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Articles 301 - 330 of 4980
Full-Text Articles in Entire DC Network
No Change In Functional Ecology Or Body Size In Response To A Global Climate Event In The Late Maastrichtian Owl Creek Formation, William T. Rizza
No Change In Functional Ecology Or Body Size In Response To A Global Climate Event In The Late Maastrichtian Owl Creek Formation, William T. Rizza
Master's Theses
During the last 300 ka of the Maastrichtian, global temperatures increased and decreased by ~2℃, likely caused by a pulse of Deccan volcanism. The Owl Creek Type Section in Mississippi records some portion of the last 400 ka of the Late Maastrichtian. It is expected that marine invertebrates will demonstrate a taxonomic, ecological, or morphological response to rapid temperature change. I anticipate a decrease in taxonomic diversity and shell volume and an increased abundance of low activity-level species, similar to the ecological impacts observed in response to Large Igneous Province eruptions in the geologic record. Clumped isotope paleotemperature reconstruction recovers …
Win-Win Ecology: Can Mosses Promote Dudleya Germination To Restore California Quarries?, Kate L. Worrell
Win-Win Ecology: Can Mosses Promote Dudleya Germination To Restore California Quarries?, Kate L. Worrell
Master's Theses
Human actions directly damage habitat for native plants; restoration ecology facilitates successful plant re-establishment in these environments. Open-pit mines leave behind steep, rocky, and nutrient-deficient habitats that are some of the most degraded ecosystems on the planet. Dudleya or ‘live-forevers’— a genus of native California succulent plants that contains many rare, threatened, or endangered species — grow on rocky cliffs and may create a successful reclamation-restoration story. However, Dudleya germination is poorly understood. Much of the literature on Dudleya cites a single field report suggesting that bryophytes facilitate germination, but no previous experiments have evaluated this proposal. In this study, …
The Impact Of Adverse Childhood Experiences On Later Desistance Among Serious Juvenile Offenders From A Broken Family Composition, Olivia Franklin
The Impact Of Adverse Childhood Experiences On Later Desistance Among Serious Juvenile Offenders From A Broken Family Composition, Olivia Franklin
Master's Theses
The current study aimed to contribute to the overall knowledge of desistance patterns among juveniles by exploring them among serious juvenile offenders who come from a broken home. Utilizing the Pathways to Desistance (PTD) dataset, this study used logistic regression to examine the impact of family composition on later desistance while controlling for various adverse childhood experiences (ACEs) one might experience. Two research questions guide this study: (1) Does family composition (i.e., “broken homes”) impact later desistance among serious adolescent offenders, while controlling for important criminological predictors (i.e., self-control and antisocial peer influence)? (2) Is the quality of one’s home …
Hypoxic Incubator: Improving Robustness/Reliability And Demonstrating Physiological Efficacy, Damon Dennis Tan
Hypoxic Incubator: Improving Robustness/Reliability And Demonstrating Physiological Efficacy, Damon Dennis Tan
Master's Theses
The Microphysiological Systems Laboratory aims to develop colorectal cancer tumor models under a hypoxic environment to assess model response to pharmaceutical compounds in vitro. To perform relevant studies, researchers have attempted to use different hypoxic inducing strategies such as a nitrogen pod and hypoxic incubator to recreate in vivo physiological responses to hypoxia. However, studies would be interrupted due to incubator functionality failure. To ensure successful and physiologically relevant studies, I improved and verified the robustness and reliability of a hypoxic incubator previously designed and manufactured in the lab. Through the testing and iterating design processes, I engineered and implemented …
3d Printed Microfluidic Fabrication Methodology, Characterization, Mechanical Design, And Applications In Electrostatic Artificial Muscles And Benthic Microbial Fuel Cells, Terak B. Hornik
Master's Theses
The fabrication of microfluidic devices often requires specialized methods. The development of these methods requires careful characterization and understanding of the processes involved. Using primarily PolyJet 3D printing technology, microfluidics offers a wide scope of applications such as microfluidic benthic microbial fuel cells (MBMFCs) and electrostatic artificial muscles. MBMFCs benefit from the confinement of the microbes resulting in close proximity between the electrode and the organisms. Using a modular design called the Sponge, assembly and upscaling is possible. Electrostatic artificial muscles benefit from a microfluidic approach due to the non-linearity of electrostatic attraction creating disproportionate benefits when miniaturized. When designed …
