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Stat1-Deficient Mice Spontaneously Develop Estrogen Receptor Alpha-Positive Luminal Mammary Carcinomas, Szeman Ruby Chan, William Vermi, Jingqin Luo, Laura Lucini, Charles Rickert, Amy M. Fowler, Silvia Lonardi, Cora Arthur, Larry Jt Young, David E. Levy, Michael J. Welch, Robert D. Cardiff, Robert D. Schreiber Jan 2012

Stat1-Deficient Mice Spontaneously Develop Estrogen Receptor Alpha-Positive Luminal Mammary Carcinomas, Szeman Ruby Chan, William Vermi, Jingqin Luo, Laura Lucini, Charles Rickert, Amy M. Fowler, Silvia Lonardi, Cora Arthur, Larry Jt Young, David E. Levy, Michael J. Welch, Robert D. Cardiff, Robert D. Schreiber

Open Access Publications

No abstract provided.


Ccl2 Upregulation Triggers Hypoxic Preconditioning-Induced Protection From Stroke, Ann M. Stowe, Bradley K. Wacker, Petra D. Cravens, Jennifer L. Perfater, Min K. Li, Ruilong Hu, Angela B. Freie, Olaf Stuve, Jeffrey M. Gidday Jan 2012

Ccl2 Upregulation Triggers Hypoxic Preconditioning-Induced Protection From Stroke, Ann M. Stowe, Bradley K. Wacker, Petra D. Cravens, Jennifer L. Perfater, Min K. Li, Ruilong Hu, Angela B. Freie, Olaf Stuve, Jeffrey M. Gidday

Open Access Publications

No abstract provided.


Bidirectional Relationship Between Functional Connectivity And Amyloid-Β Deposition In Mouse Brain, Adam W. Bero, Adam O. Bauer, Floy R. Stewart, Brian R. White, John R. Cirrito, Marcus E. Raichle, Joseph P. Culver, David M. Holtzman Jan 2012

Bidirectional Relationship Between Functional Connectivity And Amyloid-Β Deposition In Mouse Brain, Adam W. Bero, Adam O. Bauer, Floy R. Stewart, Brian R. White, John R. Cirrito, Marcus E. Raichle, Joseph P. Culver, David M. Holtzman

Open Access Publications

No abstract provided.


The Mode Of Retinal Presynaptic Inhibition Switches With Light Intensity, Tomomi Ichinose, Peter D. Lukasiewicz Jan 2012

The Mode Of Retinal Presynaptic Inhibition Switches With Light Intensity, Tomomi Ichinose, Peter D. Lukasiewicz

Open Access Publications

No abstract provided.


Splint: The Efficacy Of Orthotic Management In Rest To Prevent Equinus In Children With Cerebral Palsy, A Randomised Controlled Trial, Josina C. Maas, Annet J. Dallmeijer, Peter A. Huijing, Janice E. Brunstrom-Hernandez, Petra J. Van Kampen, Richard T. Jaspers, Jules G. Becher Jan 2012

Splint: The Efficacy Of Orthotic Management In Rest To Prevent Equinus In Children With Cerebral Palsy, A Randomised Controlled Trial, Josina C. Maas, Annet J. Dallmeijer, Peter A. Huijing, Janice E. Brunstrom-Hernandez, Petra J. Van Kampen, Richard T. Jaspers, Jules G. Becher

Open Access Publications

No abstract provided.


Mechanisms Of Remodeling In Asthmatic Airways, Adrian Shifren, Chad Witt, Chandrika Christie, Mario Castro Jan 2012

Mechanisms Of Remodeling In Asthmatic Airways, Adrian Shifren, Chad Witt, Chandrika Christie, Mario Castro

Open Access Publications

No abstract provided.


Putative Factors That May Modulate The Effect Of Exercise On Liver Fat: Insights From Animal Studies, Faidon Magkos Jan 2012

Putative Factors That May Modulate The Effect Of Exercise On Liver Fat: Insights From Animal Studies, Faidon Magkos

Open Access Publications

No abstract provided.


