Krystine Garcia-Mansfield, Ritin Sharma, Ross M. Bremner, Michael A. Smith, Ramsey Hachem, Patrick Pirrotte, Thalachallour Mohanakumar

Open Access Publications

No abstract provided.

A Comparative Study Of Sleep And Diurnal Patterns In House Mouse (Mus Musculus) And Spiny Mouse (Acomys Cahirinus), Chanung Wang, Lauren E. Guerriero, Dillon M. Huffman, Asmaa A. Ajwad, Trae C. Brooks, Sridhar Sunderam, Ashley W. Seifert, Bruce F. O'Hara

Open Access Publications

No abstract provided.

Depletion Interactions Modulate The Binding Between Disordered Proteins In Crowded Environments, Franziska Zosel, Andrea Soranno, Karin J. Buholzer, Daniel Nettels, Benjamin Schuler

Open Access Publications

No abstract provided.

End Of An Era Of Administering Erythropoiesis Stimulating Agents Among Veterans Administration Cancer Patients With Chemotherapy-Induced Anemia, Shamia Hoque, Brian J. Chen, Martin W. Schoen, Kenneth R. Carson, Jesse Keller, Bartlett J. Witherspoon, Kevin B. Knopf, Y Tony Yang, Benjamin Schooley, Chadi Nabhan, Oliver Sartor, Paul R. Yarnold, Paul Ray, Laura Bobolts, William J. Hrushesky, Michael Dickson, Charles L. Bennett

Open Access Publications

Erythropoisis stimulating agent (ESA) use was addressed in Food and Drug Administration (FDA) Oncology Drug Advisory Committee (ODAC) meetings between 2004 and 2008. FDA safety-focused regulatory actions occurred in 2007 and 2008. In 2007, black box warnings advised of early death and venous thromboembolism (VTE) risks with ESAs in oncology. In 2010, a Risk Evaluation Strategies (REMS) was initiated, with cancer patient consent that mortality and VTE risks were noted with ESAs. We report warnings and REMS impacts on ESA utilization among Veterans Administration (VA) cancer patients with chemotherapy-induced anemia (CIA). Data were from Veterans Affairs database (2003-2012). Epoetin and …

Domain-Centric Database To Uncover Structure Of Minimally Characterized Viral Genomes, John C. Bramley, Alex L. Yenkin, Mark A. Zaydman, Aaron Diantonio, Jeffrey D. Milbrandt, William J. Buchser

Open Access Publications

No abstract provided.

Histopathologic, Immunophenotypic, And Proteomics Characteristics Of Low-Grade Phyllodes Tumor And Fibroadenoma: More Similarities Than Differences, Lingxin Zhang, Chen Tang, John D. Pfeifer, Richard M. Caprioli, Audra M. Judd, Nathan H. Patterson, Michelle L. Reyzer, Jeremy L. Norris, Horacio M. Maluf

Open Access Publications

No abstract provided.

Single-Cell Rna-Seq Analysis Of Human Csf Microglia And Myeloid Cells In Neuroinflammation, Ekaterina Esaulova, Claudia Cantoni, Irina Shchukina, Konstantin Zaitsev, Robert C. Bucelli, Gregory F. Wu, Maxim N. Artyomov, Anne H. Cross, Brian T. Edelson

Open Access Publications

No abstract provided.

Efficacy And Safety Of Tocilizumab In The Treatment Of Acute Active Antibody-Mediated Rejection In Kidney Transplant Recipients, April A. Pottebaum, Karthikeyan Venkatachalam, Chang Liu, Daniel C. Brennan, Haris Murad, Andrew F. Malone, Tarek Alhamad

Open Access Publications

No abstract provided.

Acceptance And Commitment Therapy Delivered Via A Mobile Phone Messaging Robot To Decrease Postoperative Opioid Use In Patients With Orthopedic Trauma: Randomized Controlled Trial, Chris A Anthony, Edward Octavio Rojas, Valerie Keffala, Natalie Ann Glass, Apurva S Shah, Benjamin J Miller, Matthew Hogue, Michael C Willey, Matthew Karam, John Lawrence Marsh

Open Access Publications

BACKGROUND: Acceptance and commitment therapy (ACT) is a pragmatic approach to help individuals decrease avoidable pain.

