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Articles 1711 - 1740 of 7412
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Six-Year Follow-Up Of A Trial Of Antenatal Vitamin D For Asthma Reduction, Augusto A. Litonjua, Vincent J. Carey, Nancy Laranjo, Benjamin J. Stubbs, Hooman Mirzakhani, George T. O'Connor, Megan Sandel, Avraham Beigelman, Leonard B. Bacharier, Robert S. Zeiger, Michael Schatz, Bruce W. Hollis, Scott T. Weiss
Six-Year Follow-Up Of A Trial Of Antenatal Vitamin D For Asthma Reduction, Augusto A. Litonjua, Vincent J. Carey, Nancy Laranjo, Benjamin J. Stubbs, Hooman Mirzakhani, George T. O'Connor, Megan Sandel, Avraham Beigelman, Leonard B. Bacharier, Robert S. Zeiger, Michael Schatz, Bruce W. Hollis, Scott T. Weiss
Open Access Publications
No abstract provided.
Self-Reported Sleep Disturbance In Crohn’S Disease Is Not Confrmed By Objective Sleep Measures, Heba N. Iskandar, Emily E. Linan, Ami Patel, Renee Moore, Yi Lasanajak, C. Prakash Gyawali, Gregory S. Sayuk, Matthew A. Ciorba
Self-Reported Sleep Disturbance In Crohn’S Disease Is Not Confrmed By Objective Sleep Measures, Heba N. Iskandar, Emily E. Linan, Ami Patel, Renee Moore, Yi Lasanajak, C. Prakash Gyawali, Gregory S. Sayuk, Matthew A. Ciorba
Open Access Publications
No abstract provided.
Heavy Metals Contaminating The Environment Of A Progressive Supranuclear Palsy Cluster Induce Tau Accumulation And Cell Death In Cultured Neurons, Carolina Alquezar, Jessica B. Felix, Elizabeth Mccandlish, Brian T. Buckley, Dominique Caparros-Lefebvre, Celeste M. Karch, Lawrence I. Golbe, Aimee W. Kao
Heavy Metals Contaminating The Environment Of A Progressive Supranuclear Palsy Cluster Induce Tau Accumulation And Cell Death In Cultured Neurons, Carolina Alquezar, Jessica B. Felix, Elizabeth Mccandlish, Brian T. Buckley, Dominique Caparros-Lefebvre, Celeste M. Karch, Lawrence I. Golbe, Aimee W. Kao
Open Access Publications
No abstract provided.
Generation Of Light-Producing Somatic-Transgenic Mice Using Adeno-Associated Virus Vectors, Rajvinder Karda, Jonathan D. Cooper, Et Al.
Generation Of Light-Producing Somatic-Transgenic Mice Using Adeno-Associated Virus Vectors, Rajvinder Karda, Jonathan D. Cooper, Et Al.
Open Access Publications
No abstract provided.
Lack Of Neurosteroid Selectivity At Δ Vs. Γ2-Containing Gabaa Receptors In Dentate Granule Neurons, Xinguo Lu, Charles F Zorumski, Steven Mennerick
Lack Of Neurosteroid Selectivity At Δ Vs. Γ2-Containing Gabaa Receptors In Dentate Granule Neurons, Xinguo Lu, Charles F Zorumski, Steven Mennerick
Open Access Publications
GABA
Improved Small Blob Detection In 3d Images Using Jointly Constrained Deep Learning And Hessian Analysis, Yanzhe Xu, Teresa Wu, Fei Gao, Jennifer R. Charlton, Kevin M. Bennett
Improved Small Blob Detection In 3d Images Using Jointly Constrained Deep Learning And Hessian Analysis, Yanzhe Xu, Teresa Wu, Fei Gao, Jennifer R. Charlton, Kevin M. Bennett
Open Access Publications
No abstract provided.
