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Elucidating Regulatory Connections Between The Second Messenger Cyclic-Di-Gmp With Biofilm And Motility Phenotypes Of Vibrio Fischeri, Ali Razvi
Master's Theses
The symbiosis between the gram-negative marine bacterium Vibrio fischeri and its host Euprymna Scolopes occurs when the bacteria reaches and colonizes the light organ. This pathway to colonization begins in the outer marine environment and finishes within the deep crypts of the light organ, with states of biofilm formation and dispersal in between. This switch between biofilm formation to dispersal is important as the bacteria transitions from the surface on the light organ into a pore leading to the interior of the light organ. This dispersal is regulated by LAP system which is dependent on the second messenger c-di-GMP. Through …
Characterization Of Alcohol-Mediated Promotion Of Breast Cancer Stem Cells, Mckenna Below
Characterization Of Alcohol-Mediated Promotion Of Breast Cancer Stem Cells, Mckenna Below
Master's Theses
Breast cancer is the leading cause of cancer-related death in women globally, and one in eight women will be diagnosed with breast cancer at some point in her life. Alcohol consumption has been linked to increase breast cancer risk and increased risk of tumor recurrence. Understanding the molecular mechanisms of modifiable lifestyle factors such as alcohol consumption will help to lower these risks and design more effective therapeutic approaches. Estrogen Receptor positive (ER+) breast cancer comprises approximately 70% of all breast cancers, and these tumors are effectively targeted by endocrine therapy in the form of estrogen deprivation with aromatase inhibitors, …
Beta-Adrenergic Receptor Mediated Transcriptional Dysregulation In Hematopoeitc Stem And Progenitor Cells Leads To Bone Marrow Erythroid Suppresion In Multiple Myeloma Patients - Ex Vivo Investigations, Vimal Ravi Subramaniam
Beta-Adrenergic Receptor Mediated Transcriptional Dysregulation In Hematopoeitc Stem And Progenitor Cells Leads To Bone Marrow Erythroid Suppresion In Multiple Myeloma Patients - Ex Vivo Investigations, Vimal Ravi Subramaniam
Master's Theses
The sympathetic nervous system (SNS) regulates our body’s involuntary response to stress or harm. Once activated, it releases hormones and neurotransmitters known as catecholamines throughout the body to mediate its recovery. The catecholamines bind to adrenergic receptors located on various cells in a process designated as adrenergic signaling to elicit this response. This process is not always to our benefit. Adverse symptoms such as anemia can result due to adrenergic signaling. Our laboratory previously showed that burn injury triggers adrenergic receptor stimulation resulting in anemia induced by diminished erythropoiesis. The development of anemia in these studies was found to be …
Advancing Our Understanding Of Mechanosensitive Microtubule Acetylation In Neurons, Margaret Earl Utgaard
Advancing Our Understanding Of Mechanosensitive Microtubule Acetylation In Neurons, Margaret Earl Utgaard
Master's Theses
Stiffness is a signaling cue in the brain, and neuronal response to stiffness impacts development, injury and disease. Mechanotransduction is the process of cells interpreting and converting mechanical cues to biochemical signals. Tubulin acetylation increases microtubule stability and could be mechanosensitive. The impact of stiffness on tubulin acetylation and role of septins is the focus of this project.It was hypothesized that stiffer surfaces would increase tubulin acetylation. SH-SY5Y cells were plated on varying stiffness and the ratio of acetylated to alpha tubulin was measured using immunocytochemistry. This study found SH-SY5Y cells had the highest acetylation on hard surfaces. SH-SY5Y cells …
Characterization And Targeting Of Voltage-Gated Ion Channels In Meningioma Cell Lines, Erik White
Characterization And Targeting Of Voltage-Gated Ion Channels In Meningioma Cell Lines, Erik White
Master's Theses
Meningiomas (MN) are primary brain tumors originating in the meningeal covering of the central nervous system. These tissues can evolve through familial inheritance (NF2, Cowden Syndrome, or Werner Syndrome) or sporadic mutations. The WHO categorizes MNs into three grades (I-III); Grade I contain benign tumors and Grade III the most aggressive. Increasing grade coincides with an increase in genetic diversity, making universal treatments difficult. MNs are typically treated with hydroxyurea (HU), but this chemotherapy agent has many adverse side effects, leading to research in less toxic options. This study uses ion channel antagonists for T- and L-type calcium channels using …
