Digital Commons Network^™

Rory Regulates The Nlrp3 Inflammasome, Cyrielle Billon, Meghan H. Murray, Amer Avdagic, Thomas P. Burris

Open Access Publications

No abstract provided.

Thiol Isomerase Erp57 Targets And Modulates The Lectin Pathway Of Complement Activation, Oskar Eriksson, Joyce Chiu, Philip J. Hogg, John P. Atkinson, M. Kathryn Liszewski, Robert Flaumenhaft, Bruce Furie

Open Access Publications

No abstract provided.

Photoreceptors In A Mouse Model Of Leigh Syndrome Are Capable Of Normal Light-Evoked Signaling, Sidney M. Gospe Iii, Amanda M. Travis, Alexander V. Kolesnikov, Mikael Klingeborn, Luyu Wang, Vladimir J. Kefalov, Vadim Y. Arshavsky

Open Access Publications

No abstract provided.

Nfat5 Up-Regulates Expression Of The Kidney-Specific Ubiquitin Ligase Gene Rnf183 Under Hypertonic Conditions In Inner-Medullary Collecting Duct Cells, Yujiro Maeoka, Yan Wu, Takumi Okamoto, Soshi Kanemoto, Xiao Peng Guo, Atsushi Saito, Rie Asada, Koji Matsuhisa, Takao Masaki, Kazunori Imaizumi, Masayuki Kaneko

Open Access Publications

No abstract provided.

Mechanically Transformative Electronics, Sensors, And Implantable Devices, Sang-Hyuk Byun, Marie C Walicki, Kyle E Parker, Graydon B Gereau, John Bilbily, Jordan G Mccall, Et Al

Open Access Publications

Traditionally, electronics have been designed with static form factors to serve designated purposes. This approach has been an optimal direction for maintaining the overall device performance and reliability for targeted applications. However, electronics capable of changing their shape, flexibility, and stretchability will enable versatile and accommodating systems for more diverse applications. Here, we report design concepts, materials, physics, and manufacturing strategies that enable these reconfigurable electronic systems based on temperature-triggered tuning of mechanical characteristics of device platforms. We applied this technology to create personal electronics with variable stiffness and stretchability, a pressure sensor with tunable bandwidth and sensitivity, and a …

Detection Of Tar Dna-Binding Protein 43 (Tdp-43) Oligomers As Initial Intermediate Species During Aggregate Formation, Rachel L. French, Zachary R. Grese, Himani Aligireddy, Dhruva D. Dhavale, Ashley N. Reeb, Niraja Kedia, Paul T. Kotzbauer, Jan Bieschke, Yuna M. Ayala

Open Access Publications

No abstract provided.

The Complex Genetics And Biology Of Human Temperament: A Review Of Traditional Concepts In Relation To New Molecular Findings, C. Robert Cloninger, Kevin M. Cloninger, Igor Zwir, Lisa Keltikangas-Järvinen

Open Access Publications

No abstract provided.

Hepatic Monoacylglycerol Acyltransferase 1 Is Induced By Prolonged Food Deprivation To Modulate The Hepatic Fasting Response, Andrew J. Lutkewitte, Kyle S. Mccommis, George G. Schweitzer, Kari T. Chambers, Mark J. Graham, Lingjue Wang, Gary J. Patti, Angela M. Hall, Brian N. Finck

Open Access Publications

No abstract provided.

An Overview Of Mechanical Circulatory Support In Single-Ventricle Patients, Jacob R Miller, Timothy S Lancaster, Connor Callahan, Aaron M Abarbanell, Pirooz Eghtesady

Open Access Publications

The population of people with a single-ventricle is continually increasing due to improvements across the spectrum of medical care. Unfortunately, a proportion of these patients will develop heart failure. Often, for these patients, mechanical circulatory support (MCS) represents the only available treatment option. While single-ventricle patients currently represent a small proportion of the total number of patients who receive MCS, as the single-ventricle patient population increases, this number will increase as well. Outcomes for these complex single-ventricle patients who require MCS has begun to be evaluated. When considering the entire population, survival to hospital discharge is 30-50%, though this must …

Synthesis Of Oxidized Phospholipids By Sn-1 Acyltransferase Using 2–15-Hete Lysophospholipids, Gao-Yuan Liu, Sung Ho Moon, Christopher M. Jenkins, Harold F. Sims, Shaoping Guan, Richard W. Gross

Open Access Publications

No abstract provided.

