Digital Commons Network^™

Investigating Autophagy, Extracellular Vesicles, And Glycobiology, Benjamin Cook

Master's Theses

Autophagy is a cellular process of degradation which degrades cellular materials in acidic organelles called lysosomes. Impairment of lysosomal degradation can lead to lysosomal storage disorders such as Parkinson's Disease. In Parkinson's Disease neurotoxic α-synuclein can spread from cell-to-cell via extracellular vesicles. We investigated the changes in extra vesicular glycans upon perturbation of autophagy using a class of glycan binding molecules termed lectins.

We found that upon induction of autophagy causes EV glycans to increase while others remained consistent. Additionally, we found that specific glycans are increased more than others. Conversely, when lysosomal degradation was impaired, we observed a decrease …

Assessing English Language Learners' Motivation To Participate In Classroom Discussion, Holly Griskell

Master's Theses

This study assesses sixth-grade Spanish-speaking English Language Learners' (ELLs'; m age = 12.15 years old) participation and motivation to participate in classroom discussion through developing a 20-item measure, the Motivation for Classroom Discussion Questionnaire (MCD-Q) (Study 1 n = 258). We examined the relation between ELLs' bi-literacy and MCD-Q scores as well as amount of talk during discussion, measured by audio-recordings of their English Language Arts class (Study 2 n = 149). Study 1 findings indicated that the MCD-Q items cohered into five motivational constructs (value, language-efficacy, extrinsic motivation, social motivation, and interest). Study 2 findings showed the MCD-Q's predictive …

Understanding The Dynamics Of Protein Lipoylation In Staphylococcus Aureus, Sarah C. Flury

Master's Theses

Staphylococcus aureus is a commensal bacterium that also acts as an opportunistic pathogen. The pathogenicity of S. aureus has often been attributed to the wide range of virulence factors that the bacterium produces. While virulence factors do contribute a great deal, there is a growing field of research that aims to investigate the role of metabolism in bacterial virulence.

My project focuses on the necessity of a metabolic cofactor, lipoic acid. To ensure sufficient amounts of lipoic acid are available for enzyme activity, S. aureus has evolved two pathways to obtain the important nutrient. The lipoic acid salvage pathway is …

Inhibition Of Mutant Egfr In Nsclc Promotes Endothelin-1-Mediated Nsclc Disease Progression, Stephen Ollosi

Master's Theses

Angiogenesis in NSCLC has been identified as important therapeutic target in combination with EGFR TKIs. However, only small incremental advancements have been made for the use of angiogenesis inhibitors in NSCLC and it remains elusive why the inhibition of VEGF-mediated neovascularization is not therapeutically efficacious. I present experimental evidence that a subpopulation of NSCLC cells with EGFR TKI-induced EMT contributes toward the attenuation of the response to EGFR TKI therapy. One of the hallmarks of cancer is heterogeneity and I have previously demonstrated that tumor heterogeneity within NSCLC cells lines harboring EGFR kinase domain mutations gives rise to divergent resistance …

Everybody Else, Patricia Gaglia

Master's Theses

Everybody Else is a novel that follows the story of the Promise Scholars, a group of math whizzes thrust into the media spotlight after a tech billionaire launches an engineering program at their low-income, predominantly black, high school. The purpose of this novel is to explore contemporary racism in America, the complex relationship between philanthropy and poverty, and the role of technology in instigating social change. Each chapter is a complete story, representing a unique first person perspective as the students navigate the closure of their school, the dissolution of their benefactor’s interest, and their enrollment in an affluent neighboring …

Airborne Doppler Radar Observations Of Pyrocu/Cb Plume Kinematics And Thermodynamics During The 2016 Pioneer Fire, Bruno Rodriguez

Master's Theses

During a period of explosive growth of the Pioneer Fire (Idaho, August 2016), deep pyroconvective plumes were sampled by aircraft. The research aircraft was equipped with both remote sensing and in situ instrumentation, including a W-Band Doppler radar which provided high-resolution vertical velocity retrievals from within the developing pyrocumulus. Being the first direct observations of vertical velocity within a pyrocumulus cloud, they have provided unique insights into the dynamical processes governing pyroconvective environments, with important implications for the fire modeling community. The observations were quality-controlled and corrected for issues such as Doppler velocity aliasing, and the plume’s kinematic structure was …

