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Articles 421 - 450 of 4253
Full-Text Articles in Entire DC Network
Label-Free Macroscopic Fluorescence Lifetime Imaging Of Brain Tumors, Maria Lukina, Konstantin Yashin, Elena E Kiseleva, Anna Alekseeva, Varvara Dudenkova, Elena V Zagaynova, Evgenia Bederina, Igor Medyanic, Wolfgang Becker, Deependra Mishra, Mikhail Berezin, Vladislav I Shcheslavskiy, Marina Shirmanova
Label-Free Macroscopic Fluorescence Lifetime Imaging Of Brain Tumors, Maria Lukina, Konstantin Yashin, Elena E Kiseleva, Anna Alekseeva, Varvara Dudenkova, Elena V Zagaynova, Evgenia Bederina, Igor Medyanic, Wolfgang Becker, Deependra Mishra, Mikhail Berezin, Vladislav I Shcheslavskiy, Marina Shirmanova
Open Access Publications
Advanced stage glioma is the most aggressive form of malignant brain tumors with a short survival time. Real-time pathology assisted, or image guided surgical procedures that eliminate tumors promise to improve the clinical outcome and prolong the lives of patients. Our work is focused on the development of a rapid and sensitive assay for intraoperative diagnostics of glioma and identification of optical markers essential for differentiation between tumors and healthy brain tissues. We utilized fluorescence lifetime imaging (FLIM) of endogenous fluorophores related to metabolism of the glioma from freshly excised brains tissues. Macroscopic time-resolved fluorescence images of three intracranial animal …
Pleiotropic Effects Between Cardiovascular Disease Risk Factors And Measures Of Cognitive And Physical Function In Long‑Lived Adults, Julia J. Yudkovicz, Ryan L. Minster, Emma Barinas-Mitchell, Kaare Christensen, Mary Feitosa, Megan S. Barker, Anne B. Newman, Allison L. Kuipers
Pleiotropic Effects Between Cardiovascular Disease Risk Factors And Measures Of Cognitive And Physical Function In Long‑Lived Adults, Julia J. Yudkovicz, Ryan L. Minster, Emma Barinas-Mitchell, Kaare Christensen, Mary Feitosa, Megan S. Barker, Anne B. Newman, Allison L. Kuipers
Open Access Publications
No abstract provided.
Boosting And Lassoing New Prostate Cancer Snp Risk Factors And Their Connection To Selenium, David E. Booth, Venugopal Gopalakrishna-Remani, Matthew L. Cooper, Fiona R. Green, Margaret P. Rayman
Boosting And Lassoing New Prostate Cancer Snp Risk Factors And Their Connection To Selenium, David E. Booth, Venugopal Gopalakrishna-Remani, Matthew L. Cooper, Fiona R. Green, Margaret P. Rayman
Open Access Publications
No abstract provided.
Loss Of Snora73 Reprograms Cellular Metabolism And Protects Against Steatohepatitis, Arthur C. Sletten, Jessica W. Davidson, Busra Yagabasan, Samantha Moores, Michaela Schwaiger-Haber, Hideji Fujiwara, Sarah Gale, Xuntian Jiang, Rohini Sidhu, Susan Gelman, Shuang Zhao, Gary Patti, Daniel S. Ory, Jean E. Schaffer
Loss Of Snora73 Reprograms Cellular Metabolism And Protects Against Steatohepatitis, Arthur C. Sletten, Jessica W. Davidson, Busra Yagabasan, Samantha Moores, Michaela Schwaiger-Haber, Hideji Fujiwara, Sarah Gale, Xuntian Jiang, Rohini Sidhu, Susan Gelman, Shuang Zhao, Gary Patti, Daniel S. Ory, Jean E. Schaffer
Open Access Publications
No abstract provided.
Striatal Oxidative Damages And Neuroinflammation Correlate With Progression And Survival Of Lewy Body And Alzheimer Diseases, Huifangjie Li, William C. Knight, Jinbin Xu
Striatal Oxidative Damages And Neuroinflammation Correlate With Progression And Survival Of Lewy Body And Alzheimer Diseases, Huifangjie Li, William C. Knight, Jinbin Xu
Open Access Publications
No abstract provided.