Characterizing A Putative Membrane Androgen Receptor In Glioma Cell Models, Emma Yuen
Characterizing A Putative Membrane Androgen Receptor In Glioma Cell Models, Emma Yuen
Master's Theses
The goal of this current research was to explore the role of a putative membraneandrogen receptor (AR) in modulating the viability of various models of glioma/astrocytoma, relative to normal (non-tumor) astrocytes. We hypothesized that binding to the membrane AR could enhance the sensitivity of glioma cells to toxic insult (i.e., the chemotherapeutic, Temozolomide, TMZ), while leaving “normal” astrocytes unscathed. Our data reveal that binding to the putative membrane AR sensitized C6 glioma cells to TMZ and the oxidative/metabolic insult, iodoacetic acid (IAA). And while there was some evidence that binding to the membrane AR could enhance the effect of TMZ …
Rethinking Intimacy: Liberation Through Decolonial & Queer World-Making, Michelle Mae Mcguire
Rethinking Intimacy: Liberation Through Decolonial & Queer World-Making, Michelle Mae Mcguire
Master's Theses
Relationships play an important role in both the private and public spheres of our lives. If we understand our bodies to be the vessels through which we interact with all other objects, we come to understand the process of world-making as a summation of our relationships. Intimacy is the prevailing structure that helps assign meaning to these relationships. Intimacy binds together unfixed spatial and social relations that stretch across time and space. This essay examines the three intersecting sets of relations involved in intimacy as a means to deconstruct heteropatriarchal order and highlight the multiplicity of attachments and relationships that …
Lactobacillus Metabolite-Mediated Induction Of Bacteriophage, Taylor Miller-Ensminger
Lactobacillus Metabolite-Mediated Induction Of Bacteriophage, Taylor Miller-Ensminger
Master's Theses
Once considered sterile in the absence of an infection, the female urinary tract is home to a diverse community (microbiota) of bacterial species and bacteriophage (phage), viruses that infect bacteria A dominant member of the female urinary microbiota is the bacterial genus Lactobacillus. Several Lactobacillus species are even associated with urinary health. Phage infectious of bacteria in the urinary tract tend to replicate through one of two life cycles: the lytic (active) life cycle or the lysogenic (dormant) life cycle. Temperate phage can switch from the lysogenic life cycle to the lytic life cycle in the presence of an environmental …
Stigmatization Of In Transit Migration And The Devaluation Of Humanitarian Aid Resource Labor, Gabriela Perez Laurent
Stigmatization Of In Transit Migration And The Devaluation Of Humanitarian Aid Resource Labor, Gabriela Perez Laurent
Master's Theses
This analysis aims to gain insight into migrant stigmatization and the devaluation of humanitarian aid labor. Building off previous feminist scholarship on unpaid labor, this thesis seeks to add to our understanding of the dynamics of gendered devaluation of not only humanitarian volunteer labor, but also humanitarian aid support to stigmatized populations. The analysis expands on the production of illegalization and highlights the effects of stigmatization highlights the effects of stigmatization upon in transit populations on Tohono O'odham lands. Erin Hatton's framework of devaluation is applied to humanitarian aid distribution to analyze the devaluation of their labor due to proximity …
The Effect Of Gonadal Steroids Following Repeat Mild Traumatic Brain Injury On Anxiety-Like Behaviors In Rats, Trevor Nykamp
The Effect Of Gonadal Steroids Following Repeat Mild Traumatic Brain Injury On Anxiety-Like Behaviors In Rats, Trevor Nykamp
Master's Theses
Traumatic brain injury (TBI) affects millions of people in the U.S. each year. This thesis worked to address anxiety, a common emotional symptom following TBI, by utilizing a five-hit repeat mild TBI (rmTBI) experimental model. First, changes in gonadal status following injury and the severity of anxiety symptoms experienced were investigated. Our data revealed that suppressed testosterone levels following rmTBI resulted in significantly more anxiety-like behaviors across several observational variables. Even more, some of these behaviors were reduced by providing testosterone supplementation immediately following injury.Another goal of this work was to investigate the role of mitochondrial dysfunction, measured by COX4i1 …
