Digital Commons Network^™

Physics Engine On The Gpu With Opengl Compute Shaders, Quan Huy Minh Bui

Master's Theses

Any kind of graphics simulation can be thought of like a fancy flipbook. This notion is, of course, nothing new. For instance, in a game, the central computing unit (CPU) needs to process frame by frame, figuring out what is happening, and then finally issues draw calls to the graphics processing unit (GPU) to render the frame and display it onto the monitor. Traditionally, the CPU has to process a lot of things: from the creation of the window environment for the processed frames to be displayed, handling game logic, processing artificial intelligence (AI) for non-player characters (NPC), to the …

Natural And Experimental Noise Affects Acoustic Communication In Songbirds, Veronica Arlene Reed

Master's Theses

Background noise is ubiquitous and can impair acoustic communication and influence signaling behavior in animals. Despite evidence demonstrating myriad effects of anthropogenic noise on animal communication, precisely how natural background noise influences communication and behavior remains unclear. Yet, natural sources of background noise, such as rushing rivers or crashing ocean surf, share similar power spectra to sources of anthropogenic noise and can occur at high amplitudes, potentially masking acoustic signals.

To investigate the effects of water-generated noise on songbird behavior, we experimentally broadcast landscape-level playbacks of ocean surf and river noise in coastal California, USA, and riparian habitat in Idaho, …

Comparing Radiation Shielding Potential Of Liquid Propellants To Water For Application In Space, John Czaplewski

Master's Theses

The radiation environment in space is a threat that engineers and astronauts need to mitigate as exploration into the solar system expands. Passive shielding involves placing as much material between critical components and the radiation environment as possible. However, with mass and size budgets, it is important to select efficient materials to provide shielding. Currently, NASA and other space agencies plan on using water as a shield against radiation since it is already necessary for human missions. Water has been tested thoroughly and has been proven to be effective. Liquid propellants are needed for every mission and also share similar …

A Method For Visualizing The Structural Complexity Of Organizational Architectures, Jacob Michael B. King

Master's Theses

To achieve a high level of performance and efficiency, contemporary aerospace systems must become increasingly complex. While complexity management traditionally focuses on a product’s components and their interconnectedness, organizational representation in complexity analysis is just as essential. This thesis addresses this organizational aspect of complexity through an Organizational Complexity Metric (OCM) to aid complexity management. The OCM augments Sinha’s structural complexity metric for product architectures into a metric that can be applied to organizations. Utilizing nested numerical design structure matrices (DSMs), a compact visual representation of organizational complexity was developed. Within the nested numerical DSM are existing organizational datasets used …

Studying The Efficacy Of An Injectable 3-Dimensional Fibrin Extracellular Matrix To Characterize The Effects Of Antitumor Agents On Sw620 Cells In A Microfluidic Device, Thèo Anastos

Master's Theses

Colorectal cancer is the third most common cancer in the United States and there is currently a lot of research going into new antitumor agents to kill the cancer. One method for replicating the tumor response to a drug in vivo is by creating an in vitro drug testing model to replicate the in vivo condition. This research project was conducted to determine the efficacy of testing tumor cultures in a microfluidic device as a way to provide accurate drug responses in vitro instead of using in vivo subjects in clinical trials. A total of four experiments were conducted with …

Estimating Food Waste Due To Food Safety Recalls And Investigating Ways To Minimize Negative Impacts, Mykayla Latronica

Master's Theses

For years the issue of food waste has been recognized and quantified; however, food safety issues often go unrecognized as a source of food waste. One objective of this research is to estimate quantities and monetary value of fruits and vegetables implicated in food safety recalls, and thus wasted. Using publicly available data we identified all recalls involving vegetable or fruit commodities contaminated with Listeria monocytogenes, pathogenic E. coli, or Salmonella during 2015-2018. When quantities were provided, monetary value of recalled product was calculated using USDA ERS 2016 average retail prices. Although data limitations only allowed analysis of …

Options For Low-Cost Manufacturing And Safer Cell Therapies, Melis Keceli

Master's Theses

The proposed work aims to overcome the economical and feasibility-related limitations of the chimeric antigen receptor therapies by developing an artificial cell signaling pathway whose design transforms K562 cells into in vivo living vectors to synthesize therapeutic proteins upon engaging diseased cells in the treatment of ovarian cancer. There are various advantages of using K562 cells throughout this process. First, Food and Drug Administration approves the reinfusion of K562 cells into patients’ bodies. Second, K562 cells are more affordable than T lymphocytes, and finally, these cells can be easily manipulated with any desired genetic material and can keep the expression …