Five-Year Outcomes Of Transcatheter Or Surgical Aortic-Valve Replacement, Raj R. Makkar, Alan Zajarias, Et Al.
Five-Year Outcomes Of Transcatheter Or Surgical Aortic-Valve Replacement, Raj R. Makkar, Alan Zajarias, Et Al.
Open Access Publications
No abstract provided.
Anellovirus Dynamics Are Associated With Primary Graft Dysfunction In Lung Transplantation, Joshua A. Blatter, Tsuyoshi Takahashi, Brigitte Mittler, Ruben G. Nava, Varun Puri, Daniel Kreisel, David Wang
Anellovirus Dynamics Are Associated With Primary Graft Dysfunction In Lung Transplantation, Joshua A. Blatter, Tsuyoshi Takahashi, Brigitte Mittler, Ruben G. Nava, Varun Puri, Daniel Kreisel, David Wang
Open Access Publications
No abstract provided.
Patient-Derived Small Intestinal Myofibroblasts Direct Perfused, Physiologically Responsive Capillary Development In A Microfluidic Gut-On-A-Chip Model, Kristen M. Seiler, Adam Bajinting, David M. Alvarado, Mahama A. Traore, Michael M. Binkley, William H. Goo, Wyatt E. Lanik, Jocelyn Ou, Usama Ismail, Micah Iticovici, Cristi R. King, Kelli L. Vandussen, Elzbieta A. Swietlicki, Vered Gazit, Jun Guo, Cliff J. Luke, Thaddeus Stappenbeck, Matthew A. Ciorba, Steven C. George, J. Mark Meacham, Deborah C. Rubin, Misty Good, Brad W. Warner
Patient-Derived Small Intestinal Myofibroblasts Direct Perfused, Physiologically Responsive Capillary Development In A Microfluidic Gut-On-A-Chip Model, Kristen M. Seiler, Adam Bajinting, David M. Alvarado, Mahama A. Traore, Michael M. Binkley, William H. Goo, Wyatt E. Lanik, Jocelyn Ou, Usama Ismail, Micah Iticovici, Cristi R. King, Kelli L. Vandussen, Elzbieta A. Swietlicki, Vered Gazit, Jun Guo, Cliff J. Luke, Thaddeus Stappenbeck, Matthew A. Ciorba, Steven C. George, J. Mark Meacham, Deborah C. Rubin, Misty Good, Brad W. Warner
Open Access Publications
No abstract provided.
Inhibition Of Grb14, A Negative Modulator Of Insulin Signaling, Improves Glucose Homeostasis Without Causing Cardiac Dysfunction, Xunshan Ding, Rugmani Iyer, Christopher Novotny, Daniel Metzger, Heather H. Zhou, Gordon I. Smith, Mihoko Yoshino, Jun Yoshino, Samuel Klein, Gayathri Swaminath, Saswata Talukdar, Yingjiang Zhou
Inhibition Of Grb14, A Negative Modulator Of Insulin Signaling, Improves Glucose Homeostasis Without Causing Cardiac Dysfunction, Xunshan Ding, Rugmani Iyer, Christopher Novotny, Daniel Metzger, Heather H. Zhou, Gordon I. Smith, Mihoko Yoshino, Jun Yoshino, Samuel Klein, Gayathri Swaminath, Saswata Talukdar, Yingjiang Zhou
Open Access Publications
No abstract provided.
Live Neuron High-Content Screening Reveals Synaptotoxic Activity In Alzheimer Mouse Model Homogenates, Hao Jiang, Thomas J. Esparza, Terrance T. Kummer, Haining Zhong, Jens Rettig, David L. Brody
Live Neuron High-Content Screening Reveals Synaptotoxic Activity In Alzheimer Mouse Model Homogenates, Hao Jiang, Thomas J. Esparza, Terrance T. Kummer, Haining Zhong, Jens Rettig, David L. Brody
Open Access Publications
No abstract provided.