The Role Of Intersensory Redundancy In Face Recognition In 5- And 12-Month-Old Infants, Aslı Bursalıoğlu
The Role Of Intersensory Redundancy In Face Recognition In 5- And 12-Month-Old Infants, Aslı Bursalıoğlu
Master's Theses
The goal of this study was to examine the role of audiovisual synchrony in 5- and 12-month-old infants’ attention to and processing of face stimuli. Infants were tested using an online platform called Lookit. In the first phase of the experiment, infants were familiarized with two videos presented simultaneously and side-by-side. Each video displayed a woman speaking in an infant-directed manner. A soundtrack was played that matched one of the videos (experimental condition) or neither of the videos (control condition). It was hypothesized that synchronous audiovisual presentation would attract infants’ attention and promote processing, especially among 12-month-olds. Visual-paired comparison (VPC) …
A Role For Notch Signaling In Drosophila Spermatogenesis, Adrianna Soriano
A Role For Notch Signaling In Drosophila Spermatogenesis, Adrianna Soriano
Master's Theses
The Notch signaling pathway has diverse functions in male and female gonad development. In Drosophila male embryos, Notch specifies hub cell fate in somatic gonadal precursor cells (SGPs), which are important for maintaining germline stem cells and somatic cyst stem cells throughout the lifetime of adult flies. However, a role for Notch signaling in adult males has only started to emerge recently. Nonetheless, we still don’t understand how the Notch pathway functions to regulate spermatogenesis. Notch has been established to be important for the fertility of multiple systems, including mammals, and must be properly regulated for proper spermatogenesis, but the …
The Moderating Effect Of Self-Efficacy On The Relationship Between Telecommuting And Turnover Intentions, Samantha Mei-Li Scoppettone
The Moderating Effect Of Self-Efficacy On The Relationship Between Telecommuting And Turnover Intentions, Samantha Mei-Li Scoppettone
Master's Theses
In recent years, telecommuting has become a popular working arrangement. While many studies have examined various outcomes of telecommuting such as turnover intentions, there is limited literature around potential moderators of the relationship of telecommuting and turnover intentions. The present study examined the relationship between telecommuting intensity and turnover intentions and explored occupational self-efficacy as a potential moderator. It was hypothesized that occupational self-efficacy would moderate the positive relationship between telecommuting intensity and turnover intentions, meaning that the relationship would be stronger for those with lower levels of occupational self-efficacy than those with higher levels of occupational self-efficacy. A total …
The Impact Of Compensation On Engagement And Organizational Tenure: The Moderating Role Of Perceived Organizational Support, Alexis Johnson
The Impact Of Compensation On Engagement And Organizational Tenure: The Moderating Role Of Perceived Organizational Support, Alexis Johnson
Master's Theses
Compensation is a crucial tool utilized by companies to help attract, retain, and motivate employees. However, previous research has overlooked the ways in which compensation might add value to important employee outcomes such as engagement and organizational tenure. Therefore, this present study aimed to close this gap by examining the relationship between pay level and engagement, as well as pay level and organizational tenure. It was hypothesized that higher pay levels would increase the engagement dimensions of dedication, vigor, and absorption in an employee, and that higher pay levels would increase organizational tenure in an individual. It also sought to …
Influence Of Social Circles On User Recommendations, Chaitanya Krishna Kasaraneni
Influence Of Social Circles On User Recommendations, Chaitanya Krishna Kasaraneni
Master's Theses
Recommender systems are powerful tools that filter and recommend content relevant to a user. One of the most popular techniques used in recommender systems is collaborative filtering. Collaborative filtering has been successfully incorporated in many applications. However, these recommendation systems require a minimum number of users, items, and ratings in order to provide effective recommendations. This results in the infamous cold start problem where the system is not able to produce effective recommendations for new users. In recent times, with escalation in the popularity and usage of social networks, people tend to share their experiences in the form of reviews …