Implications Of Persistent Micro-Bioplastics On Biogeochemical Properties Across Soil Types, Casandra R. Leach
Implications Of Persistent Micro-Bioplastics On Biogeochemical Properties Across Soil Types, Casandra R. Leach
Master's Theses
Terrestrial microplastics are increasing in abundance and are an emerging contaminant of concern, particularly in agriculture ecosystems where plastic use and subsequent soil contamination are prevalent. Plastic film mulches make up a significant portion of the plasticulture industry and are directly linked to soil microplastic pollution where negative effects to soil biotic and abiotic functions have been observed. In response to this issue, biodegradable film mulches have been promoted as a sustainable alternative to conventional polyethylene-based mulches. These biodegradable mulches, composed of various bioplastics, are designed to be tilled back into the soil where they are expected to decompose. However, …
Drivers Of Microparticles Abundance In Freshwater Fish And Macroinvertibrates, Elizabeth Kazmierczak
Drivers Of Microparticles Abundance In Freshwater Fish And Macroinvertibrates, Elizabeth Kazmierczak
Master's Theses
Anthropogenic microparticles (MP) (i.e., particles < 5 mm) are defined as materials of manufactured origin found in the environment. They are widespread and a rapidly emerging global contaminant. MP include microplastics (< 5 mm), as well as other microfibers or particles, which can be synthetic, semi-synthetic and non-synthetic. Rivers are a critical source of plastics to oceans, and MP within rivers are retained in part though biological processes, including ingestion. MP ingestion by freshwater biota varies by proximity to point sources (e.g., wastewater treatment plants; WWTP), overall environmental concentrations, and trophic level and functional feeding groups, but few studies have examined these factors together. In our first study we examined fish collected in the North Shore Channel of the Chicago River to determine MP abundance within organisms. We then compared trophic position (i.e., δ15N) and proximity to a WWTP. With all species combined, MP concentration were not significantly different across study sites, but stable isotopes increased downstream. Considered individually, MP abundance relative to WWTP proximity varied by species, which we attributed to habitat preference and mobility. In a second project, we collected macroinvertebrates from three different watersheds in North America and compared the abundance of MP in macroinvertebrates to concentration within the environment (i.e., water column, surface, and benthic). Functional feeding groups were a significant predictor in the amount of microparticles found in macroinvertebrates. Additionally, the concentration of water column microparticles showed a positive relationship with all macroinvertebrate’s microparticle abundance. Results will aid in understanding the ecological impacts of MPs on aquatic food webs and the pathways in which they can enter.
Sadomasochistic Sensations: A Phenomenological Analysis Of Black Ontology, Embodiment, And Transcendence, Sam Forrey
Sadomasochistic Sensations: A Phenomenological Analysis Of Black Ontology, Embodiment, And Transcendence, Sam Forrey
Master's Theses
Over the past fifteen years, feminists have challenged the notion that sexual sadomasochism perpetuates racial and gender-based violence, and instead claim that the practice can be a powerful site to control and subvert oppression. In this thesis, I contribute to this growing discourse and argue that sensations experienced during practices of Black sexual sadomasochism and attention to the feelings and affects that arise from them can be used to mediate Black being in a violently antiblack United States. Through applications of Black feminist thought, Black anti-humanism, and phenomenology, I claim that antiblack oppression denies Black people the experience of tactile …
The Skin Microbiome And Cutaneous T-Cell Lymphoma, Gail Hillary Lantaca Enriquez
The Skin Microbiome And Cutaneous T-Cell Lymphoma, Gail Hillary Lantaca Enriquez
Master's Theses
Skin microbiota is associated with disease activity in cutaneous T-cell lymphoma (CTCL). A common treatment for CTCL, narrowband ultraviolet B (nbUVB) phototherapy, has shown to shape the skin microbiome in association with disease improvement in other skin disorders such as atopic dermatitis. To assess the effect of nbUVB phototherapy on the skin microbiome, we performed a longitudinal analysis of skin samples of CTCL patients receiving nbUVB. We found that the treatment led to increased bacterial diversity and reduced abundances of Staphylococcus aureus and Staphylococcus lugdunensis, both bacteria known to be pathogenic. These findings imply that nbUVB treatment changes the skin …