Oncologists’ Communication And Decision-Making Behaviors Affect Perceptions Of Sensitive Information Exchange For Adolescent And Young Adult Patients, Bryan A. Sisk, Karen Fasciano, Susan D. Block, Jennifer W. Mack
Oncologists’ Communication And Decision-Making Behaviors Affect Perceptions Of Sensitive Information Exchange For Adolescent And Young Adult Patients, Bryan A. Sisk, Karen Fasciano, Susan D. Block, Jennifer W. Mack
Open Access Publications
No abstract provided.
Exercise Training Results In Lower Amyloid Plaque Load And Greater Cognitive Function In An Intensity Dependent Manner In The Tg2576 Mouse Model Of Alzheimer's Disease, Riya Thomas, Scott D Zimmerman, Kayla M Yuede, John R Cirrito, Leon M Tai, Benjamin F Timson, Carla M Yuede
Exercise Training Results In Lower Amyloid Plaque Load And Greater Cognitive Function In An Intensity Dependent Manner In The Tg2576 Mouse Model Of Alzheimer's Disease, Riya Thomas, Scott D Zimmerman, Kayla M Yuede, John R Cirrito, Leon M Tai, Benjamin F Timson, Carla M Yuede
Open Access Publications
Three months of exercise training (ET) decreases soluble Aβ
Human Plasmacytoid Dendritic Cells And Cutaneous Melanoma, Matilde Monti, Francesca Consoli, Raffaella Vescovi, Mattia Bugatti, William Vermi
Human Plasmacytoid Dendritic Cells And Cutaneous Melanoma, Matilde Monti, Francesca Consoli, Raffaella Vescovi, Mattia Bugatti, William Vermi
Open Access Publications
The prognosis of metastatic melanoma (MM) patients has remained poor for a long time. However, the recent introduction of effective target therapies (BRAF and MEK inhibitors for BRAFV600-mutated MM) and immunotherapies (anti-CTLA-4 and anti-PD-1) has significantly improved the survival of MM patients. Notably, all these responses are highly dependent on the fitness of the host immune system, including the innate compartment. Among immune cells involved in cancer immunity, properly activated plasmacytoid dendritic cells (pDCs) exert an important role, bridging the innate and adaptive immune responses and directly eliminating cancer cells. A distinctive feature of pDCs is the production of high …
A Single-Nucleotide Polymorphism In A Plasmodium Berghei Apiap2 Transcription Factor Alters The Development Of Host Immunity, Munir Akkaya, Patrick W Sheehan, Et Al
A Single-Nucleotide Polymorphism In A Plasmodium Berghei Apiap2 Transcription Factor Alters The Development Of Host Immunity, Munir Akkaya, Patrick W Sheehan, Et Al
Open Access Publications
The acquisition of malaria immunity is both remarkably slow and unpredictable. At present, we know little about the malaria parasite genes that influence the host's ability to mount a protective immune response. Here, we show that a single-nucleotide polymorphism (SNP) resulting in a single amino acid change (S to F) in an ApiAP2 transcription factor in the rodent malaria parasite
Robust Deep Learning Classification Of Adamantinomatous Craniopharyngioma From Limited Preoperative Radiographic Images, Eric W. Prince, David D. Limbrick Jr., Et Al.
Robust Deep Learning Classification Of Adamantinomatous Craniopharyngioma From Limited Preoperative Radiographic Images, Eric W. Prince, David D. Limbrick Jr., Et Al.
Open Access Publications
No abstract provided.
