Digital Commons Network^™

Investigating The Anti-Cancer Properties Of Novel Hybrid 1,4-Dihydropyridine Derivatives In U-87mg Glioblastoma Cell, Tendai Hunyenyiwa

Master's Theses

Glioblastoma is the most devastating of brain cancers with a very high death rate and a low survival rate of less than 15 months after diagnosis. Glioblastoma is a cancer of astrocytes which are the majority of the brain glial cells that support neurons and help create the blood-brain barrier among other functions. The current approach to treating this disease is surgical removal of the main tumor, followed by radiotherapy and limited chemical intervention by the use of temozolomide (TMZ). This disease is characterized by high invasion and recurrence after surgical removal of the main tumor as a result of …

Assessment Of Eastern Massasauga Rattlesnakes (Sistrurus Catenatus) In Berrien County Historical Sites, Roshelle M. Hall

Master's Theses

The Eastern Massasauga rattlesnake (Sistrurus catenatus; EMR) is a small robust pit viper currently found in nine states and the province of Ontario, Canada. Wetland habitats have experienced significant destruction and fragmentation by humans; as a result, the current distribution of the EMR is a fraction of its historic distribution. For this reason, the EMR has been federally listed as threatened. In general, little is known about the current distribution of this rattlesnake (in the southwest corner of Michigan, the size of local populations or their stability and genetic diversity. Much of this knowledge is based upon historical data. My …

Synthesis And Screening Of Novel Hybrid Benzothiazoles In U-87 Mg Glioblastoma Cell Line, Priscilla Kyi

Master's Theses

Benzothiazole is a heteroaromatic compound known for its wide range of bioactivities including anti-cancer, anti-viral, anti-microbial, anti-inflammatory, anti-convulsant, anti-diabetic, anti-helminthic, and anti-tubercular activities. Research has shown that derivatives of benzothiazole exhibit inhibition of proliferation via apoptosis in various human cancer cell lines, such as liver cancer (Wang, et. al., 2011). In this study, a series of novel hybrid benzothiazole α-cyanostilbene derivatives and styrylbenzothiazole derivatives containing boronic acid and non-boronic acid pharmacophores were synthesized. The anti-cancer and anti-invasive properties of selected benzothiazole α-cyanostilbene derivatives on U-87MG glioblastoma cells were investigated in vitro.

U-87MG cells were incubated with synthesized novel hybrid compounds …

Servant Leadership: A Study About Organizational Health, Leadership Styles And Practices In Missao Bahia Sudoeste Of The Seventh-Day Adventist Church And The Possible Relation Between The Ministerial Areas Low Engagement Level In The Small Groups Program, Osmar Borges Lima

Master's Theses

Problem

Due to the low engagement of the pastors of Missão Bahia Sudoeste (MBSo) in the Small Groups program as compared to other field within the União Leste Brasileira (ULB) it was decided to investigate the organizational health, the leadership practices and styles, as well as the job satisfaction on the part of the MBSo’s pastors.

Method

The study was conducted among 52 pastors who represented the three levels of leadership designated by the OLA research instrument (Top Leadership, Management and Work Force) which analyses the perception of the participants six key areas of leadership, as well as six levels …

Assay Development For The Identification Of Species And Bioactive Compounds Of Morinda Citrifolia (Noni) In Dietary Supplements By Rt-Qpcr, Dna Sanger Sequencing And Spectroscopy (Uv-Vis/Ftir), Ricardo L. Fernandez Walker

Master's Theses

Regulation standards for dietary supplements lack greatly. Due to this, fraud during the manufacturing of these products might be committed. Previous investigations on herbal dietary supplements have shown that the main ingredient was not present in most of the herbal supplements tested and that these products also contained other substances not stated in the label The purpose of this study was to develop a fluorescent qPCR assay for the identification of Morinda citrifolia herbal species in dietary supplements. Primers for genetic regions rbcL and matK of M. citrifolia were designed. The potential of novel matK primer showed discrimination potential …

Infection Control In Total Knee Replacement Prosthesis Using Nitric Oxide Releasing Biomaterials, Ashley Widing

