Digital Commons Network^™

Higher Iron Stores And The Hfe 187c>G Variant Delay Onset Of Peripheral Neuropathy During Combination Antiretroviral Therapy, Asha R. Kallianpur, Wanqing Wen, Angelika L. Erwin, David B. Clifford, Todd Hulgan, Gregory K. Robbins

Open Access Publications

OBJECTIVE: People with HIV (PWH) continue to experience sensory neuropathy and neuropathic pain in the combination antiretroviral therapy (cART) era for unclear reasons. This study evaluated the role of iron in a previously reported association of iron-loading hemochromatosis (HFE) gene variants with reduced risk of neuropathy in PWH who received more neurotoxic cART, since an iron-related mechanism also might be relevant to neuropathic symptoms in PWH living in low-resource settings today.

DESIGN: This time-to-event analysis addressed the impact of systemic iron levels on the rapidity of neuropathy onset in PWH who initiated cART.

METHODS: Soluble transferrin receptor (sTFR), the sTFR-ferritin …

Prehospital Use Of A Modified Heart Pathway And Point-Of-Care Troponin To Predict Cardiovascular Events, Jason P. Stopyra, Louis Fornage, Et Al.

Open Access Publications

CLINICAL TRIAL REGISTRATION: clinicaltrials.gov (NCT02709135).

Effects Of Personality On The Developmental Trajectories Of Academic Burnout Among Korean Medical Students, Han Chae, C. Robert Cloninger, Soon Jin Lee

Open Access Publications

No abstract provided.

High-Throughput Analysis Of Adaptation Using Barcoded Strains Of Saccharomyces Cerevisiae, Vincent J Fasanello, Ping Liu, Carlos A Botero, Justin C Fay

Open Access Publications

Background: Experimental evolution of microbes can be used to empirically address a wide range of questions about evolution and is increasingly employed to study complex phenomena ranging from genetic evolution to evolutionary rescue. Regardless of experimental aims, fitness assays are a central component of this type of research, and low-throughput often limits the scope and complexity of experimental evolution studies. We created an experimental evolution system in

Results: We first confirm that barcode insertions do not alter fitness and that barcode sequencing can be used to efficiently detect fitness differences via pooled competition-based fitness assays. Next, we examine the effects …

Human Ipsc-Derived Neuronal Cells From Ctbp1-Mutated Patients Reveal Altered Expression Of Neurodevelopmental Gene Networks, S Vijayalingam, Eric Tycksen, Christina A Gurnett, Et Al

Open Access Publications

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Meningioma: A Review Of Clinicopathological And Molecular Aspects, Kristin Huntoon, Angus Martin Shaw Toland, Sonika Dahiya

Open Access Publications

Meningiomas are the most the common primary brain tumors in adults, representing approximately a third of all intracranial neoplasms. They classically are found to be more common in females, with the exception of higher grades that have a predilection for males, and patients of older age. Meningiomas can also be seen as a spectrum of inherited syndromes such as neurofibromatosis 2 as well as ionizing radiation. In general, the 5-year survival for a WHO grade I meningioma exceeds 80%; however, survival is greatly reduced in anaplastic meningiomas. The standard of care for meningiomas in a surgically-accessible location is gross total …

Fenofibrate Prevents Iron Induced Activation Of Canonical Wnt/Β-Catenin And Oxidative Stress Signaling In The Retina, Ashok Mandala, Austin Armstrong, Becky Girresch, Jiyao Zhu, Aruna Chilakala, Sanmathi Chavalmane, Kapil Chaudhary, Pratim Biswas, Judith Ogilvie, Jaya P. Gnana-Prakasam

Open Access Publications

No abstract provided.

Comprehensive Profiling Of Extracellular Rna In Hpv‑Induced Cancers Using An Improved Pipeline For Small Rna‑Seq Analysis, Fangjia Tong, Arlise Andress, Gongyu Tang, Ping Liu, Xiaowei Wang

Open Access Publications

No abstract provided.

Hla‑A Alleles Including Hla‑A29 Affect The Composition Of The Gut Microbiome: A Potential Clue To The Pathogenesis Of Birdshot Retinochoroidopathy, Peter R. Sternes, Tammy M. Martin, Michael Paley, Sarah Diamond, Mark J. Asquith, Matthew A. Brown, James T. Rosenbaum

Open Access Publications

No abstract provided.

Genomic Profiling Of Circulating Tumor Dna From Cerebrospinal Fluid To Guide Clinical Decision Making For Patients With Primary And Metastatic Brain Tumors, Lori A Ramkissoon, Sonika Dahiya, Et Al.

