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Articles 2221 - 2250 of 3983
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Computational Analysis Reveals A Key Regulator Of Cryptococcal Virulence And Determinant Of Host Response, Stacey R. Gish, Ezekiel J. Maier, Brian C. Haynes, Felipe H. Santiago-Tirado, Deepa L. Srikanta, Cynthia Z. Ma, Lucy X. Li, Matthew Williams, Erika C. Crouch, Shabaana A. Khader, Michael R. Brent, Tamara L. Doering
Computational Analysis Reveals A Key Regulator Of Cryptococcal Virulence And Determinant Of Host Response, Stacey R. Gish, Ezekiel J. Maier, Brian C. Haynes, Felipe H. Santiago-Tirado, Deepa L. Srikanta, Cynthia Z. Ma, Lucy X. Li, Matthew Williams, Erika C. Crouch, Shabaana A. Khader, Michael R. Brent, Tamara L. Doering
Open Access Publications
No abstract provided.
Modeling Reactivity To Biological Macromolecules With A Deep Multitask Network, Tyler B. Hughes, Na Le Dang, Grover P. Miller, S. Joshua Swamidass
Modeling Reactivity To Biological Macromolecules With A Deep Multitask Network, Tyler B. Hughes, Na Le Dang, Grover P. Miller, S. Joshua Swamidass
Open Access Publications
No abstract provided.
Commissioning And Initial Experience With The First Clinical Gantry-Mounted Proton Therapy System, Tianyu Zhao, Baozhou Sun, Kevin Grantham, Leith Rankine, Bin Cai, Sreekrishna M. Goddu, Lakshmi Santanam, Nels Knutson, Tiezhi Zhang, Michael Reilly, Beth Bottani, Jeffrey Bradley, Sasa Mutic, Eric E. Klein
Commissioning And Initial Experience With The First Clinical Gantry-Mounted Proton Therapy System, Tianyu Zhao, Baozhou Sun, Kevin Grantham, Leith Rankine, Bin Cai, Sreekrishna M. Goddu, Lakshmi Santanam, Nels Knutson, Tiezhi Zhang, Michael Reilly, Beth Bottani, Jeffrey Bradley, Sasa Mutic, Eric E. Klein
Open Access Publications
No abstract provided.
The Fallacy Of Univariate Solutions To Complex Systems Problems, Christina N. Lessov-Schlaggar, Joshua B. Rubin, Bradley L. Schlaggar
The Fallacy Of Univariate Solutions To Complex Systems Problems, Christina N. Lessov-Schlaggar, Joshua B. Rubin, Bradley L. Schlaggar
Open Access Publications
No abstract provided.
Evaluation Of The Vitek Ms Matrix-Assisted Laser Desorption Ionization–Time Of Flight Mass Spectrometry System For Identification Of Clinically Relevant Filamentous Fungi, Allison R. Mcmullen, Meghan A. Wallace, David H. Pincus, Kathy Wilkey, Carey-Ann Burnham
Evaluation Of The Vitek Ms Matrix-Assisted Laser Desorption Ionization–Time Of Flight Mass Spectrometry System For Identification Of Clinically Relevant Filamentous Fungi, Allison R. Mcmullen, Meghan A. Wallace, David H. Pincus, Kathy Wilkey, Carey-Ann Burnham
Open Access Publications
No abstract provided.
Proficient Replication Of The Yeast Genome By A Viral Dna Polymerase, Joseph L. Stodola, Carrie M. Stith, Peter M. Burgers
Proficient Replication Of The Yeast Genome By A Viral Dna Polymerase, Joseph L. Stodola, Carrie M. Stith, Peter M. Burgers
Open Access Publications
No abstract provided.
Emerging Executive Functioning And Motor Development In Infants At High And Low Risk For Autism Spectrum Disorder, Tanya St. John, Annette M. Estes, Stephen R. Dager, Penelope Kostopoulos, Jason J. Wolff, Juhi Pandey, Jed T. Elison, Sarah J. Paterson, Robert T. Schultz, Kelly Botteron, Heather Hazlett, Joseph Piven
Emerging Executive Functioning And Motor Development In Infants At High And Low Risk For Autism Spectrum Disorder, Tanya St. John, Annette M. Estes, Stephen R. Dager, Penelope Kostopoulos, Jason J. Wolff, Juhi Pandey, Jed T. Elison, Sarah J. Paterson, Robert T. Schultz, Kelly Botteron, Heather Hazlett, Joseph Piven
Open Access Publications
No abstract provided.
