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Integrase Inhibitors Effective Against Human T-Cell Leukemia Virus Type 1, Muhammad E. Seegulam, Lee Ratner Jan 2011

Integrase Inhibitors Effective Against Human T-Cell Leukemia Virus Type 1, Muhammad E. Seegulam, Lee Ratner

Open Access Publications

No abstract provided.


Il-15 Deficiency Promotes Tumor Growth In Tax Transgenic Mice, Daniel Rauch, Sirosh Bokhari, John Harding, Lee Ratner Jan 2011

Il-15 Deficiency Promotes Tumor Growth In Tax Transgenic Mice, Daniel Rauch, Sirosh Bokhari, John Harding, Lee Ratner

Open Access Publications

No abstract provided.


The Effects Of Xmrv Gene Expression On The Mouse Prostate, Daniel Rauch, Sirosh Bokhari, John Harding, Lee Ratner Jan 2011

The Effects Of Xmrv Gene Expression On The Mouse Prostate, Daniel Rauch, Sirosh Bokhari, John Harding, Lee Ratner

Open Access Publications

No abstract provided.


The Loop-Less Tmcdc34 E2 Mutant Defective In Polyubiquitination In Vitro And In Vivo Supports Yeast Growth In A Manner Dependent On Ubp14 And Cka2, Agnieszka Lass, Ross Cocklin, Kenneth M. Scaglione, Michael Skowyra, Sergey Korolev, Mark Goebl, Dorota Skowyra Jan 2011

The Loop-Less Tmcdc34 E2 Mutant Defective In Polyubiquitination In Vitro And In Vivo Supports Yeast Growth In A Manner Dependent On Ubp14 And Cka2, Agnieszka Lass, Ross Cocklin, Kenneth M. Scaglione, Michael Skowyra, Sergey Korolev, Mark Goebl, Dorota Skowyra

Open Access Publications

No abstract provided.


Autophagy In Antigen-Presenting Cells Results In Presentation Of Citrullinated Peptides To Cd4 T Cells, Jamie M. Ireland, Emil R. Unanue Jan 2011

Autophagy In Antigen-Presenting Cells Results In Presentation Of Citrullinated Peptides To Cd4 T Cells, Jamie M. Ireland, Emil R. Unanue

Open Access Publications

Antibody responses to citrullinated self-proteins are found in autoimmunities, particularly in rheumatoid arthritis, where they serve as a diagnostic indicator. We show here that processing of the protein hen egg-white lysozyme (HEL) resulted in citrullination of peptides presented on class II MHC molecules by antigen-presenting cells. The presentation of the citrullinated peptides but not of the unmodified peptides was associated with autophagy. Dendritic cells (DCs), macrophages, and thymic DCs presented citrullinated peptides constitutively. Their treatment with 3-methyladenine (3MA) blocked presentation of citrullinated HEL peptides, but presentation of unmodified peptides was not affected. Presentation of citrullinated peptides was not detected on …


A Genomic Storm In Critically Injured Humans, Wenzhong Xiao, Bernard H. Brownstein, Et Al Jan 2011

A Genomic Storm In Critically Injured Humans, Wenzhong Xiao, Bernard H. Brownstein, Et Al

Open Access Publications

No abstract provided.


Cd103+ Pulmonary Dendritic Cells Preferentially Acquire And Present Apoptotic Cell-Associated Antigen, A Nicole Desch, Gwendalyn J. Randolph, Kenneth Murphy, Emmanuel L. Gautier, Ross M. Kedl, Mireille H. Lahoud, Irina Caminschi, Ken Shortman, Peter M. Henson, Claudia V. Jakubzick Jan 2011

Cd103+ Pulmonary Dendritic Cells Preferentially Acquire And Present Apoptotic Cell-Associated Antigen, A Nicole Desch, Gwendalyn J. Randolph, Kenneth Murphy, Emmanuel L. Gautier, Ross M. Kedl, Mireille H. Lahoud, Irina Caminschi, Ken Shortman, Peter M. Henson, Claudia V. Jakubzick

Open Access Publications

Cells undergoing programmed cell death (apoptosis) are removed in situ by macrophages and dendritic cells (DCs) through a specialized form of phagocytosis (efferocytosis). In the lung, there are two primary DC subsets with the potential to migrate to the local lymph nodes (LNs) and initiate adaptive immune responses. In this study, we show that only CD103(+) DCs were able to acquire and transport apoptotic cells to the draining LNs and cross present apoptotic cell-associated antigen to CD8 T cells. In contrast, both the CD11b(hi) and the CD103(+) DCs were able to ingest and traffic latex beads or soluble antigen. CD103(+) …


The Tumor Suppressor Gene Trp53 Protects The Mouse Lens Against Posterior Subcapsular Cataracts And The Bmp Receptor Acvr1 Acts As A Tumor Suppressor In The Lens, Luke A. Wiley, Ramya Rajagopal, Lisa K. Dattilo, David C. Beebe Jan 2011

The Tumor Suppressor Gene Trp53 Protects The Mouse Lens Against Posterior Subcapsular Cataracts And The Bmp Receptor Acvr1 Acts As A Tumor Suppressor In The Lens, Luke A. Wiley, Ramya Rajagopal, Lisa K. Dattilo, David C. Beebe

Open Access Publications

No abstract provided.