Open Access Publications

Despite advances in systemic therapies for solid tumors, the development of brain metastases remains a significant contributor to overall cancer mortality and requires improved methods for diagnosing and treating these lesions. Similarly, the prognosis for malignant primary brain tumors remains poor with little improvement in overall survival over the last several decades. In both primary and metastatic central nervous system (CNS) tumors, the challenge from a clinical perspective centers on detecting CNS dissemination early and understanding how CNS lesions differ from the primary tumor, in order to determine potential treatment strategies. Acquiring tissue from CNS tumors has historically been accomplished …

Protocol For A Proof-Of-Concept Observational Study Evaluating The Potential Utility And Acceptability Of A Telemedicine Solution For The Post-Anesthesia Care Unit, Thaddeus P Budelier, Christopher Ryan King, Shreya Goswami, Anchal Bansal, Stephen H Gregory, Troy S Wildes, Joanna Abraham, Sherry L Mckinnon, Amy Cooper, Ivan Kangrga, Jackie L Martin Jr., Melissa Milbrandt, Alex S Evers, Michael S Avidan

Open Access Publications

No abstract provided.

Cd19 Antibody-Drug Conjugate Therapy In Dlbcl Does Not Preclude Subsequent Responses To Cd19-Directed Car T-Cell Therapy, Bicky Thapa, Paolo F. Caimi, Kirit M. Ardeshna, Melhem Solh, Carmelo Carlo-Stella, Brad S. Kahl, Mehdi Hamadani

Open Access Publications

No abstract provided.

Hitting The Target: Natural History Of The Hip Based On Achieving An Acetabular Safe Zone Following Periacetabular Osteotomy, Cody C Wyles, Juan S Vargas, Mark J Heidenreich, Kristin C Mara, Christopher L Peters, John C Clohisy, Robert T Trousdale, Rafael J Sierra

Open Access Publications

BACKGROUND: Periacetabular osteotomy (PAO) remains the gold-standard treatment for acetabular dysplasia in skeletally mature patients with preserved cartilage. The purpose of this multicenter cohort study was to delineate the long-term radiographic natural history of the dysplastic hip following PAO based on the final position of the acetabular fragment.

METHODS: We evaluated patients who underwent PAO performed by 4 hip preservation surgeons to treat acetabular dysplasia with or without concomitant retroversion from 1996 to 2012 at 3 academic institutions. There were 288 patients with a mean clinical and radiographic follow-up of 9 years (range, 5 to 21 years). Postoperative radiographs made …

A Harmonized Meta-Knowledgebase Of Clinical Interpretations Of Somatic Genomic Variants In Cancer, Alex H. Wagner, Kilannin Krysiak, Malachi Griffith, Obi L. Griffith, Et Al.

Open Access Publications

No abstract provided.

Diet Modifies Pioglitazone’S Influence On Hepatic Pparγ-Regulated Mitochondrial Gene Expression, Sakil Kulkarni, Jiansheng Huang, Eric Tycksen, Paul F. Cliften, David A. Rudnick

Open Access Publications

No abstract provided.

Surgical Treatment Of Femoroacetabular Impingement: Hip Arthroscopy Versus Surgical Hip Dislocation: A Propensity-Matched Analysis, Jeffrey J Nepple, Ira Zaltz, Christopher M Larson, Paul E Beaulé, Young-Jo Kim, Michael B Millis, Rafael J Sierra, John C Clohisy, Anchor Group

Open Access Publications

BACKGROUND: Surgical treatment of femoroacetabular impingement (FAI) continues to evolve and is most commonly approached with either hip arthroscopy (HA) or surgical dislocation (SD) of the hip. The purpose of this study was to compare the outcomes of similar patients undergoing surgical treatment of FAI with either HA or SD.

METHODS: A prospective multicenter cohort study of patients undergoing primary surgical treatment of FAI was performed. Follow-up at a minimum of 1 year (mean, 4.3 years) was available for 621 hips (81.7%), including 399 procedures with HA and 222 procedures with SD. Propensity scores were calculated and reflect the likelihood …

Management Of Healthcare Personnel Living With Hepatitis B, Hepatitis C, Or Human Immunodeficiency Virus In Us Healthcare Institutions, David K Henderson, Louise-Marie Dembry, Costi D Sifri, Tara N Palmore, E Patchen Dellinger, Deborah S Yokoe, Christine Grady, Theo Heller, David Weber, Carlos Del Rio, Neil O Fishman, Valerie M Deloney, Tammy Lundstrom, Hilary M Babcock

Open Access Publications

No abstract provided.