Radiation And Checkpoint Inhibitor Immunotherapy Lead To Long Term Disease Control In A Metastatic Rcc Patient With Brain Metastases, Maria Levitin, Joel Ofori, Woo Jae Shin, Jiayi Huang, Mackenzie Daly, Dengfeng Cao, Russell Pachynski
Radiation And Checkpoint Inhibitor Immunotherapy Lead To Long Term Disease Control In A Metastatic Rcc Patient With Brain Metastases, Maria Levitin, Joel Ofori, Woo Jae Shin, Jiayi Huang, Mackenzie Daly, Dengfeng Cao, Russell Pachynski
Open Access Publications
Renal cell carcinoma (RCC) comprises 4.2% of all new cancer cases in the United States and 30% of cases are metastatic (mRCC) at diagnosis. Brain metastatic RCC historically has poor prognosis, but the development of immune checkpoint inhibitors has revolutionized their care and may be successfully combined with SBRT to improve prognosis. Here, we present a case of a patient with mRCC who had brain metastases treated with concurrent immune checkpoint inhibitors and SBRT. He continues to survive with good functional status years following his initial diagnosis. We discuss the relevant history regarding treatment approach in patients with brain metastatic …
Solvent/Detergent-Treated Plasma In The Management Of Pediatric Patients Who Require Replacement Of Multiple Coagulation Factors: An Open-Label, Multicenter, Post-Marketing Study, Philip C Spinella, Santiago Borasino, Jeffrey Alten
Solvent/Detergent-Treated Plasma In The Management Of Pediatric Patients Who Require Replacement Of Multiple Coagulation Factors: An Open-Label, Multicenter, Post-Marketing Study, Philip C Spinella, Santiago Borasino, Jeffrey Alten
Open Access Publications
No abstract provided.
When Sting Meets Viruses: Sensing, Trafficking And Response, Zhaohe Li, Siqi Cai, Yutong Sun, Li Li, Siyuan Ding, Xin Wang
When Sting Meets Viruses: Sensing, Trafficking And Response, Zhaohe Li, Siqi Cai, Yutong Sun, Li Li, Siyuan Ding, Xin Wang
Open Access Publications
To effectively defend against microbial pathogens, the host cells mount antiviral innate immune responses by producing interferons (IFNs), and hundreds of IFN-stimulated genes (ISGs). Upon recognition of cytoplasmic viral or bacterial DNAs and abnormal endogenous DNAs, the DNA sensor cGAS synthesizes 2',3'-cGAMP that induces STING (stimulator of interferon genes) undergoing conformational changes, cellular trafficking, and the activation of downstream factors. Therefore, STING plays a pivotal role in preventing microbial pathogen infection by sensing DNAs during pathogen invasion. This review is dedicated to the recent advances in the dynamic regulations of STING activation, intracellular trafficking, and post-translational modifications (PTMs) by the …
Altered Outer Hair Cell Mitochondrial And Subsurface Cisternae Connectomics Are Candidate Mechanisms For Hearing Loss In Mice, Guy Perkins, Jeong Han Lee, Seojin Park, Mincheol Kang, Maria C. Perez-Flores, Saeyeon Ju, Grady Phillips, Anna Lysakowski, Michael Anne Gratton, Ebenezer N. Yamoah
Altered Outer Hair Cell Mitochondrial And Subsurface Cisternae Connectomics Are Candidate Mechanisms For Hearing Loss In Mice, Guy Perkins, Jeong Han Lee, Seojin Park, Mincheol Kang, Maria C. Perez-Flores, Saeyeon Ju, Grady Phillips, Anna Lysakowski, Michael Anne Gratton, Ebenezer N. Yamoah
Open Access Publications
Organelle crosstalk is vital for cellular functions. The propinquity of mitochondria, ER, and plasma membrane promote regulation of multiple functions, which include intracellular Ca