Mice With Missense And Nonsense Nf1 Mutations Display Divergent Phenotypes Compared With Human Neurofibromatosis Type I, Kairong Li, Ashley N. Turner, Min Chen, Stephanie N. Brosius, Trenton R. Schoeb, Ludwine M. Messiaen, David M. Bedwell, Kurt R. Zinn, Corina Anastasaki, David H. Gutmann, Bruce R. Korf, Robert A. Kesterson
Mice With Missense And Nonsense Nf1 Mutations Display Divergent Phenotypes Compared With Human Neurofibromatosis Type I, Kairong Li, Ashley N. Turner, Min Chen, Stephanie N. Brosius, Trenton R. Schoeb, Ludwine M. Messiaen, David M. Bedwell, Kurt R. Zinn, Corina Anastasaki, David H. Gutmann, Bruce R. Korf, Robert A. Kesterson
Open Access Publications
No abstract provided.
A Software Tool To Automatically Assure And Report Daily Treatment Deliveries By A Cobalt-60 Radiation Therapy Device, Deshan Yang, H. Omar Wooten, Olga Green, Harold H. Li, Shi Liu, Xiaoling Li, Vivian Rodriguez, Sasa Mutic, Rojano Kashani
A Software Tool To Automatically Assure And Report Daily Treatment Deliveries By A Cobalt-60 Radiation Therapy Device, Deshan Yang, H. Omar Wooten, Olga Green, Harold H. Li, Shi Liu, Xiaoling Li, Vivian Rodriguez, Sasa Mutic, Rojano Kashani
Open Access Publications
No abstract provided.
Oxidative Dna Damage Stalls The Human Mitochondrial Replisome, Gorazd Stojkovič, Alena V. Makarova, Paulina H. Wanrooij, Josefin Forslund, Peter M. Burgers, Sjoerd Wanrooij
Oxidative Dna Damage Stalls The Human Mitochondrial Replisome, Gorazd Stojkovič, Alena V. Makarova, Paulina H. Wanrooij, Josefin Forslund, Peter M. Burgers, Sjoerd Wanrooij
Open Access Publications
No abstract provided.
Whole Genome Sequencing For Genomics-Guided Investigations Of Escherichia Coli O157:H7 Outbreaks, Brigida Rusconi, Fatemeh Sanjar, Sara S.K. Koenig, Mark K. Mammel, Phillip I. Tarr, Mark Eppinger
Whole Genome Sequencing For Genomics-Guided Investigations Of Escherichia Coli O157:H7 Outbreaks, Brigida Rusconi, Fatemeh Sanjar, Sara S.K. Koenig, Mark K. Mammel, Phillip I. Tarr, Mark Eppinger
Open Access Publications
No abstract provided.
Metabolic Alterations In Children With Environmental Enteric Dysfunction, Richard D. Semba, Michelle Shardell, Indi Trehan, Ruin Moaddel, Kenneth M. Maleta, M. Isabel Ordiz, Klaus Kraemer, Mohammed Khadeer, Luigi Ferrucci, Mark J. Manary
Metabolic Alterations In Children With Environmental Enteric Dysfunction, Richard D. Semba, Michelle Shardell, Indi Trehan, Ruin Moaddel, Kenneth M. Maleta, M. Isabel Ordiz, Klaus Kraemer, Mohammed Khadeer, Luigi Ferrucci, Mark J. Manary
Open Access Publications
No abstract provided.
Cartilage-Specific Knockout Of The Mechanosensory Ion Channel Trpv4 Decreases Age-Related Osteoarthritis, Christopher J. O'Conor, Sendhilnathan Ramalingam, Nicole A. Zelenski, Halei C. Benefield, Isaura Rigo, Dianne Little, Chia-Lung Wu, Di Chen, Wolfgang Liedtke, Amy L. Mcnulty, Farshid Guilak
Cartilage-Specific Knockout Of The Mechanosensory Ion Channel Trpv4 Decreases Age-Related Osteoarthritis, Christopher J. O'Conor, Sendhilnathan Ramalingam, Nicole A. Zelenski, Halei C. Benefield, Isaura Rigo, Dianne Little, Chia-Lung Wu, Di Chen, Wolfgang Liedtke, Amy L. Mcnulty, Farshid Guilak
Open Access Publications
No abstract provided.