Genetic Architecture Of Reciprocal Social Behavior In Toddlers: Implications For Heterogeneity In The Early Origins Of Autism Spectrum Disorder, Natasha Marrus, Julia D Grant, Brooke Harris-Olenak, Jordan Albright, Drew Bolster, Jon Randolph Haber, Theodore Jacob, Yi Zhang, Andrew C Heath, Arpana Agrawal, John N Constantino, Jed T Elison, Anne L Glowinski

Open Access Publications

Impairment in reciprocal social behavior (RSB), an essential component of early social competence, clinically defines autism spectrum disorder (ASD). However, the behavioral and genetic architecture of RSB in toddlerhood, when ASD first emerges, has not been fully characterized. We analyzed data from a quantitative video-referenced rating of RSB (vrRSB) in two toddler samples: a community-based volunteer research registry (n = 1,563) and an ethnically diverse, longitudinal twin sample ascertained from two state birth registries (n = 714). Variation in RSB was continuously distributed, temporally stable, significantly associated with ASD risk at age 18 months, and only modestly explained by sociodemographic …

Tumor Microenvironment-Targeted Nanoparticles Loaded With Bortezomib And Rock Inhibitor Improve Efficacy In Multiple Myeloma, Cinzia Federico, Kinan Alhallak, Jennifer Sun, Kathleen Duncan, Feda Azab, Gail P. Sudlow, Pilar De La Puente, Barbara Muz, Vaishali Kapoor, Luna Zhang, Fangzheng Yuan, Matea Markovic, Joseph Kotsybar, Katherine Wasden, Nicole Guenthner, Shannon Gurley, Justin King, Daniel Kohnen, Noha N. Salama, Dinesh Thotala, Dennis E. Hallahan, Ravi Vij, John F. Dipersio, Samuel Achilefu, Abdel Kareem Azab

Open Access Publications

No abstract provided.

Stretchable, Dynamic Covalent Polymers For Soft, Long-Lived Bioresorbable Electronic Stimulators Designed To Facilitate Neuromuscular Regeneration, Yeon Sik Choi, Ying Yan, Matthew R. Macewan, Wilson Z. Ray, Et Al.

Open Access Publications

No abstract provided.

Phase 2 Study Of Ruxolitinib And Decitabine In Patients With Myeloproliferative Neoplasm In Accelerated And Blast Phase, John O. Mascarenhas, Camille N. Abboud, Et Al.

Open Access Publications

No abstract provided.

Tp53 Abnormalities Correlate With Immune Infiltration And Associate With Response To Flotetuzumab Immunotherapy In Aml, Jayakumar Vadakekolathu, Michael P. Rettig, John F. Dipersio, Et Al.

Open Access Publications

No abstract provided.

Understanding Patient Transfers Across Multiple Clinics In Zambia Among Hiv Infected Adults, Kombatende Sikombe, Aaloke Mody, Jillian Kadota, Jesse Jake Pry, Sandra Simbeza, Ingrid Eshun-Wilson, Sitali Richard Situmbeko, Chama Bukankala, Laura Beres, Njekwa Mukamba, Mwanza Wa Mwanza, Carolyn Bolton-Moore, Charles B. Holmes, Elvin H. Geng, Izukanji Sikazwe

Open Access Publications

Many patients in HIV care in Africa considered lost to follow up (LTFU) at one facility are reportedly accessing care in another. The success of these unofficial transfers as measured by time to re-entry at the new-facility, prevalence of treatment interruptions, speed of ART-initiation, and overall continuity of care is not well characterized but may reveal opportunities for improvement. We traced a random sample of LTFU HIV-infected patients in Zambia. Among those found alive and reported in care at a new-facility, we reviewed records at the receiving facility to verify transfer; and when verified, documented the transfer experience. We used …

The Herbivore's Dilemma: Trends In And Factors Associated With Heterosexual Relationship Status And Interest In Romantic Relationships Among Young Adults In Japan-Analysis Of National Surveys, 1987-2015, Cyrus Ghaznavi, Haruka Sakamoto, Shuhei Nomura, Anna Kubota, Daisuke Yoneoka, Kenji Shibuya, Peter Ueda

Open Access Publications

BACKGROUND: It has been suggested that an increasing proportion of young adults in Japan have lost interest in romantic relationships, a phenomenon termed "herbivorization". We assessed trends in heterosexual relationship status and self-reported interest in heterosexual romantic relationships in nationally representative data.