Year In Review 2010: Critical Care- Neurocritical Care, Michael T. Scalfani, Michael N. Diringer Jan 2011

Year In Review 2010: Critical Care- Neurocritical Care, Michael T. Scalfani, Michael N. Diringer

Open Access Publications

No abstract provided.


Effect Of Supplementation During Pregnancy With L-Arginine And Antioxidant Vitamins In Medicalfood On Pre-Eclampsia In High Risk Population: Randomised Controlled Trial, Felipe Vadillo-Ortega, Otilia Perichant-Perera, Salvador Espino, Marco Antonio Avila-Vergara, Isabel Ibarra, Roberto Ahued, Myrna Godines, Samuel Parry, George Macones, Jerome F. Strauss Jan 2011

Effect Of Supplementation During Pregnancy With L-Arginine And Antioxidant Vitamins In Medicalfood On Pre-Eclampsia In High Risk Population: Randomised Controlled Trial, Felipe Vadillo-Ortega, Otilia Perichant-Perera, Salvador Espino, Marco Antonio Avila-Vergara, Isabel Ibarra, Roberto Ahued, Myrna Godines, Samuel Parry, George Macones, Jerome F. Strauss

Open Access Publications

No abstract provided.


Notch1 Loss Of Heterozygosity Causes Vascular Tumors And Lethal Hemorrhage In Mice, Zhenyi Liu, Ahu Turkoz, Erin N. Jackson, Joseph C. Corbo, John A. Engelbach, Joel R. Garbow, David R. Piwnica-Worms, Raphael Kopan Jan 2011

Notch1 Loss Of Heterozygosity Causes Vascular Tumors And Lethal Hemorrhage In Mice, Zhenyi Liu, Ahu Turkoz, Erin N. Jackson, Joseph C. Corbo, John A. Engelbach, Joel R. Garbow, David R. Piwnica-Worms, Raphael Kopan

Open Access Publications

No abstract provided.


Cd2ap In Mouse And Human Podocytes Controls A Proteolytic Program That Regulates Cytoskeletal Structure And Cellular Survival, Andrey S. Shaw, Suma Yaddanapudi, Mehmet M. Altintas, Andreas D. Kistler, Isabel Fernandez, Clemens C. Moller, Changli Wei, Vasil Peev, Jan B. Flesche, Anna-Lena Forst, Jing Li, Jaakko Patrakka, Zhijie Xiao, Florian Grahammer, Et Al. Jan 2011

Cd2ap In Mouse And Human Podocytes Controls A Proteolytic Program That Regulates Cytoskeletal Structure And Cellular Survival, Andrey S. Shaw, Suma Yaddanapudi, Mehmet M. Altintas, Andreas D. Kistler, Isabel Fernandez, Clemens C. Moller, Changli Wei, Vasil Peev, Jan B. Flesche, Anna-Lena Forst, Jing Li, Jaakko Patrakka, Zhijie Xiao, Florian Grahammer, Et Al.

Open Access Publications

No abstract provided.


Oscar Is A Collagen Receptor That Costimulates Osteoclastogenesis In Dap12-Deficient Humans And Mice, Alexander David Barrow, Marina Cella, Marco Colonna, Nicolas Raynal, Thomas Levin Anderson, David A. Slatter, Dominique Bihan, Nicholas Pugh, Taesoo Kim, Jaerang Rho, Takako Nedishi-Koga, Jean-Marie Delaisse, Hiroshi Takayanagi, Joseph Lorenzo, Et Al. Jan 2011

Oscar Is A Collagen Receptor That Costimulates Osteoclastogenesis In Dap12-Deficient Humans And Mice, Alexander David Barrow, Marina Cella, Marco Colonna, Nicolas Raynal, Thomas Levin Anderson, David A. Slatter, Dominique Bihan, Nicholas Pugh, Taesoo Kim, Jaerang Rho, Takako Nedishi-Koga, Jean-Marie Delaisse, Hiroshi Takayanagi, Joseph Lorenzo, Et Al.