Exploring Evolutionary Relationships Of New World Astragalus Through Phylogenomic Analyses, Victoria Martinez
Exploring Evolutionary Relationships Of New World Astragalus Through Phylogenomic Analyses, Victoria Martinez
Master's Theses
The legume Astragalus is the single most diverse genus of plants encompassing nearly 3,000 species. Not only is Astragalus remarkably diverse, but many species have considerable economic importance. For example, toxic Astragalus species also known as “locoweed” contain the chemical swainsonine which affects the reproductive and developmental traits of livestock and causes $100 million in annual losses in the United States alone. The genus is primarily distributed in temperate regions and is particularly diverse in southwest Asia (ca. 2,000 spp.), the Sino-Himalayas (ca. 400 spp.), western North America (ca. 400 spp.), and the Andes (ca.100 spp.; Wojciechowski, 2005; Podlech & …
Lactobacillus-Mediated Phage Induction And Inhibition Of Growth Of Escherichia Coli, Natalie Stegman
Lactobacillus-Mediated Phage Induction And Inhibition Of Growth Of Escherichia Coli, Natalie Stegman
Master's Theses
Bacterial species inhabit both the “healthy” and symptomatic female urinary tract. Lactobacillus species are frequently dominant members of the healthy urinary tract microbiota (urobiome), and thus have been associated with the lack of lower urinary tract symptoms (LUTS). In contrast, colonization by Escherichia coli is the most common cause of urinary tract infections (UTIs). Prior research has found that strains of Lactobacillus can inhibit the growth of uropathogens such as E. coli as well as vaginosis-associated pathogens. Investigations into the means by which lactobacilli inhibit pathogenic growth have primarily focused on their production of hydrogen peroxide (H2O2) and lactic acid, …
The Effect Of Environmental Pollutants On The Spotted Turtle Gut Microbiota, Roza Gawin
The Effect Of Environmental Pollutants On The Spotted Turtle Gut Microbiota, Roza Gawin
Master's Theses
Heavy metals are a common pollutant from many industrial processes. In addition to the various diseases that these pollutants cause, they can also affect the composition and structure of the gut microbiome of many organisms which is in many cases associated with overall organism health. The effect of these pollutants on the gut microbiota of the spotted turtle is unknown. Here we characterize the gut microbiome of the spotted turtle and explore the effect of various environmental pollutants on its composition. We found significant differences in the composition of the gut microbiome based on turtle sampling location (geographic), turtle sampling …
Transcriptome-Wide Association Study Of The Plasma Proteme Reveals Cis And Trans Regulatory Mechanisms Underlying Complex Traits, Henry Wittich
Transcriptome-Wide Association Study Of The Plasma Proteme Reveals Cis And Trans Regulatory Mechanisms Underlying Complex Traits, Henry Wittich
Master's Theses
Most genetic variants associated with complex human traits exist in non-coding regions, and thus the mechanism by which they affect a trait can be unclear. Genetic regulation of transcription and translation are key mechanisms through which genetic variants impact traits. Quantitative trait locus (QTL) mapping studies leverage data produced by advanced sequencing and assay technology to identify variants associated with the abundance of a molecular trait like RNA expression (eQTL) or protein levels (pQTL). While proximal genetic variants (cis-acting), like those in promoter or enhancer regions of genes, tend to have the largest effect sizes on RNA transcript and protein …
Regulation Of Spermatogenesis By The Btb Transcription Factor Ribbon, Madeline Kyung Hee Hakala
Regulation Of Spermatogenesis By The Btb Transcription Factor Ribbon, Madeline Kyung Hee Hakala
Master's Theses
The transcription factor Ribbon (Rib) plays an essential role in Drosophila testis development and function. Increased expression of rib throughout development results in significant morphology defects in the adult testis. If overexpression is limited to germ cells and somatic cells in the adult, more mild defects are observed. To better understand how Rib regulates spermatogenesis, we are interested in identifying its transcriptional targets in this context. Through bulk RNA sequencing, differential expression analysis, and subsequent filtering of results, we identified 301 genes with significant changes in expression when rib was overexpressed. Given the previously described role of Rib in the …
Impacts Of Stormwater And Land Cover On The Abundance, Transport, And Composition Of Anthropogenic Litter In Urban Watersheds, Bailey Austin Schwenk
Impacts Of Stormwater And Land Cover On The Abundance, Transport, And Composition Of Anthropogenic Litter In Urban Watersheds, Bailey Austin Schwenk