Master's Theses

Replacing a weight-bearing joint is accompanied by long procedures, even longer recovery times, and intensive monitoring. This burden increases after infection; a complication requiring revision surgeries and therefore extensive additional recovery time. Infection can present itself at any time during the process, making it hard to predict. Currently, a two-part revision surgery is completed by removing all infected tissue and implanting an antibiotic spacer. The spacer fills the joint gap and is removed prior to the revision total knee replacement. A revision total knee replacement follows the same procedure as the initial surgery. Not only is this detrimental to patient …

Testosterone Replacement Therapy For The Recovery From Chronic Vestibular Dysfunction Following Repeat Mild Traumatic Brain Injury In Male Long-Evans Hooded Rats, Arthur Segismundo

Master's Theses

Repeat mild traumatic brain injury (rmTBI) is a major public health concern leading to both chronic hypogonadism and vestibular impairment. Following rmTBI, vestibular symptoms are one of the most common complaints and hypogonadism occurs in a majority of patients. Gonadal hormones have a well-established role in neuroplasticity and axonal regeneration. The loss of gonadal hormones due to rmTBI may delay recovery. A clinically relevant closed-headed rmTBI male rodent model was utilized to examine the role of testosterone replacement therapy on chronic vestibular dysfunction. This is the first study to demonstrate both hypogonadism and vestibular dysfunction in the acute and chronic …

Microplastic In Aquatic Food Webs: Museum Specimens And Ingestion Experiments Reveal Controls On Microplastic Ingestion By Freshwater Fish, Loren Hou

Master's Theses

Plastic is pervasive in modern economies and ecosystems. Early research suggests freshwater fish commonly ingest microplastic (particles < 5 mm), which may influence fish digestive tissues, but no studies have examined historical patterns in microplastic consumption or rates of microplastic retention in fish. We measured microplastic in digestive tissue of specimens collected and preserved over the last century (Field Museum, Chicago). We selected Micropterus salmoides (largemouth bass), Notropis stramineus (sand shiner), Ictalurus punctatus (channel catfish), and Neogobius melanostomus (round goby) because each was well represented in the museum collection, with specimens from urban rivers. Specimens from 1900-2018 showed increases in microplastic concentration from the 1950's to present. in a second project, we collected round gobies from Lake Michigan in Chicago to conduct feeding experiments to measure microplastic ingestion and retention rates. the majority of microplastic was excreted within 72 hours of ingestion. Results will aid in understanding ecological interactions of microplastic and freshwater fish, informing further work on the movement of microplastic in aquatic food webs.

From The Technology Gap To The Graduation Gap: Implications Of Technology Access And Postsecondary Success, Abigail Evans

Master's Theses

The gap in technology access in the United States is indicative of the larger inequalities that continue to plague our modern society. This research project focuses on the relationship between technology access and postsecondary success. Previous studies have established there is a connection between technology access and academic success, but many questions about how and when students access technology remain unanswered. in this thesis, I gather information from disparate sources to try and draw conclusions about the current state of technology in postsecondary education. This included research on technology use patterns among numerous demographic groups, information of the social behaviors …

College Students Experiencing Food Insecurity At San Jose State University, Elizabeth Agramont-Justiniano

Master's Theses

The purpose of this research was twofold: to learn more about how students at San Jose State University experience food insecurity and to learn how food insecurity is addressed by this public university given the rise and prevalence of neoliberalism in higher education. Three focus groups were conducted gauging how 16 students defined food insecurity and what their experiences with food insecurity at college were like. A total of eight individual interviews took place after the focus groups, delving further into how it feels to experience food insecurity at SJSU and the students’ recommendations for improvement. The overwhelming majority of …

The Whiteness Of The Elephant In The Room: How White Guilt, White Fragility, And Colorblind Racial Ideology Shape Environmental And Social Justice Activism In Santa Cruz County, Robert Michael Foran

Master's Theses

Using frameworks from critical race theory, social movement theory, and community-based activism, this thesis explores the phenomena of white fragility, white guilt, and colorblind racial ideology and how they impact the ways predominantly white-identified social and environmental justice organizations approach, build, and maintain solidarity with communities of color in Santa Cruz County, California. A qualitative approach was employed to investigate the experiences of white-identified activists and how they attempt to engage in this constantly challenging process. Using twenty-two semi-structured interviews and eight group observations, I explored how white-identified individuals negotiate the transformation from ‘moral passivity’ to meaningful, personal relationships with …

Reproductive Performance, Foraging Effort, And Diet Of An Apex Predator, The Common Murre, At One Of The Largest Nesting Colonies In The California Current System, Stephanie Rianne Schneider

