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Coded Apertures For X-Ray Scatter Imaging, David J. Brady, Daniel L. Marks, Kenneth P. Maccabe, Joseph A. O'Sullivan Jan 2013

Coded Apertures For X-Ray Scatter Imaging, David J. Brady, Daniel L. Marks, Kenneth P. Maccabe, Joseph A. O'Sullivan

Open Access Publications

No abstract provided.


Advancing The Translation Of Optical Imaging Agents For Clinical Imaging, Eva M. Sevick-Muraca, Walter J. Akers, Bishnu P. Joshi, Gary D. Lurker, Cathy S. Cutler, Lawrence J. Marnett, Christopher H. Contag, Thomas D. Wang, Ali Azhdarinia Jan 2013

Advancing The Translation Of Optical Imaging Agents For Clinical Imaging, Eva M. Sevick-Muraca, Walter J. Akers, Bishnu P. Joshi, Gary D. Lurker, Cathy S. Cutler, Lawrence J. Marnett, Christopher H. Contag, Thomas D. Wang, Ali Azhdarinia

Open Access Publications

No abstract provided.


The Adverse Effects Of Reduced Cerebral Perfusion On Cognition And Brain Structure In Older Adults With Cardiovascular Disease, Michael L. Alosco, John Gunstad, Beth A. Jerskey, Xiaomeng Xu, Uraina S. Clark, Jason Hassenstab, Denise M. Cote, Edward G. Walsh, Donald R. Labbe, Richard Hoge, Ronald A. Cohen, Lawrence H. Sweet Jan 2013

The Adverse Effects Of Reduced Cerebral Perfusion On Cognition And Brain Structure In Older Adults With Cardiovascular Disease, Michael L. Alosco, John Gunstad, Beth A. Jerskey, Xiaomeng Xu, Uraina S. Clark, Jason Hassenstab, Denise M. Cote, Edward G. Walsh, Donald R. Labbe, Richard Hoge, Ronald A. Cohen, Lawrence H. Sweet

Open Access Publications

No abstract provided.


Risk Factors For Mixed Complicated Skin And Skin Structure Infections To Help Tailor Appropriate Empiric Therapy, Marya Zilberberg, Scott T. Micek, Marin H. Kollef, Ahmed Shelbaya, Andrew F. Shorr Dec 2012

Risk Factors For Mixed Complicated Skin And Skin Structure Infections To Help Tailor Appropriate Empiric Therapy, Marya Zilberberg, Scott T. Micek, Marin H. Kollef, Ahmed Shelbaya, Andrew F. Shorr

Open Access Publications

No abstract provided.


The Influence Of Insurance Status On Access To And Utilization Of A Tertiary Hand Surgery Referral Center, Ryan P. Calfee, Chirag M. Shah, Colin D. Canham, Ambrose H.W. Wong, Richard H. Gelberman, Charles A. Goldfarb Dec 2012

The Influence Of Insurance Status On Access To And Utilization Of A Tertiary Hand Surgery Referral Center, Ryan P. Calfee, Chirag M. Shah, Colin D. Canham, Ambrose H.W. Wong, Richard H. Gelberman, Charles A. Goldfarb

Open Access Publications

No abstract provided.


Educating Medical Students In Musculoskeletal Surgery And Medicine: How To Get A Course Up And Running At Your Institution: Aoa Critical Issues, Charles S. Day, Joseph Bernstein, Martin I. Boyer Dec 2012

Educating Medical Students In Musculoskeletal Surgery And Medicine: How To Get A Course Up And Running At Your Institution: Aoa Critical Issues, Charles S. Day, Joseph Bernstein, Martin I. Boyer

Open Access Publications

No abstract provided.


Periacetabular Osteotomy And Combined Femoral Head-Neck Junction Osteochondroplasty: A Minimum Two-Year Follow-Up Cohort Study, Nader A. Nassif, Perry L. Schoenecker, Robert Thorsness, John C. Clohisy Nov 2012

Periacetabular Osteotomy And Combined Femoral Head-Neck Junction Osteochondroplasty: A Minimum Two-Year Follow-Up Cohort Study, Nader A. Nassif, Perry L. Schoenecker, Robert Thorsness, John C. Clohisy

Open Access Publications

No abstract provided.


