Digital Commons Network^™

Bogotá River Anthropogenic Contamination Alters Microbial Communities And Promotes Spread Of Antibiotic Resistance Genes, Carlos Eduardo Posada-Perlaza, Adán Ramírez-Rojas, Paola Porras, Boahemaa Adu-Oppong, Ana-María Botero-Coy, Félix Hernández, Juan M. Anzola, Lorena Díaz, Gautam Dantas, Alejandro Reyes, María Mercedes Zambrano

Open Access Publications

No abstract provided.

Indirect Cost Of Traumatic Brachial Plexus Injuries In The United States, Thomas S. Hong, Andrea Tian, Ryan Sachar, Wilson Z. Ray, David M. Brogan, Christopher J. Dy

Open Access Publications

No abstract provided.

Optimizing Efficiency And Safety In External Beam Radiotherapy Using Automated Plan Check (Apc) Tool And Six Sigma Methodology, Shi Liu, Karl K. Bush, Julian Bertini, Yabo Fu, Jonathan M. Lewis, Daniel J. Pham, Yong Yang, Thomas R. Niedermayr, Lawrie Skinner, Lei Xing, Beth M. Beadle, Annie Hsu, Nataliya Kovalchuk

Open Access Publications

No abstract provided.

A Regulatory Variant Of Chrm3 Is Associated With Cannabis-Induced Hallucinations In European Americans, Zhongshan Cheng, Chureerat Phokaew, Yi-Ling Chou, Dongbing Lai, Jacquelyn L. Meyers, Arpana Agrawal, Lindsay A. Farrer, Henry R. Kranzler, Joel Gelernter

Open Access Publications

No abstract provided.

Modelling Resilience In Adolescence And Adversity: A Novel Framework To Inform Research And Practice, Gin S. Malhi, Pritha Das, Erica Bell, Greg Mattingly, Zola Mannie

Open Access Publications

No abstract provided.

Whole-Cortex Mapping Of Common Genetic Influences On Depression And A Social Deficits Dimension, Alexander S. Hatoum, Andrew E. Reineberg, Harry R. Smolker, John K. Hewitt, Naomi P. Friedman

Open Access Publications

No abstract provided.

Multi-Ancestry Sleep-By-Snp Interaction Analysis In 126,926 Individuals Reveals Lipid Loci Stratified By Sleep Duration, Raymond Noordam, Yun Ju Sung, Karen Schwander, Lisa De Las Fuentes, Treva K. Rice, Dabeeru C. Rao, Mary Feitosa, Aldi Kraja, Mike Province, Et Al.

Open Access Publications

No abstract provided.

Allogeneic Transplantation In Elderly Patients ≥65 Years With Non-Hodgkin Lymphoma: A Time-Trend Analysis, Nirav N. Shah, Ravi Vij, Et Al.

Open Access Publications

No abstract provided.

End Points For Sickle Cell Disease Clinical Trials: Renal And Cardiopulmonary, Cure, And Low-Resource Settings, Ann T. Farrell, Shalini Shenoy, Et Al.

Open Access Publications

No abstract provided.

End Points For Sickle Cell Disease Clinical Trials: Patient-Reported Outcomes, Pain, And The Brain, Ann T. Farrell, Allison A. King, Et Al.

Open Access Publications

No abstract provided.

Mechanisms Underlying Bone Loss Associated With Gut Inflammation, Ke Ke, Manoj Arra, Yousef Abu-Amer

Open Access Publications

Patients with gastrointestinal diseases frequently suffer from skeletal abnormality, characterized by reduced bone mineral density, increased fracture risk, and/or joint inflammation. This pathological process is characterized by altered immune cell activity and elevated inflammatory cytokines in the bone marrow microenvironment due to disrupted gut immune response. Gastrointestinal disease is recognized as an immune malfunction driven by multiple factors, including cytokines and signaling molecules. However, the mechanism by which intestinal inflammation magnified by gut-residing actors stimulates bone loss remains to be elucidated. In this article, we discuss the main risk factors potentially contributing to intestinal disease-associated bone loss, and summarize current …

A Review Of The Immunomodulating Components Of Maternal Breast Milk And Protection Against Necrotizing Enterocolitis, Lila S Nolan, Olivia B Parks, Misty Good

Open Access Publications

Breast milk contains immunomodulating components that are beneficial to newborns during maturation of their immune system. Human breast milk composition is influenced by an infant's gestational and chronological age, lactation stage, and the mother and infant's health status. Major immunologic components in human milk, such as secretory immunoglobulin A (IgA) and growth factors, have a known role in regulating gut barrier integrity and microbial colonization, which therefore protect against the development of a life-threatening gastrointestinal illness affecting newborn infants called necrotizing enterocolitis (NEC). Breast milk is a known protective factor in the prevention of NEC when compared with feeding with …

