Digital Commons Network^™

Spatial Mapping Of The Collagen Distribution In Human And Mouse Tissues By Force Volume Atomic Force Microscopy, Annalisa Calò, Yevgeniy Romin, Rami Srouji, Constantinos P. Zambirinis, Ning Fan, Anthony Santella, Elvin Feng, Sho Fujisawa, Mesruh Turkekul, Sharon Huang, Amber L. Simpson, Michael D'Angelica, William R. Jarnagin, Katia Manova-Todorova

Open Access Publications

No abstract provided.

Serum Urate Lowering With Allopurinol And Kidney Function In Type 1 Diabetes, Alessandro Doria, Janet B. Mcgill, Et Al.

Open Access Publications

No abstract provided.

The Nemp Family Supports Metazoan Fertility And Nuclear Envelope Stiffness, Yonit Tsatskis, Ariz Mohammad, Karen Krchma, Jun Wu, Didier Hodzic, Daniel Potter, Tim Schedl, Kyunghee Choi, Helen Mcneill, Et Al

Open Access Publications

Human genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in

Impact Of Preoperative Chlorhexidine Gluconate (Chg) Application Methods On Preoperative Chg Skin Concentration, Bobby G Warren, Alicia Nelson, David K Warren, Meghan A Baker, Candace Miller, Tracey Habrock, Jahnavi Bongu, Abinav Gowda, Jacob Johnson, Deverick J Anderson, Cdc Prevention Epicenters Program

Open Access Publications

Elective surgical patients routinely bathe with chlorhexidine gluconate (CHG) at home days prior to their procedures. However, the impact of home CHG bathing on surgical site CHG concentration is unclear. We examined 3 different methods of applying CHG and hypothesized that different application methods would impact resulting CHG skin concentration.

Affording Autism An Early Brain Development Re-Definition, Ami Klin, Megan Micheletti, Cheryl Klaiman, Sarah Shultz, John N Constantino, Warren Jones

Open Access Publications

The national priority to advance early detection and intervention for children with autism spectrum disorder (ASD) has not reduced the late age of ASD diagnosis in the US over several consecutive Centers for Disease Control and Prevention (CDC) surveillance cohorts, with traditionally under-served populations accessing diagnosis later still. In this review, we explore a potential perceptual barrier to this enterprise which views ASD in terms that are contradicted by current science, and which may have its origins in the current definition of the condition and in its historical associations. To address this perceptual barrier, we propose a re-definition of ASD …

Targeting Cxcr4 In Aml And All, Daniel Cancilla, Michael P Rettig, John F Dipersio

Open Access Publications

The interaction of acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) blasts with the bone marrow microenvironment regulates self-renewal, growth signaling, as well as chemotherapy resistance. The chemokine receptor, CXC receptor 4 (CXCR4), with its ligand chemokine ligand 12 (CXCL12), plays a key role in the survival and migration of normal and malignant stem cells to the bone marrow. High expression of CXCR4 on AML and ALL blasts has been shown to be a predictor of poor prognosis for these diseases. Several small molecule inhibitors, short peptides, antibodies, and antibody drug conjugates have been developed for the purposes of …

Risk Factors For Incident Dementia Among Older Cubans, Geeske Peeters, Arianna Almirall Sanchez, Jorge Llibre Guerra, Brian Lawlor, Rose Anne Kenny, Kristine Yaffe, Juan Llibre Rodriguez

Open Access Publications

No abstract provided.

The Pathway To Secondary Prevention Of Alzheimer's Disease, Eric Mcdade, Martin M Bednar, H Robert Brashear, David S Miller, Paul Maruff, Christopher Randolph, Zahinoor Ismail, Maria C Carrillo, Christopher J Weber, Lisa J Bain, Ann Marie Hake

Open Access Publications

Alzheimer's disease (AD) is a continuum consisting of a preclinical stage that occurs decades before symptoms appear. As researchers make advances in investigating the continuum, the importance of developing drugs for secondary prevention is garnering increased discussion. For efficacious drug development for secondary prevention it is important to define what are the earliest biological stages of AD. The Alzheimer's Association Research Roundtable convened November 27 to 28, 2018 to focus on pre-clinical AD. This review will address the biological approach to defining pre-clinical AD, detection, identification of at-risk individuals, and lessons learned from trials such as A4 and TOMMORROW.