Of The Wide-Eyed In Uncertain Times: The Education Of Girls During The Third Reich, Ingmar D. Clausing

Master's Theses

The aim of this thesis is to describe how both the state school system and the Hitler Youth educated girls during the Third Reich. Conventional theories have suggested a number of ideological suppositions regarding the overall curricular emphasis, but this study contends that such simplistic determinations do not capture the full spread of the educational experience. This thesis asks if girls in Nazi Germany were truly just indoctrinated or if schooling had legitimate academic purposes. Based on actual textbooks that were studied by girls for every subject area, at different grade levels, and in different types of schools, as well …

The Moderating Effect Of Self-Efficacy On The Relationship Between Telecommuting And Turnover Intentions, Samantha Mei-Li Scoppettone

Master's Theses

In recent years, telecommuting has become a popular working arrangement. While many studies have examined various outcomes of telecommuting such as turnover intentions, there is limited literature around potential moderators of the relationship of telecommuting and turnover intentions. The present study examined the relationship between telecommuting intensity and turnover intentions and explored occupational self-efficacy as a potential moderator. It was hypothesized that occupational self-efficacy would moderate the positive relationship between telecommuting intensity and turnover intentions, meaning that the relationship would be stronger for those with lower levels of occupational self-efficacy than those with higher levels of occupational self-efficacy. A total …

Andrews University Communication Under The Covid-19 Pandemic: Feedback Analysis Of International Students, Brice B. Eboule

Master's Theses

This research is an informative analysis of international students’ feedback on the Andrews University (AU) crisis communication during the COVID-19 pandemic in 2020. Participants were 21 years or older, on student visas, living on-campus or in student communities and had attended AU for at least 2 years. The theory informing this study is situational crisis communication theory (SCCT). The SCCT argues that the severity of the crisis defines which communicational crisis strategy will be more effective in minimizing attributions and adverse press while both maintaining and enhancing the organization's credibility. The findings of this study indicated that 84 percent of …

When God Gets Angry: Towards A Theology Of Divine Wrath, Lukas Daeubler

Master's Theses

Topic

One of the most significant concerns regarding the character and love of God is God’s wrath, especially in the Old Testament. For many, it is impossible to believe in a God who punishes and kills rather than a God who shows compassion and love for all people. They neglect either the violent parts of the Bible, since they seem to contradict the image of a loving God displayed in the Gospels. This of course directly questions the integrity of God and His word. As a response, some theologians have published papers on this topic, but many Christians and denominations …

The Removal Of Sin In Second Temple Jewish Literature, Odiaka Walker

Master's Theses

Problem

This thesis explored the Second Temple literary background of the concept that Jesus appeared at the end of the ages to take away sin, in Heb 9:26. As such, the research question which guided the paper was: what did Old Testament and Intertestamental writers believe about the removal of sin at the end of the ages? The answer to this question infers other questions: who would remove sin? From where would sin be removed? How was sin defined? How would sin be removed? When would sin be removed (are there time specifications involved)?

Method

The terms ἀφαιρέω, ἀφίημι, ἀπαλείφω, …

Examining Organizational Factors And Their Impact On Older Adults In Life Plan Communities, Ajla Basic

Master's Theses

Aging in America continues to reveal multi-faceted concerns for both the industry and retirees; insufficient retirement savings, loneliness, and a high influx of older adults entering the retirement scene. It is expected that by 2030, 18% of the nation's population, the baby boomers, will have turned 65 (Cohn & Taylor, 2010). This demographic reality has led to increased research seeking answers to questions which emerge about the retirement age population. The Age Well Study is a longitudinal study looking at the impact of residing in a Life Plan Community. The data is collected through self-report measures by residents in the …

Plasmodium Tlap-2 Is A Microtubule-Associated Protein With Microtubule Stabilization Properties, Grifin Berge

Master's Theses

Microtubules facilitate major cellular and morphological changes in eukaryotic cells, including the protozoan parasite Plasmodium. Microtubule-associated proteins (MAPs), only very few of which have been characterized in the malaria parasite, regulate the highly dynamic microtubules. Thioredoxin-like associated protein 2 (TLAP2) is a MAP unique to the phylum apicomplexa, which in addition to Plasmodium includes the important human pathogen Toxoplasma. Here we report on the cloning and microtubule-binding activity of TLAP2 of the rodent malaria parasite Plasmodium berghei (PbTLAP2). PbTLAP2 is coded by a single exon gene and consists of 598 amino acids. The protein contains a putative C-terminal microtubule-binding domain. …