Brown Adipose Tissue Monocytes Support Tissue Expansion, Alexandre Gallerand, Hannah P. Luehmann, Deborah H. Sultan, Yongjian Liu, Et Al
Brown Adipose Tissue Monocytes Support Tissue Expansion, Alexandre Gallerand, Hannah P. Luehmann, Deborah H. Sultan, Yongjian Liu, Et Al
Open Access Publications
No abstract provided.
Statistical Guidelines For Handling Missing Data In Traumatic Brain Injury Clinical Research, Jessica L. Nielson, Shelly R. Cooper, Seth A. Seabury, Davide Luciani, Anthony Fabio, Nancy R. Temkin, Adam R. Ferguson, Track-Tbi Investigators
Statistical Guidelines For Handling Missing Data In Traumatic Brain Injury Clinical Research, Jessica L. Nielson, Shelly R. Cooper, Seth A. Seabury, Davide Luciani, Anthony Fabio, Nancy R. Temkin, Adam R. Ferguson, Track-Tbi Investigators
Open Access Publications
No abstract provided.
Joint Degeneration In A Mouse Model Of Pseudoachondroplasia: Er Stress, Inflammation, And Block Of Autophagy, Jacqueline T Hecht, Alka C Veerisetty, Mohammad G Hossain, Debabrata Patra, Frankie Chiu, Francoise Coustry, Karen L Posey
Joint Degeneration In A Mouse Model Of Pseudoachondroplasia: Er Stress, Inflammation, And Block Of Autophagy, Jacqueline T Hecht, Alka C Veerisetty, Mohammad G Hossain, Debabrata Patra, Frankie Chiu, Francoise Coustry, Karen L Posey
Open Access Publications
Pseudoachondroplasia (PSACH), a short limb skeletal dysplasia associated with premature joint degeneration, is caused by misfolding mutations in cartilage oligomeric matrix protein (COMP). Here, we define mutant-COMP-induced stress mechanisms that occur in articular chondrocytes of MT-COMP mice, a murine model of PSACH. The accumulation of mutant-COMP in the ER occurred early in MT-COMP articular chondrocytes and stimulated inflammation (TNFα) at 4 weeks, and articular chondrocyte death increased at 8 weeks while ER stress through CHOP was elevated by 12 weeks. Importantly, blockage of autophagy (pS6), the major mechanism that clears the ER, sustained cellular stress in MT-COMP articular chondrocytes. Degeneration …
A Genome-Engineered Bioartificial Implant For Autoregulated Anticytokine Drug Delivery, Yun-Rak Choi, Kelsey H Collins, Luke E Springer, Lara Pferdehirt, Alison K Ross, Chia-Lung Wu, Franklin T Moutos, Natalia S Harasymowicz, Jonathan M Brunger, Christine T N Pham, Farshid Guilak
A Genome-Engineered Bioartificial Implant For Autoregulated Anticytokine Drug Delivery, Yun-Rak Choi, Kelsey H Collins, Luke E Springer, Lara Pferdehirt, Alison K Ross, Chia-Lung Wu, Franklin T Moutos, Natalia S Harasymowicz, Jonathan M Brunger, Christine T N Pham, Farshid Guilak
Open Access Publications
[Figure: see text].