The Zebrafish Xenograft Platform-A Novel Tool For Modeling Kshv-Associated Diseases, Eric S Pringle, Jaime Wertman, Nicole Melong, Andrew J Coombs, Andrew L Young, David O'Leary, Chansey Veinotte, Carolyn-Ann Robinson, Michael N Ha, Graham Dellaire, Todd E Druley, Craig Mccormick, Jason N Berman

Open Access Publications

Kaposi's sarcoma associated-herpesvirus (KSHV, also known as human herpesvirus-8) is a gammaherpesvirus that establishes life-long infection in human B lymphocytes. KSHV infection is typically asymptomatic, but immunosuppression can predispose KSHV-infected individuals to primary effusion lymphoma (PEL); a malignancy driven by aberrant proliferation of latently infected B lymphocytes, and supported by pro-inflammatory cytokines and angiogenic factors produced by cells that succumb to lytic viral replication. Here, we report the development of the first

Changes In Food Cravings And Eating Behavior After A Dietary Carbohydrate Restriction Intervention Trial, Katherene O-B Anguah, Majid M Syed-Abdul, Qiong Hu, Miriam Jacome-Sosa, Colette Heimowitz, Vicki Cox, Elizabeth J Parks

Open Access Publications

Compared to low-fat diets, low-carbohydrate (CHO) diets cause weight loss (WL) over a faster time frame; however, it is unknown how changes in food cravings and eating behavior contribute to this more rapid WL in the early phases of dieting. We hypothesized that reductions in food cravings and improved eating behaviors would be evident even after a relatively short (4-week) duration of CHO-restriction, and that these changes would be associated with WL. Adult participants (

Gna11 Brain Somatic Pathogenic Variant In An Individual With Phacomatosis Pigmentovascularis, Joseph M. Sliepka, Yi-Shan Lee, Et Al.

Open Access Publications

No abstract provided.

Selective Small Molecule Parg Inhibitor Causes Replication Fork Stalling And Cancer Cell Death, Jerry H. Houl, Roderick A. Stegeman, Tom Ellenberger, In-Kwon Kim, Et Al.

Open Access Publications

No abstract provided.

Diffusion Basis Spectrum Imaging Provides Insights Into Ms Pathology, Peng Sun, Ajit George, Dana C. Perantie, Kathryn Trinkaus, Zezhong Ye, Robert T. Naismith, Sheng-Kwei Song, Anne H. Cross

Open Access Publications

No abstract provided.

Resolution Of Secondary Hemophagocytic Lymphohistiocytosis After Treatment With The Jak1/2 Inhibitor Ruxolitinib, Scott R. Goldsmith, Sana Saif Ur Rehman, Cara L. Shirai, Kiran Vij, John F. Dipersio

Open Access Publications

No abstract provided.

New Statistical Method Identifes Cytokines That Distinguish Stool Microbiomes, Dake Yang, Jethro Johnson, Xin Zhou, Elena Deych, Berkley Shands, Blake Hanson, Erica Sodergren, George Weinstock, William D. Shannon

Open Access Publications

No abstract provided.

De Novo Assembly Of The Brugia Malayi Genome Using Long Reads From A Single Minion Flowcell, Joseph R. Fauver, John Martin, Gary J. Weil, Makedonka Mitreva, Peter U. Fischer

Open Access Publications

No abstract provided.

Report From A Multidisciplinary Meeting On Anxiety As A Non-Motor Manifestation Of Parkinson’S Disease, Gregory M. Pontone, Eric J. Lenze, Et Al.

Open Access Publications

No abstract provided.

Infammatory Bowel Disease-Associated Ubiquitin Ligase Rnf183 Promotes Lysosomal Degradation Of Dr5 And Trail-Induced Caspase Activation, Yan Wu, Yuka Kimura, Takumi Okamoto, Koji Matsuhisa, Rie Asada, Atsushi Saito, Fumika Sakaue, Kazunori Imaizumi, Masayuki Kaneko

Open Access Publications

No abstract provided.

Evaluating Glial And Neuronal Blood Biomarkers Gfap And Uch-L1 As Gradients Of Brain Injury In Concussive, Subconcussive And Non-Concussive Trauma: A Prospective Cohort Study, Linda Papa, Mark R Zonfrillo, Robert D Welch, Lawrence M Lewis, Carolina F Braga, Ciara N Tan, Neema J Ameli, Marco A Lopez, Crystal A Haeussler, Diego Mendez Giordano, Philip A Giordano, Jose Ramirez, Manoj K Mittal

Open Access Publications

Objectives: To evaluate the ability of glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase (UCH-L1) to detect concussion in children and adult trauma patients with a normal mental status and assess biomarker concentrations over time as gradients of injury in concussive and non-concussive head and body trauma.