OBJECTIVE: This study aims to evaluate the effects of ACT delivered via an automated mobile messaging robot on postoperative opioid use and patient-reported outcomes (PROs) in patients with orthopedic trauma who underwent operative intervention for their injuries.

METHODS: Adult patients presenting to a level 1 trauma center who underwent operative fixation of a traumatic upper or lower extremity fracture and who used mobile phone text messaging were eligible for the study. Patients were randomized in a 1:1 ratio to either the intervention group, who …

Atypical Cadherin Fat4 Orchestrates Lymphatic Endothelial Cell Polarity In Response To Flow, Kelly L Betterman, Drew L Sutton, Genevieve A Secker, Jan Kazenwadel, Anna Oszmiana, Lillian Lim, Naoyuki Miura, Lydia Sorokin, Benjamin M Hogan, Mark L Kahn, Helen Mcneill, Natasha L Harvey

Open Access Publications

The atypical cadherin FAT4 has established roles in the regulation of planar cell polarity and Hippo pathway signaling that are cell context dependent. The recent identification of FAT4 mutations in Hennekam syndrome, features of which include lymphedema, lymphangiectasia, and mental retardation, uncovered an important role for FAT4 in the lymphatic vasculature. Hennekam syndrome is also caused by mutations in collagen and calcium binding EGF domains 1 (CCBE1) and ADAM metallopeptidase with thrombospondin type 1 motif 3 (ADAMTS3), encoding a matrix protein and protease, respectively, that regulate activity of the key prolymphangiogenic VEGF-C/VEGFR3 signaling axis by facilitating the proteolytic cleavage and …

Influence Of Adiposity, Insulin Resistance, And Intrahepatic Triglyceride Content On Insulin Kinetics, Gordon I Smith, David C Polidori, Mihoko Yoshino, Monica L Kearney, Bruce W Patterson, Bettina Mittendorfer, Samuel Klein

Open Access Publications

BACKGROUNDInsulin is a key regulator of metabolic function. The effects of excess adiposity, insulin resistance, and hepatic steatosis on the complex integration of insulin secretion and hepatic and extrahepatic tissue extraction are not clear.METHODSA hyperinsulinemic-euglycemic clamp and a 3-hour oral glucose tolerance test were performed to evaluate insulin sensitivity and insulin kinetics after glucose ingestion in 3 groups: (a) lean subjects with normal intrahepatic triglyceride (IHTG) and glucose tolerance (lean-NL; n = 14), (b) obese subjects with normal IHTG and glucose tolerance (obese-NL; n = 24), and (c) obese subjects with nonalcoholic fatty liver disease (NAFLD) and prediabetes (obese-NAFLD; n …

Prevention And Management Of Dermatologic Adverse Events Associated With Tumor Treating Fields In Patients With Glioblastoma, Mario E Lacouture, Milan J Anadkat, Matthew T Ballo, Fabio Iwamoto, Suriya A Jeyapalan, Renato V La Rocca, Margaret Schwartz, Jennifer N Serventi, Martin Glas

Open Access Publications

No abstract provided.

Inappropriate Antibiotic Surgical Prophylaxis In Pediatric Patients: A National Point-Prevalence Study, Brian R Lee, Alison C Tribble, Jeffrey S Gerber, Adam L Hersh, Matthew P Kronman, Jason G Newland

Open Access Publications

No abstract provided.

Landscape Of Somatic Single Nucleotide Variants And Indels In Colorectal Cancer And Impact On Survival, Syed H. Zaidi, Yin Cao, Et Al.

Open Access Publications

No abstract provided.

Ly6clo Non-Classical Monocytes Promote Resolution Of Rhesus Rotavirus-Mediated Perinatal Hepatic Infammation, Anas Alkhani, Claire S. Levy, Margaret Tsui, Katherine A. Rosenberg, Katya Polovina, Aras N. Mattis, Matthias Mack, Steven Van Dyken, Bruce M. Wang, Jacquelyn J. Maher, Amar Nijagal

Open Access Publications

No abstract provided.

