Digital Commons Network^™

Notch-1 Specifically Activates Erk1/2 In Multiple Breast Cancer Subtypes, Allison Schuyler Rogowski

Master's Theses

Notch-1 is a cell fate regulatory protein and a potent breast oncogene. Notch-1 and its ligand Jagged-1 are over-expressed in human breast cancers that are associated with poor overall survival (Reedijk, Odorcic et al. 2005). Deregulated Notch signaling may contribute to tumorigenesis by increasing proliferation, inhibiting differentiation, and preventing apoptosis (Miele, Golde et al. 2006). The mitogen-activated protein kinase (MAPK) pathway is a critical cell signaling pathway that has been implicated in the development and progression of cancer (Hanahan and Weinberg 2000). Four major MAPK pathways are involved in both cell growth and apoptosis. The regulation of these pathways is …

Role Of Type Ii Transmembrane Serine Proteases In Coronavirus Production, Gitanjali Cuckemane Subramanya

Master's Theses

Proteolytic cleavage of Coronavirus spike proteins at the appropriate time and location results in efficient virus entry activation. Type II transmembrane serine proteases (TTSPs), specifically, transmembrane protease serine 2 (TMPRSS2) when expressed on target cells, enhance SARS coronavirus entry by activating spike cleavage. This study investigated the effect of TTSPs expressed in Coronavirus producer cells. Murine Hepatitis Virus strain A59 (MHV A59) viruses produced in the absence of TMPRSS2 required target cell protease activity - either cell surface serine proteases or endosomal acidophilic proteases - for entry. MHV A59 viruses produced in the presence of TMPRSS2 were less infectious overall, …

The Effects Of Anti-Price Gouging Legislation On Supply Chain Dynamics, Jason Edward Maynard

Master's Theses

The purpose of this thesis is to model the effects of anti-price gouging (APG) legislation on the costs to businesses during the recovery period of a disaster. A system dynamics model of a business’s replenishment procedures is used to simulate the effects of APG legislation on business performance. Economists have published expansive research on the effects of price ceilings on supply and demand, but there is little research evidence on the operational consequences of price ceiling legislation on business costs. APG legislation increases consumer’s forward buying and shortage gaming after a disaster by removing price incentives to be frugal. Forward …

Effects Of Embodiment On Perceptual And Affective Responses To Infant Crying, Jennifer B. Bisson

Master's Theses

Three experiments were conducted to investigate how changes in bodily states might be related to perceptions of infant vocalizations. In Study 1, participants were asked to hold a pencil between their lips, mimicking a smile, while listening to infant crying. Although there were no embodied effects for perceptual ratings, results indicated that this manipulation decreased participants’ self-reported, negative affect. In Study 2, participants were played both infant crying and birdsong while exposed to similar embodied manipulations, including activation of muscles related to approach and withdrawal behavior. There were no embodied effects for ratings of crying or for affect. Comparing Study …

Investigating Wood Welding Parameters Using A Prototype Welding Machine, Timothy R. Melin

Master's Theses

Understanding how different processing variables influence wood welded bonds is vital if the technique will ever be used to create engineered lumber without using adhesives. A variation of vibration welding, wood welding uses pressure and friction to bond materials together. During welding, heat causes a softening in the wood, a naturally occurring composite material. This softening leads to fiber entanglement and a bond forms upon cooling.

The goal of this research was to investigate several processing aspects of the wood welding procedure. A prototype wood welding machine, designed and fabricated from the ground up, was used to investigate the effects …

Emerging Trends In Greenhouse Gas Thresholds Of Significance For Use Under The California Environmental Quality Act, Nancy E. Mathison

Master's Theses

This study determined the state of the practice and emerging trends in developing greenhouse gas (GHG) thresholds of significance for use under the California Environmental Policy Act (CEQA). To describe the adopted, proposed or considered approaches for developing thresholds of significance by air districts and the thought processes behind these decisions, information was obtained through surveys and phone interviews from twelve employees of air districts in California, State agencies, and consultants that are considered experts on this issue. The results of this study include a comparison matrix of the approaches of the three air districts that have adopted or proposed …

Modeling Of A Gyro-Stabilized Helicopter Camera System Using Neural Networks, Nicholas Joseph Layshot

Master's Theses

On-board gimbal systems for camera stabilization in helicopters are typically based on linear models. Such models, however, are inaccurate due to system nonlinearities and complexities. As an alternative approach, artificial neural networks can provide a more accurate model of the gimbal system based on their non-linear mapping and generalization capabilities.