METHODS: We used data from seven rounds of the National Fertility Survey (1987-2015) and included adults aged 18-39 years (18-34 years in the 1987 survey; sample size 11,683-17,675). Current heterosexual relationship status (married; unmarried but in a relationship; single) was estimated by sex, age group and survey year, with singles further categorized into those reporting interest vs. no …

A Feasibility Study To Evaluate Early Treatment Response Of Brain Metastases One Week After Stereotactic Radiosurgery Using Perfusion Weighted Imaging, Jiayi Huang, Mikhail Milchenko, Yuan J. Rao, Pamela Lamontagne, Christopher Abraham, Clifford G. Robinson, Yi Huang, Joshua S. Shimony, Keith M. Rich, Tammie Benzinger

Open Access Publications

BACKGROUND: To explore if early perfusion-weighted magnetic resonance imaging (PWI) may be a promising imaging biomarker to predict local recurrence (LR) of brain metastases after stereotactic radiosurgery (SRS).

METHODS: This is a prospective pilot study of adult brain metastasis patients who were treated with SRS and imaged with PWI before and 1 week later. Relative cerebral blood volume (rCBV) parameter maps were calculated by normalizing to the mean value of the contralateral white matter on PWI. Cox regression was conducted to explore factors associated with time to LR, with Bonferroni adjusted p<0.0006 for multiple testing correction. LR rates were estimated with the Kaplan-Meier method and compared using the log-rank test.

RESULTS: Twenty-three patients were enrolled from 2013 through …

Comparison Of The Ekblom-Bak Submaximal Test To A Maximal Test In A Cohort Of Healthy Younger And Older Adults In The United States, Stephanie A Schultz, Jennifer Byers, Tammie L S Benzinger, Dominic Reeds, Andrei G Vlassenko, W Todd Cade, Manu S Goyal

Open Access Publications

Cardiorespiratory fitness (CRF) is routinely investigated in diverse populations, including in older adults of varying physical activity levels. Commonly performed maximal exercise testing protocols might be contraindicated and/or inadequate for older individuals who have physical or cognitive impairment. Moreover, early termination of an attempted maximal exercise test could result in underestimation of CRF in this population. The goal of the current study was to compare CRF estimates using the Ekblom-Bak (EB) submaximal exercise test - previously validated in a cohort of Scandinavian adults - versus a subsequent maximal exercise test in a diverse, Midwestern United States cohort. Fifteen generally healthy …

High-Resolution Manometry Determinants Of Refractoriness Of Reflux Symptoms To Proton Pump Inhibitor Therapy, Mentore Ribolsi, Edoardo Savarino, Benjamin Rogers, Arvind Rengarajan, Marco Della Coletta, Matteo Ghisa, Michele Cicala, C. Prakash Gyawali

Open Access Publications

No abstract provided.

Structural Basis Of Chikungunya Virus Inhibition By Monoclonal Antibodies, Qun Fei Zhou, Julie M. Fox, James T. Earnest, Thiam-Seng Ng, Arthur S. Kim, Guntur Fibriansah, Victor A. Kostyuchenko, Jian Shi, Bo Shu, Michael S. Diamond, Shee-Mei Lok

Open Access Publications

No abstract provided.

Development Of A New Macrophage-Specifc Trap Mouse (Mactrap) And Definition Of The Renal Macrophage Translational Signature, Andreas Hofmeister, Maximilian C. Thomaßen, Sabrina Markert, André Marquardt, Mathieu Preußner, Martin Rußwurm, Ralph T. Schermuly, Ulrich Steinhoff, Hermann-Josef Gröne, Joachim Hoyer, Benjamin D. Humphreys, Ivica Grgic

Open Access Publications

No abstract provided.

Plasmacytoid Dendritic Cell Impairment In Metastatic Melanoma By Lactic Acidosis, Matilde Monti, Raffaella Vescovi, Francesca Consoli, Davide Farina, Daniele Moratto, Alfredo Berruti, Claudia Specchia, William Vermi

Open Access Publications

The introduction of targeted therapies and immunotherapies has significantly improved the outcome of metastatic melanoma (MM) patients. These approaches rely on immune functions for their anti-melanoma response. Plasmacytoid dendritic cells (pDCs) exhibit anti-tumor function by production of effector molecules, type I interferons (I-IFNs), and cytokines. Tissue and blood pDCs result compromised in MM, although these findings are still partially conflicting. This study reports that blood pDCs were dramatically depleted in MM, particularly in patients with high lactate dehydrogenase (LDH) and high tumor burden; the reduced pDC frequency was associated with poor overall survival. Circulating pDCs resulted also in significant impairment …