Cxcl12 Mediates Trophic Interactions Between Endothelial And Tumor Cells In Glioblastoma, Shyam Rao, Rajarshi Sengupta, Eun Joo Choe, B. Mark Woerner, Erin Jackson, Tao Sun, Jeffrey Leonard, David Piwnica-Worms, Joshua B. Rubin Jan 2012

Cxcl12 Mediates Trophic Interactions Between Endothelial And Tumor Cells In Glioblastoma, Shyam Rao, Rajarshi Sengupta, Eun Joo Choe, B. Mark Woerner, Erin Jackson, Tao Sun, Jeffrey Leonard, David Piwnica-Worms, Joshua B. Rubin

Open Access Publications

No abstract provided.


A Cross-Species Analysis Of Micrornas In The Developing Avian Face, Kara E. Powder, Yuan-Chieh Ku, Samantha A. Brugmann, Rose A. Veile, Nicole A. Renaud, Jill A. Helms, Michael Lovett Jan 2012

A Cross-Species Analysis Of Micrornas In The Developing Avian Face, Kara E. Powder, Yuan-Chieh Ku, Samantha A. Brugmann, Rose A. Veile, Nicole A. Renaud, Jill A. Helms, Michael Lovett

Open Access Publications

No abstract provided.


Listeriolysin O Is Strongly Immunogenic Independently Of Its Cytotoxic Activity, Javier A. Carrero, Hector Vivanco-Cid, Emil R. Unanue Jan 2012

Listeriolysin O Is Strongly Immunogenic Independently Of Its Cytotoxic Activity, Javier A. Carrero, Hector Vivanco-Cid, Emil R. Unanue

Open Access Publications

No abstract provided.


Leishmania Amazonensis Arginase Compartmentalization In The Glycosome Is Important For Parasite Infectivity, Maria Fernanda Laranjeira Da Silva, Ricardo Andrade Zampieri, Sandra M. Muxel, Stephen M. Beverley, Lucile M. Floeter-Winter Jan 2012

Leishmania Amazonensis Arginase Compartmentalization In The Glycosome Is Important For Parasite Infectivity, Maria Fernanda Laranjeira Da Silva, Ricardo Andrade Zampieri, Sandra M. Muxel, Stephen M. Beverley, Lucile M. Floeter-Winter

Open Access Publications

No abstract provided.


Spontaneous Activity Promotes Synapse Formation In A Cell-Type-Dependent Manner In The Developing Retina, Florentina Soto, Xiaofeng Ma, Jacob L. Cecil, Bradly Q. Vo, Susan M. Culican, Daniel Kerschensteiner Jan 2012

Spontaneous Activity Promotes Synapse Formation In A Cell-Type-Dependent Manner In The Developing Retina, Florentina Soto, Xiaofeng Ma, Jacob L. Cecil, Bradly Q. Vo, Susan M. Culican, Daniel Kerschensteiner

Open Access Publications

No abstract provided.


Aflibercept In The Treatment Of Metastatic Colorectal Cancer, Tzu-Fei Wang, Albert Craig Lockhart Jan 2012

Aflibercept In The Treatment Of Metastatic Colorectal Cancer, Tzu-Fei Wang, Albert Craig Lockhart

Open Access Publications

No abstract provided.


Temperament, Character And Serotonin Activity In The Human Brain: A Positron Emission Tomography Study Based On A General Population Cohort, L. Tuominen, J. Salo, J. Hirvonen, K. Någren, P. Laine, T. Melartin, E. Isometsä, J. Viikari, C. R. Cloninger, O. Raitakari, J. Hietala, L. Keltikangas-Järvinen Jan 2012

Temperament, Character And Serotonin Activity In The Human Brain: A Positron Emission Tomography Study Based On A General Population Cohort, L. Tuominen, J. Salo, J. Hirvonen, K. Någren, P. Laine, T. Melartin, E. Isometsä, J. Viikari, C. R. Cloninger, O. Raitakari, J. Hietala, L. Keltikangas-Järvinen

Open Access Publications

No abstract provided.