This thesis investigates the applications of artificial neural networks to model the inertial characteristics (on the azimuth axis) of the inner gimbal in a gyro-stabilized multi-gimbal system. The neural network is trained with time-domain data obtained from gyro rate sensors of an actual camera system. The network performance is evaluated …

Physiologic, Psychologic, And Oxidative Stress Responses To Multimodal Exercise In An Endometrial Cancer Survivor Undergoing High-Dose Chemotherapy: A Case Study, Lauren E. Dinsmore

Master's Theses

Exercise training, as a rehabilitative strategy, may be a vital factor in combatting the noxious toxicities related to cancer treatment. Research employing mixed modality exercise consistently demonstrates health benefits ranging from enhanced aerobic capacity and muscular strength to attenuated psychological distress. The primary aim of this case study was to examine the effects of exercise training on physiological and psychological parameters in an endometrial cancer survivor undergoing high-dose chemotherapy. Secondly, believed to play a role in toxicity development and progression, oxidative stress has yet to be studied in cancer survivors. The second aim of this case study was to determine …

Renewable Source Thermoplastics, Travis Palmer Ball

Master's Theses

This thesis is concerned with developing renewable resource thermoplastic materials to replace existing non-renewable or possibly hazardous industry standard products.

Cerenol TPU Incorporation

Dupont has recently developed a renewable source Polyol (Cerenol) which is derived from 1,3 propane diol processed from corn feeds. This material, which is a three carbon ether repeat unit, is in the pre-commercial stage and is meant to directly compete with petroleum based polyols as a drop-in replacement in thermoplastic polyurethanes. A model kinetic study was performed to compare relative reactivity of the Cerenol polyol to standard four carbon repeat unit petroleum-based polyol ether (PTMEG). A …

Reproductive Life History Of Fundulus Jenkensi And Comparative Development Of Five Sympatric Fundulid Species, Eric Thomas Lang

Master's Theses

Fundulus jenkinsi is recognized federally and within the state of Mississippi as a Species of Concern. Little is known about the life history of this coastal killifish, but a detailed reproductive histology study of F. jenkinsi and a diagnostic key of the early life stages of select members of Fundulidae can provide the foundation needed to accurately identify it and quantify reproductive parameters in this rare species in need of conservation. Monthly gonadosomatic index (GSI) of male and female F. jenkinsi were documented, and spawning phases and oocyte stages were examined using reproductive histology. In addition, various stages of …

Explaining The Variability Of Free-Living And Attached Bacterioplankton Abundances In The Bay Of St. Louis, Mississippi, Allison K. Mojzis

Master's Theses

The Bay of St. Louis (BSL) is a shallow and vertically well-mixed estuary on the Gulf Coast of Mississippi and supports the recreational and commercial activities of the surrounding towns of Bay St. Louis, Diamondhead, DeLisle, and Pass Christian. In addition to residential communities, various industrial and commercial sites inhabit the watershed and coastline. The Hollywood casino, DuPont titanium dioxide plant, and multiple sew_age treatment plants, as well as nonpoint sources of pollution, contribute to poor water quality. To evaluate spatial and temporal changes in BSL water quality, freeliving and attached bacterioplankton concentrations were enumerated by epifluorescence microscopy. Nine stations …

Utility Of Feeding Priority As A Measure Of Dominance In Garnett's Bushbaby (Otolemur Garnettii), Kyle Daniel Edens

Master's Theses

The current study examined dominance behaviors in bushbabies and examined whether feeding priority (i.e., first access to a food source) is a viable measure of dominance. Several measures of dominance were employed. Among the measures of dominance investigated were agonistic interactions, grooming, displacement, and deference of space. The results indicated that females initiated more agonistic interactions than males, but the other measures of dominance did not support the hypothesis that females were the dominant sex. The results were partially consistent with the hypothesis that feeding priority is a viable measure of dominance in that females obtained feeding priority in the …