Sustained Oxygenation Accelerates Diabetic Wound Healing By Promoting Epithelialization And Angiogenesis And Decreasing Inflammation, Ya Guan, Hong Niu, Zhongting Liu, Yu Dang, Jie Shen, Mohamed Zayed, Liang Ma, Jianjun Guan
Sustained Oxygenation Accelerates Diabetic Wound Healing By Promoting Epithelialization And Angiogenesis And Decreasing Inflammation, Ya Guan, Hong Niu, Zhongting Liu, Yu Dang, Jie Shen, Mohamed Zayed, Liang Ma, Jianjun Guan
Open Access Publications
Nonhealing diabetic wounds are common complications for diabetic patients. Because chronic hypoxia prominently delays wound healing, sustained oxygenation to alleviate hypoxia is hypothesized to promote diabetic wound healing. However, sustained oxygenation cannot be achieved by current clinical approaches, including hyperbaric oxygen therapy. Here, we present a sustained oxygenation system consisting of oxygen-release microspheres and a reactive oxygen species (ROS)-scavenging hydrogel. The hydrogel captures the naturally elevated ROS in diabetic wounds, which may be further elevated by the oxygen released from the administered microspheres. The sustained release of oxygen augmented the survival and migration of keratinocytes and dermal fibroblasts, promoted angiogenic …
Genetic And Biochemical Characterization Of The Na+/H+ Antiporters Of Pseudomonas Aeruginosa, Sara Foreman, Kristina Ferrara, Teri N Hreha, Ana E Duran-Pinedo, Jorge Frias-Lopez, Blanca Barquera
Genetic And Biochemical Characterization Of The Na+/H+ Antiporters Of Pseudomonas Aeruginosa, Sara Foreman, Kristina Ferrara, Teri N Hreha, Ana E Duran-Pinedo, Jorge Frias-Lopez, Blanca Barquera
Open Access Publications
Pseudomonas aeruginosa has four Na
Glial-Specific Deletion Of Med12 Results In Rapid Hearing Loss Via Degradation Of The Stria Vascularis, Teng-Wei Huang, Amrita A. Iyer, Jeanne M. Manalo, Junsung Woo, Navish A. Bosquez Huerta, Melissa M. Mcgovern, Heinrich Schrewe, Fredrick A. Pereira, Andrew K. Groves, Kevin K. Ohlemiller, Benjamin Deneen
Glial-Specific Deletion Of Med12 Results In Rapid Hearing Loss Via Degradation Of The Stria Vascularis, Teng-Wei Huang, Amrita A. Iyer, Jeanne M. Manalo, Junsung Woo, Navish A. Bosquez Huerta, Melissa M. Mcgovern, Heinrich Schrewe, Fredrick A. Pereira, Andrew K. Groves, Kevin K. Ohlemiller, Benjamin Deneen
Open Access Publications
Mediator protein complex subunit 12 (Med12) is a core component of the basal transcriptional apparatus and plays a critical role in the development of many tissues. Mutations in Med12 are associated with X-linked intellectual disability syndromes and hearing loss; however, its role in nervous system function remains undefined. Here, we show that temporal conditional deletion of Med12 in astrocytes in the adult CNS results in region-specific alterations in astrocyte morphology. Surprisingly, behavioral studies revealed rapid hearing loss after adult deletion of Med12 that was confirmed by a complete abrogation of auditory brainstem responses. Cellular analysis of the cochlea revealed degeneration …
Hif1Α Is Required For Nk Cell Metabolic Adaptation During Virus Infection, Francisco Victorino, Tarin M. Bigley, Eugene Park, Cong-Hui Yao, Jeanne Benoit, Li-Ping Yang, Sytse J. Piersma, Elvin J. Lauron, Rebecca M. Davidson, Gary J. Patti, Wayne M. Yokoyama
Hif1Α Is Required For Nk Cell Metabolic Adaptation During Virus Infection, Francisco Victorino, Tarin M. Bigley, Eugene Park, Cong-Hui Yao, Jeanne Benoit, Li-Ping Yang, Sytse J. Piersma, Elvin J. Lauron, Rebecca M. Davidson, Gary J. Patti, Wayne M. Yokoyama
Open Access Publications
Natural killer (NK) cells are essential for early protection against virus infection and must metabolically adapt to the energy demands of activation. Here, we found upregulation of the metabolic adaptor hypoxia-inducible factor-1α (HIF1α) is a feature of mouse NK cells during murine cytomegalovirus (MCMV) infection in vivo. HIF1α-deficient NK cells failed to control viral load, causing increased morbidity. No defects were found in effector functions of HIF1αKO NK cells; however, their numbers were significantly reduced. Loss of HIF1α did not affect NK cell proliferation during in vivo infection and in vitro cytokine stimulation. Instead, we found that HIF1α-deficient NK cells …
