Digital Commons Network^™

Wormbase 2014: New Views Of Curated Biology, Tamberlyn Bieri, Philip Ozersky, Tim Schedl, John Spieth, Et Al

Open Access Publications

No abstract provided.

Global Expression Analysis Of The Yeast Lachancea (Saccharomyces) Kluyveri Reveals New Urc Genes Involved In Pyrimidine Catabolism, Anna Andersson Rasmussen, Dineshkumar Kandasamy, Halfdan Beck, Seth D. Crosby, Olof Bjornberg, Klaus D. Schnackerz, Jure Piskur

Open Access Publications

No abstract provided.

The Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is A Potent Allosteric Modulator Of N-Methyl-D-Aspartate Receptors, Steven M. Paul, James J. Doherty, Albert J. Robichaud, Gabriel M. Belfort, Brian Y. Chow, Rebecca S. Hammond, Devon C. Crawford, Andrew J. Linsenbardt, Hong-Jin Shu, Yukitoshi Izumi, Steven J. Mennerick, Charles F. Zorumski

Open Access Publications

No abstract provided.

Structure And Function Of The Smoothened Extracellular Domain In Vertebrate Hedgehog Signaling, Sigrid Nachtergaele, Daniel M. Whalen, Laurel K. Mydock, Zhonghua Zhao, Tomas Malinauskas, Kathiresan Krishnan, Philip W. Ingham, Douglas F. Covey, Christian Siebold, Rajat Rohatgi

Open Access Publications

No abstract provided.

Blackops: Increasing Confidence In Variant Detection Through Mappability Filtering, Christopher R. Cabanski, Matthew D. Wilkerson, Matthew Soloway, Joel S. Parker, Jinze Liu, Jan F. Prins, J S. Marron, Charles M. Perou, D Neil Hayes

Open Access Publications

No abstract provided.

Isolation And Characterization Of The Herpes Simplex Virus 1 Terminase Complex, Jason D. Heming, Jamie B. Huffman, Lisa M. Jones, Fred L. Homa

Open Access Publications

No abstract provided.

Latent Gammaherpesvirus 68 Infection Induces Distinct Transcriptional Changes In Different Organs, Susan P. Canny, Gautam Goel, Tiffany A. Reese, Xin Zhang, Ramnik Xavier, Herbert W. Virgin

Open Access Publications

No abstract provided.

Nuclear Ubiquitination By Fbxl5 Modulates Snail1 Dna Binding And Stability, Rosa Vinas-Castells, Alex Frias, Estefania Robles-Lanuza, Kun Zhang, Gregory D. Longmore, Antonio Garcia De Herreros, Victor M. Diaz

Open Access Publications

No abstract provided.

Estimating Absolute Methylation Levels At Single-Cpg Resolution From Methylation Enrichment And Restriction Enzyme Sequencing Methods, Michael Stevens, Jeffrey B. Cheng, Daofeng Li, Mingchao Xie, Chibo Hong, Cécile L. Maire, Keith L. Ligon, Martin Hirst, Marco A. Marra, Joseph F. Costello, Ting Wang

Open Access Publications

No abstract provided.

Histone Posttranslational Modifications And Cell Fate Determination: Lens Induction Requires The Lysine Acetyltransferases Cbp And P300, Louise Wolf, Wilbur Harrison, Jie Huang, Qing Xie, Ningna Xiao, Jian Sun, Lingkun Kong, Salil A. Lachke, Murali R. Kuracha, Venkatesh Govindarajan, Paul K. Brindle, Ruth Ashery-Padan, David C. Beebe, Paul A. Overbeek, Ales Cvekl

Open Access Publications

No abstract provided.

Bves And Ndrg4 Regulate Directional Epicardial Cell Migration Through Autocrine Extracellular Matrix Deposition, Emily C. Benesh, Paul M. Miller, Elise R. Pfaltzgraff, Nathan E. Grega-Larson, Hillary A. Hager, Bong Hwan Sung, Xianghu Qu, H. Scott Baldwin, Alissa M. Weaver, David M. Bader

Open Access Publications

No abstract provided.