Master's Theses

Common Murre (Uria aalge) are the most abundant avian apex predator nesting in the California Current System (CCS) and nesting is the most energetically demanding phase of their lifecycle. The preyscape within flight distance of their nesting colony determines whether murres produce young, how hard they must work to do so, and what prey types are available to them. This study characterized the reproductive performance, foraging effort, and prey composition of murres nesting at a previously unstudied and large nesting colony in the CCS, Castle Rock National Wildlife Refuge, over an 11-year period (2007 - 2017) intended to capture a …

Current Feedback-Based High Load Current Low Drop-Out Voltage Regulator In 65-Nm Cmos Technology, Melody Teoh

Master's Theses

The motivation for this paper was to design a current feedback-based high load current, low drop-out (LDO) voltage regulator. A bandgap voltage reference (BGR) was also designed in conjunction with the LDO to simulate realistic environments. The schematic was designed with Cadence Virtuoso Schematic XL, using the Taiwan Semiconductor Manufacturing Company (TSMC) 65-nm CMOS library, used for Internet of Things (IoT) System on Chip (SoC) applications. The proposed capacitor-less LDO with BGR provided an average temperature coefficient (TC) of 13.34 ppm/℃ within the range of -40 to 125 ℃. This was in accordance with military standards to gain a higher …

Assessment Of Peregrine Falcon (Falco Peregrinus Anatum) Nesting Habitat In The San Francisco Bay Area, Prabha Venu

Master's Theses

Human encroachment into natural environments fragments and degrades the habitat for many species and raptors such as the peregrine falcon (Falco peregrinus) have adapted to the urban environment, co-existing with humans and other wildlife. The habitat preference of the American peregrine falcon subpopulation, F. p. anatum was investigated in the densely urbanized San Francisco Bay Area. In this research, Geographic Information Systems (GIS) applications to evaluate ten environmental attributes and their influence on 47 nesting sites were used. Distances from peregrine falcon nesting sites to two federally listed prey species the California least tern (Sterna antillarum browni) and the western …

Psychological Presence In Immersive Virtual Environments, Steven L. Wu

Master's Theses

Immersive virtual environments are simulated locations that attempt to create a sense of presence, or the psychological feeling that an individual is acting within the simulated environment rather than their physical one. When interfacing with an interactive virtual environment, evidence suggests that aspects of psychological presence are affected, such as time perception and situation awareness. As such, this study hypothesized presence as the construct by which immersive virtual environment usage influences time perception and situation awareness. Two levels of presence were manipulated using a monitor and Oculus Rift. Forty-one participants were tasked with a scavenger hunt in both monitor and …

What Does Walk Score® Really Measure?, Jorge Simbaqueba

Master's Theses

The Walk Score® (WS) algorithm works by identifying the closest amenities (grocery stores, banks, restaurants, and schools) and awarding points based on the distance to them from a given location. Scores have a range between 0 and 100. In 2011, the Walk Score® (WS) founders and advisory board modified the algorithm to better account for pedestrian friendliness by adding block length and intersection density data into the model to represent roadway characteristics and named it Street Smart Walk Score®.

Modelers attempting to quantify accessibility often focus on two components: a transportation element (or resistance factor) and an activity element (or …

The Effects Of Parathyroid Hormone And Bisphosphonate On The Cartilage And Subchondral Bone Of The Temporomandibular Joint, Alexandro De Araujo Lima

Master's Theses

Introduction:Parathyroid hormone increases bone strength primarily by stimulating bone formation, whereas Bisphosphonate, an antiresorptive drug, reduce bone resorption by blocking osteoclast activity. Here we examined the effects of alendronate (ALN), a type of bisphosphonate, and we also examine the effects of parathyroid hormone (PTH), which has an anabolic effect and increases bone remodeling when treated intermittently (I-PTH). I-PTH treatment leads to increased bone volume fraction, tissue density and trabecular thickness of the subchondral bone. I-PTH treatment also increases proteoglycan synthesis with a concomitant increase in mineralization of the Mandibular Condyle Cartilage (MCC). We hypothesize that combined treatment of I-PTH …

Low Plasma Hdl Cholesterol Is Associated With Greater Risk For Cardiovascular Disease In Subjects With Metabolic Syndrome, Hana M. Alyousef

Master's Theses

Low plasma HDL cholesterol (HDL-c) has been recognized as a biomarker of cardiovascular disease (CVD) and diabetes. Also, low HDL-c is one of the characteristics of metabolic syndrome (MetS).

