Digital Commons Network^™

Comparison Of Plga And Pcl Ratios In Kartogenin-Containing Nano-Scaffolds Produced Via The Electrospinning Process, John Graham Roberson

Honors Theses

Microfracture surgery is the most common procedure to treat osteochondral lesions in the knee. However, instead of developing the original hyaline cartilage at the site of treatment, this procedure leads to the development of fibrocartilage, which lacks the durability and function of hyaline cartilage. A small molecule compound, Kartogenin (KGN), is known to promote the differentiation of STEM cells into chondrocytes and can be incorporated into a polymer nanoscaffold via the electrospinning technique. The scaffold could serve as a release mechanism for the KGN as the polymer degrades in the body. This study implemented the use of two different polymers, …

The Relationship Between Ptsd-Related Symptoms And Skin Disease Symptom Severity In A Dermatological Sample, Kristin Barnett

Honors Theses

Previous research has demonstrated associations between stress and physical health conditions, including skin disease. The stress cycle, including its associated hormonal responses and stress behaviors, contributes to more severe skin disease symptoms. Psychological stress and anxiety-disorder symptoms are known to be associated with skin disease severity; however, research has yet to examine the relationships between stress disorders and skin disease severity. Therefore, stress disorders (e.g., posttraumatic stress disorder [PTSD]) are hypothesized to have a similar relationship with skin disease severity, wherein greater severity of PTSD-related symptoms would be positively associated with skin disease severity. Participants from Amazon’s Mechanical Turk (N …

Synthesis And Characterization Of Redox-Active Multidentate Ligands For Catalytic C-H Bond Oxidation And Carbon Dioxide Reduction, Caroline Hodge

Honors Theses

This thesis focuses on two research projects. The first project reported in Chapter 1 involves the synthesis and application of a tetradentate ligand (2-(1,1-di(pyridin-2-yl)ethyl)-1,10-phenanthroline, PhenPY2Me) that is metalated with iron to give a catalyst capable of carbon-hydrogen (C-H) bond oxidation. C-H bond oxidation provides a method that may allow some transformations in organic syntheses to be streamlined. The mononuclear iron complex supported by PhenPY2Me was found to dimerize in the presence of O₂ in a non-coordinating solvent. These iron complexes and a previously reported system were assessed and compared in C-H bond oxidation with model substrates using the sacrificial …

Occupational Fine Particulate Matter Exposure And Its Associated Effects On The Cardiovascular System: A Systematic Review, Jordan Rickwa

Honors Theses

Fine particulate matter (PM2.5), the solid and liquid portion of air pollution under 2.5 microns in diameter, has been shown to cause numerous negative effects on the body. These inhalable particles are often researched for their effects on the respiratory system in outdoor settings, however systemic health impacts have been observed following inhalation of PM2.5 . Additionally, exposures to PM2.5 can occur in occupational settings but are less frequently studied compared to outdoors. This literature review seeks to identify studies that determined associations between inhaled PM2.5 and the resulting cardiovascular effects in occupational settings. We conducted a search of literature …

Targeting Platelets Using Ionic Liquid Coated Nanoparticles, Karen Mun Wong

Honors Theses

Platelets are key players in our body’s inflammatory processes upon activation, which can create physiological problems. Researchers are actively seeking solutions by targeting platelets with therapeutics. The objective of the research in this thesis was to investigate a new and potentially less invasive drug delivery platform using nanoparticles. The topic of the project was to explore the world of ionic liquids and their abilities, when coated on nanoparticles, to bind to platelets. A library of choline carboxylic acid-based ionic liquids (ILs) was first synthesized via salt metathesis while PLGA-based nanoparticles were simultaneously being synthesized via the nanoprecipitation method. The ionic …

Covid-19 Impact On The Hospitalization Rates For Eating Disorders, Jennifer Ess

Honors Theses

The COVID-19 pandemic has had an impact in a variety of ways. With the quarantine restrictions placed during this time, many individuals had turned to social media as an outlet to cope with the loss of intimate time with friends and outside family. This increase in social media use, especially Tik Tok and Instagram, can negatively impact a person's outlook on certain situations. Throughout this pandemic, mental health issues, specifically eating disorders, have shown a rise in cases during this time. Current research shows that numbers have more than doubled during pandemic times, and also shows many different factors that …

Panda Diplomacy: China's Use Of Soft Power To Influence The World, Anna Reed

Honors Theses

Although giant pandas lack a long-standing history in Imperial China, they hold a strong connection to the Chinese Communist Party and Chinese Nationalism in the modern day. This research attempts to answer the question of whether giant pandas are an influential tool of soft power and achieve the purpose of promoting a “softer” image of China globally. Through a literature review and the method of a survey, research revealed that giant pandas are a successful tool of soft power. Overall animals serve a larger purpose in policy than simply a pet object. They can influence people and nations.