Functional Dna Methylation Differences Between Tissues, Cell Types, And Across Individuals Discovered Using The M&M Algorithm, Bo Zhang, Nan Lin, Rebecca F. Lowdon, Daofeng Lil, Michael Stevens, Hyung Joo Lee, Xiaoyun Xing, Jia Zhou, Vasavi Sundaram, Ginell Elliott, Junchen Gu, Pamela A.F. Madden, Ting Wang, Et Al

Open Access Publications

No abstract provided.

Mapping Functional Transcription Factor Networks From Gene Expression Data, Brian C. Haynes, Ezekiel J. Maier, Michael H. Kramer, Patricia I. Wang, Holly Brown, Michael R. Brent

Open Access Publications

No abstract provided.

The Landscape Of Rna Polymerase Ii Transcription Initiation In C. Elegans Reveals Promoter And Enhancer Architectures, Ron A.-J Chen, Thomas A. Down, Przemyslaw Stempor, Q. Brent Chen, Thea A. Egelhofer, Ladeana W. Hillier, Tess E. Jeffers, Julie Ahringer

Open Access Publications

No abstract provided.

Relationships Among Hiv Infection, Metabolic Risk Factors, And Left Ventricular Structure And Function, William Todd Cade, Edgar Turner Overton, Kristin Mondy, Lisa De Las Fuentes, Victor G. Davila-Roman, Alan D. Waggoner, Dominic N. Reeds, Sherry Lassa-Claxton, Melissa J. Krauss, Linda R. Peterson, Keven E. Yarasheski

Open Access Publications

No abstract provided.

What's New In Orthopaedic Trauma, William M. Ricci, Andre Spiguel, Christopher Mcandrew, Michael Gardner

Open Access Publications

No abstract provided.

Progression Of Foot Deformity In Charcot Neuropathic Osteoarthropathy, Mary K. Hastings, Jeffrey E. Johnson, Michael J. Strube, Charles F. Hildebolt, Kathryn L. Bohnert, Fred W. Prior, David R. Sinacore

Open Access Publications

No abstract provided.

Counting Unstained, Confluent Cells By Modified Bright-Field Microscopy, L. Louis Drey, Michael Graber, Jan Bieschke

Open Access Publications

We present a very simple procedure yielding high-contrast images of adherent, confluent cells such as human neuroblastoma (SH-EP) cells by ordinary bright-field microscopy. Cells are illuminated through a color filter and a pinhole aperture placed between the condenser and the cell culture surface. Refraction by each cell body generates a sharp, bright spot when the image is defocused. The technique allows robust, automatic cell counting from a single bright-field image in a wide range of focal positions using free, readily available image-analysis tools. Contrast may be enhanced by swelling cell bodies with a brief incubation in PBS. The procedure was …

What's New In Spine Surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, Jeffrey C. Wang

Open Access Publications

No abstract provided.

Global Analysis Of Drosophila Cys2-His2 Zinc Finger Proteins Reveals A Multitude Of Novel Recognition Motifs And Binding Determinants, Ryan G. Christensen, Gary D. Stormo, Et Al

Open Access Publications

No abstract provided.

Obesity Is Associated With Poor Surgical Outcome In Crohn's Disease, Talha Malik, Ashish Manne, Robert Oster, Austin Eckhoff, Seidu Inusah, Alexandra M Gutierrez

Open Access Publications

BACKGROUND: Published data suggest a link between obesity and adverse outcomes in Crohn's disease (CD). We aimed to test the hypothesis that obese CD patients would be more likely than non-obese CD patients to have poor surgical outcome when undergoing surgery for a complication of CD.

METHODS: We designed a retrospective cohort study to test our hypothesis. The population comprised of adult CD patients who underwent CD related surgery at a tertiary referral center. The exposed and unexposed cohorts were represented by patients who were obese vs. non-obese at the pre-op visit respectively. Outcome was represented by successful vs. unsuccessful …

Ulnar Collateral Ligament Injuries Of The Thumb: Phalangeal Translation During Valgus Stress In Human Cadavera, Kathleen E. Mckeon, Richard H. Gelberman, Ryan P. Calfee

Open Access Publications

No abstract provided.