Lactate-Protechypoglycemia (Lph), Matthew L Goodwin, L Bruce Gladden, Maarten W N Nijsten

Open Access Publications

Here, we provide an overview of the concept of a lactate-protected hypoglycemia ("LPH"), originally proposed as lowering glucose while simultaneously increasing lactate concentration as a method by which tumors might be targeted. Central to this hypothesis is that lactate can act as a critical salvage fuel for the central nervous system, allowing for wide perturbations in whole body and central nervous system glucose concentrations. Further, many tumors exhibit "the Warburg" effect, consuming glucose and producing and exporting lactate despite adequate oxygenation. While some recent data have provided evidence for a "reverse-Warburg," where some tumors may preferentially consume lactate, many of …

Harnessing Real-World Data To Inform Decision-Making: Multiple Sclerosis Partners Advancing Technology And Health Solutions (Ms Paths), Ellen M Mowry, Tammie L S Benzinger, Robert T Naismith, Et Al

Open Access Publications

No abstract provided.

Reaching Consensus On Principles Of Stakeholder Engagement In Research, Melody S. Goodman, Nicole Ackermann, Deborah J. Bowen, Members Of The Delphi Panel, Vetta Sanders Thompson

Open Access Publications

No abstract provided.

Building Access To Care In Adult Sickle Cell Disease: Defining Models Of Care, Essential Components, And Economic Aspects, Julie Kanter, Allison King, Et Al.

Open Access Publications

No abstract provided.

Abatacept Is Effective As Gvhd Prophylaxis In Unrelated Donor Stem Cell Transplantation For Children With Severe Sickle Cell Disease, Alexander Ngwube, Niketa Shah, Kamar Godder, David Jacobsohn, Monica L. Hulbert, Shalini Shenoy

Open Access Publications

No abstract provided.

Inhibition Of Pikfyve Kinase Prevents Infection By Zaire Ebolavirus And Sars-Cov-2, Yuan-Lin Kang, Yi-Ying Chou, Paul W. Rothlauf, Zhuoming Liu, Timothy K. Soh, David Cureton, James Brett Case, Rita E. Chen, Michael S. Diamond, Sean P.J. Whelan, Tom Kirchhausen

Open Access Publications

No abstract provided.

A Mobile App Directory Of Occupational Therapists Who Provide Home Modifications: Development And Preliminary Usability Evaluation, An Thi Nguyen, Emily Kling Somerville, Sandra Martina Espín-Tello, Marian Keglovits, Susan Lynn Stark

Open Access Publications

BACKGROUND: Home modifications provided by occupational therapists (OTs) are effective in improving daily activity performance and reducing fall risk among community-dwelling older adults. However, the prevalence of home modification is low. One reason is the lack of a centralized database of OTs who provide home modifications.

OBJECTIVE: This study aimed to develop and test the usability of a mobile app directory of OTs who provide home modifications in the United States.

METHODS: In phase 1, a prototype was developed by identifying OTs who provide home modifications through keyword Web searches. Referral information was confirmed by phone or email. In phase …

Digital Translucence: Adapting Telemedicine Delivery Post-Covid-19, Thomas Kannampallil, Jun Ma

Open Access Publications

No abstract provided.

Multitasking By The Oc Lineage During Bone Infection: Bone Resorption, Immune Modulation, And Microbial Niche, Philip M Roper, Christine Shao, Deborah J Veis

Open Access Publications

Bone infections, also known as infectious osteomyelitis, are accompanied by significant inflammation, osteolysis, and necrosis. Osteoclasts (OCs) are the bone-resorbing cells that work in concert with osteoblasts and osteocytes to properly maintain skeletal health and are well known to respond to inflammation by increasing their resorptive activity. OCs have typically been viewed merely as effectors of pathologic bone resorption, but recent evidence suggests they may play an active role in the progression of infections through direct effects on pathogens and via the immune system. This review discusses the host- and pathogen-derived factors involved in the in generation of OCs during …

Quality Of Life With Second Or Third Line Nab-Paclitaxel-Based Regimens In Advanced Non-Small-Cell Lung Cancer, Santiago Ponce Aix, Ramaswamy Govindan, Daniel Morgensztern, Et Al

Open Access Publications

No abstract provided.

Amelioration Of Congenital Tufting Enteropathy In Epcam (Trop1)-Deficient Mice Via Heterotopic Expression Of Trop2 In Intestinal Epithelial Cells, Gaku Nakato, Sohshi Morimura, Michael Lu, Xu Feng, Chuanjin Wu, Mark C Udey

Open Access Publications

TROP1 (EpCAM) and TROP2 are homologous cell surface proteins that are widely expressed, and often co-expressed, in developing and adult epithelia. Various functions have been ascribed to EpCAM and TROP2, but responsible mechanisms are incompletely characterized and functional equivalence has not been examined. Adult intestinal epithelial cells (IEC) express high levels of EpCAM, while TROP2 is not expressed. EpCAM deficiency causes congenital tufting enteropathy (CTE) in humans and a corresponding lethal condition in mice. We expressed TROP2 and EpCAM in the IEC of EpCAM-deficient mice utilizing a villin promoter to assess EpCAM and TROP2 function. Expression of EpCAM or TROP2 …