The Utilization And Optimization Of Omics Trait Prediction Models Within And Across Diverse Populations, Ashley Mulford

Master's Theses

Most cancer chemotherapeutic agents are ineffective in a subset of patients; thus, it is important to consider the role of genetic variation in drug response. Lymphoblastoid cell lines (LCLs) derived from 1000 Genomes Project populations of diverse ancestries are a useful model for determining how genetic factors impact variation in cytotoxicity. In our study, LCLs from three 1000 Genomes Project populations of diverse ancestries were previously treated with increasing concentrations of eight chemotherapeutic drugs and cell growth inhibition was measured at each dose with half-maximal inhibitory concentration (IC50) or area under the dose-response curve (AUC) as our phenotype for each …

Beta-Adrenergic Receptor Mediated Transcriptional Dysregulation In Hematopoeitc Stem And Progenitor Cells Leads To Bone Marrow Erythroid Suppresion In Multiple Myeloma Patients - Ex Vivo Investigations, Vimal Ravi Subramaniam

Master's Theses

The sympathetic nervous system (SNS) regulates our body’s involuntary response to stress or harm. Once activated, it releases hormones and neurotransmitters known as catecholamines throughout the body to mediate its recovery. The catecholamines bind to adrenergic receptors located on various cells in a process designated as adrenergic signaling to elicit this response. This process is not always to our benefit. Adverse symptoms such as anemia can result due to adrenergic signaling. Our laboratory previously showed that burn injury triggers adrenergic receptor stimulation resulting in anemia induced by diminished erythropoiesis. The development of anemia in these studies was found to be …

Advancing Our Understanding Of Mechanosensitive Microtubule Acetylation In Neurons, Margaret Earl Utgaard

Master's Theses

Stiffness is a signaling cue in the brain, and neuronal response to stiffness impacts development, injury and disease. Mechanotransduction is the process of cells interpreting and converting mechanical cues to biochemical signals. Tubulin acetylation increases microtubule stability and could be mechanosensitive. The impact of stiffness on tubulin acetylation and role of septins is the focus of this project.It was hypothesized that stiffer surfaces would increase tubulin acetylation. SH-SY5Y cells were plated on varying stiffness and the ratio of acetylated to alpha tubulin was measured using immunocytochemistry. This study found SH-SY5Y cells had the highest acetylation on hard surfaces. SH-SY5Y cells …

Characterization And Targeting Of Voltage-Gated Ion Channels In Meningioma Cell Lines, Erik White

Master's Theses

Meningiomas (MN) are primary brain tumors originating in the meningeal covering of the central nervous system. These tissues can evolve through familial inheritance (NF2, Cowden Syndrome, or Werner Syndrome) or sporadic mutations. The WHO categorizes MNs into three grades (I-III); Grade I contain benign tumors and Grade III the most aggressive. Increasing grade coincides with an increase in genetic diversity, making universal treatments difficult. MNs are typically treated with hydroxyurea (HU), but this chemotherapy agent has many adverse side effects, leading to research in less toxic options. This study uses ion channel antagonists for T- and L-type calcium channels using …

Anthropogenic Particle (Including Microplastic And Microfiber) Transport And Retention In Streams Under Varied Environmental Conditions, Elizabeth Marjorie Berg