A Silicon Valley Life: A Silicon Valley Love Story, Sharon Simonson
A Silicon Valley Life: A Silicon Valley Love Story, Sharon Simonson
Master's Theses
In the last three decades, Silicon Valley has become one of the world’s most watched and imitated communities. Daily news reporters, long-form journalists, cinema and television-programming producers have crafted a public image, but it represents nothing of the lives of hundreds of thousands of Valley residents. These fabrications obscure and diminish our complex human profile and reduce our uniquely beautiful geography to a place to generate financial profits, with all the damaging disregard such attitudes foster. The essays of A Silicon Valley Life: A Silicon Valley Love Story seek to show our true self: our rich mix of people drawn …
Inclusive Leadership, Psychological Empowerment, And Affective Organizational Commitment: A Mediated Model, Mariah Lyn Van Buskirk
Inclusive Leadership, Psychological Empowerment, And Affective Organizational Commitment: A Mediated Model, Mariah Lyn Van Buskirk
Master's Theses
Inclusive leadership has become an important contextual factor to study in organizations given its impact on positive workplace outcomes. However, little is known about the ability of inclusive leadership to affect a wider range of outcomes and the various mediating mechanisms between inclusive leadership and outcomes. Therefore, the present study explored the mediating role of psychological empowerment on the relationship between inclusive leadership and affective organizational commitment. It was hypothesized that inclusive leadership would be positively related to affective organizational commitment both directly and indirectly through psychological empowerment. Results of an online survey from 189 employed individuals showed that inclusive …
“In The University But Not Of The University”: Examining Institutionalized Counterspaces Through A Staff Perspective, Omar A. Ramirez
“In The University But Not Of The University”: Examining Institutionalized Counterspaces Through A Staff Perspective, Omar A. Ramirez
Master's Theses
Using a qualitative case study, this thesis examines a university counterspace that serves Students of Color through the perspective of the staff who work in that space. The case study aimed to explore four areas of investigation: the interviewees’ knowledge and perceptions of 1) the history of their counterspace; 2) the purpose of their counterspace; 3) the benefits of their counterspace; and 4) challenges of their counterspace. The counterspace was a program within a large, 4-year, public, R-1 research university. Five staff from the counterspace were interviewed. A thematic analysis of the data suggests that students were an essential part …
Deported Veterans: The Unintended Consequences Of “Good Moral Character”, Jonathan Deras
Deported Veterans: The Unintended Consequences Of “Good Moral Character”, Jonathan Deras
Master's Theses
The purpose of this research is to argue that U.S. immigration policy, specifically the 1996 IIRIRA (also known as IIRAIRA), needs to change regarding the legal treatment of immigrant U.S. military veteran deportees due to the following concepts. The first concept is to articulate how the criminalization of immigration, and how the military system intersects to facilitate the Deportation of U.S veterans. A key concept in this analysis is the standard of “good moral character” set by the U.S. government that enlistees need to meet to be accepted into the military; this standard is also used against immigrant veterans during …
#Younevertoldme: What Jewish American Children Learn About Palestinian Displacement During The Founding Of The State Of Israel, Nancy Sheftel-Gomes
#Younevertoldme: What Jewish American Children Learn About Palestinian Displacement During The Founding Of The State Of Israel, Nancy Sheftel-Gomes
Master's Theses