Examining Relationship Interactions Of Adult Children Of Alcoholics, Diana I. Loera

Master's Theses

The following study explores the factors associated with security of romantic attachment in Adult Children of Alcoholics (ACOAs). ACOAs are more vulnerable to inconsistent parenting and consequently are more likely to develop negative internal models of self, a stable construct that affects romantic attachments (Bowlby, 1982; Ainsworth et al, 1989; Bartholomew, 1990). This study examined associations between parent, and peer relationships as possible resiliencies. It was hypothesized that ACOAs will report less secure attachments with their parents (as measured by the IPPA), less romantic attachment anxiety and avoidance (as measured by the ECR-R), and no significant difference in peer attachment …

Assessing Potential Industry Growth For Economic Development In Oakland, Ca, Sonia Aery

Master's Theses

This study prepares a set of career ladders for the population of Oakland. Career ladders are long-term progression pathways to help individuals advance, particularly in high wage, high growth careers. Career ladders combine different statistics on the demographics of a population with statistics about the area’s economic vitality and potential. This combination helps to identify the potential to strengthen an area’s economy and enhance individuals’ qualifications and wages.

One of the main reasons that people and large firms are attracted to a given city is the potential for economic stability. A stable economy is the result of the availability of …

Water Quality Performance Of A Reciprocating Biofilm Reactor For Treatment Of Dairy Wastewater, Jason Patrick Kane

Master's Theses

Removal of organic matter and nitrogen from concentrated wastewaters is often a complex and costly process that is rarely implemented in animal agriculture, such as the dairy industry, despite regulatory pressures and the high cost of land for manure application in some regions. This paper describes results from the first implementation for treatment of dairy farm wastewater of the relatively simple ReCip® technology. ReCip® typically consists of two basins filled with rock aggregate through which wastewater is flowed in series. One basin is full of wastewater and the other is only partially full. Wastewater is alternately pumped between the basins …

Expression Of The Artemisia Annua Β-Caryophyllene Synthase In Synechocystis Sp. Strain Pcc6803 Results In Cyanobacterial Sesquiterpene Accumulation, Robert Eric Reinsvold

Master's Theses

The sesquiterpene β-caryophyllene is a ubiquitous component of many plant resins and has been used in the cosmetic industry to provide a woody, spicy aroma. Recent clinical studies have shown its potential effectiveness as an antibiotic, anesthetic, and anti-inflammatory agent. Additionally, there is significant interest in sesquiterpene accumulation in phototrophic microorganisms for the production of biofuels. Currently, the isolation of β-caryophyllene relies on purification methods from oleoresins extracted from large amounts of plant material. The design of a cyanobacterium platform that produces β-caryophyllene may provide a more sustainable and controllable means of production, allowing for an increase in yield without …

An Investigation Into The Use Of Color As A Device To Convey Memes During The Little Ice Age, Peter Allen White

Master's Theses

Color is used as a tool in visual communication to express ideas in a symbolic fashion. It can also be used as a guide to assist the viewer in the visual narrative. Artwork created in the period of time between 1300 to 1850 in northern and central Europe provides a comprehensive perspective in the use of color as symbol and color as an elucidative devise. This period of time is known as the Little Ice Age, the duration of which spans European history between the Medieval period and the Romantic era. The extreme climatic conditions of this era caused profound …

Development And Validation Of A Light Weight, Energy Dense, Ready To Eat (Rte) Bar, Jacob Wilhelm-Maria Heick

Master's Theses

DEVELOPMENT AND VALIDATION OF A LIGHT WEIGHT, ENERGY DENSE, READY TO EAT (RTE) BAR

Jacob Wilhelm-Maria Heick

Providing additional calories in the form of an RTE bar to endurance athletes will increase performance and muscle re-synthesis, reduce muscle breakdown, and shorten recovery time. An RTE bar containing a blend of dairy proteins and carbohydrates will create a product with superior functionality, including bioactive and immunity enhancing properties from dairy derived ingredients. The protein will provide benefits in the form of easily digestible calories, essential amino acids and physical satiate.