Diazoxide Maintains Human Myocyte Volume Homeostasis During Stress, Sara K. Maffit, Angela D. Sellitto, Ashraf S. Al-Dadah, Richard B. Schuessler, Ralph J. Damiano Jr., Jennifer S. Lawton Jan 2012

Diazoxide Maintains Human Myocyte Volume Homeostasis During Stress, Sara K. Maffit, Angela D. Sellitto, Ashraf S. Al-Dadah, Richard B. Schuessler, Ralph J. Damiano Jr., Jennifer S. Lawton

Open Access Publications

No abstract provided.


Pediatric Glioma-Associated Kiaa1549:Braf Expression Regulates Neuroglial Cell Growth In A Cell Type-Specific And Mtor-Dependent Manner, Aparna Kaul, Yi-Hsien Chen, Ryan J. Emnett, Sonika Dahiya, David H. Gutmann Jan 2012

Pediatric Glioma-Associated Kiaa1549:Braf Expression Regulates Neuroglial Cell Growth In A Cell Type-Specific And Mtor-Dependent Manner, Aparna Kaul, Yi-Hsien Chen, Ryan J. Emnett, Sonika Dahiya, David H. Gutmann

Open Access Publications

No abstract provided.


Lmp-420, A Small Molecular Inhibitor Of Tnf-Α, Prolongs Islet Allograft Survival By Induction Of Suppressor Of Cytokine Signaling-1: Synergistic Effect With Cyclosporin-A, Nataraju Angaswamy, Naohiko Fukami, Venkataswarup Tiriveedhi, George J. Cianciolo, T Mohanakumar Jan 2012

Lmp-420, A Small Molecular Inhibitor Of Tnf-Α, Prolongs Islet Allograft Survival By Induction Of Suppressor Of Cytokine Signaling-1: Synergistic Effect With Cyclosporin-A, Nataraju Angaswamy, Naohiko Fukami, Venkataswarup Tiriveedhi, George J. Cianciolo, T Mohanakumar

Open Access Publications

No abstract provided.


Wormbase 2012: More Genomes, More Data, New Website, Karen Yook, Tamberlyn Bieri, Bill Nash, Philip Ozersky, John Spieth Jan 2012

Wormbase 2012: More Genomes, More Data, New Website, Karen Yook, Tamberlyn Bieri, Bill Nash, Philip Ozersky, John Spieth

Open Access Publications

No abstract provided.


Acute Respiratory Distress Syndrome: Pathophysiology And Therapeutic Options, Charalampos Pierrakos, Menelaos Karanikolas, Sabino Scolletta, Vasilios Karamouzos, Dimitrios Velissaris Jan 2012

Acute Respiratory Distress Syndrome: Pathophysiology And Therapeutic Options, Charalampos Pierrakos, Menelaos Karanikolas, Sabino Scolletta, Vasilios Karamouzos, Dimitrios Velissaris

Open Access Publications

No abstract provided.


Whole-Genome Sequencing To Identify Mutants And Polymorphisms In Chlamydomonas Reinhardtii, Susan K. Dutcher, Linya Li, Huawen Lin, Leslie Meyer, Thomas H. Giddings Jr., Alan L. Kwan, Brian L. Lewis Jan 2012

Whole-Genome Sequencing To Identify Mutants And Polymorphisms In Chlamydomonas Reinhardtii, Susan K. Dutcher, Linya Li, Huawen Lin, Leslie Meyer, Thomas H. Giddings Jr., Alan L. Kwan, Brian L. Lewis

Open Access Publications

No abstract provided.


Schistosome-Derived Omega-1 Drives Th2 Polarization By Suppressing Protein Synthesis Following Internalization By The Mannose Receptor, Bart Everts, Leonie Hussaarts, Nicole N. Driessen, Moniek H.J. Meevissen, Gabriele Schramm, Alwin J. Van Der Ham, Barbara Van Der Hoeven, Thomas Scholzen, Sven Burgdorf, Markus Mohrs, Edward J. Pearce, Cornelis H. Hokke, Helmut Haas, Hermelijn H. Smits, Maria Yazdanbakhsh Jan 2012