Master's Theses
Anthropogenic litter (AL; trash) is defined as any manufactured item that ends up in the environment. AL consists of many different materials including glass, metal, and plastic, the latter of which typically represents a dominant constituent and has been a major focus of research. Plastic litter and other AL types are pervasive to all types of ecosystems, are persistent in the environment, and are increasing. Rivers are a major conduit transporting AL to oceans. However, rivers also retain and transform AL. More research is needed to understand AL dynamics within rivers, which will improve global models of AL movement and …
Pattern, Process And The Evolution Of Sexual Dimorphism In Three-Spine Stickleback Fish Gasterosteus Aculeatus From Vancouver Island, British Columbia, Katie Van Dame
Master's Theses
Males and females of a species often differ from one another in phenotype—a phenomenon known as sexual dimorphism. Sexual dimorphism is most often attributed to sexual selection. However, sexual dimorphism also derives from natural selection when resource competition generates disruptive selection favoring specialization on different resources, resulting in niche partitioning and the evolution of dimorphism in traits related to competition. Sexual dimorphism may be an important route to increased individual fitness (i.e., more resources, more survival). For example, ecologically driven divergent selection between sexes may derive from differences in their environments, resulting in the evolution of dimorphism in traits related …
Dynamic Maze Puzzle Navigation Using Deep Reinforcement Learning, Luisa Shu Yi Chiu
Dynamic Maze Puzzle Navigation Using Deep Reinforcement Learning, Luisa Shu Yi Chiu
Master's Theses
The implementation of deep reinforcement learning in mobile robotics offers a great solution for the development of autonomous mobile robots to efficiently complete tasks and transport objects. Reinforcement learning continues to show impressive potential in robotics applications through self-learning and biological plausibility. Despite its advancements, challenges remain in applying these machine learning techniques in dynamic environments. This thesis explores the performance of Deep Q-Networks (DQN), using images as an input, for mobile robot navigation in dynamic maze puzzles and aims to contribute to advancements in deep reinforcement learning applications for simulated and real-life robotic systems. This project is a step …
History & Evolution Of Plastic Mulching Technology: An Ethnography Of California Strawberry Plasticulture, Kalea Conrad
History & Evolution Of Plastic Mulching Technology: An Ethnography Of California Strawberry Plasticulture, Kalea Conrad
Master's Theses
This ethnography draws on key informant interviews and participant observation to produce a case study about plastic mulching as an important industry standard in specialty crop production. It documents the historic adoption and present role of plastic mulching technology in California strawberry production and addresses the characteristics of commercial standard management that inhibit the adoption of alternative mulching practices. It complements extensive research on strawberry pathology and fumigation, breeding innovations, fertilizer and pesticide treatments, and maximization of yields to incorporate participants’ lived experiences and knowledge of mulch origins, the technology adoption process, mulch benefits and drawbacks, the state of agricultural …
Dual Base Sige Is-Hbt For Use In Biosensing Applications, Liam Stephen Hayes
Dual Base Sige Is-Hbt For Use In Biosensing Applications, Liam Stephen Hayes
Master's Theses
The proposed research is for a novel SiGe-based Ion-Sensitive Dual Hetero-junction Bipolar Transistor (IS-HBT) to be used in both trans-dermal biological sensing as well as Lab-on-Chip (LOC) applications. The end goals for the device designed are two: For one, the research done for this work will be used to substantiate the claims made by Zafar et al. [1] that an HBT-style structure is better suited for biosensing application rather than a conventional Field Effect Transistor (FET) based geometries. Secondly, it provides the final element to be integrated along with a selectivity membrane, as well as with a reverse-iontophoresis system to …
Survey Of Soilborne Pathogens Infecting Strawberry In Oxnard, California & Effect Of Planting Date And Chill Treatment On Yield Of Strawberry, Samantha Z. Simard
Survey Of Soilborne Pathogens Infecting Strawberry In Oxnard, California & Effect Of Planting Date And Chill Treatment On Yield Of Strawberry, Samantha Z. Simard
Master's Theses