#YouNeverToldMe: What Jewish American Children Learn about Palestinian Displacement during the founding of the State of Israel examines how the education of Jewish American children in Jewish educational K-12 settings about the founding of the state of Israel omits details and events about the displacement of Palestinians and how knowledge gaps limit the possibility of dialogue among Jewish and Arab/Palestinian college students, and have a negative effect on Jewish identity. Within the methodological structure of Grounded Theory young adults, former students of the researcher, answer questions concerning their memories of what they learned about the founding of the state of …
Human Trafficking And The Media, Samantha N. Blum
Human Trafficking And The Media, Samantha N. Blum
Master's Theses
This paper focuses on how the media can affect the publics knowledge about human trafficking. Specific attention is paid to what human trafficking is and what the different types of criteria that need to be met are. Of the criteria that is met, the paper looks at the overlapping of requirements between human trafficking and other offenses. More importantly throughout the paper is analyzations on police officers’ beliefs about knowing what human trafficking is, what still needs to be done, and their stance on the current definition. The research presented demonstrates the need for more positive psychological approaches when talking …
Envrment: Investigating Experience In A Virtual User-Composed Environment, Matthew Key
Envrment: Investigating Experience In A Virtual User-Composed Environment, Matthew Key
Master's Theses
Virtual Reality is a technology that has long held society's interest, but has only recently began to reach a critical mass of everyday consumers. The idea of modern VR can be traced back decades, but because of the limitations of the technology (both hardware and software), we are only now exploring its potential. At present, VR can be used for tele-surgery, PTSD therapy, social training, professional meetings, conferences, and much more. It is no longer just an expensive gimmick to go on a momentary field trip; it is a tool, and as with the automobile, personal computer, and smartphone, it …
Study Of Plants Used Against Infections By California Native American Tribes, Maria J. Rojas
Study Of Plants Used Against Infections By California Native American Tribes, Maria J. Rojas
Master's Theses
The objectives of this research were to evaluate the antibacterial activity and to determine the chemical composition of a list of medicinal plants used by Native Americans in California. Artemisia californica, Mimulus aurantiacus, Equisetum telmateia, Equisetum hyemale, and Marah fabacea were selected from a list of plants reported as having been used for ailments related to infections by tribes located in California. The extracts obtained through steam distillation from E. telmateia, E. hyemale and M. fabacea were assayed for in vitro antibacterial activity against 16 Gram-negative and 6 Gram-positive bacteria using disk diffusion assays and measuring the diameters of inhibition …
From Concrete To The Classroom: A Street Dance Toolkit, Tarayjah Hoey-Gordon
From Concrete To The Classroom: A Street Dance Toolkit, Tarayjah Hoey-Gordon
Master's Theses
Minimal research exists in the way of successfully and appropriately incorporating the study of Hip-Hop culture into public education dance curriculum. Many of the available resources about this topic are not academic, standards based, or developed through research studies. The purpose of creating a Street Dance Toolkit was to analyze the ways in which access to an extended curriculum based on Hip-Hop culture can be used to expand a dance educator’s knowledge of Street Dance as a formal technique in a public school setting. The process of designing and analyzing the toolkit to establish a formalized street dance curriculum was …
A Restorative Resource: Dance-Based Non-Profits That Operate To Benefit Sex Trafficked Victims, Jessica Coleman
A Restorative Resource: Dance-Based Non-Profits That Operate To Benefit Sex Trafficked Victims, Jessica Coleman
Master's Theses
The purpose of this study was to bring awareness to dance-based non-profits which operate for the purpose of being a restorative resource for victims of sex trafficking. The goal of the researcher was to answer these five essential questions: Q1 What is the structure of the program? Q2 What are the outreach strategies being used to bring in participants? Q3 What kind of curriculum is being used in the program? Q4 What are the benefits that dance-based non-profits provide for victims of sex trafficking? Q5 How are the benefits of these programs being measured? This research was significant because with …