Master's Theses

Microplastics (plastic particles <5 mm) and other anthropogenic particles (i.e., synthetic, semi-synthetic and anthropogenically modified cellulose particles < 5mm) are pollutants of concern in aquatic ecosystems worldwide. Anthropogenic particles enter food chains, adsorb harmful chemical pollutants, and are ubiquitous in aquatic ecosystems. Streams are key sites of anthropogenic particle input, retention, and transport, and empirical measurements of particle movement in lotic ecosystems are needed to inform global budgets of anthropogenic particles and microplastics. However, factors that influence anthropogenic particle retention in lotic ecosystems are poorly understood. We demonstrate how environmental characteristics affect plastic transport and retention in streams in experimental and observational studies. In our experimental study, we used particle spiraling metrics to directly measure microplastic retention in outdoor, experimental streams at Notre Dame's Linked Experimental Ecosystem Facility (ND-LEEF). We tested the impact of stream discharge (i.e., high, low), benthic biofilms (i.e., well-established biofilms, reduced biofilms post-scouring), and benthic substrate type (i.e., cobble, pea gravel, sand, mixed substrate) on retention of microplastic fibers using pulsed releases and synchronized water sample collection at 3 sites downstream. We also collected benthic surface samples for biomass and microplastic density. Samples were filtered directly (water samples) or after peroxide digestion (benthic samples), and experimental microplastic fibers were enumerated visually using a dissecting microscope. Microplastic deposition rates were significantly higher with (1) higher discharge, (2) well established benthic biofilm (as opposed to bare substrate), and (3) larger and more homogeneous substrates. The observational study examined anthropogenic particles (including microplastics and microfibers) in the Milwaukee River during storm events. Lotic ecosystems are highly variable (e.g., seasonal changes, storm events), and most research assessing anthropogenic particle pollution extrapolates stream particle loads based on measurements during only one point in time. This limits the accuracy of anthropogenic particle and microplastic dynamics models in rivers, where frequent changes in discharge drives retention and transport of fine particles. In this study, we used automated samplers to collect water from the Milwaukee River during four distinct storm events in the spring and summer of 2018. We quantified anthropogenic particle abundance using standard methods and used nearby USGS gauges to determine discharge. Anthropogenic particle concentrations varied significantly among the four sampling periods, highlighting the temporal variability of anthropogenic particle transport across dates. When data from the sampling periods were pooled, there was a decrease in anthropogenic particle concentration in the water column after storm events, indicating that floods may "flush" microplastics from the river. Unexpectedly, anthropogenic particle concentrations were not correlated with other water quality metrics, including concentrations of total suspended solids, fecal coliform, chloride, nitrate, and sulfate, indicating that these metrics cannot be used to estimate microplastic concentrations and likely have distinct driving factors. These results provide novel insights into the environmental factors controlling anthropogenic particle and microplastic fate and are critical to understanding the role of lotic retention and transport in global plastic budgets.

Does Manipulating Source Gender Predict A Person's Open-Mindedness As A Function Of Sexism?, Tanyelle Annette Galman

Master's Theses

The present research examines whether Communication Source Gender influences a message recipients' level of Open-Minded Cognition, and whether Ambivalent Sexism moderates this effect. Participants were asked to think of themselves as part of a military panel which considers proposals to military spending. Then after reading a proposal from either Cassandra Smith or David Smith, participants were asked to indicate whether they would be open to hearing more from the author. Participants were then instructed to complete the Ambivalent Sexism Inventory (Glick & Fiske, 1996). In total there were 395 participants in this study. Results show that there was no main …

Rethinking Intimacy: Liberation Through Decolonial & Queer World-Making, Michelle Mae Mcguire

Master's Theses

Relationships play an important role in both the private and public spheres of our lives. If we understand our bodies to be the vessels through which we interact with all other objects, we come to understand the process of world-making as a summation of our relationships. Intimacy is the prevailing structure that helps assign meaning to these relationships. Intimacy binds together unfixed spatial and social relations that stretch across time and space. This essay examines the three intersecting sets of relations involved in intimacy as a means to deconstruct heteropatriarchal order and highlight the multiplicity of attachments and relationships that …

Menstrual Pain Trajectories And Their Psychological And Behavioral Predictors, Hannah Marie Alves Hagy

Master's Theses

Despite the high prevalence of menstrual pain (i.e., dysmenorrhea) and the negative impact on quality of life, there is a dearth of research on how menstrual pain changes over time. There is also a critical need to understand psychological and behavioral predictors of these menstrual pain trajectories because dysmenorrhea is a known risk factor for the development of chronic pelvic pain (CPP) and chronic non-pelvic pain (CNPP). Given that current treatments for CPP and CNPP have had limited success, developing preventative strategies for dysmenorrhea is of high importance. Relying on longitudinal survey data collected as part of a larger investigation, …

A Fair Share: How Awareness Of Inequality, Allocation Method, And System Justification Affect Perceptions Of Distributive Fairness, David Thomas Igliozzi

Master's Theses

In considering the different ways people view inequality and various proposed solutions,this study draws on classic psychological theories of distributive justice which outline three modes of allocation strategies: equality, equity, and need. While Deustch’s (1975) work on these three allocation alternatives laid the groundwork for years of distributive justice research that would follow, little empirical work has actually experimentally evaluated the conditions under which people might be more or less willing to support equity, equality, or need-based strategies. There is evidence that certain individual difference measures can predict support for redistribution. That is—those who rate highly on system justification, political …

The Evolutionary And Morphological Diversification Of The Subtribe Papionina, Sophie B. Labelle