Survey to quantify the frequency of the five main pathogens (Macrophomina phaseolina, Fusarium oxysporum f. sp. fragariae races 1 and 2, Verticillium dahliae, and Phytophthora spp.) infecting strawberry in the Oxnard growing district of California. M. phaseolina was the most prevalent pathogen detected in diseased plants in the Oxnard growing district, present in 67.6% of samples positive for at least one pathogen. F. oxysporum f. sp. fragariae race 1 (35.3%), V. dahlia (8.8%), F. oxysporum f. sp. fragariae race 2 (5.9%) and Phytophthora spp. (2.9%) followed at lower prevalence. Associations were found between fewer drip irrigation lines …
Understanding The Mystery Of R-Loops And Their Relationship To Nucleolar Stress, Kevin Shane
Understanding The Mystery Of R-Loops And Their Relationship To Nucleolar Stress, Kevin Shane
Master's Theses
Genomic instability is an increase in the likelihood of DNA mutations and genetic changes during cell division, a common feature in cancer cells. One cause of genomic instability comes from the aberrant formation of three-stranded nucleic acid structures called R-loops. R-loop form when an RNA strand hybridizes to its complementary strand of DNA, forming a stable RNA:DNA hybrid and displacing one free strand of DNA 1. Accumulation of unscheduled R-loops can lead to replication stress, fork collision, gene expression changes, and double-strand breaks that are underlying causes of genome instability and the development of many diseases, including cancer 2. Many …
Barriers To And Solutions For Fuel Treatments In The Central California Coast Ranges, Sierra Dawn Lyman
Barriers To And Solutions For Fuel Treatments In The Central California Coast Ranges, Sierra Dawn Lyman
Master's Theses
In recent years, the Western United States has experienced an increase in fire activity due to multiple factors, including anthropogenic climate change, historical forest management focused on suppression, and the expanding wildland urban interface (WUI). In response, California is working to accelerate the pace and scale of forest management and fire hazard reduction efforts. Although fuel treatment projects are being implemented, they often encounter various barriers. While existing literature highlights these barriers, it tends to overlook the solutions being applied in practice to overcome them. Using an ethnographic approach that includes key informant interviews and participant observation in four sites …
Of Geese And Grass: Investigating Impacts Of Brant Grazing On Eeelgrass, Dakota L. Osborne
Of Geese And Grass: Investigating Impacts Of Brant Grazing On Eeelgrass, Dakota L. Osborne
Master's Theses
Grazing pressure is important in structuring plant communities, particularly in aquatic environments. Eelgrass (Zostera marina), a keystone species in estuaries across North America, is experiencing widespread population declines. As a keystone species, eelgrass provides numerous important functions, including: 1) water filtration, 2) sediment stabilization, 3) providing refuge and nursery habitat for numerous species, and 4) carbon sequestration. Benefits which could be lost if eelgrass beds continue to diminish. California has experienced some of the greatest eelgrass declines, and Morro Bay, CA experienced a 96% decrease in eelgrass from 2007 to 2017. Most studies to date have examined bottom-up …
Seal Counting On Our Plages (S.C.O.O.P.), Kaanan Kharwa
Seal Counting On Our Plages (S.C.O.O.P.), Kaanan Kharwa
Master's Theses
The Vertebrate Integrative Physiology (VIP) lab monitors the population of northern elephant seals at the largest mainland breeding colony, located at Piedras Blancas (San Simeon, CA). As the population expands, more human-seal interactions and conflicts over land use occur. The VIP lab's work informs California State Parks and helps with the management of the rookery. Currently, members of the VIP lab fly a drone over the beaches, capture multiple images, and manually count the seals, which takes around 14 to 21 hours of analysis per survey. Machine learning methods such as Convolutional Neural Networks (CNN) and Region-based Convolutional Neural Networks …
Terrestrial Salinization Impacts On Growth And Behavior Of A Common Detritivore Armadillidium Vulgare (Isopoda), Danielle Harmoney Orcutt
Terrestrial Salinization Impacts On Growth And Behavior Of A Common Detritivore Armadillidium Vulgare (Isopoda), Danielle Harmoney Orcutt
Master's Theses
Climate change and human activities are changing the nutritional landscape by increasing the availability of some essential elements and decreasing others. Sodium (Na) is an essential element in heterotrophs, which is required for water regulation, nerve function, and muscle function. Heterotrophs can acquire Na through diet and environment, often experiencing limited availability of Na due to plants concentrating Na 10-100 times less than heterotrophs need. The Sodium Subsidy-Stress (SSS) hypothesis posits that organismal performance follows a hump-shaped curve of a physiological response, where Na acts as a subsidy, increasing organismal performance such as growth until an optimal threshold is reached, …