Dynamically Linking Influenza Virus Infection Kinetics, Lung Injury, Inflammation, And Disease Severity, Margaret A. Myers, Amanda P. Smith, Lindey C. Lane, David J. Moquin, Rosemary Aogo, Stacie Woolard, Paul Thomas, Peter Vogel, Amber M. Smith
Dynamically Linking Influenza Virus Infection Kinetics, Lung Injury, Inflammation, And Disease Severity, Margaret A. Myers, Amanda P. Smith, Lindey C. Lane, David J. Moquin, Rosemary Aogo, Stacie Woolard, Paul Thomas, Peter Vogel, Amber M. Smith
Open Access Publications
Influenza viruses cause a significant amount of morbidity and mortality. Understanding host immune control efficacy and how different factors influence lung injury and disease severity are critical. We established and validated dynamical connections between viral loads, infected cells, CD8
Contemporary Clinical Isolates Of Staphylococcus Aureus From Pediatric Osteomyelitis Patients Display Unique Characteristics In A Mouse Model Of Hematogenous Osteomyelitis, Philip M. Roper, Kara R. Eichelberger, Linda Cox, Luke O'Connor, Christine Shao, Caleb A. Ford, Stephanie A. Fritz, James E. Cassat, Deborah J. Veis
Contemporary Clinical Isolates Of Staphylococcus Aureus From Pediatric Osteomyelitis Patients Display Unique Characteristics In A Mouse Model Of Hematogenous Osteomyelitis, Philip M. Roper, Kara R. Eichelberger, Linda Cox, Luke O'Connor, Christine Shao, Caleb A. Ford, Stephanie A. Fritz, James E. Cassat, Deborah J. Veis
Open Access Publications
No abstract provided.
Cognitive Dysfunction After Analgesia And Sedation: Out Of The Operating Room And Into The Pediatric Intensive Care Unit, Ashley D Turner, Travis Sullivan, Kurt Drury, Trevor A Hall, Cydni N Williams, Kristin P Guilliams, Sarah Murphy, A M Iqbal O'Meara
Cognitive Dysfunction After Analgesia And Sedation: Out Of The Operating Room And Into The Pediatric Intensive Care Unit, Ashley D Turner, Travis Sullivan, Kurt Drury, Trevor A Hall, Cydni N Williams, Kristin P Guilliams, Sarah Murphy, A M Iqbal O'Meara
Open Access Publications
In the midst of concerns for potential neurodevelopmental effects after surgical anesthesia, there is a growing awareness that children who require sedation during critical illness are susceptible to neurologic dysfunctions collectively termed pediatric post-intensive care syndrome, or PICS-p. In contrast to healthy children undergoing elective surgery, critically ill children are subject to inordinate neurologic stress or injury and need to be considered separately. Despite recognition of PICS-p, inconsistency in techniques and timing of post-discharge assessments continues to be a significant barrier to understanding the specific role of sedation in later cognitive dysfunction. Nonetheless, available pediatric studies that account for analgesia …
Decoding Neural Activity In Sulcal And White Matter Areas Of The Brain To Accurately Predict Individual Finger Movement And Tactile Stimuli Of The Human Hand, Chad Bouton, Nikunj Bhagat, Santosh Chandrasekaran, Jose Herrero, Noah Markowitz, Elizabeth Espinal, Joo-Won Kim, Richard Ramdeo, Junqian Xu, Matthew F Glasser, Stephan Bickel, Ashesh Mehta
Decoding Neural Activity In Sulcal And White Matter Areas Of The Brain To Accurately Predict Individual Finger Movement And Tactile Stimuli Of The Human Hand, Chad Bouton, Nikunj Bhagat, Santosh Chandrasekaran, Jose Herrero, Noah Markowitz, Elizabeth Espinal, Joo-Won Kim, Richard Ramdeo, Junqian Xu, Matthew F Glasser, Stephan Bickel, Ashesh Mehta
Open Access Publications