Master's Theses

Analysis of variation is critical in understanding evolutionary processes. The subtribe Papionina, defined commonly as baboons and their closest relatives, is a highly morphologically diverse group of primates that is useful for the examination of the relationship between variation and evolution. The subtribe is also a valuable behavioral, ecological, and morphological analogy for hominins. This study uses landmark-based cranial geometric morphometric data and multivariate analysis to test whether the pattern of morphological diversification present in Papionina is consistent with genetic drift and/or selection. The study sample consists of six extant genera of Papionin, represented by ~500 individuals collected by Michelle …

Do Conditional Cash Transfers Increase School Enrollment? Evidence From Brazil, Jeanette L. Silvernale

Master's Theses

Conditional cash transfer programs have been widely deployed across the globe. They seek to bolster human capital by providing benefits contingent upon a variety of actions such as school attendance and regular health checkups. Bolsa Familia is the most extensive conditional cash transfer program, serving 46 million Brazilian citizens. Despite its expansive size, there have been seldom large-scale micro evaluations of the program. Limited data has resulted in small sample sizes drawn from a single point in time. Our study diverges from the rest and utilizes a novel administrative dataset with an overall sample of nearly 60 million and a …

An Efficient Design Methodology For Complex Sequential Asynchronous Digital Circuits, Tomasz Chadzynski

Master's Theses

Asynchronous digital logic as a design alternative offers a smaller circuit area and lower power consumption but suffers from increased complexity and difficulties related to logic hazards and elements synchronization. The presented work proposes a design methodology based on the speed-independent sequential logic theory, oriented toward asynchronous hardware implementation of complex multi-step algorithms. Targeting controller-centric devices that perform data-driven non-linear execution, the methodology offers a CSP language-based controller workflow description approach and the specification of a project implementation template supported by a two-stage design process. First, the CSP layer describes complex speed-independent controller behavior offering better scalability and maintainability than …

A Meta-Analysis Of Fmri Studies On Emotion Processing In Major Depressive Disorder, Madison Morocco

Master's Theses

The processing of an emotional stimulus involves a multi-step process that includes appraising and identifying a stimulus as well as producing an affective state in response. Many individuals with depressive disorders such as major depressive disorder (MDD) experience impairments related to emotion processing, likely caused by changes in the structure and function of brain regions important for emotion processing. However, the precise neural differences underlying emotion processing impairments in MDD remain unclear given conflicting findings in the neuroimaging literature. This lack of clarity has hindered the development of novel neurostimulation treatments for MDD, which require targeting of specific brain areas. …

Transfer Learning For Hyperspectral Images Utilizing Channel Selection Techniques And Ensemble Methods, Scott Daniel Vogel

Master's Theses

Hyperspectral images contain information from a wider range of the electromagnetic spectrum than natural images which gives them potential for better classification ability. However, hyperspectral datasets are typically small due to the expensive equipment needed to obtain the images, which can limit classification performance. One solution to this problem is transfer learning, in which a model trained on one dataset is reused for a separate dataset. Research has shown that transfer learning between hyperspectral datasets can give improved performance over models without transfer learning when training data are limited. Since extra hyperspectral data are not always available, the solution proposed …

Lstm-Enabled Level Curve Tracking In Scalar Fields Using Multiple Mobile Robots, Kunj J. Parikh

Master's Theses

Autonomous mobile sensor networks are ideal candidates for exploring large-scaleunknown fields with tasks ranging from source seeking, level curve tracking, mapping an unknown field, and many more. In this work, we investigate the problem of level curve tracking in unknown scalar fields using a limited number of mobile sensors. The level curve tracking problem has been studied in many applications such as monitoring the propagation of fire boundaries and the algae blooms. We design and implement a long short term memory (LSTM) enabled control strategy for a mobile sensor network to detect and track the desired level curve. We develop …

Identifying Key Residues Involved In Allosteric Regulation Of Human Sirt1 Deacetylation Activity, Angelina Huynh

Master's Theses

SIRT1 is a mammalian NAD+-dependent lysine deacetylase involved in the regulation of physiological processes. Sirtuin-activating compounds (STACs) such as resveratrol bind to the allosteric site within the N-terminal domain (NTD) to regulate activity. Understanding these allosteric effects on SIRT1 would provide insights into drug design to modulate SIRT1-dependent deacetylation on specific substrates. The overall goal of this research is to identify key residues that are involved in allosteric activation of the enzyme, also known as an allosteric switch-like region. Using computational methods based on the primary sequence of SIRT1, we identified residues 186-193 to have a propensity to exhibit switch-like …