Mapping A Complete Neural Population In The Retina, Olivier Marre, Dario Amodei, Nikhil Deshmukh, Kolia Sadeghi, Frederick Soo, Timothy E. Holy, Michael J. Berry Oct 2012

Mapping A Complete Neural Population In The Retina, Olivier Marre, Dario Amodei, Nikhil Deshmukh, Kolia Sadeghi, Frederick Soo, Timothy E. Holy, Michael J. Berry

Open Access Publications

Recording simultaneously from essentially all of the relevant neurons in a local circuit is crucial to understand how they collectively represent information. Here we show that the combination of a large, dense multielectrode array and a novel, mostly automated spike-sorting algorithm allowed us to record simultaneously from a highly overlapping population of >200 ganglion cells in the salamander retina. By combining these methods with labeling and imaging, we showed that up to 95% of the ganglion cells over the area of the array were recorded. By measuring the coverage of visual space by the receptive fields of the recorded cells, …


Hunter-Gatherer Energetics And Human Obesity, Herman Pontzer, David A. Raichlen, Brian M. Wood, Audax Z. P. Mabulla, Susan B. Racette, Frank W. Marlowe Jul 2012

Hunter-Gatherer Energetics And Human Obesity, Herman Pontzer, David A. Raichlen, Brian M. Wood, Audax Z. P. Mabulla, Susan B. Racette, Frank W. Marlowe

Open Access Publications

No abstract provided.


Loss Of Intranetwork And Internetwork Resting State Functional Connections With Alzheimer's Disease Progression, Mathew R. Brier, Jewell B. Thomas, Abraham Z. Snyder, Tammie L. Benzinger, Dongyang Zhang, Marcus E. Raichle, David M. Holtzman, John C. Morris, Beau M. Ances Jun 2012

Loss Of Intranetwork And Internetwork Resting State Functional Connections With Alzheimer's Disease Progression, Mathew R. Brier, Jewell B. Thomas, Abraham Z. Snyder, Tammie L. Benzinger, Dongyang Zhang, Marcus E. Raichle, David M. Holtzman, John C. Morris, Beau M. Ances

Open Access Publications

Alzheimer's disease (AD) is the most common cause of dementia. Much is known concerning AD pathophysiology but our understanding of the disease at the systems level remains incomplete. Previous AD research has used resting-state functional connectivity magnetic resonance imaging (rs-fcMRI) to assess the integrity of functional networks within the brain. Most studies have focused on the default-mode network (DMN), a primary locus of AD pathology. However, other brain regions are inevitably affected with disease progression. We studied rs-fcMRI in five functionally defined brain networks within a large cohort of human participants of either gender (n = 510) that ranged in …


What's New In Spine Surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, Jeffrey C. Wang Jun 2012

What's New In Spine Surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, Jeffrey C. Wang

Open Access Publications

No abstract provided.


Detection Thresholds Of Macaque Otolith Afferents, Xiong-Jie Yu, J David Dickman, Dora E. Angelaki Jun 2012

Detection Thresholds Of Macaque Otolith Afferents, Xiong-Jie Yu, J David Dickman, Dora E. Angelaki

Open Access Publications

The vestibular system is our sixth sense and is important for spatial perception functions, yet the sensory detection and discrimination properties of vestibular neurons remain relatively unexplored. Here we have used signal detection theory to measure detection thresholds of otolith afferents using 1 Hz linear accelerations delivered along three cardinal axes. Direction detection thresholds were measured by comparing mean firing rates centered on response peak and trough (full-cycle thresholds) or by comparing peak/trough firing rates with spontaneous activity (half-cycle thresholds). Thresholds were similar for utricular and saccular afferents, as well as for lateral, fore/aft, and vertical motion directions. When computed …


Synaptic Nmda Receptors Mediate Hypoxic Excitotoxic Death, Christine M. Wroge, Joshua Hogins, Larry Eisenman, Steven Mennerick May 2012

Synaptic Nmda Receptors Mediate Hypoxic Excitotoxic Death, Christine M. Wroge, Joshua Hogins, Larry Eisenman, Steven Mennerick