Assessment Of Mediterranean Diet Adherence Using The Kidmed Diet 2.0 Tool: College Student Questionnaire, Nakia Cyrice Hilton
Assessment Of Mediterranean Diet Adherence Using The Kidmed Diet 2.0 Tool: College Student Questionnaire, Nakia Cyrice Hilton
Master's Theses
The Mediterranean Diet has garnered increasing popularity due to its multifaceted health benefits. The MedDiet enhances well-being across all age groups, emphasizing high consumption of fruits, vegetables, legumes, nuts, olive oil, and whole grains and moderate fish, poultry, and dairy intake. Recent research underscores the significant impact of Mediterranean diet adherence on college students' physical and mental health. The diet's emphasis on nutrient-dense foods rich in vitamins, minerals, and antioxidants supports cognitive function, which is pivotal for academic performance. Moreover, the abundant presence of healthy fats, particularly from olive oil and fatty fish, may contribute to improved mood regulation, potentially …
Adherence To Mediterranean Diet Principles In Minority College Students, Bridgette Lorraine Barbre
Adherence To Mediterranean Diet Principles In Minority College Students, Bridgette Lorraine Barbre
Master's Theses
Every year, millions of young adults attend college. The Centers for Disease Control and Prevention (CDC) lists heart disease and diabetes as the top health concerns for minority Americans. African American and Hispanic/Latino communities could see a reduction in illness risk by promoting physical activity and healthy eating habits such as the Mediterranean Diet. Research indicates that young adults may benefit significantly from taking charge of their eating habits at the crucial point in their transition from high school to college. By determining the dietary patterns of minority college students, as related to the Mediterranean diet principles, this study intends …
Division I Collegiate Baseball Pitching Performance In Relation To Forearm Kinematics And Kinetics, Christopher W. Watson
Division I Collegiate Baseball Pitching Performance In Relation To Forearm Kinematics And Kinetics, Christopher W. Watson
Master's Theses
This thesis investigates physical and anthropometric factors influenced by forearm rotation biases associated with supination and pronation on pitch characteristics among Division I college baseball pitchers. The study involved twenty-two participants who underwent comprehensive physical assessments, including measures of forearm strength, range of motion, and grip strength, as well as finger and hand length measurements. Ball flight metrics were collected during intrasquad scrimmages using advanced radar tracking technology. Results revealed significant relationships between distinct physical biases of strength in pronation and supination, pinch strength, anthropometrics such as middle finger length, and specific pitch characteristics. This study lays the groundwork for …
Robotic Odor Source Localization Using Vision And Olfaction Sensing, Sunzid Hassan
Robotic Odor Source Localization Using Vision And Olfaction Sensing, Sunzid Hassan
Master's Theses
Robotic Odor Source Localization (ROSL) technology allows autonomous agents like robots to find an odor source in unknown environments. A successful odor source location depends crucially on an effective navigation algorithm that directs the robot towards the odor source. This thesis is a combination of three projects. First, we detail development of a versatile multi-modal robotic platform for ROSL real-world ROSL experimentation and discussed real-world validation of a traditional olfactionbased ROSL algorithm. Secondly, we introduced vision in ROSL by proposing a fusion navigation algorithm that integrates deep-learning enabled vision and olfaction-based navigation. This hybrid approach tackles challenges such as turbulent …
Identifying The Interactors Of Otud6b-2 That Are Important For Its Function On C-Myc, Farah Albatsh
Identifying The Interactors Of Otud6b-2 That Are Important For Its Function On C-Myc, Farah Albatsh
Master's Theses
The complexity of molecular signaling pathways, particularly in cancer research, has made the proto-oncogene c-Myc a key focus due to its role as a master regulator of cellular processes such as growth, division, and apoptosis. Dysregulation of c-Myc is linked to various cancers, making it a highly sought therapeutic target despite challenges in directly inhibiting its function. Recent efforts have shifted towards indirect targeting methods, including BET inhibitors, cyclin-dependent kinase inhibitors, and siRNA formulations. A novel approach using PROTACs and the investigation of c-Myc-specific deubiquitinases (DUBs) has shown potential, particularly the emerging player OTUD6B-2. This study aims to identify and …