Tert, A Promoter Of Cns Malignancies, Bhuvic Patel, Rukayat Taiwo, Albert H. Kim, Gavin P. Dunn

Open Access Publications

As cells replicate their DNA during mitosis, telomeres are shortened due to the inherent limitations of the DNA replication process. Maintenance of telomere length is critical for cancer cells to overcome cellular senescence induced by telomere shortening. Telomerase reverse transcriptase (TERT) is the rate-limiting catalytic subunit of telomerase, an RNA-dependent DNA polymerase that lengthens telomeric DNA to maintain telomere homeostasis.

Association Of Sex And Apoe Ε4 With Brain Tau Deposition And Atrophy In Older Adults With Alzheimer’S Disease, Shaozhen Yan, Chaojie Zheng, Manish D. Paranjpe, Jian Li, Tammie L.S. Benzinger, Jie Lu, Yun Zhou

Open Access Publications

No abstract provided.

Increased Aqueous Humor Gdf15 Is Associated With Worse Visual Field Loss In Pseudoexfoliative Glaucoma Patients, Jonathan B. Lin, Arsham Sheybani, Andrea Santeford, Alicia De Maria, Rajendra S. Apte

Open Access Publications

No abstract provided.

Functional Analysis Of Rare Genetic Variants In Complement Factor I (Cfi) Using A Serum-Based Assay In Advanced Age-Related Macular Degeneration, Anuja Java, Peter Baciu, Rafael Widjajahakim, Yun Ju Sung, Jae Yang, David Kavanagh, John Atkinson, Johanna Seddon

Open Access Publications

No abstract provided.

Discovery Of A Novel Simian Pegivirus In Common Marmosets (Callithrix Jacchus) With Lymphocytic Enterocolitis, Anna S. Heffron, Michael Lauck, Elizabeth D. Somsen, Elizabeth C. Townsend, Adam L. Bailey, Megan Sosa, Jens Eickhoff, Saverio Capuano Iii, Christina M. Newman, Jens H. Kuhn, Andres Mejia, Heather A. Simmons, David H. O'Connor

Open Access Publications

No abstract provided.

Human Ferroportin Mediates Proton-Coupled Active Transport Of Iron, Shuang Li, Yihu Yang, Weikai Li

Open Access Publications

No abstract provided.

T Follicular Helper Phenotype Predicts Response To Histone Deacetylase Inhibitors In Relapsed/Refractory Peripheral T-Cell Lymphoma, Paola Ghione, Neha Mehta-Shah, Shakthi Bhaskar, Et Al.

Open Access Publications

No abstract provided.

Intentional And Unintentional Nonadherence To Hydroxyurea Among People With Sickle Cell Disease: A Qualitative Study, Jason R. Hodges, Shannon M. Phillips, Sarah Norell, Chinonyelum Nwosu, Hamda Khan, Lingzi Luo, Sherif M. Badawy, Allison King, Paula Tanabe, Marsha Treadwell, Lucia Rojas Smith, Cecelia Calhoun, Jane S. Hankins, Jerlym Porter

Open Access Publications

No abstract provided.

Reassessing Rabbit Antithymocyte Globulin Induction In Kidney Transplantation (Rethink): An Analysis Of The North American Pediatric Renal Trials And Collaborative Studies (Naprtcs) Registry, Isa F. Ashoor, Karen Martz, Shirley Galbiati, Robbie A. Beyl, Vikas R. Dharnidharka, Naprtcs Investigators

Open Access Publications

No abstract provided.

Impact Of Functional Status On Outcomes Of Simultaneous Pancreas-Kidney Transplantation: Risks And Opportunities For Patient Benefit, Krista L. Lentine, Tarek Alhamad, Wisit Cheungpasitporn, Jane C. Tan, Su-Hsin Chang, Matthew Cooper, Darshana M. Dadhania, David A. Axelrod, Mark A. Schnitzler, Rosemary Ouseph, Franco H. Cabeza Rivera, Bertram L. Kasiske, Kenneth J. Woodside, Ronald F. Parsons

Open Access Publications

No abstract provided.

Acvr1/Jak1/Jak2 Inhibitor Momelotinib Reverses Transfusion Dependency And Suppresses Hepcidin In Myelofibrosis Phase 2 Trial, Stephen T. Oh, Et Al.

Open Access Publications

No abstract provided.