Marrow Adipose Tissue Expansion Coincides With Insulin Resistance In Magp1-Deficient Mice, Tezin A. Walji, Sarah E. Turecamo, Alejandro Coca Sanchez, Bryan A. Anthony, Grazia Abou-Ezzi, Erica L. Scheller, Daniel C. Link, Robert P. Mecham, Clarissa S. Craft
Marrow Adipose Tissue Expansion Coincides With Insulin Resistance In Magp1-Deficient Mice, Tezin A. Walji, Sarah E. Turecamo, Alejandro Coca Sanchez, Bryan A. Anthony, Grazia Abou-Ezzi, Erica L. Scheller, Daniel C. Link, Robert P. Mecham, Clarissa S. Craft
Open Access Publications
No abstract provided.
Video Capsule Endoscopy In Left Ventricular Assist Device Recipients With Obscure Gastrointestinal Bleeding, Surachai Amornsawadwattana, Michael Nassif, David Raymer, Shane Larue, Chien-Huan Chen
Video Capsule Endoscopy In Left Ventricular Assist Device Recipients With Obscure Gastrointestinal Bleeding, Surachai Amornsawadwattana, Michael Nassif, David Raymer, Shane Larue, Chien-Huan Chen
Open Access Publications
No abstract provided.
Activity Level And Severity Of Dysplasia Predict Age At Bernese Periacetabular Osteotomy For Symptomatic Hip Dysplasia, Travis Matheney, Ira Zaltz, Young-Jo Kim, Perry Schoenecker, Michael Millis, David Podeszwa, David Zurakowski, Paul Beaule, John Clohisy
Activity Level And Severity Of Dysplasia Predict Age At Bernese Periacetabular Osteotomy For Symptomatic Hip Dysplasia, Travis Matheney, Ira Zaltz, Young-Jo Kim, Perry Schoenecker, Michael Millis, David Podeszwa, David Zurakowski, Paul Beaule, John Clohisy
Open Access Publications
No abstract provided.
Personality Polygenes, Positive Affect, And Life Satisfaction, Andrew C. Heath, Et Al
Personality Polygenes, Positive Affect, And Life Satisfaction, Andrew C. Heath, Et Al
Open Access Publications
No abstract provided.
Structural Basis Of Control Of Inward Rectifier Kir2 Channel Gating By Bulk Anionic Phospholipids, Sun-Joo Lee, Feifei Ren, Eva-Maria Zangerl-Plessl, Sarah Heyman, Anna Stary-Weinzinger, Peng Yuan, Colin G. Nichols
Structural Basis Of Control Of Inward Rectifier Kir2 Channel Gating By Bulk Anionic Phospholipids, Sun-Joo Lee, Feifei Ren, Eva-Maria Zangerl-Plessl, Sarah Heyman, Anna Stary-Weinzinger, Peng Yuan, Colin G. Nichols
Open Access Publications
No abstract provided.
Protocol For The Electroencephalography Guidance Of Anesthesia To Alleviate Geriatric Syndromes (Engages) Study: A Pragmatic, Randomised Clinical Trial, T. S. Wildes, A. C. Winter, H. R. Maybrier, A. M. Mickle, E. J. Lenze, S. Stark, N. Lin, S. L. Mckinnon, M. R. Muench, M. R. Murphy, R. T. Upadhyayula, B. A. Fritz, K. E. Escallier, G. P. Apakama, D. A. Emmert, T. J. Graetz, T. W. Stevens, B. J. Palanca, R. Hueneke, S. Melby, B. Torres, M. S. Avidan, Et Al
Protocol For The Electroencephalography Guidance Of Anesthesia To Alleviate Geriatric Syndromes (Engages) Study: A Pragmatic, Randomised Clinical Trial, T. S. Wildes, A. C. Winter, H. R. Maybrier, A. M. Mickle, E. J. Lenze, S. Stark, N. Lin, S. L. Mckinnon, M. R. Muench, M. R. Murphy, R. T. Upadhyayula, B. A. Fritz, K. E. Escallier, G. P. Apakama, D. A. Emmert, T. J. Graetz, T. W. Stevens, B. J. Palanca, R. Hueneke, S. Melby, B. Torres, M. S. Avidan, Et Al
Open Access Publications
No abstract provided.
Short-Wavelength Light-Blocking Eyeglasses Attenuate Symptoms Of Eye Fatigue, Jonathan B. Lin, Blair W. Gerratt, Carl J. Bassi, Rajendra S. Apte
Short-Wavelength Light-Blocking Eyeglasses Attenuate Symptoms Of Eye Fatigue, Jonathan B. Lin, Blair W. Gerratt, Carl J. Bassi, Rajendra S. Apte
Open Access Publications
No abstract provided.