A formulation was developed and optimized, resulting in a final product …

No-Till Vegetable Production At The Cal Poly Organic Farm, Nathaniel Jay Harkleroad

Master's Theses

Tillage and subsequent bare soil have been linked to erosion, nutrient leaching, reduced biological diversity, loss of organic matter, and release of CO2 into the atmosphere (Brady and Weil, 2004). The usefulness of an organic no-till system for transplanted vegetables was explored over two growing seasons. In 2007-2008, in a randomized complete block design, treatments of tilled and no-till (T and NT, respectively) were seeded to a dense grain and legume winter cover crop. Tilled plots were mown and disk-ploughed two times; NT plots retained a mow-killed mulch on the soil surface. There were less weeds in NT plots. A …

The Development And Validation Of A Finite Element Model Of A Canine Rib For Use With A Bone Remodeling Algorithm., Scott J. Sylliaasen

Master's Theses

Studies are currently being performed to determine the effects of bisphosphonate treatments on the structure and density of bone tissue. One of the pathways for gaining a better understanding of the effects of this and other treatments involves creating a computer simulation. Theory suggests that bone tissue structure and density are directly related to the manner in which the tissue is loaded. Remodeling is the process in which bone tissue is resorbed in areas of low stress distributions, and generated in areas of high stress distributions. Previous studies have utilized numerical methods and finite element methods to predict bone structure …

Artificial Skin Tactile Sensor For Prosthetic And Robotic Applications, Ross James Miller

Master's Theses

To solve the problem of limited tactile sensing in humanoid robotics as well as provide for future planned mechanical prostheses, an innovative tactile sensor system was created and embedded into two realistic-looking artificial skin gloves. These artificial skin tactile sensors used small piezoelectric ceramic disks to measure applied force at multiple points on each glove. The gloves were created using silicone rubber to simulate both the texture and look of human skin, while maintaining both flexibility and durability. The sensor outputs were buffered by high-impedance voltage-following operational amplifiers, and then read sequentially using a multiplexing scheme by a microcontroller. Sensor …

Assessment Of Morphology And Hemodynamics In Normal And Remodeled Microvasculature With Parameter Sensitivity Analysis, Shilpi Ghosh

Master's Theses

The goal of this study was to compare the morphological and hemodynamic characteristics of normal and remodeled vascular networks in the mouse gracilis muscle. To this end, previously developed models to assess flows and vascular branching were used to assess the normal and remodeled microcirculatory networks. The analysis revealed that the average individual vessel flow rates for vessels of similar caliber and total volumetric flow rates in the networks do not change for vessels of the same caliber after remodeling. Connectivity changes and average diameters primarily change in the larger arterioles after remodeling. A few correlations could be made between …

Anaerobic Co-Digestion Of Wastewater Treatment Pond Algae With Wastewater Sludge, Daniel Eric Heimel

Master's Theses

Microalgae harvested from wastewater treatment ponds can be anaerobically digested to produce biogas, a renewable fuel resource. However, past experiments have shown some limitations of algae digestion. Algal cell walls are thought to be resistant to digestion, and the high protein content of algae can lead to ammonia toxicity in digesters. Co-digestion of algae with substrates containing higher C:N ratios (e.g., waste paper) can be used to maintain non-inhibitory ammonia concentrations and increase methane production. However, high carbon waste co-substrates have become costly or are not readily available in many communities. Although domestic wastewater sludge has only a marginally higher …

Development Of Cubesat Vibration Testing Capabilities For The Naval Postgraduate School And Cal Poly San Luis Obispo, Marissa Brummitt

Master's Theses

The Naval Postgraduate School is currently developing their first CubeSat, the Solar Cell Array Tester CubeSat, or NPS-SCAT. Launching a CubeSat, such as NPS-SCAT, requires environmental testing to ensure not only the success of the mission, but also the safety of other CubeSats housed in the same deployer. This thesis will address the development of CubeSat vibration testing methodology at NPS, including subsystem testing, engineering unit qualification, and flight unit testing. In addition, the new Cal Poly CubeSat Test POD Mk III will be introduced and evaluated based upon comparison with the Poly Picosatellite Orbital Deployer (P-POD). Using examples from …