Insulin-Independent Reversal Of Type-1 Diabetes Following Transplantation Of Adult Brown Adipose Tissue Supplemented With Igf-1, Subhadra C. Gunawardana, David W. Piston

Open Access Publications

No abstract provided.

High-Density Speckle Contrast Optical Tomography Of Cerebral Blood Flow Response To Functional Stimuli In The Rodent Brain, Tanja Dragojević, Ernesto E. Vidal Rosas, Joseph L. Hollmann, Joseph P. Culver, Carles Justicia, Turgut Durduran

Open Access Publications

No abstract provided.

Graft Immaturity And Safety Concerns In Transplanted Human Kidney Organoids, Sun Ah Nam, Kohei Uchimura, Benjamin D. Humphreys, Et Al.

Open Access Publications

No abstract provided.

Neutrophils Promote Vla-4–Dependent B Cell Antigen Presentation And Accumulation Within The Meninges During Neuroinflammation, Chelsea R. Parker Harp, Angela S. Archambault, Matthew Cheung, Jesse W. Williams, Rafael S. Czepielewski, Patrick C. Duncker, Aaron J. Kilgore, Aidan T. Miller, Benjamin M. Segal, Alfred H. J. Kim, Gwendalyn J. Randolph, Gregory F. Wu

Open Access Publications

No abstract provided.

Stunting Is Preceded By Intestinal Mucosal Damage And Microbiome Changes And Is Associated With Systemic Inflammation In A Cohort Of Peruvian Infants, Mara Zambruni, Theresa J Ochoa, Anoma Somasunderam, Miguel M Cabada, Maria L Morales, Makedonka Mitreva, Bruce A Rosa, Gonzalo J Acosta, Natalia I Vigo, Maribel Riveros, Sara Arango, David Durand, Maitreyee N Berends, Peter Melby, Netanya S Utay

Open Access Publications

Stunting, defined as height-for-age

Heterogeneity Diffusion Imaging Of Gliomas: Initial Experience And Validation, Qing Wang, Gloria J. Guzmán Pérez-Carrillo, Maria Rosana Ponisio, Pamela Lamontagne, Sonika Dahiya, Daniel S. Marcus, Mikhail Milchenko, Joshua Shimony, Jingxia Liu, Gengsheng Chen, Amber Salter, Parinaz Massoumzadeh, Michelle M. Miller-Thomas, Keith M. Rich, Jonathan Mcconathy, Tammie L. S. Benzinger, Yong Wang

Open Access Publications

OBJECTIVES: Primary brain tumors are composed of tumor cells, neural/glial tissues, edema, and vasculature tissue. Conventional MRI has a limited ability to evaluate heterogeneous tumor pathologies. We developed a novel diffusion MRI-based method-Heterogeneity Diffusion Imaging (HDI)-to simultaneously detect and characterize multiple tumor pathologies and capillary blood perfusion using a single diffusion MRI scan.

METHODS: Seven adult patients with primary brain tumors underwent standard-of-care MRI protocols and HDI protocol before planned surgical resection and/or stereotactic biopsy. Twelve tumor sampling sites were identified using a neuronavigational system and recorded for imaging data quantification. Metrics from both protocols were compared between World Health …

Glutathione Synthesis Contributes To Virulence Of Streptococcus Agalactiae In A Murine Model Of Sepsis, Elizabeth A Walker, Gary C Port, Michael G Caparon, Blythe E Janowiak

Open Access Publications

No abstract provided.

Early Increase Of Csf Strem2 In Alzheimer's Disease Is Associated With Tau Related-Neurodegeneration But Not With Amyloid-Β Pathology, Marc Suarez-Calvet, Yuetiva Deming, Laura Piccio, Celeste M. Karch, Carlos Cruchaga, Et Al

Open Access Publications

No abstract provided.

Csf1r Antagonism Limits Local Restimulation Of Antiviral Cd8+ T Cells During Viral Encephalitis, Kristen E. Funk, Robyn S. Klein

Open Access Publications

No abstract provided.