Millions of people worldwide suffer motor or sensory impairment due to stroke, spinal cord injury, multiple sclerosis, traumatic brain injury, diabetes, and motor neuron diseases such as ALS (amyotrophic lateral sclerosis). A brain-computer interface (BCI), which links the brain directly to a computer, offers a new way to study the brain and potentially restore impairments in patients living with these debilitating conditions. One of the challenges currently facing BCI technology, however, is to minimize surgical risk while maintaining efficacy. Minimally invasive techniques, such as stereoelectroencephalography (SEEG) have become more widely used in clinical applications in epilepsy patients since they can …
Centering Inclusivity In The Design Of Online Conferences-An Ohbm-Open Science Perspective, Elizabeth Levitis, Janine D. Bijsterbosch, Et Al
Centering Inclusivity In The Design Of Online Conferences-An Ohbm-Open Science Perspective, Elizabeth Levitis, Janine D. Bijsterbosch, Et Al
Open Access Publications
As the global health crisis unfolded, many academic conferences moved online in 2020. This move has been hailed as a positive step towards inclusivity in its attenuation of economic, physical, and legal barriers and effectively enabled many individuals from groups that have traditionally been underrepresented to join and participate. A number of studies have outlined how moving online made it possible to gather a more global community and has increased opportunities for individuals with various constraints, e.g., caregiving responsibilities. Yet, the mere existence of online conferences is no guarantee that everyone can attend and participate meaningfully. In fact, many elements …
A Bone-Specific Adipogenesis Pathway In Fat-Free Mice Defines Key Origins And Adaptations Of Bone Marrow Adipocytes With Age And Disease, Xiao Zhang, Hero Robles, Kristann L. Magee, Madelyn R. Lorenz, Zhaohua Wang, Charles A. Harris, Clarissa S. Craft, Erica L. Scheller
A Bone-Specific Adipogenesis Pathway In Fat-Free Mice Defines Key Origins And Adaptations Of Bone Marrow Adipocytes With Age And Disease, Xiao Zhang, Hero Robles, Kristann L. Magee, Madelyn R. Lorenz, Zhaohua Wang, Charles A. Harris, Clarissa S. Craft, Erica L. Scheller
Open Access Publications
Bone marrow adipocytes accumulate with age and in diverse disease states. However, their origins and adaptations in these conditions remain unclear, impairing our understanding of their context-specific endocrine functions and relationship with surrounding tissues. In this study, by analyzing bone and adipose tissues in the lipodystrophic 'fat-free' mouse, we define a novel, secondary adipogenesis pathway that relies on the recruitment of adiponectin-negative stromal progenitors. This pathway is unique to the bone marrow and is activated with age and in states of metabolic stress in the fat-free mouse model, resulting in the expansion of bone marrow adipocytes specialized for lipid storage …
Biological Resurfacing In A Canine Model Of Hip Osteoarthritis, Bradley T Estes, Masataka Enomoto, Franklin T Moutos, Megan A Carson, Jeffrey M Toth, Peter Eggert, Jonathan Stallrich, Vincent P Willard, Deborah J Veis, Dianne Little, Farshid Guilak, B Duncan X Lascelles
Biological Resurfacing In A Canine Model Of Hip Osteoarthritis, Bradley T Estes, Masataka Enomoto, Franklin T Moutos, Megan A Carson, Jeffrey M Toth, Peter Eggert, Jonathan Stallrich, Vincent P Willard, Deborah J Veis, Dianne Little, Farshid Guilak, B Duncan X Lascelles
Open Access Publications
[Figure: see text].
Parrot Is A Flexible Recurrent Neural Network Framework For Analysis Of Large Protein Datasets, Daniel Griffith, Alex S. Holehouse
Parrot Is A Flexible Recurrent Neural Network Framework For Analysis Of Large Protein Datasets, Daniel Griffith, Alex S. Holehouse
Open Access Publications