Effect Of Quality Health Care And Support Network On Maternal And Children Outcome In Uganda, Chukwuemeka Ugwu

Master's Theses

About 300,000 women mostly of developing countries die due to pregnancy-related birth complications every year (Smith & Rodriguez. 2015). In Uganda, the maternal death is 1 in every 44 women (State of the World's Mothers' Index 2015, by Save the Children). This places the country as 141 out of 179 by the same ranking. Existing data attributes this anomaly mainly to lack of prompt obstetrics services (Wilunda et al, 2015). Thus, this paper presents empirical evidence of the effect of quality health care and support network on the outcome of a mother and her children during maternity. We employed survey …

Acceptability And Correlates Of Pre-Exposure Prophylaxis Use For Hiv Prevention Among High-Risk Drug Users In Treatment, Pramila Karki

Master's Theses

Background

Although people who use drugs (PWUD) are a key population recommended to receive pre-exposure prophylaxis (PrEP) to prevent HIV, few data are available to guide PrEP delivery in this underserved group. We therefore examined the willingness to initiate PrEP, the anticipation of HIV risk reduction while on PrEP, and the acceptability of PrEP based on a number of known PrEP attributes among high-risk PWUD.

Methods

In a cross-sectional study of 400 HIV-negative, opioid dependent individuals enrolled in a methadone program and reporting recent risk behaviors, we examined independent correlates of being willing to initiate PrEP. Participants also ranked the …

Factors Influencing Maternal Involvement In Early Childhood: Exploring The Roles Of Maternal Stress And Children’S Narrative Representations Of Mothers, Rahmet Akpolat

Master's Theses

For children from low-income families, parent school involvement can be a crucial protective factor that supports children’s cognitive and emotional development. The present study seeks to explore how maternal stress in early childhood is associated with mothers’ later school involvement and whether children’s internalized positive, disciplinary and negative maternal representations act as potential mediators of this relationship. Currently, little research has been done on the contextual factors influencing parent school involvement in early childhood and this study aims to fill this gap in the literature. The data included 169 children and mothers from low-income families. Mothers completed questionnaires designed to …

Analysis Of A Newly Digitized Long-Term Dataset Of Environmental Observations From Long Island Sound, Jacob Snyder

Master's Theses

Project Oceanology, a non-profit oceanographic educational organization has been collecting data including pH, oxygen, and temperature conditions as well as abundances of benthic invertebrates and near-shore fish catches since 1972 from Eastern Long Island Sound. These data had been stored solely on single-copy paper sheets and were therefore inaccessible to analysis. I digitized more than 100,000 abiotic measurements and 50,000 species abundance and size data collected over the past 45 years, and developed a web-based SQL database housed on the Long Island Sound Integrated Coastal Observing System (LISICOS) server. The database will ultimately become a searchable, downloadable, user-friendly web-based tool …

A Novel Model Of “Remedy And Elimination Of Tuberculosis”, Akanksha Mishra

Master's Theses

Tuberculosis (TB), is one of the top ten causes of death worldwide. TB is commonly linked to poverty and creates poverty as it is the single largest cause of death in the 15-49-year-old age group in South-East Asia (WHO, 2017). It is also linked to the HIV population, and its leading cause of death. TB is effected by socio-economic factors, cultural factors, and health policy. My goal of this dissertation is to identify systematic approaches that shall support the mission set by World Health Organization (WHO): to eliminate TB globally by the year 2050. Measures might include addressing social barriers …

Design And Analysis Of Bio-Inspired Nacelle For Current Energy Turbine, Michael Coe

Master's Theses

he world’s oceans contain a substantial amount of energy, stored in ocean currents and waves. Ocean current energy can be extracted using similar principles to existing wind energy platforms. A problem with such extraction methods is that the velocity of the fluid in ocean currents is too low for efficient energy generation. A potential solution to this problem is the use of a concentrator or diffuser to increase fluid velocity to the blades, but this carries with it extra costs. A more cost effective solution to this problem is presented by the use of a down flow current turbine in …