Dignity And Respect In The Salsa Dance Classroom: Fostering Healthy Self-Esteem To Promote Compassion, Diana Sanchez
Dignity And Respect In The Salsa Dance Classroom: Fostering Healthy Self-Esteem To Promote Compassion, Diana Sanchez
Master's Theses
Many students that have attempted to take salsa dance classes often express their disillusionment in the way in which they are treated by salsa dance instructors. Salsa dance classes have the possibility to function to awaken in the student greater integration with the society in which people live, while stimulating actions, improving self-esteem, and self-confidence, improving vocabulary, awakening sensitivity, attenuating shyness, as well as increasing communicative and social skills. If the content of a course is well designed and delivered with an intentional student-centered approach, it can positively contribute to greater and more sincere learning. In this sense, the objective …
Strictly Ballroom: Examining How The Culture Of Collegiate Ballroom Dance Influences Body Image Perceptions, Rachel Neil
Strictly Ballroom: Examining How The Culture Of Collegiate Ballroom Dance Influences Body Image Perceptions, Rachel Neil
Master's Theses
The purpose of this study was to examine the influence that collegiate ballroom dance programs have on participants’ body image perception and self-esteem and to identify what sort of effect those perceptions have on performance satisfaction. In this project the researcher surveyed twenty-four students, ten males and fourteen females, who were presently involved in a collegiate ballroom dance program with a goal of identifying what sort of influence the culture of their ballroom dance programs had on each participant’s body image and self-esteem. The research instrument used in this study was an electronic survey that included yes or no questions, …
Facilitating The Acculturation Of Children Among Russian Immigrant Mothers, Anna Goncharova
Facilitating The Acculturation Of Children Among Russian Immigrant Mothers, Anna Goncharova
Master's Theses
While biculturalism is considered the preferred strategy of acculturation for most, the existing research does not address the degree to which immigrant mothers support bicultural acculturation of their children and how these mothers enact biculturalism. Although existing research demonstrates that parental involvement and social capital of immigrant parents are important for the success of their children, studies do not delineate the personal meanings and the process of maternal involvement in the acculturation of their children into American society. This research addresses these questions and describes maternal goals towards acculturation and depicts how Russian immigrant mothers facilitate acculturation of their children …
Stability Analysis Of Krylov Subspace Spectral Methods For The 1-D Wave Equation In Inhomogeneous Media, Bailey Rester
Stability Analysis Of Krylov Subspace Spectral Methods For The 1-D Wave Equation In Inhomogeneous Media, Bailey Rester
Master's Theses
Krylov subspace spectral (KSS) methods are high-order accurate, explicit time-stepping methods for partial differential equations (PDEs) that also possess the stability characteristic of implicit methods. Unlike other time-stepping approaches, KSS methods compute each Fourier coefficient of the solution from an individualized approximation of the solution operator of the PDE. As a result, KSS methods scale effectively to higher spatial resolution. This thesis will present a stability analysis of a first-order KSS method applied to the wave equation in inhomogeneous media.
My Child’S Keeper: Child Vulnerability And Quality Of Life On Parental Stress And Grit, Abigail Armstrong
My Child’S Keeper: Child Vulnerability And Quality Of Life On Parental Stress And Grit, Abigail Armstrong
Master's Theses
There is a reciprocal relationship between parenting stress and child distress that has been well documented (e.g., Rechenberg, Grey & Sadler, 2017). These effects generalize to physical outcomes such that higher maternal depression has been associated with poorer child health-related quality of life (HRQOL; Jaser, Whittemore, Ambrosino, Lindemann, & Grey, 2008). In the same way that parental distress has been shown to affect the child, parental perceptions of child vulnerability in children with chronic illness has also been associated with negative outcomes, including child depressive symptoms (Mullins et al., 2004), increased health care use (Spurrier et al., 2000), and increased …