Myd88-Dependent Influx Of Monocytes And Neutrophils Impairs Lymph Node B Cell Responses To Chikungunya Virus Infection Via Irf5, Nos2 And Nox2, Mary K. Mccarthy, Glennys V. Reynoso, Emma S. Winkler, Matthias Mack, Michael S. Diamond, Heather D. Hickman, Thomas E. Morrison
Myd88-Dependent Influx Of Monocytes And Neutrophils Impairs Lymph Node B Cell Responses To Chikungunya Virus Infection Via Irf5, Nos2 And Nox2, Mary K. Mccarthy, Glennys V. Reynoso, Emma S. Winkler, Matthias Mack, Michael S. Diamond, Heather D. Hickman, Thomas E. Morrison
Open Access Publications
Humoral immune responses initiate in the lymph node draining the site of viral infection (dLN). Some viruses subvert LN B cell activation; however, our knowledge of viral hindrance of B cell responses of important human pathogens is lacking. Here, we define mechanisms whereby chikungunya virus (CHIKV), a mosquito-transmitted RNA virus that causes outbreaks of acute and chronic arthritis in humans, hinders dLN antiviral B cell responses. Infection of WT mice with pathogenic, but not acutely cleared CHIKV, induced MyD88-dependent recruitment of monocytes and neutrophils to the dLN. Blocking this influx improved lymphocyte accumulation, dLN organization, and CHIKV-specific B cell responses. …
Apoptotic Stress Induces Bax-Dependent, Caspase-Independent Redistribution Of Linc Complex Nesprins, Liora Lindenboim, Dan Grozki, Ayelet R. Amsalem-Zafran, Aida Peña-Blanco, Gregg G. Gundersen, Christoph Borner, Didier Hodzic, Ana J. Garcia-Sáez, Howard J. Worman, Reuven Stein
Apoptotic Stress Induces Bax-Dependent, Caspase-Independent Redistribution Of Linc Complex Nesprins, Liora Lindenboim, Dan Grozki, Ayelet R. Amsalem-Zafran, Aida Peña-Blanco, Gregg G. Gundersen, Christoph Borner, Didier Hodzic, Ana J. Garcia-Sáez, Howard J. Worman, Reuven Stein
Open Access Publications
No abstract provided.
Site-Specific Effects Of Neurosteroids On Gaba(A) Receptor Activation And Desensitization, Yusuke Sugasawa, Wayland W.L. Cheng, John R. Bracamontes, Zi-Wei Chen, Lei Wang, Allison L. Germann, Spencer R. Pierce, Thomas C. Senneff, Kathiresan Krishnan, David E. Reichert, Douglas F. Covey, Gustav Akk, Alex S. Evers
Site-Specific Effects Of Neurosteroids On Gaba(A) Receptor Activation And Desensitization, Yusuke Sugasawa, Wayland W.L. Cheng, John R. Bracamontes, Zi-Wei Chen, Lei Wang, Allison L. Germann, Spencer R. Pierce, Thomas C. Senneff, Kathiresan Krishnan, David E. Reichert, Douglas F. Covey, Gustav Akk, Alex S. Evers
Open Access Publications
This study examines how site-specific binding to three identified neurosteroid-binding sites in the α
Braf Alteration In Central And Peripheral Nervous System Tumors, Komal Srinivasa, Kevin A Cross, Sonika Dahiya
Braf Alteration In Central And Peripheral Nervous System Tumors, Komal Srinivasa, Kevin A Cross, Sonika Dahiya
Open Access Publications
No abstract provided.
To “Heed The Call” Amidst The Covid-19 Pandemic, Andrew W. Kuhn, Francesca R. Coxe, Kyle N. Kunze, David N. Bernstein
To “Heed The Call” Amidst The Covid-19 Pandemic, Andrew W. Kuhn, Francesca R. Coxe, Kyle N. Kunze, David N. Bernstein
Open Access Publications
No abstract provided.
Validation Of A Parkinson Disease Predictive Model In A Population-Based Study, Irene M. Faust, Brad A. Racette, Susan Searles Nielsen
Validation Of A Parkinson Disease Predictive Model In A Population-Based Study, Irene M. Faust, Brad A. Racette, Susan Searles Nielsen
Open Access Publications
No abstract provided.