Open Access Publications

Excessive NMDA receptor activation and excitotoxicity underlies pathology in many neuropsychiatric and neurological disorders, including hypoxia/ischemia. Thus, the development of effective therapeutics for these disorders demands a complete understanding of NMDA receptor (NMDAR) activation during excitotoxic insults. The extrasynaptic NMDAR hypothesis posits that synaptic NMDARs are neurotrophic/neuroprotective and extrasynaptic NMDARs are neurotoxic. The extrasynaptic hypothesis is built in part on observed selectivity for extrasynaptic receptors of a neuroprotective use-dependent NMDAR channel blocker, memantine. In rat hippocampal neurons, we found that a neuroprotective concentration of memantine shows little selectivity for extrasynaptic NMDARs when all receptors are tonically activated by exogenous glutamate. …


Lower Extremity-Specific Measures Of Disability And Outcomes In Orthopaedic Surgery, Matthew V. Smith, Sandra E. Klein, John C. Clohisy, Geneva R. Baca, Robert H. Brophy, Rick W. Wright Mar 2012

Lower Extremity-Specific Measures Of Disability And Outcomes In Orthopaedic Surgery, Matthew V. Smith, Sandra E. Klein, John C. Clohisy, Geneva R. Baca, Robert H. Brophy, Rick W. Wright

Open Access Publications

No abstract provided.


Weight Perceptions And Perceived Risk For Diabetes And Heart Disease Among Overweight And Obese Women, Suffolk County, New York, 2008, Susan Darlow, Melody S. Goodman, Jewel D. Stafford, Christina R. Lachance, Kimberly A. Kaphingst Jan 2012

Weight Perceptions And Perceived Risk For Diabetes And Heart Disease Among Overweight And Obese Women, Suffolk County, New York, 2008, Susan Darlow, Melody S. Goodman, Jewel D. Stafford, Christina R. Lachance, Kimberly A. Kaphingst

Open Access Publications

No abstract provided.


A Window Into Domain Amplification Through Piccolo In Teleost Fish, Michael L. Nonet Jan 2012

A Window Into Domain Amplification Through Piccolo In Teleost Fish, Michael L. Nonet

Open Access Publications

No abstract provided.


Population-Based Rare Variant Detection Via Pooled Exome Or Custom Hybridization Capture With Or Without Individual Indexing, Enrique Ramos, Benjamin T. Levinson, Sara Chasnoff, Andrew Hughes, Andrew L. Young, Katherine Thornton, Allie Li, Francesco L.M Vallania, Michael Province, Todd E. Druley Jan 2012

Population-Based Rare Variant Detection Via Pooled Exome Or Custom Hybridization Capture With Or Without Individual Indexing, Enrique Ramos, Benjamin T. Levinson, Sara Chasnoff, Andrew Hughes, Andrew L. Young, Katherine Thornton, Allie Li, Francesco L.M Vallania, Michael Province, Todd E. Druley

Open Access Publications

No abstract provided.


Diagnosing Symptomatic Hiv-Associated Neurocognitive Disorders: Self-Report Versus Performance-Based Assessment Of Everyday Functioning, David B. Clifford, Et Al Jan 2012

Diagnosing Symptomatic Hiv-Associated Neurocognitive Disorders: Self-Report Versus Performance-Based Assessment Of Everyday Functioning, David B. Clifford, Et Al

Open Access Publications

No abstract provided.


Trigeminal Neuralgia Post-Styloidectomy In Eagle Syndrome: A Case Report, John W. Blackett, Daniel J. Ferraro, John J. Stephens, Joshua L. Dowling, Jerry J. Jaboin Jan 2012

Trigeminal Neuralgia Post-Styloidectomy In Eagle Syndrome: A Case Report, John W. Blackett, Daniel J. Ferraro, John J. Stephens, Joshua L. Dowling, Jerry J. Jaboin

Open Access Publications

No abstract provided.


Multi-Species Data Integration And Gene Ranking Enrich Significant Results In An Alcoholism Genome-Wide Association Study, Arpana Agrawal, Et Al Jan 2012

Multi-Species Data Integration And Gene Ranking Enrich Significant Results In An Alcoholism Genome-Wide Association Study, Arpana Agrawal, Et Al

Open Access Publications

No abstract provided.


Structural Rearrangements Underlying Ligand-Gating In Kir Channels, Shizhen Wang, Sun-Joo Lee, Sarah Heyman, Decha Enkvetchakul, Colin G. Nichols Jan 2012

Structural Rearrangements Underlying Ligand-Gating In Kir Channels, Shizhen Wang, Sun-Joo Lee, Sarah Heyman, Decha Enkvetchakul, Colin G. Nichols

Open Access Publications

No abstract provided.