Maternal Glucose And Fatty Acid Kinetics And Infant Birth Weight In Obese Women With Type 2 Diabetes, W. Todd Cade, Rachel A. Tinius, Dominic N. Reeds, Bruce W. Patterson, Alison G. Cahill
Maternal Glucose And Fatty Acid Kinetics And Infant Birth Weight In Obese Women With Type 2 Diabetes, W. Todd Cade, Rachel A. Tinius, Dominic N. Reeds, Bruce W. Patterson, Alison G. Cahill
Open Access Publications
No abstract provided.
Propagated Infra-Slow Intrinsic Brain Activity Reorganizes Across Wake And Slow Wave Sleep, Anish Mitra, Abraham Z. Snyder, Enzo Tagliazucchi, Helmut Laufs, Marcus E. Raichle
Propagated Infra-Slow Intrinsic Brain Activity Reorganizes Across Wake And Slow Wave Sleep, Anish Mitra, Abraham Z. Snyder, Enzo Tagliazucchi, Helmut Laufs, Marcus E. Raichle
Open Access Publications
Propagation of slow intrinsic brain activity has been widely observed in electrophysiogical studies of slow wave sleep (SWS). However, in human resting state fMRI (rs-fMRI), intrinsic activity has been understood predominantly in terms of zero-lag temporal synchrony (functional connectivity) within systems known as resting state networks (RSNs). Prior rs-fMRI studies have found that RSNs are generally preserved across wake and sleep. Here, we use a recently developed analysis technique to study propagation of infra-slow intrinsic blood oxygen level dependent (BOLD) signals in normal adults during wake and SWS. This analysis reveals marked changes in propagation patterns in SWS vs. wake. …
Abnormal White Matter Blood-Oxygen-Level-Dependent Signals In Chronic Mild Traumatic Brain Injury, Serguei V. Astafiev, Gordon L. Shulman, Nicholas V. Metcalf, Jennifer Rengachary, Christine L. Macdonald, Deborah L. Harrington, Jun Maruta, Joshua S. Shimony, Jamshid Ghajar, Mithun Diwakar, Ming-Xiong Huang, Roland R. Lee, Maurizio Corbetta
Abnormal White Matter Blood-Oxygen-Level-Dependent Signals In Chronic Mild Traumatic Brain Injury, Serguei V. Astafiev, Gordon L. Shulman, Nicholas V. Metcalf, Jennifer Rengachary, Christine L. Macdonald, Deborah L. Harrington, Jun Maruta, Joshua S. Shimony, Jamshid Ghajar, Mithun Diwakar, Ming-Xiong Huang, Roland R. Lee, Maurizio Corbetta
Open Access Publications
No abstract provided.
Mechanism-Based Combination Treatment Dramatically Increases Therapeutic Efficacy In Murine Globoid Cell Leukodystrophy, Jacqueline A. Hawkins-Salsbury, Lauren Shea, Xuntian Jiang, Daniel A. Hunter, A Miguel Guzman, Adarsh S. Reddy, Elizabeth Y. Qin, Yedda Li, Steven J. Gray, Daniel S. Ory, Mark S. Sands
Mechanism-Based Combination Treatment Dramatically Increases Therapeutic Efficacy In Murine Globoid Cell Leukodystrophy, Jacqueline A. Hawkins-Salsbury, Lauren Shea, Xuntian Jiang, Daniel A. Hunter, A Miguel Guzman, Adarsh S. Reddy, Elizabeth Y. Qin, Yedda Li, Steven J. Gray, Daniel S. Ory, Mark S. Sands
Open Access Publications
Globoid cell leukodystrophy (GLD, Krabbe disease) is a lysosomal storage disease (LSD) caused by a deficiency in galactocerebrosidase (GALC) activity. In the absence of GALC activity, the cytotoxic lipid, galactosylsphingosine (psychosine), accumulates in the CNS and peripheral nervous system. Oligodendrocytes and Schwann cells are particularly sensitive to psychosine, thus leading to a demyelinating phenotype. Although hematopoietic stem-cell transplantation provides modest benefit in both presymptomatic children and the murine model (Twitcher), there is no cure for GLD. In addition, GLD has been relatively refractory to virtually every experimental therapy attempted. Here, Twitcher mice were simultaneously treated with CNS-directed gene therapy, substrate …
Adamtsl2 Deletion Results In Bronchial Fibrillin Microfibril Accumulation And Bronchial Epithelial Dysplasia: A Novel Mouse Model Providing Insights On Geleophysic Dysplasia, Dirk Hubmacher, Lauren W. Wang, Robert P. Mecham, Dieter P. Reinhardt, Suneel S. Apte
Adamtsl2 Deletion Results In Bronchial Fibrillin Microfibril Accumulation And Bronchial Epithelial Dysplasia: A Novel Mouse Model Providing Insights On Geleophysic Dysplasia, Dirk Hubmacher, Lauren W. Wang, Robert P. Mecham, Dieter P. Reinhardt, Suneel S. Apte
Open Access Publications
No abstract provided.