Schistosome-Derived Omega-1 Drives Th2 Polarization By Suppressing Protein Synthesis Following Internalization By The Mannose Receptor, Bart Everts, Leonie Hussaarts, Nicole N. Driessen, Moniek H.J. Meevissen, Gabriele Schramm, Alwin J. Van Der Ham, Barbara Van Der Hoeven, Thomas Scholzen, Sven Burgdorf, Markus Mohrs, Edward J. Pearce, Cornelis H. Hokke, Helmut Haas, Hermelijn H. Smits, Maria Yazdanbakhsh

Open Access Publications

Omega-1, a glycosylated T2 ribonuclease (RNase) secreted by Schistosoma mansoni eggs and abundantly present in soluble egg antigen, has recently been shown to condition dendritic cells (DCs) to prime Th2 responses. However, the molecular mechanisms underlying this effect remain unknown. We show in this study by site-directed mutagenesis of omega-1 that both the glycosylation and the RNase activity are essential to condition DCs for Th2 polarization. Mechanistically, we demonstrate that omega-1 is bound and internalized via its glycans by the mannose receptor (MR) and subsequently impairs protein synthesis by degrading both ribosomal and messenger RNA. These experiments reveal an unrecognized …


Zbtb46 Expression Distinguishes Classical Dendritic Cells And Their Committed Progenitors From Other Immune Lineages, Ansuman T. Satpathy, Wumesh Kc, Jörn C. Albring, Brian T. Edelson, Nicole M. Kretzer, Deepta Bhattacharya, Theresa L. Murphy, Kenneth M. Murphy Jan 2012

Zbtb46 Expression Distinguishes Classical Dendritic Cells And Their Committed Progenitors From Other Immune Lineages, Ansuman T. Satpathy, Wumesh Kc, Jörn C. Albring, Brian T. Edelson, Nicole M. Kretzer, Deepta Bhattacharya, Theresa L. Murphy, Kenneth M. Murphy

Open Access Publications

Distinguishing dendritic cells (DCs) from other cells of the mononuclear phagocyte system is complicated by the shared expression of cell surface markers such as CD11c. In this study, we identified Zbtb46 (BTBD4) as a transcription factor selectively expressed by classical DCs (cDCs) and their committed progenitors but not by plasmacytoid DCs (pDCs), monocytes, macrophages, or other lymphoid or myeloid lineages. Using homologous recombination, we replaced the first coding exon of Zbtb46 with GFP to inactivate the locus while allowing detection of Zbtb46 expression. GFP expression in Zbtb46(gfp/+) mice recapitulated the cDC-specific expression of the native locus, being restricted to cDC …


Hippocampal Shape And Volume Changes With Antipsychotics In Early Stage Psychotic Illness, Daniel Mamah, Michael P. Harms, Deanna Barch, Martin Styner, Jeffrey A. Lieberman, Lei Wang Jan 2012

Hippocampal Shape And Volume Changes With Antipsychotics In Early Stage Psychotic Illness, Daniel Mamah, Michael P. Harms, Deanna Barch, Martin Styner, Jeffrey A. Lieberman, Lei Wang

Open Access Publications

No abstract provided.


Prefrontal And Striatal Activity Related To Values Of Objects And Locations, Soyoun Kim, Xinying Cai, Jaewon Hwang, Daeyeol Lee Jan 2012

Prefrontal And Striatal Activity Related To Values Of Objects And Locations, Soyoun Kim, Xinying Cai, Jaewon Hwang, Daeyeol Lee

Open Access Publications

No abstract provided.


Temporal Evolution Of Gamma Activity In Human Cortex During An Overt And Covert Word Repetition Task, Eric C. Leuthardt, Xiao-Mei Pei, Jonathan Breshears, Charles Gaona, Mohit Sharma, Zac Freudenberg, Dennis Barbour, Gerwin Schalk Jan 2012

Temporal Evolution Of Gamma Activity In Human Cortex During An Overt And Covert Word Repetition Task, Eric C. Leuthardt, Xiao-Mei Pei, Jonathan Breshears, Charles Gaona, Mohit Sharma, Zac Freudenberg, Dennis Barbour, Gerwin Schalk

Open Access Publications

No abstract provided.