The Impact Of Perceived Risk From Challenge Courses On Group Cohesion, Ryan R. Soares

Master's Theses

The purpose of this study was to assess the impact of perceived risk from high elements in a challenge course on group cohesion. Participants who have not participated in a challenge course will be selected from a First Year Experience cohort at a California State University (n=100). Six randomly selected teams of 12 to 17 people will participate in three and a half hour challenge course programs. Half of the groups completed only low elements, while the other half completed a combination of low and high elements. A pre, mid, and post test of the Group Cohesion Evaluation Questionnaire was …

Movement Of Selected Nearshore Temperate Reef Fishes Along California's Central Coast, Leslie Jaye Longabach

Master's Theses

Worldwide fisheries decline has spurred the utilization of new conservation and management approaches, including the implementation of marine reserves. The diversity of goals and expected outcomes should guide the marine reserve design process, coupled with a thorough understanding of the ecology of all species targeted for protection. Central California’s network of coastal marine protected areas (MPAs) was established in an environment of some uncertainty regarding the expected outcomes for temperate nearshore fish species, especially the Sebastes genus (rockfishes). Movement behavior of temperate reef-fishes plays an important role in the level of protection that a reserve will afford a species. Consistent …

Comparisons Of Fish Species Inside And Outside Of Marine Protected Areas Off The South Central Coast Of California, David E. Rasmussen

Master's Theses

COMPARISONS OF FISH SPECIES INSIDE AND OUTSIDE OF MARINE PROTECTED AREAS OFF THE SOUTH CENTRAL COAST OF CALIFORNIA

David E. Rasmussen

From 2004-2008 and 2008-2009 Cal Poly University researchers conducted two separate tag and recapture studies of nearshore fish populations along California’s central coast. Three locations were sampled that have experienced different degrees of fishing pressure. Big Creek MPA has been closed to all fishing from 1993 onwards and is the farthest from port of all locations. Cambria lies closest to port of the three locations and because of this has the highest fishing pressure. Piedras Blancas lies midway between …

Development Of A Subject Specific Finite Element Model Used To Predict The Effects Of A Single Leg Extension Exercise, Garrett Thomas Gleeson

Master's Theses

The study presented attempts to prove the concept that mechanical changes in the structure of a bone can be predicted for a specific exercise by a subject specific model created from CT data, MRI data, EMG data, and a physiologic FE model. Previous work generated a subject specific FE model of a femur via CT and MRI data as well as created a set of subject specific biomechanical muscle forces that are required to perform a single leg extension exercise. The FE model and muscle forces were implemented into a single leg extension FE code (ABAQUS) along with a specialized …

Process Characterization Of The Reactive-Ion Etching Of Borosilicate Glass For Microfluidic Channels, Ann Christine Huang

Master's Theses

The ability to work with small amounts of fluids is an emerging technology that can greatly benefit the biomedical industry, diagnostics, and society as a whole. Typically, these microfluidic devices are fabricated using polydimethylsiloxane (PDMS). Although it is optically clear, relatively inert, and easy to manipulate, PDMS does have its limitations. These include its tendency to swell when it comes in contact with certain chemicals and its hydrophobicity, which makes it difficult to analyze aqueous samples. Glass is an alternative material that addresses both issues. Etching is used to create these channels in glass. Wet etching procedures are typically isotropic …

Multi-Frequency Processing For Lumen Enhancement With Wideband Intravascular Ultrasound, Rory A. Carrillo

Master's Theses

The application of high frequency ultrasound is the key to higher resolution intravascular ultrasound (IVUS) images. The need to further improve the IVUS spatial resolution may drive the transducer center frequency even higher than the current 40 MHz range. However, increasing the center frequency may be challenging as it leads to stronger scattering echoes from blood. The high level of blood scattering echoes may obscure the arterial lumen and make image interpretation difficult. Blood backscatter levels increase with transmission center frequency at a much greater rate compared to arterial tissue. These different frequency dependencies provide a potential method to distinguish …