The rise of high-throughput experiments has transformed how scientists approach biological questions. The ubiquity of large-scale assays that can test thousands of samples in a day has necessitated the development of new computational approaches to interpret this data. Among these tools, machine learning approaches are increasingly being utilized due to their ability to infer complex nonlinear patterns from high-dimensional data. Despite their effectiveness, machine learning (and in particular deep learning) approaches are not always accessible or easy to implement for those with limited computational expertise. Here we present PARROT, a general framework for training and applying deep learning-based predictors on …
Maternal Fructose Diet-Induced Developmental Programming, Michael D Thompson, Brian J Debosch
Maternal Fructose Diet-Induced Developmental Programming, Michael D Thompson, Brian J Debosch
Open Access Publications
Developmental programming of chronic diseases by perinatal exposures/events is the basic tenet of the developmental origins hypothesis of adult disease (DOHaD). With consumption of fructose becoming more common in the diet, the effect of fructose exposure during pregnancy and lactation is of increasing relevance. Human studies have identified a clear effect of fructose consumption on maternal health, but little is known of the direct or indirect effects on offspring. Animal models have been utilized to evaluate this concept and an association between maternal fructose and offspring chronic disease, including hypertension and metabolic syndrome. This review will address the mechanisms of …
An Essential, Kinetoplastid-Specific Gdp-Fuc: Β-D-Gal Α-1,2-Fucosyltransferase Is Located In The Mitochondrion Of Trypanosoma Brucei, Giulia Bandini, Sebastian Damerow, Maria Lucia Sempaio Guther, Hongjie Guo, Angela Mehlert, Jose Carlos Paredes Franco, Stephen Beverley, Michael A.J. Ferguson
An Essential, Kinetoplastid-Specific Gdp-Fuc: Β-D-Gal Α-1,2-Fucosyltransferase Is Located In The Mitochondrion Of Trypanosoma Brucei, Giulia Bandini, Sebastian Damerow, Maria Lucia Sempaio Guther, Hongjie Guo, Angela Mehlert, Jose Carlos Paredes Franco, Stephen Beverley, Michael A.J. Ferguson
Open Access Publications
Fucose is a common component of eukaryotic cell-surface glycoconjugates, generally added by Golgi-resident fucosyltransferases. Whereas fucosylated glycoconjugates are rare in kinetoplastids, the biosynthesis of the nucleotide sugar GDP-Fuc has been shown to be essential in
Critical Period After Stroke Study (Cpass): A Phase Ii Clinical Trial Testing An Optimal Time For Motor Recovery After Stroke In Humans, Alexander W. Dromerick, Shashwati Geed, Jessica Barth, Kathaleen Brady, Margot L. Gianetti, Abigail Mitchell, Matthew A. Edwardson, Ming T. Tan, Yizhao Zhou, Elissa L. Newport, Dorothy F. Edwards
Critical Period After Stroke Study (Cpass): A Phase Ii Clinical Trial Testing An Optimal Time For Motor Recovery After Stroke In Humans, Alexander W. Dromerick, Shashwati Geed, Jessica Barth, Kathaleen Brady, Margot L. Gianetti, Abigail Mitchell, Matthew A. Edwardson, Ming T. Tan, Yizhao Zhou, Elissa L. Newport, Dorothy F. Edwards
Open Access Publications
No abstract provided.
Efficacy And Breadth Of Adjuvanted Sars-Cov-2 Receptor-Binding Domain Nanoparticle Vaccine In Macaques, Hannah A. D. King, Rita E. Chen, James B. Case, Michael S. Diamond, Et Al
Efficacy And Breadth Of Adjuvanted Sars-Cov-2 Receptor-Binding Domain Nanoparticle Vaccine In Macaques, Hannah A. D. King, Rita E. Chen, James B. Case, Michael S. Diamond, Et Al
Open Access Publications
No abstract provided.
Ip3r-Driven Increases In Mitochondrial Ca2+ Promote Neuronal Death In Npc Disease, Scott A. Tiscione, Maria Casas, Jonathan D. Horvath, Vincent Lam, Keiko Hino, Daniel S. Ory, L. Fernando Santana, Sergi Simó, Rose E. Dixon, Eamonn J. Dickson
Ip3r-Driven Increases In Mitochondrial Ca2+ Promote Neuronal Death In Npc Disease, Scott A. Tiscione, Maria Casas, Jonathan D. Horvath, Vincent Lam, Keiko Hino, Daniel S. Ory, L. Fernando Santana, Sergi Simó, Rose E. Dixon, Eamonn J. Dickson
Open Access Publications
No abstract provided.