Open Access Publications

No abstract provided.


Arhgap24 Inactivates Rac1 In Mouse Podocytes, And A Mutant Form Is Associated With Familial Focal Segmental Glomerulosclerosis, Shreeram Akilesh, Hani Suleiman, Christine Stander, Haiyang Yu, Peter Lavin, Rasheed Gbadegesin, Corinne Antignac, Martin Pollack, Jeffrey B. Kopp, Michelle P. Winn, Andrey S. Shaw Jan 2011

Arhgap24 Inactivates Rac1 In Mouse Podocytes, And A Mutant Form Is Associated With Familial Focal Segmental Glomerulosclerosis, Shreeram Akilesh, Hani Suleiman, Christine Stander, Haiyang Yu, Peter Lavin, Rasheed Gbadegesin, Corinne Antignac, Martin Pollack, Jeffrey B. Kopp, Michelle P. Winn, Andrey S. Shaw

Open Access Publications

No abstract provided.


Dna Repair And Synthetic Lethality, Gong-She Guo, Feng-Mei Zhang, Rui-Jie Gao, Robert Delsite, Zhi-Hui Feng, Simon N. Powell Jan 2011

Dna Repair And Synthetic Lethality, Gong-She Guo, Feng-Mei Zhang, Rui-Jie Gao, Robert Delsite, Zhi-Hui Feng, Simon N. Powell

Open Access Publications

No abstract provided.


Molecular Determinants Of Human T-Lymphotropic Virus Type 1 Transmission And Spread, Michael D. Lairmore, Rajaneesh Anupam, Nadine Bowden, Robyn Haines, Rashade A. H. Hayness Ii, Lee Ratner, Patrick L. Green Jan 2011

Molecular Determinants Of Human T-Lymphotropic Virus Type 1 Transmission And Spread, Michael D. Lairmore, Rajaneesh Anupam, Nadine Bowden, Robyn Haines, Rashade A. H. Hayness Ii, Lee Ratner, Patrick L. Green

Open Access Publications

No abstract provided.


Five Questions About Non-Mevalonate Isoprenoid Biosynthesis, Audrey R. Odom Jan 2011

Five Questions About Non-Mevalonate Isoprenoid Biosynthesis, Audrey R. Odom

Open Access Publications

No abstract provided.


Genetic Basis For In Vivo Daptomycin Resistance In Enterococci, Elizabeth Lobos, Erica Sodergren, George M. Weinstock, Et Al Jan 2011

Genetic Basis For In Vivo Daptomycin Resistance In Enterococci, Elizabeth Lobos, Erica Sodergren, George M. Weinstock, Et Al

Open Access Publications

No abstract provided.


Prevention Of Intraoperative Awareness In A High-Risk Surgical Population, Michael S. Avidan, Beth A. Burnside, Lini Zhang, Saima Kamal, Brian Torres, Alex S. Evers, Stephen Gradwohl, Ben J. Palanca, Nan Lin, David Glick, Leah Karl, Michael O'Connor, George A. Mashour Jan 2011

Prevention Of Intraoperative Awareness In A High-Risk Surgical Population, Michael S. Avidan, Beth A. Burnside, Lini Zhang, Saima Kamal, Brian Torres, Alex S. Evers, Stephen Gradwohl, Ben J. Palanca, Nan Lin, David Glick, Leah Karl, Michael O'Connor, George A. Mashour

Open Access Publications

No abstract provided.


Prevention Of Nosocomial Pneumonia In The Intensive Care Unit: Beyond The Use Of Bundles, Marin H. Kollef Jan 2011

Prevention Of Nosocomial Pneumonia In The Intensive Care Unit: Beyond The Use Of Bundles, Marin H. Kollef

Open Access Publications

No abstract provided.


Weight Loss, Exercise, Or Both And Physical Function In Obese Older Adults, Dennis T. Villareal, Suresh Chode, Nehu Parimi, David R. Sinacore, Krupa Shah, Tiffany Hilton, Reina Armamento-Villareal, Nicola Napoli, Clifford Qualls Jan 2011

Weight Loss, Exercise, Or Both And Physical Function In Obese Older Adults, Dennis T. Villareal, Suresh Chode, Nehu Parimi, David R. Sinacore, Krupa Shah, Tiffany Hilton, Reina Armamento-Villareal, Nicola Napoli, Clifford Qualls

Open Access Publications

No abstract provided.