Youth Sport Development Pathways And Experiences Of Ncaa Division I Women's College Soccer Players, Emily Hardell

Master's Theses

As youth sport has become increasingly professionalized, many believe that the route to elite level play is through early specialization. Early specialization is a contentious issue, and many risk factors have been associated with high levels and intensities of training in youth. Youth today participate in highly competitive sport in pursuit of elite levels of play, recognition, and financial gain. Early specialization is thought to be a requirement for advancement, yet little is known about the early experiences of team sport athletes who grew up in the US. This is the story of 15 elite female athletes who “made it” …

Community Structure And Zonation Of Antarctic Benthic Invertebrates: Using A Remotely Operated Vehicle Under Ice To Define Biological Patterns, Dorota Szuta

Master's Theses

The Ross Sea, Antarctica is a deep bay of the Southern Ocean that exhibits seasonal sea ice and is adjacent to a permanent ice shelf overlying seawater. In 2008 and 2009, imagery of the seafloor under the McMurdo Ice Shelf and under the seasonal ice in the Ross Sea was collected via remotely operated vehicle (ROV) at depths to 300 m. Distinct differences in Antarctic benthic communities were observed over multiple environmental gradients. Species abundance typically exhibited a unimodal distribution with depth with mid-depth peaks, reflecting a food limitation at the deep end and potentially ice disturbance on the shallow …

The Common Lot Of Nature: The Stoic Concept Of Death In The Writings Of St. Ambrose, Nathan Michael Falls Hall

Master's Theses

The Common Lot of Nature is a comparative analysis which questions the completeness of St. Ambrose’s Christian faith. The comparison focuses specifically on notions of death, and how one should deal with its presence in one’s life. This emphasis was chosen because Ambrose was a Christian bishop who was heavily influenced by Stoicism, and these two worldviews held contrasting beliefs on how death fits into the lives of human beings. The paper begins with an outline of other research regarding Stoicism or its potential connections with Christianity. The following two sections discuss how Stoics and 4th century Christians conceptualized death …

Geophysical Characterization Of A Rare Earth Element Enriched Carbonatite Terrane At Mountain Pass, California Eastern Mojave Desert, Kevin Denton

Master's Theses

Mountain Pass, California, located in the eastern Mojave Desert, hosts one of the world's richest rare earth element (REE) deposits. The REE-rich rocks occur in a 2.5 km- wide, north-northwest trending zone of Mesoproterozoic (1.4–1.42 Ga) stocks and dikes, which intrude a larger Paleoproterozoic (1.7 Ga) schist-gneiss terrane that extends ~10 km southward from Clark Mountain to the Mescal Range. Several REE-enriched bodies make up the Mountain Pass intrusive suite including shonkinite, syenite, and granite comprising an ultrapotassic intrusive suite and the Sulphide Queen carbonatite body.

Two-dimensional modeling of gravity, magnetic, and electrical resistivity data reveals that the Mountain Pass …

A Full Factorial Analysis Of Polymerization Conditions Of Sodium Alginate Beads To Determine The Effect On Diffusivity And Concentration Limit Of Tryptophan And Glucose, Allison Schulkins

Master's Theses

The purpose of this work is to develop an experimental setup with associated mathematical analysis to analyze the changes in diffusivity through calcium alginate gel beads made under different polymerization conditions. The diffusivity of the solutes glucose and tryptophan was calculated by measuring the concentration change over time as solute diffused out of the alginate spheres and into the bulk. The alginate beads were generated using different polymerization conditions following a two-level, three-factor, full-factorial matrix with alginate concentration, cross-linker concentration, and cross-linking time as the factors. The diffusivities showed variations between different conditions, which were analyzed to determine the main …

Gendered Impacts Of Community-Based Conservation Initiatives In Kimana/Tikondo Group Ranch Outside Of Amboseli National Park, Megan Clemens