Evolutionarily Novel Functional Networks In The Human Brain?, Dante Mantini, Maurizio Corbetta, Gian Luca Romani, Guy A. Orban, Wim Vanduffel

Open Access Publications

Primate evolution has been accompanied by complex reorganizations in brain anatomy and function. Little is known, however, about the relationship between anatomical and functional changes induced through primate evolution. Using functional magnetic resonance imaging, we assessed spatial and temporal correspondences of cortical networks in humans and monkeys. We provided evidence for topologically and functionally correspondent networks in sensory-motor and attention regions. More specifically, we revealed a possible monkey equivalent of the human ventral attention network. For other human networks, such as the language and the default-mode networks, we detected topological correspondent networks in the monkey, but with different functional signatures. …

The Disruption Of Celf6, A Gene Identified By Translational Profiling Of Serotonergic Neurons, Results In Autism-Related Behaviors, Joseph D. Dougherty, Susan E. Maloney, David F. Wozniak, Michael A. Rieger, Lisa Sonnenblick, Giovanni Coppola, Nathaniel G. Mahieu, Juliet Zhang, Jinlu Cai, Gary J. Patti, Brett S. Abrahams, Daniel H. Geschwind, Nathaniel Heintz

Open Access Publications

The immense molecular diversity of neurons challenges our ability to understand the genetic and cellular etiology of neuropsychiatric disorders. Leveraging knowledge from neurobiology may help parse the genetic complexity: identifying genes important for a circuit that mediates a particular symptom of a disease may help identify polymorphisms that contribute to risk for the disease as a whole. The serotonergic system has long been suspected in disorders that have symptoms of repetitive behaviors and resistance to change, including autism. We generated a bacTRAP mouse line to permit translational profiling of serotonergic neurons. From this, we identified several thousand serotonergic-cell expressed transcripts, …

Impulsivity And Self-Control During Intertemporal Decision Making Linked To The Neural Dynamics Of Reward Value Representation, Koji Jimura, Maria S. Chushak, Todd S. Braver

Open Access Publications

A characteristic marker of impulsive decision making is the discounting of delayed rewards, demonstrated via choice preferences and choice-related brain activity. However, delay discounting may also arise from how subjective reward value is dynamically represented in the brain when anticipating an upcoming chosen reward. In the current study, brain activity was continuously monitored as human participants freely selected an immediate or delayed primary liquid reward and then waited for the specified delay before consuming it. The ventromedial prefrontal cortex (vmPFC) exhibited a characteristic pattern of activity dynamics during the delay period, as well as modulation during choice, that is consistent …

Identification Of A Pan-Cancer Oncogenic Microrna Superfamily Anchored By A Central Core Seed Motif, Mark P. Hamilton, Kimal Rajapakshe, Sean M. Hartig, Boris Reva, Michael D. Mclellan, Cyriac Kandoth, Li Ding, Travis I. Zack, Preethi H. Gunaratne, David A. Wheeler, Cristian Coarfa, Sean E. Mcguire

Open Access Publications

No abstract provided.

Observer Ratings Of Neighborhoods: Comparison Of Two Methods, Elena M. Andresen, Theodore K. Malmstrom, Mario Schootman, Fredric D. Wolinsky, J. Philip Miller, Douglas K. Miller

Open Access Publications

No abstract provided.

Genomic And Metabolic Disposition Of Non-Obese Type 2 Diabetic Rats To Increased Myocardial Fatty Acid Metabolism, Sriram Devanathan, Samuel T. Nemanich, Attila Kovacs, Nicole Fettig, Robert J. Gropler, Kooresh I. Shoghi

Open Access Publications

No abstract provided.

Monitoring Of Brain Oxygen Saturation (Invos) In A Protocol To Direct Blood Transfusions During Cardiac Surgery: A Prospective Randomized Clinical Trial, George Vretzakis, Stavroula Georgopoulou, Konstantinos Stamoulis, Vassilios Tassoudis, Dimitrios Mikroulis, Athanasios Giannoukas, Nikolaos Tsilimingas, Menelaos Karanikolas

Open Access Publications

No abstract provided.

Candidate Genes That May Be Responsible For The Unusual Resistances Exhibited By Bacillus Pumilus Safr-032 Spores, Madhan R. Tirumalai, Rajat Rastogi, Nader Zamani, Elisha O'Bryant Williams, Shamail Allen, Fatma Diouf, Sharon Kwende, George M. Weinstock, Kasthuri J. Venkateswaran, George E. Fox

Open Access Publications

No abstract provided.