Role Of Nadph Oxidase Versus Neutrophil Proteases In Antimicrobial Host Defense, R. Robert Vethanayagam, Nikolaos G. Almyroudis, Melissa J. Grimm, David C. Lewandowski, Christine T. N Pham, Timothy S. Blackwell, Ruta Petraitiene, Vidmantas Petraitis, Thomas J. Walsh, Constantin F. Urban, Brahm H. Segal Jan 2011

Role Of Nadph Oxidase Versus Neutrophil Proteases In Antimicrobial Host Defense, R. Robert Vethanayagam, Nikolaos G. Almyroudis, Melissa J. Grimm, David C. Lewandowski, Christine T. N Pham, Timothy S. Blackwell, Ruta Petraitiene, Vidmantas Petraitis, Thomas J. Walsh, Constantin F. Urban, Brahm H. Segal

Open Access Publications

No abstract provided.


In-Depth Analysis Of The Antibody Response Of Individuals Exposed To Primary Dengue Virus Infection, Ruklanthi De Alwis, Martina Beltramello, William B. Messer, Soila Sukupolvi-Petty, Wahala M. P. B. Wahala, Annette Kraus, Nicholas P. Olivarez, Quang Pham, James Brian, Wen-Yang Tsai, Wei-Kung Wang, Scott Halstead, Srisakul Kliks, Michael S. Diamond, Ralph Baric, Antonio Lanzavecchia, Federica Sallusto, Aravinda M. De Silva Jan 2011

In-Depth Analysis Of The Antibody Response Of Individuals Exposed To Primary Dengue Virus Infection, Ruklanthi De Alwis, Martina Beltramello, William B. Messer, Soila Sukupolvi-Petty, Wahala M. P. B. Wahala, Annette Kraus, Nicholas P. Olivarez, Quang Pham, James Brian, Wen-Yang Tsai, Wei-Kung Wang, Scott Halstead, Srisakul Kliks, Michael S. Diamond, Ralph Baric, Antonio Lanzavecchia, Federica Sallusto, Aravinda M. De Silva

Open Access Publications

No abstract provided.


Astrovirus Mlb1 Is Not Associated With Diarrhea In A Cohort Of Indian Children, Lori R. Holtz, Irma K. Bauer, Priya Rajendran, Gagandeep Kang, David Wang Jan 2011

Astrovirus Mlb1 Is Not Associated With Diarrhea In A Cohort Of Indian Children, Lori R. Holtz, Irma K. Bauer, Priya Rajendran, Gagandeep Kang, David Wang

Open Access Publications

No abstract provided.


Glucose And Fatty Acids Synergize To Promote B-Cell Apoptosis Through Activation Of Glycogen Synthase Kinase 3beta Independent Of Jnk Activation, Katsuya Tanabe, Yang Liu, Syed D. Hasan, Sara C. Martinez, Corentin Cras-Meneur, Cris M. Welling, Ernesto Bernal-Mizrachi, Yukio Tanizawa, Christopher J. Rhodes, Erik Zmuda, Tsonwin Hai, Nada A. Abumrad, M. Alan Permutt Jan 2011

Glucose And Fatty Acids Synergize To Promote B-Cell Apoptosis Through Activation Of Glycogen Synthase Kinase 3beta Independent Of Jnk Activation, Katsuya Tanabe, Yang Liu, Syed D. Hasan, Sara C. Martinez, Corentin Cras-Meneur, Cris M. Welling, Ernesto Bernal-Mizrachi, Yukio Tanizawa, Christopher J. Rhodes, Erik Zmuda, Tsonwin Hai, Nada A. Abumrad, M. Alan Permutt

Open Access Publications

No abstract provided.


Fine Mapping Of Genetic Variants In Bin1, Clu, Cr1 And Picalm For Association With Cerebrospinal Fluid Biomarkers For Alzheimer’S Disease, John S. K. Kauwe, Carlos Cruchaga, Celeste M. Karch, Brooke Sadler, Mo Lee, Kevin Mayo, Wayne Latu, Manti Su'a, Anne M. Fagan, David M. Holtzman, John C. Morris, Alzheimer's Disease Neuroimaging Initative, Alison M. Goate Jan 2011

Fine Mapping Of Genetic Variants In Bin1, Clu, Cr1 And Picalm For Association With Cerebrospinal Fluid Biomarkers For Alzheimer’S Disease, John S. K. Kauwe, Carlos Cruchaga, Celeste M. Karch, Brooke Sadler, Mo Lee, Kevin Mayo, Wayne Latu, Manti Su'a, Anne M. Fagan, David M. Holtzman, John C. Morris, Alzheimer's Disease Neuroimaging Initative, Alison M. Goate

Open Access Publications

No abstract provided.