Master's Theses

Community-based conservation has become a common solution to addressing local communities needs and concerns when it comes to conservation initiatives associated with, or outside the boundaries of national parks. Community-based initiatives associated with Amboseli National Park in southern Kenya mark one of the first attempts to include local communities in conservation initiatives and management as well as establish systems of benefit sharing between conservation and local communities. However, a critique of community-based conservation initiatives points out they often assume community homogeneity. Assumption of community homogeneity leads to inequities in benefits sharing, exclusion of subgroups (women, ethnic minorities) or even exacerbate …

Exploring Employment Equity: Diversity & Inclusion In Canada’S Legislation & Policy, Vanessa Toussaint Miller

Master's Theses

Multiculturalism is considered very much a part of Canada’s national heritage and identity, becoming the first nation to adopt multiculturalism as an official policy in 1971. Over the last 40 years, the Canadian population has undergone significant changes bringing in immigrants with different cultures, ideologies, religions and ways of life. Despite the various changes in society, the multiculturalism policies have remained the same. This thesis examines Canada’s Employment Equity-a policy intended to eliminate systemic discrimination in the workplace-and its effectivity at creating a diverse and inclusive workforce. The main research question is, in the past five years, has Employment Equity …

How Patriotic Are Albanians? The Comparative Study Of Patriotic Attitudes In Albania And The Albanian Diaspora, Anxhela Spahiu

Master's Theses

In today’s post-modern digital world, patriotism may not be as prevalent as in the past. In this thesis, my principal aim is to investigate to what extent Albanians, a nationality to which I belong, identify with a patriotic attitude toward Albania. I chose to focus not only on Albanians who live in the diaspora, like myself, but also on Albanians who live in Albania. I believe that to understand national pride to its fullest, you must study the attitudes of those who live in the country of origin as well as of those who live in the diaspora. Many people …

Afro-Latinx Transnational Identities: Adults In The San Francisco Bay And Los Angeles Area, Koby Heramil

Master's Theses

This paper examines the identity construction of Afro-Latinas/os/x in the San Francisco Bay and Los Angeles Area. Marginalized communities predominately Black and Latina/ o/x concentrated are at the epicenter of disenfranchisement caused by the globalization of neoliberalism. Neoliberal reforms to education restrain the various nuances of pluralistic teaching, focusing only on the performance of standardized tests thus pressuring schools to center their interest in securing funding. This has greater implications for low-income communities of color where multicultural pedagogy is limited. More importantly, this association of neoliberalism reforms to education affects Afro-Latinx individuals, because they are maligned in the conversation about …

The Resisters: Contemporary Ethiopia Through A Feminist Lens, Eldana Mathias Temesgen

Master's Theses

Based on the recent mass protests in Ethiopia, there is a strong indication that the Oromo people of Ethiopia, who are at the forefront of these protests, have been placed in a position of marginal importance, influence and power in their society. Due to the power and agency wielded by the government, some ethnic groups in Ethiopia, including the Oromo ethnic group, claim to be underrepresented on a political, economic, and social scale, which has led to conflict.

The nuances of ethnic based conflict, such as the situation in Ethiopia, have been tackled through several disciplines and examined through different …

A Physical Framework For Evaluating Flood Inundation Risk Under Different Water Management Scenarios, Sage Hardesty

Master's Theses

In the United States, many river floodplains contain critical infrastructure that is vulnerable to extreme hydrologic events. These structures are designed based on flood frequency analysis aimed at quantifying the magnitude of the extreme events. However, many floodplains are ungauged or poorly gauged, making flood frequency analysis significantly uncertain. This research topic focuses on estimating flood frequency peaks for an ungauged critical infrastructure within Connecticut’s Naugatuck River Basin utilizing a physically based approach consisting of a distributed rainfall-runoff model forced by long-term reanalysis meteorological data and a hydraulic model driven by high-resolution LiDAR derived terrain elevation data. The hydrologic model …

Investigating How Anticipation Of Object States Drives Event Comprehension, Kyra Krass

Master's Theses

Previous literature has suggested that, when given change of state events in a visual world paradigm task, individuals anticipate either the object that can be acted upon or the goal. This study investigated under what circumstances an individual anticipates one over the other. We used reversible action verbs (e.g. open/close), destruction verbs (e.g., eat), and creation verbs (e.g., knit) in the past and future tense to investigate how anticipation differs across these conditions. Individuals heard sentences such as "The woman will open the umbrella" while seeing four objects on a screen: the initial state (e.g., a closed umbrella), the end …