Refuge: Seeking Solace Amidst Chaos, Andrew Deur

Honors Theses

“REFUGE: Seeking Solace Amidst Chaos” is an eight-movement suite composed for small jazz ensemble that explores the book of Psalms and the recurring idea of refuge in God that the psalmist describes. Featuring original compositions and arrangements by Andrew Deur, the suite tells the story of humankind’s relationship with God over the course of their creation and their fall into brokenness. As danger, adversity, struggle, and pain become prominent figures in humanity, the psalmist cries out to the Lord for help, and while the response does not always match their expectation or timeframe, God hears their prayers and answers with …

An Interdisciplinary Analysis Of Dehumanization During The Holocaust, Alissa Marie Davies

Honors Theses

The body of literature surrounding the Holocaust and dehumanization is extensive. Multiple theories have been proffered to try and explain the Holocaust’s causation, each with varying degrees of acceptance from the Jewish and global communities. Meanwhile dehumanization has been studied however often through the lens of a singular field. Despite the abundance of research on the Holocaust, the subject of perpetrators has had limited exploration as of yet. The present analysis seeks to examine the mechanics of dehumanization and how these mechanics could explain the behaviors behind the perpetration of the Holocaust and by extension, other genocides. This analysis will …

Perceptions Of Trauma-Informed Care In An Intimate Partner Violence Resource Center, Kailyn Alderman

Honors Theses

Every year, an estimated 10 million people experience intimate partner violence (IPV) in the United States (Huecker et al., 2021). The long-term implications of surviving IPV can be debilitating and limited community resources influence the likeliness of physical and psychological recovery. Trauma-informed care (TIC) is a set of practices that may produce improvements in the quality of life for IPV survivors. There are a variety of definitions of TIC and empowerment, which may serve as a barrier to implementing these practices. The present study examined employee and volunteer perceptions of trauma-informed practices and empowerment at a domestic violence agency. The …

Comparing Behavioral Activation With And Without A Values Component: A Systematic Review, Natalie Komoll

Honors Theses

Major depressive disorder is one of the most prevalent psychological disorders within the global population and has been for many years. Over the years, numerous interventions have been developed to treat major depressive disorder, including cognitive-behavioral therapy. One form of cognitive-behavioral therapy for depression, known as behavioral activation, focuses on increasing contact with pleasant activities that are reinforcing. Many modifications of behavioral activation have been made over the years, including the version Martell and colleagues (2010) created which modified the traditional approach by decreasing the number of sessions. This new approach, known as brief behavioral activation, also asks clients to …

The Effect Of Estrogen On Gdnf Production Of Skeletal Muscle In Vitro, Hope Welter

Honors Theses

As life expectancy continues to rise, the number of people over age 65 in the U.S. is increasing. An aging population brings with it impacts on the national health system and associated economic expenditures. As individuals age, the skeletomuscular system suffers reduced function due to disease or conditions such as sarcopenia. Sarcopenia is characterized by muscular atrophy resulting from reduced muscle innervation. Exercise has been linked to prevention of sarcopenia, a suspected result of increased production of glial cell line-derived neurotrophic factor (GDNF). GDNF promotes neuronal survival, regeneration, and the formation of neuromuscular junctions. Therefore, treatments like exercise that increase …

Effects Of Parent Intervention Via Tele-Practice On Children With Autism Spectrum Disorder In Rural Mississippi, Erin Bowens

Honors Theses

Background

The present study explored the use of parent intervention via tele-practice for children with Autism Spectrum Disorders (ASD) and how effective that intervention was in increasing the child’s language and communication skills and the parents’ strategy use in the rural state of Mississippi.

Methods

Two dyads of participants were used. Dyad 1 included a mother and her 4-year-old son with high-functioning ASD, and Dyad 2 included a mother and her 4-year-old daughter with severe ASD. Standardized tests were administered to gather data about the children’s diagnoses. The study included four phases across four months, including pre-test, intervention, post-test, and …

Bystanders Without An Excuse: On The Moral Duty To Revolt, Meghna Melkote

Honors Theses

Che Guevara, an Argentine revolutionary who served as a key player in the Cuban Revolution, was known for his forceful rhetoric calling people to action to engage in revolution. His language was the language of duty - when he called on people to act, he did so with moral force behind his words. In the face of nascent revolution and discontent, he called upon those aggrieved to “tremble with indignation every time that an injustice is committed in the world” and act accordingly1. Guevara is appealing to a common intuition many leaders in social justice seem to have; there is …

Towards Asymmetric Mannich Reactions And Alkylation Of Indoles, Bianco Bicalho

Honors Theses

In the presence of trimethylsilyl trifluoromethanesulfonate (TMSOTf) and 2,6-lutidine, acylated thiones undergo Aldol and Mannich reactions with aldehydes and nitrones to yield complex nitrogen-containing compounds. The use of a chiral metal-ligand complex is hypothesized to accelerate the reaction and increase stereochemical control during product formation. N-Alkylindoles undergo Friedel-Crafts alkylation with acetates in the presence of TMSOTf and 2,6-lutidine to produce 3-alkyl indoles. Varying Substitution on the indole at the 5 position and removal of the alkyl group from the 1 position both show continued reactivity at the 3 position even in the presence of TMSOTf.