Leishmania Rna Virus: When The Host Pays The Toll, Mary-Anne Hartley, Catherine Ronet, Haroun Zangger, Stephen M. Beverley, Nicolas Fasel Jan 2012

Leishmania Rna Virus: When The Host Pays The Toll, Mary-Anne Hartley, Catherine Ronet, Haroun Zangger, Stephen M. Beverley, Nicolas Fasel

Open Access Publications

No abstract provided.


An Enhancer From The 8q24 Prostate Cancer Risk Region Is Sufficient To Direct Reporter Gene Expression To A Subset Of Prostate Stem-Like Epithelial Cells In Transgenic Mice, Man-Chun Ting, Chun-Peng Liao, Chunli Yan, Li Jia, Susan Groshen, Baruch Frenkel, Pradip Roy-Burman, Gerhard A. Coetzee, Robert Maxson Jan 2012

An Enhancer From The 8q24 Prostate Cancer Risk Region Is Sufficient To Direct Reporter Gene Expression To A Subset Of Prostate Stem-Like Epithelial Cells In Transgenic Mice, Man-Chun Ting, Chun-Peng Liao, Chunli Yan, Li Jia, Susan Groshen, Baruch Frenkel, Pradip Roy-Burman, Gerhard A. Coetzee, Robert Maxson

Open Access Publications

No abstract provided.


The Adp Receptor P2ry12 Regulates Osteoclast Function And Pathologic Bone Remodeling, Xinming Su, Desiree H. Floyd, Jingyu Xiang, Jochen G. Schneider, Ozge Uluckan, Emanuela Heller, Hongju Deng, Kaiming Wu, Angela C. Hirbe, Dorota Grabowska, Mark C. Eagleton, Sarah Townsley, Lynne Collins, David Piwnica-Worms, Clarissa S. Craft, Thomas H. Steinberg, Michelle A. Hurchla, Katherine N. Weilbaecher Jan 2012

The Adp Receptor P2ry12 Regulates Osteoclast Function And Pathologic Bone Remodeling, Xinming Su, Desiree H. Floyd, Jingyu Xiang, Jochen G. Schneider, Ozge Uluckan, Emanuela Heller, Hongju Deng, Kaiming Wu, Angela C. Hirbe, Dorota Grabowska, Mark C. Eagleton, Sarah Townsley, Lynne Collins, David Piwnica-Worms, Clarissa S. Craft, Thomas H. Steinberg, Michelle A. Hurchla, Katherine N. Weilbaecher

Open Access Publications

No abstract provided.


Multiple Myeloma-Associated Chromosomal Translocation Activates Orphan Snorna Aca11 To Suppress Oxidative Stress, Liang Chu, Mack Y. Su, Leonard B. Maggi Jr., Lan Lu, Chelsea Mullins, Seth Crosby, Gaofeng Huang, Wee Joo Chng, Ravi Vij, Michael H. Tomasson Jan 2012

Multiple Myeloma-Associated Chromosomal Translocation Activates Orphan Snorna Aca11 To Suppress Oxidative Stress, Liang Chu, Mack Y. Su, Leonard B. Maggi Jr., Lan Lu, Chelsea Mullins, Seth Crosby, Gaofeng Huang, Wee Joo Chng, Ravi Vij, Michael H. Tomasson

Open Access Publications

No abstract provided.


Targeting Chk1 In P53-Deficient Triple-Negative Breast Cancer Is Therapeutically Beneficial In Human-In-Mouse Tumor Models, Cynthia X. Ma, Shirong Cai, Shunqiang Li, Christine E. Ryan, Zhangfang Guo, W. Timothy Schaiff, Li Lin, Jeremy Hoog, Reece J. Goiffon, Aleix Prat, Rebecca L. Aft, Matthew J. Ellis, Helen Piwnica-Worms Jan 2012

Targeting Chk1 In P53-Deficient Triple-Negative Breast Cancer Is Therapeutically Beneficial In Human-In-Mouse Tumor Models, Cynthia X. Ma, Shirong Cai, Shunqiang Li, Christine E. Ryan, Zhangfang Guo, W. Timothy Schaiff, Li Lin, Jeremy Hoog, Reece J. Goiffon, Aleix Prat, Rebecca L. Aft, Matthew J. Ellis, Helen Piwnica-Worms

Open Access Publications

No abstract provided.