Oxygen Isotopic Composition Of Nitrate Produced By Freshwater Nitrification, Danielle Boshers

Master's Theses

Identifying sources of nitrate (NO₃^-) in the environment is important to elucidate causes of water quality impairment and eutrophication. Measurements of naturally occurring stable isotope ratios of nitrogen (¹⁵N/¹⁴N) and oxygen (¹⁸O/¹⁶O) in NO₃^-, can be used to determine the sources, dispersal, and fate of natural and contaminant NO₃^- in aquatic environments. To this end, it is necessary to know how NO₃^- isotopologues are modified by biological reactions, as heavy and light isotopes have different reaction rates. One important microbial reaction that …

The Timecourse Of Phonological Competition In Spoken Word Recognition: A Comparison Of Adults And Very Young Children, Elizabeth Schoen Simmons

Master's Theses

Spoken word recognition (SWR) is the mapping of speech sounds to words from many potential candidates in one’s lexicon. In adults, words that are phonetically similar, of high frequency, or semantically related compete for recognition. An ongoing debate in the literature is whether or not very young children encode spoken words with fine-grained temporal and phonetic detail. Specifically, whether they represent words wholistically or as smaller phonetic units similar to that of adults. The adult literature demonstrates that words that are phonetically similar at onset (cohorts) and offset (rhymes) compete for recognition. As it happens, rhymes have the potential to …

Eeg Characterization During Motor Tasks That Are Difficult For Movement Disorder Patients, Adam Joshua Aslam

Master's Theses

Movement disorders are a group of syndromes that often arise due to neurological abnormalities. Approximately 40 million Americans are affected by some form of movement disorder, significantly impacting patients’ quality of life and their ability to live independently. Deep brain stimulation (DBS) is one treatment that has shown promising results in the past couple decades, however, the currently used open-loop system has several drawbacks. By implementing a closed-loop or adaptive DBS (aDBS) system, the need for expensive parameter reprogramming sessions would be reduced, side-effects may be relieved, and habituation could be avoided. Several biomarkers, for example signals or activity derived …

Interfacing A Hirudo Medicinalis Retzius Cell With Insulated Gate Of Mosfet, Rachel M. Smith

Master's Theses

Much work has been done to study the external stimulation of nervous tissue as well as the transmission of neural signals to electronics. Peter Fromherz was one of the pioneers in this area of electrophysiology, with a series of experiments in the 1990s that aimed to characterize and optimize the interface between neural tissue and transistors. In this thesis, Kurt Sjoberg and I interfaced a Retzius cell isolated from a Hirudo medicinalis ganglion with the insulated gate of a MOSFET. The goal was to see change in membrane potential that could be related Fromherz’s original 1991 work. Our experimental setup …

The Value Of Choice: An Exploratory Case Study On The Intrinsic Motivation Of Dance Students Within The Creative Process, Jenna M. Gonsalves

Master's Theses

This exploratory case study was designed to analyze the impact choice making has on the intrinsic motivation of middle school dance students including self determination theory’s basic needs of competence, relatedness, and autonomy. Data were collected using multiple sources including observation rubrics and semi-structured pre- and post- group interviews. Two groups of students ages 11-14 created dances for performance. One group participated in a collaborative approach to the creative process and had the opportunity to make choices. The other group participated in a teacher-led creative process and did not have the opportunity to make choices. A thematic content analysis of …

Building The More Confident Student Choreographer Through Writing: The Use Of Prompts To Guide The Choreographic Process, Yvette Bennett

Master's Theses

The purpose of this research was to implement specific writing prompts into a high-school curriculum that aids in the choreographic process in an effort to bring about confident student choreographers. This research evaluated the choreographic process using a series of writing prompts to support participants with the goal of producing successful student choreographed dance works throughout a semester long high school dance course. The researcher posed the following three essential questions: How does the writing prompt aid in the choreographic process? What did the participants learn about the choreographic process by using writing prompts? Do the participants feel a sense …