Study Of Environmental Enteropathy And Malnutrition (Seem) In Pakistan: Protocols For Biopsy Based Biomarker Discovery And Validation, Najeeha T. Iqbal, Ta-Chiang Liu, Michael J. Barratt, Vanderlene L. Kung, Jeffrey I. Gordon, Et Al

Open Access Publications

No abstract provided.

International Meta-Analysis Of Ptsd Genome-Wide Association Studies Identifies Sex- And Ancestry-Specific Genetic Risk Loci, Laura J. Bierut, Elliot C. Nelson, John P. Rice, Nancy L. Saccone, Andrew C. Heath, Et Al.

Open Access Publications

No abstract provided.

Abcc9-Related Intellectual Disability Myopathy Syndrome Is A Katp Channelopathy With Loss-Of-Function Mutations In Abcc9, Conor Mcclenaghan, Theresa Harter, Monica Sala-Rabanal, Chris H. Emfinger, Yan Huang, Soma S. Singareddy, Colin G. Nichols, Jamie Gunn, David F. Wozniak, Attila Kovacs, Maria S. Remedi, Et Al.

Open Access Publications

No abstract provided.

Fast Objective Coupled Planar Illumination Microscopy, Cody J. Greer, Timothy E. Holy

Open Access Publications

No abstract provided.

Shared Autonomic Pathways Connect Bone Marrow And Peripheral Adipose Tissues Across The Central Neuraxis, Natalie K Y Wee, Madelyn R Lorenz, Yusuf Bekirov, Mark F Jacquin, Erica L Scheller

Open Access Publications

Bone marrow adipose tissue (BMAT) is increased in both obesity and anorexia. This is unique relative to white adipose tissue (WAT), which is generally more attuned to metabolic demand. It suggests that there may be regulatory pathways that are common to both BMAT and WAT and also those that are specific to BMAT alone. The central nervous system (CNS) is a key mediator of adipose tissue function through sympathetic adrenergic neurons. Thus, we hypothesized that central autonomic pathways may be involved in BMAT regulation. To test this, we first quantified the innervation of BMAT by tyrosine hydroxylase (TH) positive nerves …

Clinical Variables And Genetic Risk Factors Associated With The Acute Outcome Of Ischemic Stroke: A Systematic Review, Nuria P. Torres-Aguila, Laura Ibañez, Laura Heitsch, Carlos Cruchaga, Jin-Moo Lee, Et Al.

Open Access Publications

No abstract provided.

Metabolomic Networks Connect Host-Microbiome Processes To Human Clostridioides Difficile Infections, John I. Robinson, William H. Weir, Jan R. Crowley, Tiffany Hink, Kimberly A. Reske, Jennie H. Kwon, Carey-Ann D. Burnham, Erik R. Dubberke, Peter J. Mucha, Jeffrey P. Henderson

Open Access Publications

No abstract provided.

Hyper-Activation Of Stat3 Sustains Progression Of Non-Papillary Basal-Type Bladder Cancer Via Fosl1 Regulome, William Vermi, Et Al

Open Access Publications

No abstract provided.

Type-2-Diabetes Alters Csf But Not Plasma Metabolomic And Ad Risk Profiles In Vervet Monkeys, Kylie Kavanagh, Stephen M. Day, Morgan C. Pait, William R. Mortiz, Christopher B. Newgard, Olga Ilkayeva, Donald A. Mcclain, Shannon L. Macauley

Open Access Publications

No abstract provided.

Inhibition Of E-Selectin (Gmi-1271) Or E-Selectin Together With Cxcr4 (Gmi-1359) Re-Sensitizes Multiple Myeloma To Therapy, Barbara Muz, Feda Azab, Mark Fiala, Justin King, Daniel Kohnen, William E. Fogler, Ted Smith, John L. Magnani, Ravi Vij, Abdel Kareem Azab

Open Access Publications

No abstract provided.

Differential Neural Dynamics Underling Pragmatic And Semantic Affordance Processing In Macaque Ventral Premotor Cortex, Monica Maranesi, Stefania Bruni, Alessandro Livi, Francesco Donnarumma, Giovanni Pezzulo, Luca Bonini

Open Access Publications

No abstract provided.