Combination Of Dasatinib With Chemotherapy In Previously Untreated Core Binding Factor Acute Myeloid Leukemia: Calgb 10801, Guido Marcucci, Geoffrey L. Uy, Et Al.

Open Access Publications

No abstract provided.

Mutualist And Pathogen Traits Interact To Affect Plant Community Structure In A Spatially Explicit Model, John W. Schroeder, Andrew Dobson, Scott A. Mangan, Daniel F. Petticord, Edward Allen Herre

Open Access Publications

No abstract provided.

Distinct Neural Networks Associated With Obsession And Delusion: A Connectome-Wide Association Study, Tae Young Lee, Wi Hoon Jung, Yoo Bin Kwak, Youngwoo B Yoon, Junhee Lee, Minah Kim, Euitae Kim, Jun Soo Kwon

Open Access Publications

BACKGROUND: Obsession and delusion are theoretically distinct from each other in terms of reality testing. Despite such phenomenological distinction, no extant studies have examined the identification of common and distinct neural correlates of obsession and delusion by employing biologically grounded methods. Here, we investigated dimensional effects of obsession and delusion spanning across the traditional diagnostic boundaries reflected upon the resting-state functional connectivity (RSFC) using connectome-wide association studies (CWAS).

METHODS: Our study sample comprised of 96 patients with obsessive-compulsive disorder, 75 patients with schizophrenia, and 65 healthy controls. A connectome-wide analysis was conducted to examine the relationship between obsession and delusion …

Neural Networks To Predict Radiographic Brain Injury In Pediatric Patients Treated With Extracorporeal Membrane Oxygenation, Neel Shah, Abdelaziz Farhat, Jefferson Tweed, Ziheng Wang, Jeon Lee, Rafe Mcbeth, Michael Skinner, Fenghua Tian, Ravi Thiagarajan, Lakshmi Raman

Open Access Publications

Brain injury is a significant source of morbidity and mortality for pediatric patients treated with Extracorporeal Membrane Oxygenation (ECMO). Our objective was to utilize neural networks to predict radiographic evidence of brain injury in pediatric ECMO-supported patients and identify specific variables that can be explored for future research. Data from 174 ECMO-supported patients were collected up to 24 h prior to, and for the duration of, the ECMO course. Thirty-five variables were collected, including physiological data, markers of end-organ perfusion, acid-base homeostasis, vasoactive infusions, markers of coagulation, and ECMO-machine factors. The primary outcome was the presence of radiologic evidence of …

Doing What We Know, Knowing What To Do: Californians Linking Action With Science For Prevention Of Breast Cancer (Clasp-Bc), Jon F Kerner, Marion H E Kavanaugh-Lynch, Lourdes Baezconde-Garbanati, Christopher Politis, Aviva Prager, Ross C Brownson

Open Access Publications

Given the lack of progress in breast cancer prevention, the California Breast Cancer Research Program (CBCRP) plans to apply current scientific knowledge about breast cancer to primary prevention at the population level. This paper describes the first phase of Californians Linking Action with Science for Prevention of Breast Cancer (CLASP-BC). The foci of Phase 1 are building coalitions and coalition capacity building through community engagement in community-based participatory research (CBPR) and dissemination and implementation (D&I) research training. Based on the successful implementation and evaluation of Phase 1, the foci of Phase 2 (presented separately in this special issue) will be …

Gene Expression In Meniscal Tears At The Time Of Arthroscopic Partial Meniscectomy Predicts The Progression Of Osteoarthritis Within 6 Years Of Surgery, Joseph D. Lamplot, Muhammad Farooq Rai, William P. Tompkins, Michael V. Friedman, Eric J. Schmidt, Linda J. Sandell, Robert H. Brophy

Open Access Publications

No abstract provided.

Survival Following Allogeneic Transplant In Patients With Myelofibrosis, Krisstina Gowin, Kierstin Luber, Et Al.

Open Access Publications

No abstract provided.