Complete Genome Sequence Of Treponema Paraluiscuniculi, Strain Cuniculi A: The Loss Of Infectivity To Humans Is Associated With Genome Decay, David Smajs, Marie Zobanikova, Michal Strouhal, Darina Cejkova, Shannon Dugan-Rocha, Petra Pospisilova, Steven J. Norris, Tom Albert, Xiang Qin, Kym Hallsworth-Pepin, Christian Buhay, Donna M. Muzny, Lei Chen, Richard A. Gibbs, George M. Weinstock Jan 2011

Complete Genome Sequence Of Treponema Paraluiscuniculi, Strain Cuniculi A: The Loss Of Infectivity To Humans Is Associated With Genome Decay, David Smajs, Marie Zobanikova, Michal Strouhal, Darina Cejkova, Shannon Dugan-Rocha, Petra Pospisilova, Steven J. Norris, Tom Albert, Xiang Qin, Kym Hallsworth-Pepin, Christian Buhay, Donna M. Muzny, Lei Chen, Richard A. Gibbs, George M. Weinstock

Open Access Publications

No abstract provided.


Characterizing Associations And Snp-Environment Interactions For Gwas-Identified Prostate Cancer Risk Markers—Results From Bpc3, Sara Lindstrom, Fredrick Schumacher, Afshan Siddiq, Ruth C. Travis, Daniele Campa, Sonja I. Berndt, W. Ryan Diver, Gianluca Severi, Naomi Allen, Gerald Andriole, Bas Bueno-De-Mesquita, Stephen J. Chanock, David Crawford, J. Michael Gaziano, Graham G. Giles, Edward Giovannucci, Carolyn Guo, Christopher A. Haiman, Richard B. Hayes, Jytte Halkjaer, David J. Hunter, Mattias Johansson, Rudolf Kaaks, Laurence N. Kolonel, Carmen Navarro, Elio Riboli, Carlotta Sacerdote, Meir Stampfer, Daniel O. Stram, Michael J. Thun, Dimitrios Trichopoulos, Jarmo Virtamo, Stephanie J. Weinstein, Meredith Yeager, Brian Henderson, Jing Ma, Loic Le Marchand, Demetrius Albanes, Peter Kraft Jan 2011

Characterizing Associations And Snp-Environment Interactions For Gwas-Identified Prostate Cancer Risk Markers—Results From Bpc3, Sara Lindstrom, Fredrick Schumacher, Afshan Siddiq, Ruth C. Travis, Daniele Campa, Sonja I. Berndt, W. Ryan Diver, Gianluca Severi, Naomi Allen, Gerald Andriole, Bas Bueno-De-Mesquita, Stephen J. Chanock, David Crawford, J. Michael Gaziano, Graham G. Giles, Edward Giovannucci, Carolyn Guo, Christopher A. Haiman, Richard B. Hayes, Jytte Halkjaer, David J. Hunter, Mattias Johansson, Rudolf Kaaks, Laurence N. Kolonel, Carmen Navarro, Elio Riboli, Carlotta Sacerdote, Meir Stampfer, Daniel O. Stram, Michael J. Thun, Dimitrios Trichopoulos, Jarmo Virtamo, Stephanie J. Weinstein, Meredith Yeager, Brian Henderson, Jing Ma, Loic Le Marchand, Demetrius Albanes, Peter Kraft

Open Access Publications

No abstract provided.


Binocular Disparity Tuning And Visual–Vestibular Congruency Of Multisensory Neurons In Macaque Parietal Cortex, Yun Yang, Sheng Liu, Syed A. Chowdhury, Gregory C. Deangelis, Dora E. Angelaki Jan 2011

Binocular Disparity Tuning And Visual–Vestibular Congruency Of Multisensory Neurons In Macaque Parietal Cortex, Yun Yang, Sheng Liu, Syed A. Chowdhury, Gregory C. Deangelis, Dora E. Angelaki

Open Access Publications

No abstract provided.


Haploinsufficiency Of Human Apoe Reduces Amyloid Deposition In A Mouse Model Of Amyloid-Β Amyloidosis, Jungsu Kim, Hong Jiang, Seonha Park, Adam E.M. Eltorai, Floy R. Stewart, Hyejin Yoon, Jacob M. Basak, Mary Beth Finn, David M. Holtzman Jan 2011

Haploinsufficiency Of Human Apoe Reduces Amyloid Deposition In A Mouse Model Of Amyloid-Β Amyloidosis, Jungsu Kim, Hong Jiang, Seonha Park, Adam E.M. Eltorai, Floy R. Stewart, Hyejin Yoon, Jacob M. Basak, Mary Beth Finn, David M. Holtzman

Open Access Publications

No abstract provided.