How To Combat The Negative Effects Of Punishment Drift On Children, Madison Alliston

Honors Theses

Approximately 2.7 million children have a parent that is currently incarcerated in the United States. Despite the fact that these children are innocent, they face a myriad of negative consequences due to the separation from their parents. The negative effect of incarceration on children is known as punishment drift. Because the effects of incarceration tend to “drift” onto children, these individuals typically face psychological impacts (e.g., social anxiety and depression), economic impacts (e.g., poverty and food insecurity), and environmental impacts (e.g., foster care) from punishment drift. Despite all of the detrimental effects, there have been very few policy solutions implemented …

Empower! A Poetry Curriculum For The 21st Century Learner, Misty Maina

Honors Theses

By providing today’s high school students with a multimodal curriculum centered around critical inquiry, worldview, personal relevance, and by providing students will many opportunities to respond to these principles with their own writings, students will be empowered to engage with their learning and the world in meaningful and intentional ways. Empower! poetry curriculum is designed to help students ask questions about themselves, their immediate surroundings and influences, and about the world around them. Students will be encouraged to take the time and energy for deeper thinking and reflection as they engage with the activities of Empower! While there will be …

Development Of A Non-Invasive Dna Extraction Method From Teeth, Monalisa Heng

Honors Theses

Forensic dentistry has evolved from simple morphological investigations to genetic and molecular analysis. One of the most important techniques is DNA analysis which requires viable samples from an individual or crime site. The orofacial region can be a good source for DNA samples because the tissues can resist environmental, thermal, electrical, and mechanical challenges. Teeth are especially useful as a source of genetic material because the DNA located in the pulp is surrounded by protective mineral tissue. The DNA in the pulp tissue is currently accessed through destructive methods involving crushing, pulverization, and splitting the tooth. Unfortunately, destructive methods destroy …

Literature Review On Outer Hair Cell Regeneration And Potential Hearing Restoration, Serena Karlov

Honors Theses

The cochlea is the portion of the inner ear responsible for hearing, containing both the organ of Corti and auditory hair cells. Sound wave vibrations mechanically bend the stereocilia on the three rows of outer hair cells and one row of inner hair cells. These hair cells transduce this mechanical energy into electrical impulses that are relayed from the auditory nerve to the brain, where sounds are processed. In this review I provide an overview of inner ear anatomy, ear physiology, and auditory transduction. I then move on to specifically focus on the importance of outer hair cells, their regeneration, …

The Gibbs House: Visual Storytelling Through Brand Identity And Placemaking, Elizabeth Tran

Honors Theses

Managed by Western Michigan University’s (WMU) Office for Sustainability, the Gibbs House has a rich history of existing as the functioning university urban farm since the late 60s. Throughout the years, the location has transformed into a learning laboratory as well as a permaculture research and demonstration site for WMU students and the Kalamazoo community. As individuals scramble to come up with solutions to combat climate change, the two-acre plot becomes a vital resource where students are able to participate in sustainable practices that are both hands-on and outdoors. It pushes forward transformative ideas like composting, food forestry, and permaculture …

Teaching Language Variation In K-12 Schools, Samantha Phillips

Honors Theses

The language used in most classrooms throughout the United States is standard American English (SAE). Although this language is difficult to define, it is often perceived as the correct or proper usage of the English language. Students grow up learning that there is one correct way to speak and write, and consequently, they learn that any variation from this standard must be incorrect or improper. Student speakers of stigmatized variations of English face academic, social, and personal consequences such as poor academic performance, isolation from peers, and assimilation. The ideology that promotes SAE as correct also ignores the connection between …

Fast Photochemical Oxidation And Footprinting Of Proteins Via Trifluoromethyl Radical Chemistry, Elaine Morrow

Honors Theses

Fast photochemical oxidation of proteins (FPOP) is a useful tool in proteomics because of the ability for modifications to occur on the scale of microseconds which reduces the modifications to tertiary and quaternary structure allowing for more accurate labeling of the protein. Labels for FPOP are generated from various radicals in our experiments which include hydroxyl radicals and trifluoromethyl radicals. Hydroxyl radicals are easily generated by using an excimer laser (KrF laser, 248 nm) or a UV flash lamp (as a part of the Fox™ System) by the photolysis of hydrogen peroxide. Trifluoromethyl radicals, however, need hydroxyl radicals to be …