Viral-Immune Cell Interactions At The Maternal-Fetal Interface In Human Pregnancy, Elaine L Parker, Rachel B Silverstein, Sonam Verma, Indira U Mysorekar
Viral-Immune Cell Interactions At The Maternal-Fetal Interface In Human Pregnancy, Elaine L Parker, Rachel B Silverstein, Sonam Verma, Indira U Mysorekar
Open Access Publications
The human decidua and placenta form a distinct environment distinguished for its promotion of immunotolerance to infiltrating semiallogeneic trophoblast cells to enable successful pregnancy. The maternal-fetal interface also successfully precludes transmission of most pathogens. This barrier function occurs in conjunction with a diverse influx of decidual immune cells including natural killer cells, macrophages and T cells. However, several viruses, among other microorganisms, manage to escape destruction by the host adaptive and innate immune system, leading to congenital infection and adverse pregnancy outcomes. In this review, we describe mechanisms of pathogenicity of two such viral pathogens, Human cytomegalovirus (HCMV) and Zika …
Lung Secretoglobin Scgb1a1 Influences Alveolar Macrophage-Mediated Inflammation And Immunity, Min Xu, Wei Yang, Xuanchuan Wang, Deepak Kumar Nayak
Lung Secretoglobin Scgb1a1 Influences Alveolar Macrophage-Mediated Inflammation And Immunity, Min Xu, Wei Yang, Xuanchuan Wang, Deepak Kumar Nayak
Open Access Publications
Alveolar macrophage (AM) is a mononuclear phagocyte key to the defense against respiratory infections. To understand AM's role in airway disease development, we examined the influence of Secretoglobin family 1a member 1 (SCGB1A1), a pulmonary surfactant protein, on AM development and function. In a murine model, high-throughput RNA-sequencing and gene expression analyses were performed on purified AMs isolated from mice lacking in
A Novel Method For High-Dimensional Anatomical Mapping Of Extra-Axial Cerebrospinal Fluid: Application To The Infant Brain, Mahmoud Mostapha, Sun Hyung Kim, Alan C Evans, Stephen R Dager, Annette M Estes, Robert C Mckinstry, Kelly N Botteron, Guido Gerig, Stephen M Pizer, Robert T Schultz, Heather C Hazlett, Joseph Piven, Jessica B Girault, Mark D Shen, Martin A Styner
A Novel Method For High-Dimensional Anatomical Mapping Of Extra-Axial Cerebrospinal Fluid: Application To The Infant Brain, Mahmoud Mostapha, Sun Hyung Kim, Alan C Evans, Stephen R Dager, Annette M Estes, Robert C Mckinstry, Kelly N Botteron, Guido Gerig, Stephen M Pizer, Robert T Schultz, Heather C Hazlett, Joseph Piven, Jessica B Girault, Mark D Shen, Martin A Styner
Open Access Publications
Cerebrospinal fluid (CSF) plays an essential role in early postnatal brain development. Extra-axial CSF (EA-CSF) volume, which is characterized by CSF in the subarachnoid space surrounding the brain, is a promising marker in the early detection of young children at risk for neurodevelopmental disorders. Previous studies have focused on global EA-CSF volume across the entire dorsal extent of the brain, and not regionally-specific EA-CSF measurements, because no tools were previously available for extracting local EA-CSF measures suitable for localized cortical surface analysis. In this paper, we propose a novel framework for the localized, cortical surface-based analysis of EA-CSF. The proposed …
Characterization Of The Complete Mitochondrial Genomes Of Two Sibling Species Of Parasitic Roundworms, Haemonchus Contortus And Teladorsagia Circumcincta, Nikola Palevich, Paul H Maclean, Young-Jun Choi, Makedonka Mitreva
Characterization Of The Complete Mitochondrial Genomes Of Two Sibling Species Of Parasitic Roundworms, Haemonchus Contortus And Teladorsagia Circumcincta, Nikola Palevich, Paul H Maclean, Young-Jun Choi, Makedonka Mitreva
Open Access Publications
No abstract provided.