Uni-Directional Ciliary Membrane Protein Trafficking By A Cytoplasmic Retrograde Ift Motor And Ciliary Ectosome Shedding, Muqing Cao, Jue Ning, Carmen I. Hernandez-Lara, Olivier Belzile, Qian Wang, Susan K. Dutcher, Yanjie Liu, William J. Snell
Uni-Directional Ciliary Membrane Protein Trafficking By A Cytoplasmic Retrograde Ift Motor And Ciliary Ectosome Shedding, Muqing Cao, Jue Ning, Carmen I. Hernandez-Lara, Olivier Belzile, Qian Wang, Susan K. Dutcher, Yanjie Liu, William J. Snell
Open Access Publications
The role of the primary cilium in key signaling pathways depends on dynamic regulation of ciliary membrane protein composition, yet we know little about the motors or membrane events that regulate ciliary membrane protein trafficking in existing organelles. Recently, we showed that cilium-generated signaling in Chlamydomonas induced rapid, anterograde IFT-independent, cytoplasmic microtubule-dependent redistribution of the membrane polypeptide, SAG1-C65, from the plasma membrane to the periciliary region and the ciliary membrane. Here, we report that the retrograde IFT motor, cytoplasmic dynein 1b, is required in the cytoplasm for this rapid redistribution. Furthermore, signaling-induced trafficking of SAG1-C65 into cilia is unidirectional and …
Dorsal Inlay Buccal Mucosal Graft (Asopa) Urethroplasty For Anterior Urethral Stricture, Stephen D. Marshall, Valary T. Raup, Steven B. Brandes
Dorsal Inlay Buccal Mucosal Graft (Asopa) Urethroplasty For Anterior Urethral Stricture, Stephen D. Marshall, Valary T. Raup, Steven B. Brandes
Open Access Publications
Asopa described the inlay of a graft into Snodgrass's longitudinal urethral plate incision using a ventral sagittal urethrotomy approach in 2001. He claimed that this technique was easier to perform and led to less tissue ischemia due to no need for mobilization of the urethra. This approach has subsequently been popularized among reconstructive urologists as the dorsal inlay urethroplasty or Asopa technique. Depending on the location of the stricture, either a subcoronal circumferential incision is made for penile strictures, or a midline perineal incision is made for bulbar strictures. Other approaches for penile urethral strictures include the non-circumferential penile incisional …
Selective Cognitive And Psychiatric Manifestations In Wolfram Syndrome, Allison N. Bischoff, Angela M. Reiersen, Anna Buttlaire, Amal Al-Lozi, Tasha Doty, Bess A. Marshall, Tamara Hershey, Washington University Wolfram Syndrome Research Group
Selective Cognitive And Psychiatric Manifestations In Wolfram Syndrome, Allison N. Bischoff, Angela M. Reiersen, Anna Buttlaire, Amal Al-Lozi, Tasha Doty, Bess A. Marshall, Tamara Hershey, Washington University Wolfram Syndrome Research Group
Open Access Publications
No abstract provided.
Tyk2 Protein-Coding Variants Protect Against Rheumatoid Arthritis And Autoimmunity, With No Evidence Of Major Pleiotropic Effects On Non-Autoimmune Complex Traits, Robert S. Fulton, David E. Larson, Tracie L. Deluca, Michelle O'Laughlin, Catrina C. Fronick, Lucinda L. Fulton, Elaine R. Mardis, Et Al
Tyk2 Protein-Coding Variants Protect Against Rheumatoid Arthritis And Autoimmunity, With No Evidence Of Major Pleiotropic Effects On Non-Autoimmune Complex Traits, Robert S. Fulton, David E. Larson, Tracie L. Deluca, Michelle O'Laughlin, Catrina C. Fronick, Lucinda L. Fulton, Elaine R. Mardis, Et Al
Open Access Publications
No abstract provided.
Visual Learning Induces Changes In Resting-State Fmri Multivariate Pattern Of Information, Roberto Guidotti, Cosimo Del Gratta, Antonello Baldassarre, Gian Luca Romani, Maurizio Corbetta
Visual Learning Induces Changes In Resting-State Fmri Multivariate Pattern Of Information, Roberto Guidotti, Cosimo Del Gratta, Antonello Baldassarre, Gian Luca Romani, Maurizio Corbetta
Open Access Publications
No abstract provided.