Development Of A Novel Xenotransplantation Strategy For Treatment Of Diabetes Mellitus In Rat Hosts And Translation To Non-Human Primates, Marc R. Hammerman Jan 2012

Development Of A Novel Xenotransplantation Strategy For Treatment Of Diabetes Mellitus In Rat Hosts And Translation To Non-Human Primates, Marc R. Hammerman

Open Access Publications

No abstract provided.


Integrated Signaling In Developing Lymphocytes: The Role Of Dna Damage Responses, Jeffrey J. Bednarski, Barry P. Sleckman Jan 2012

Integrated Signaling In Developing Lymphocytes: The Role Of Dna Damage Responses, Jeffrey J. Bednarski, Barry P. Sleckman

Open Access Publications

No abstract provided.


Quantitative Brain Electrical Activity In The Initial Screening Of Mild Traumatic Brain Injuries, Brian O'Neil, Leslie S. Prichep, Roseanne Naunhemi, Robert Chabot Jan 2012

Quantitative Brain Electrical Activity In The Initial Screening Of Mild Traumatic Brain Injuries, Brian O'Neil, Leslie S. Prichep, Roseanne Naunhemi, Robert Chabot

Open Access Publications

No abstract provided.


Heart Rate Variability Changes At 2400 M Altitude Predicts Acute Mountain Sickness On Further Ascent At 3000–4300 M Altitudes, Heikki M. Karinen, Arja Uusitalo, Henri Vaha-Ypya, Mika Kahonen, Juha E. Peltonen, Phyllis K. Stein, Jari Viik, Heikki O. Tikkanen Jan 2012

Heart Rate Variability Changes At 2400 M Altitude Predicts Acute Mountain Sickness On Further Ascent At 3000–4300 M Altitudes, Heikki M. Karinen, Arja Uusitalo, Henri Vaha-Ypya, Mika Kahonen, Juha E. Peltonen, Phyllis K. Stein, Jari Viik, Heikki O. Tikkanen

Open Access Publications

No abstract provided.


Fee-For-Service As A Business Model Of Growing Importance: The Academic Biobank Experience, Sandra A. Mcdonald, Kara Sommerkamp, Maureen Egan-Palmer, Karen Kharasch, Victoria Holtschlag Jan 2012

Fee-For-Service As A Business Model Of Growing Importance: The Academic Biobank Experience, Sandra A. Mcdonald, Kara Sommerkamp, Maureen Egan-Palmer, Karen Kharasch, Victoria Holtschlag

Open Access Publications

No abstract provided.


Organization Of Vomeronasal Sensory Coding Revealed By Fast Volumetric Calcium Imaging, Diwakar Turaga, Timothy E. Holy Jan 2012

Organization Of Vomeronasal Sensory Coding Revealed By Fast Volumetric Calcium Imaging, Diwakar Turaga, Timothy E. Holy

Open Access Publications

No abstract provided.


Structural Features Based Genome-Wide Characterization And Prediction Of Nucleosome Organization, Yanglan Gan, Jihong Guan, Shuigeng Zhou, Weixiong Zhang Jan 2012

Structural Features Based Genome-Wide Characterization And Prediction Of Nucleosome Organization, Yanglan Gan, Jihong Guan, Shuigeng Zhou, Weixiong Zhang

Open Access Publications

No abstract provided.


Neural Correlates Of Prior Expectations Of Motion In The Lateral Intraparietal And Middle Temporal Areas, Vinod Rao, Gregory C. Deangelis, Lawrence H. Snyder Jan 2012

Neural Correlates Of Prior Expectations Of Motion In The Lateral Intraparietal And Middle Temporal Areas, Vinod Rao, Gregory C. Deangelis, Lawrence H. Snyder

Open Access Publications

No abstract provided.


Astrocyte-Derived Thrombospondins Mediate The Development Of Hippocampal Presynaptic Plasticity In Vitro, Devon C. Crawford, Xiaoping Jiang, Amanda Taylor, Steven Mennerick Jan 2012

Astrocyte-Derived Thrombospondins Mediate The Development Of Hippocampal Presynaptic Plasticity In Vitro, Devon C. Crawford, Xiaoping Jiang, Amanda Taylor, Steven Mennerick

Open Access Publications

No abstract provided.