Design: Large prospective cohort study.

Setting: Three level I trauma centres in the USA.

Participants: Paediatric and adult trauma patients of all ages, with and without head trauma, presenting with a normal mental status (Glasgow Coma Scale score of 15) within 4 hours of injury. Rigorous screening for concussive symptoms was conducted. …

The Effect Of Gut Microbiome Composition On Human Immune Responses: An Exploration Of Interference By Helminth Infections, Ivonne Martin, Maria M M Kaisar, Aprilianto E Wiria, Firdaus Hamid, Yenny Djuardi, Erliyani Sartono, Bruce A Rosa, Makedonka Mitreva, Taniawati Supali, Jeanine J Houwing-Duistermaat, Maria Yazdanbakhsh, Linda J Wammes

Open Access Publications

No abstract provided.

Vaccine-Induced Skewing Of T Cell Responses Protects Against Chikungunya Virus Disease, Rebecca M Broeckel, Nicole Haese, Takeshi Ando, Igor Dmitriev, Craig N Kreklywich, John Powers, Michael Denton, Patricia Smith, Thomas E Morrison, Mark Heise, Victor Defilippis, Ilhem Messaoudi, David T Curiel, Daniel N Streblow

Open Access Publications

Chikungunya virus (CHIKV) infections can cause severe and debilitating joint and muscular pain that can be long lasting. Current CHIKV vaccines under development rely on the generation of neutralizing antibodies for protection; however, the role of T cells in controlling CHIKV infection and disease is still unclear. Using an overlapping peptide library, we identified the CHIKV-specific T cell receptor epitopes recognized in C57BL/6 infected mice at 7 and 14 days post-infection. A fusion protein containing peptides 451, 416, a small region of nsP4, peptide 47, and an HA tag (CHKVf5) was expressed using adenovirus and cytomegalovirus-vectored vaccines. Mice vaccinated with …

Confronting The Opioid Crisis: Practical Pain Management And Strategies: Aoa 2018 Critical Issues Symposium, Hassan R Mir, Anna N Miller, William T Obremskey, A Alex Jahangir, Joseph R Hsu

Open Access Publications

The United States is in the midst of an opioid crisis. Clinicians have been part of the problem because of overprescribing of narcotics for perioperative pain management. Clinicians need to understand the pathophysiology and science of addiction to improve perioperative management of pain for their patients. Multiple modalities for pain management exist that decrease the use of narcotics. Physical strategies, cognitive strategies, and multimodal medication can all provide improved pain relief and decrease the use of narcotics. National medical societies are developing clinical practice guidelines for pain management that incorporate multimodal strategies and multimodal medication. Changes to policy that improve …

The Human Milk Protein-Lipid Complex Hamlet Disrupts Glycolysis And Induces Death In Streptococcus Pneumoniae, Hazeline Roche-Hakansson, Goutham Vansarla, Laura R. Marks, Anders P. Hakansson

Open Access Publications

No abstract provided.

The Telomere-Binding Protein Rif2 And Atp-Bound Rad50 Have Opposing Roles In The Activation Of Yeast Tel1atm Kinase, Sarem Hailemariam, Paolo De Bona, Roberto Galletto, Marcel Hohl, John H. Petrini, Peter M. Burgers

Open Access Publications

No abstract provided.

Developing Priorities To Achieve Health Equity Through Diabetes Translation Research: A Concept Mapping Study, Allison Phad, Shelly Johnston, Rachel G Tabak, Stephanie Mazzucca, Debra Haire-Joshu

Open Access Publications

Introduction: The goal of diabetes translation research is to advance research into practice and ensure equitable benefit from scientific evidence. This study uses concept mapping to inform and refine future directions of diabetes translation research with the goal of achieving health equity in diabetes prevention and control.

Research design and methods: This study used concept mapping and input from a national network of diabetes researchers and public health practitioners. Concept mapping is a mixed-method, participant-based process. First, participants generated statements by responding to a focus prompt ("

Results: Ten clusters were identified containing between 6 and 12 statements from 95 …

Adaptation Of An Evidence-Based Cardiovascular Health Intervention For Rural African Americans In The Southeast, Kiana D. Bess, Leah Frerichs, Tiffany Young, Giselle Corbie-Smith, Gaurav Dave, Kia Davis, Shirley Mcfarlin, Sable Watson, Mysha Wynn, Crystal W. Cene

Open Access Publications

No abstract provided.