Objective: To assess whether low HDL-c and/or low HDL functionality are associated with higher risk for CVD in subjects classified with MetS.

Methods: Forty-subjects with MetS (11 men /29 women, 52.4 ± 9.5 years participated in the study. Anthropometric data [weight, height, BMI, waist circumference (WC), blood pressure (BP)], fasting plasma biomarkers [lipids, glucose, liver enzymes: alanine aminotransferase (ALT), and aspartate aminotransferase (AST), plasma insulin, and glycosylated hemoglobin (HbA1c)], biomarkers of …

Understanding Macro-Scale Patterns In Urban Tree Canopy And Inequity Across Socio-Cultural And Biophysical Regions, Elliott Volin

Master's Theses

Urban forests provide a variety of ecosystem services that influence environmental and social welfare within developed areas. Prior studies have evaluated the effects of inequitable distribution of urban tree canopy (UTC) on ecological and social benefits, leading to inequalities within individual cities. However, it is not well established how such relationships vary among urban areas in different biophysical and socio-cultural regions. The objective of our study was to identify regional and continental trends in the relationships of UTC with socioeconomic/ demographic factors and characteristics of urban regions (e.g., development patterns, timing). To address our objective, we utilized iTree Landscape and …

Tall Tales Of Danger And Security: How A Critical Human Security Approach Can Address Major Contradictions Revealed Through A Critical Narrative Analysis Of Dominant U.S. Security Strategies, Stephen Schneider

Master's Theses

Over many generations, humans have developed many perspectives and practices regarding the best ways to recognize and address what they perceive to be dangerous. Stories are used to help shape and narrate perceptions about the world, and they serve to pass on vital information that impacts how a society responds to threats and vulnerabilities. These narratives of danger and security are subjective to the experiences and political intentions of society, and therefore in many ways are partial and biased in their assessments and policies. This results in flawed security practices that may actually exacerbate threats or create new insecurities. What …

Triple Bottom Line As A Method To Increase Business Value And Foster Positive Social And Environmental Change, Jayleene West

Master's Theses

The Triple Bottom Line (TBL) business model has transformed the business world by changing the way businesses operate. By focusing on the people and the environment, businesses have grown to see substantial profit and avoid risks along the way. Companies are using the TBL to build their brand and customer loyalty by enhancing the environment and society. This paper analyzes four companies that are leaders in their industry and are founded on the TBL; Seventh Generation, New Belgium Brewing, Patagonia, and Ben & Jerry’s. Recommendations have been made by performing a literature review on the advantages and disadvantages of the …

Looming Large: An Analysis And Evaluation On The Growth Of The Urban Informal Economy In Nigeria., Tamunotonye A. Sekibo Iii

Master's Theses

The Informal Economy looms large! The importance, magnitude and significance of the vast range of socio-economic activities taking place within and across diverse spaces of informality, particularly in nations situated in the Global South; can neither be overstated or underestimated. According to the International Labor Organization (ILO, 2018 p.v), approximately 60% of the world’s employed population - 2 billion people - obtain their source of income through their engagement in informal spaces.

Medication Error Prevention: Improving Patient Health Outcome, Brigitta Van Ewijk

Master's Theses

Medication administration errors were reported to have an error rate of 60% in early research mainly in the form of the wrong dose, time, or rate. Working conditions were found to be one of the main contributors to these errors. Recognizing and reporting medication errors are key to the implementation of the reduction of this critical health problem (Hughes & Blegen, 2008). DataRay Inc. (n.d.), states that almost one in five medication doses administered in hospitals is given in error. The two most common errors were (1) dispensing medicine at the wrong time (43% of incidents) and (2) omitting a …

Reexamining Overuse Of Frequent Observation For New Admissions On Psychiatric Units To Increase Nurse/Patient Engagement, Samuel Novela

Master's Theses

People in California who suffer from mental health conditions are often admitted involuntarily to hospitals on 72 hour psychiatric evaluation holds if they are deemed imminently dangerous to themselves, or others, or are gravely disabled. Observational patient safety checks are performed and based on patient acuity and hospital standards. Variations exist among different clinical settings with regard to best practices and the patient subpopulations that may warrant less frequent safety checks. Nurses experience different levels of satisfaction with regard to frequency of safety checks because there is no national consensus on which subsets of patients may require them. A senior …