Black Carbon And Meteorological Parameters At Two Locations In Northern Mississippi, Ashton Swader

Honors Theses

Black Carbon, which is a component of fine particulate matter, is a known pollutant that has been linked to the development of several diseases including cardiovascular disease. This pollutant can be measured by taking samples of air within a certain region and analyzing them using a transmissometer. It is known that black carbon concentrations tend to be higher in urban areas when compared to rural areas within a region. Black carbon concentrations can also vary depending on certain meteorological parameters such as temperature and humidity. There were no current studies that analyze the air quality in northern Mississippi due to …

'The Power Of A Suit' And Other Tools For The Modern Music Marketer, Andrew Gardner

Honors Theses

The following thesis records the creation of a new persona. Mr. Neptoon is a concept, a brand, and most importantly, an authentic musician. He is an artist who wants to make and spread his art as widely as possible. We document the career trajectory from September 2021 to March 2022. The high-stakes experiment: utilize big-picture marketing goals to inform an approach to crafting the art and commercial material. Research informs the artistic direction. Research informs the messaging and marketing direction. The artist is creating and selling a full-length, fourteen-track concept album—aided by the project's marketing research — to be completed …

The Effects Of Covid-19 On Well-Being Of Healthcare Workers, Hannah Meissner

Honors Theses

The development of the new coronavirus disease, COVID-19, led to the spread of turmoil across the United States and further around the globe. With the virus creating uncertainty among the population, the evidence began to demonstrate that individuals could have devastating health effects, including death. Healthcare workers are among those who were on the frontlines in order to care for the infected, ultimately increasing their own chances of acquiring the virus and putting their health at risk. These workers have experienced a direct impact due to this exposure in the form of isolation, anxiety, depression, suicide, and sleep disturbances. With …

An Analysis Of The Extent To Which Responsible Technology Is Taught In R1 And R2 Research Universities In Michigan., Maisie Blaukamp

Honors Theses

Responsible technology development, use, and communication is crucial as technological innovations scale. An increasing topic of conversation in the technology and education industries is how to educate individuals to interact with technology in an ethical way, as harmful technologies and use of technologies are creating negative impacts on individuals, businesses, and society. This research examines the extent to which responsible technology is taught in major Michigan universities.

An analysis of courses and course descriptions at 8 R1 and R2 universities shows that there is a lack of responsible technology education in business colleges, courses teaching technology development, and courses teaching …

Tropical Cyclone Translation Speeds In The Northern Atlantic Ocean, Marybeth Melcher

Honors Theses

Over the past 40 years, tropical cyclones have caused over $1,076.9B in damage in the United States. The fatalities from tropical cyclones are just as devastating. Hurricane Katrina of 2005 caused over 1,800 deaths; Harvey in 2017 just under 90 deaths; Ike of 2018 took 112 deaths; and horrifically, Maria of 2017 claimed nearly 3,000 lives. The destruction that tropical cyclones have caused is astronomical, and a factor of tropical cyclones that is responsible for this level of destruction is their translation speeds. Tropical cyclone translation speed (TCTS) is the speed at which a hurricane is moving--the duration of time …

Racial Health And Productivity Inequalities In The United States, Elissia Vecere

Honors Theses

Across America, it is frequently seen that there are may differences by race in economic and social outcomes. This variability can be seen in judicial, social, and economic systems. The breakdown of economic systems presenting racial variability can be displayed via workplace statistics. There is a general discrepancy between the workplace statistics represented with Black and White employees. These differences frequently are blamed on the productivity and background education supplied by the employee upon being hired. However, the levels of variation across these two races varies minutely in comparison to the differences in wages supplied. When all factors are kept …

The Rebrand Of Sheamoisture, Anna Lechard

Honors Theses

I would like to start with why I chose the company SheaMoisture to rebrand. SheaMoisture was introduced to me by a hairstylist. I was looking for a product that was affordable and healthy for my hair. Before knowing of this company I would not have picked it off the shelf for myself. Not many hair care companies are affordable, hair type specific, and ethically sounded meaning they have good company values, an interesting origin story, and contain clean ingredients. However, with all these good things said, I did not understand that with the current branding in place which is why …

Ethical Monetization For Social Media Companies, Leo Phillips

Honors Theses

The most popular social media companies today all monetize primarily through the same revenue stream, advertising. Popular social media strategies have developed similar methods to increase the advertising revenue that each user generates. These strategies for monetization have become ever increasingly exploitative and harmful to the social media user population as these major companies are gripped in a technological arms race to capture as much of their user’s time and attention as possible. The effects of increased social media use are a general overall decline in our society’s physical, emotional, and social health (Haugen, 2021 & Harris, 2019). These health …