Metabolite-Specific Echo-Planar Imaging Of Hyperpolarized [1-- 13 C]Pyruvate At 4.7 T, Tyler Blazey, Galen D. Reed, Joel R. Garbow, Cornelius Von Morze
Metabolite-Specific Echo-Planar Imaging Of Hyperpolarized [1-- 13 C]Pyruvate At 4.7 T, Tyler Blazey, Galen D. Reed, Joel R. Garbow, Cornelius Von Morze
Open Access Publications
Although hyperpolarization (HP) greatly increases the sensitivity of
Elac2/Rnasez-Linked Cardiac Hypertrophy In Drosophila Melanogaster, Ekaterina Migunova, Joanna Theophilopoulos, Marisa Mercadante, Jing Men, Chao Zhou, Edward B Dubrovsky
Elac2/Rnasez-Linked Cardiac Hypertrophy In Drosophila Melanogaster, Ekaterina Migunova, Joanna Theophilopoulos, Marisa Mercadante, Jing Men, Chao Zhou, Edward B Dubrovsky
Open Access Publications
A severe form of infantile cardiomyopathy (CM) has been linked to mutations in ELAC2, a highly conserved human gene. It encodes Zinc phosphodiesterase ELAC protein 2 (ELAC2), which plays an essential role in the production of mature tRNAs. To establish a causal connection between ELAC2 variants and CM, here we used the Drosophila melanogaster model organism, which carries the ELAC2 homolog RNaseZ. Even though RNaseZ and ELAC2 have diverged in some of their biological functions, our study demonstrates the use of the fly model to study the mechanism of ELAC2-related pathology. We established transgenic lines harboring RNaseZ with CM-linked mutations …
Spontaneous Multimodal Neural Transmission Suggests That Adult Spinal Networks Maintain An Intrinsic State Of Readiness To Execute Sensorimotor Behaviors, Maria F. Bandres, Jefferson Gomes, Jacob G. Mcpherson
Spontaneous Multimodal Neural Transmission Suggests That Adult Spinal Networks Maintain An Intrinsic State Of Readiness To Execute Sensorimotor Behaviors, Maria F. Bandres, Jefferson Gomes, Jacob G. Mcpherson
Open Access Publications
Spontaneous action potential discharge (spAP) is both ubiquitous and functionally relevant during neural development. spAP remains a prominent feature of supraspinal networks in maturity, even during unconsciousness. Evidence suggests that spAP persists in mature spinal networks during wakefulness, and one function of spAP in this context could be maintenance of a "ready state" to execute behaviors. The extent to which spAP persists in mature spinal networks during unconsciousness remains unclear, and its function(s), if any, are likewise unresolved. Here, we attempt to reconcile some of the questions and contradictions that emerge from the disintegrated picture of adult spinal spAP currently …
Breast Cancer Derived Gm-Csf Regulates Arginase 1 In Myeloid Cells To Promote An Immunosuppressive Microenvironment, Xinming Su, Yalin Xu, Gregory C Fox, Jingyu Xiang, Kristin A Kwakwa, Jennifer L Davis, Jad I Belle, Wen-Chih Lee, Wing H Wong, Francesca Fontana, Leonel Hernandez-Aya, Takayuki Kobayashi, Helen M Tomasson, Junyi Su, Suzanne J Bakewell, Sheila A Stewart, Christopher Egbulefu, Partha Karmakar, Melissa A Meyer, Deborah J Veis, David G Denardo, Gregory M Lanza, Samuel Achilefu, Katherine N Weilbaecher
Breast Cancer Derived Gm-Csf Regulates Arginase 1 In Myeloid Cells To Promote An Immunosuppressive Microenvironment, Xinming Su, Yalin Xu, Gregory C Fox, Jingyu Xiang, Kristin A Kwakwa, Jennifer L Davis, Jad I Belle, Wen-Chih Lee, Wing H Wong, Francesca Fontana, Leonel Hernandez-Aya, Takayuki Kobayashi, Helen M Tomasson, Junyi Su, Suzanne J Bakewell, Sheila A Stewart, Christopher Egbulefu, Partha Karmakar, Melissa A Meyer, Deborah J Veis, David G Denardo, Gregory M Lanza, Samuel Achilefu, Katherine N Weilbaecher
Open Access Publications
Tumor-infiltrating myeloid cells contribute to the development of the immunosuppressive tumor microenvironment. Myeloid cell expression of arginase 1 (Arg-1) promotes a protumor phenotype by inhibiting T cell function and depleting extracellular L-arginine, but the mechanism underlying this expression, especially in breast cancer, is poorly understood. In breast cancer clinical samples and in our mouse models, we identified tumor derived GM-CSF as the primary regulator of myeloid cell Arg-1 expression and local immune suppression through a gene knockout screen of breast tumor cell-produced factors. The induction of myeloid cell Arg-1 required GM-CSF and a low pH environment. GM-CSF signaling through STAT3, …