Finding And Making Home: Poems And Reflections Of Undergraduate Children Of Immigrants, Gladys Perez

Master's Theses

The number of children of immigrants within the United States has grown over the past few decades and more so we are seeing a greater number of these children pursuing a higher education. With a growing number of undergraduate children of immigrants growing, there is a need to understand how they see themselves as a part of the United States. Previous studies take into consideration how these students navigate higher education, however, there is a lack of research on these students’ larger understanding of belonging within the overall nation. Poetry as data and a process was the grounding methodology that …

From La Costa Chica To Pasadena: Transnational Racial Politics Of Afro-Mexicans, Antonio Rodriguez-Santiago

Master's Theses

The ethnographic research in this thesis focuses on one group of Afro-Mexicans who migrated to Pasadena, California, from Mexico’s Costa Chica, on the Pacific Coast of Oaxaca and Guerrero, the area where a social movement for Afro-Mexican recognition and collective rights was founded in 1997. This study, using a framework of racial theory, examines the process of racial formation in a transnational setting, which has made this group different in many ways from the Black residents who remain in the Costa Chica. The study also considers how mestizaje, the Mexican national racial ideology that endorses a mixed-race society while …

Now Hiring: Exploring Deportee Transnational Identities And Socio-Economic Reintegration In Baja California, Mexico’S Call Center Industry, Brenda Vargas

Master's Theses

The anti-immigrant rhetoric in the U.S. intensified deportation, including that of Mexican and Salvadorian migrants with some having served in the U.S. military. Despite weak social connections and explicit/structural barriers in Mexico, many deportees make the decision to stay in Mexico. The focus of this thesis is male deportees belonging to the “1.5 generation,” aged late 20’s-early 60’s, who, after spending their childhood and adulthood in the U.S., have undergone deportation and are faced with social and economic reintegration in the northern border area of Baja California, Mexico. Through 15 in-depth semi-structured interviews, I explore transnational identity negotiations that impact …

The Integration Of Syrian Refugees In Turkey Via Education, Aysenur Hacioglu

Master's Theses

The Syrian conflict, which was initiated as a pro-democratic movement against Bashar Assad’s government, has displaced millions of people both internally and externally. Since the beginning of the conflict, 6.6 million people are internally displaced, while 5.6 million people seek refuge in other countries. Many Syrians scattered to neighboring countries, principally Turkey, Lebanon, Jordan, Iraq, and Egypt. Turkey, who shares the longest borderline with Syria, hosts 63 percent of the total number of Syrian refugees, currently at more than 3.5 million (UNHCR, 2018b). However, Turkey as the country with the highest number of refugees in the world does not legally …

The Investigation Of The Chlorine Initiated Oxidation Of 2-Phenylethanol And Stability Of Superalkali Lithium Substituted Silyls., Adam Otten

Master's Theses

This thesis investigates the combustion potential of 2-phenylethanol and the superalkali properties of small lithium substituted silicon compounds. All combustion experiments were performed at the Advanced Light Source of Lawrence Berkeley National Laboratory at the Chemical Dynamics Beamline 9.0.2. The chlorine initiated oxidation of 2PE was investigated at 298 and 550 K using a multiplex photoionization mass spectrometer, coupled with the tunable vacuum ultraviolet radiation. Reaction products were identified using kinetic time traces and photoionization spectra.

Additionally, the stability of small superalkali silicon-lithium compounds has also been investigated. All structures and energetics were calculated using the CBS-QB3 composite method.

The …

The Best Interests Of The Child Or The State? The Rights Of The Child In Non-Lpr Cancellation Of Removal, Lizzie Bird

Master's Theses

This thesis argues that the United States is failing to fulfill its obligations under the Convention on the Rights of the Child (CRC) in its adjudication of the hardship standard in non-LPR cancellation of removal. It is well-documented that the current interpretation of the “exceptional and extremely unusual hardship” standard results in the separation of families and de facto deportation of children, many of whom are U.S. citizens. This thesis contends that this practice is not only unjust, but also unlawful.

First, it argues that the CRC in general and Article 3 (the “best interests” principle) in particular have risen …