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Honors Theses

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Prototypicality And Need To Belong: How One’S Standing In The Group Affects Parochial Cooperation, Huidi Yuan Jan 2024

Prototypicality And Need To Belong: How One’S Standing In The Group Affects Parochial Cooperation, Huidi Yuan

Honors Theses

This study explores the dynamics of parochial cooperation within intergroup social dilemmas, specifically examining the roles of harm, prototypicality, and the need to belong (NTB). Utilizing an experimental design and an adapted investment game, the study investigates how these factors influence individuals' decisions to engage in cooperation that is biased towards their own group, especially when such actions potentially harm outgroup members. The findings reveal a strong preference for parochial cooperation over universal cooperation and free-riding, consistent with previous research on ingroup favoritism. Notably, this preference is significantly moderated by the harm condition, where participants reduced their parochial investments when …


Cd46 Interaction With Adenovirus Type 64, A Causative Agent For Viral Pink Eye, Hanglin (Henry) Zhu Jan 2024

Cd46 Interaction With Adenovirus Type 64, A Causative Agent For Viral Pink Eye, Hanglin (Henry) Zhu

Honors Theses

Human adenovirus type 64 (Ad64) is a causative agent of contagious viral pink eye. We do not understand why Ad64 causes eye infections. One likely reason is the presence of a receptor molecule on the exposed surface of eye cells, but not other cells. Ad64 binds to a protein called CD46 on the cell surface. We aim to visualize how CD46 binds to the surface of Ad64. I mixed the extracellular portion of CD46 with purified Ad64 virus, then visualized it using negative stain transmission electron microscopy. In order to gain insight into how the virus binds CD46, we used …


Les Perceptions Françaises De La Technologie Racontées À Travers Le Temps Avec Jacques Tati, Agnès Varda, Jr Et Michel Serres, Na'dyah Wynn Jan 2024

Les Perceptions Françaises De La Technologie Racontées À Travers Le Temps Avec Jacques Tati, Agnès Varda, Jr Et Michel Serres, Na'dyah Wynn

Honors Theses

Les perceptions françaises de la technologie racontées à travers le temps avec Jacques Tati, Agnès Varda, JR et Michel Serres (French Perceptions of Technology Told Through Time with Jacques Tati, Agnès Varda, JR et Michel Serres), explores the relationship between technology and society as depicted in French cinema. By analyzing the works of filmmakers Jacques Tati, Agnès Varda, and JR, the thesis examines how these directors themselves have portrayed the impact of technology on French culture and society over time. in the end, Michel Serres helps explain the changes of perception over time by comparing the works of the three …


Cd46 Isoforms And Viral Receptor For Adenovirus Type 64d, Corina Stasiak Jan 2024

Cd46 Isoforms And Viral Receptor For Adenovirus Type 64d, Corina Stasiak

Honors Theses

Adenovirus Type 64 (Ad.64) belongs to the adenovirus subgroup D, which causes epidemic keratoconjunctivitis (EKC), otherwise known as viral pink eye. There is currently no known effective treatment for EKC. Membrane Cofactor Protein (CD46) is an integral membrane glycoprotein that, in previous studies, has been identified as a protein receptor for the closely related Ad.37. It has been determined that Ad.64 uses CD46 as a receptor on the cell surface in HeLa cells. CD46 is alternatively spliced when expressed to have different isoforms of interest, including the BC and C isoforms. Certain cell types, like A549 lung carcinoma cells, express …


Cd46 Is A Protein Receptor For Human Adenovirus Type 64, Alexander Michael Robertson Jan 2024

Cd46 Is A Protein Receptor For Human Adenovirus Type 64, Alexander Michael Robertson

Honors Theses

Adenoviruses are important gene delivery vectors and causative agents for a variety of human diseases such as the common cold and gastrointestinal infections. Human adenovirus type 64 (Ad64; formerly 19c) and type 37 are associated with epidemic keratoconjunctivitis. Based upon its high homology and similar disease tropism to Ad37, we hypothesized that Ad64 would have the same protein receptor, CD46 (membrane cofactor protein), as Ad37. We show that a recombinant Ad64 containing an enhanced Green Fluorescent Protein transgene (Ad64.eGFP) enters Chinese hamster ovary cells expressing human CD46 (CHO-CD46) on the surface. Entry into human cervical carcinoma (HeLa) cells is increased …


#Booktok: Social Media’S Influence On Literature, Madison Hyatt Jan 2024

#Booktok: Social Media’S Influence On Literature, Madison Hyatt

Honors Theses

Exploring the social media phenomenon, TikTok, and its influence on the community, #Booktok is the newest way readers stay up to date on new books, and what to read. Is this a good thing? A bad thing? And how has this new way of consuming books influenced reading and literature?


The Impacts Of Identity On Perceptions Of Safety On A Predominately White Campus, Rebecca Delrosso Jan 2024

The Impacts Of Identity On Perceptions Of Safety On A Predominately White Campus, Rebecca Delrosso

Honors Theses

This quantitative study examines the relationship between students’ marginalized identities of race, gender, and sexuality and their perceptions of safety at a predominantly white institution (PWI). Survey data collected from undergraduates at a small liberal arts university reveal associations between minority identities and feelings of discomfort, insecurity, discrimination, and vulnerability on campus. The findings highlight the need for PWIs to prioritize secure and inclusive environments through policies, practices, and support systems.


Exploration Of Sulfonamides And Benzothiazoles As Peptide-Based Cleavable Linkers, Abigail Dalton Jan 2024

Exploration Of Sulfonamides And Benzothiazoles As Peptide-Based Cleavable Linkers, Abigail Dalton

Honors Theses

Cleavable linkers have demonstrated great potential in various applications of medicinal organic chemistry, such as in modern therapeutic development. Linkers are stable compounds that cleave in specific conditions to release molecular cargo. We have developed cleavable linkers based on nucleophilic aromatic substitution reactions on sulfonamide and benzothiazole substrates in small molecule and in peptide studies. Sulfonamides, commonly with an electron-withdrawing group, reacted in high conversion of starting material to the sulfide product in small molecule studies, but was unable to successfully cleave the sulfonamide linker on peptide in mild conditions. Next, a benzothiazole sulfone substrate was analyzed and optimized in …


Unpredictable Positive Experience Response (Uper) Training In Male And Female Rats: Effects On Cognition, Emotional Resilience, And Neuroplasticity Markers, Eve M. Barringer Jan 2024

Unpredictable Positive Experience Response (Uper) Training In Male And Female Rats: Effects On Cognition, Emotional Resilience, And Neuroplasticity Markers, Eve M. Barringer

Honors Theses

This study investigated the effects of positive anticipation on depression-like symptoms in Long Evans male and female rats, using Unpredictable Positive Experience Response (UPER) training. Rats that received UPER training (UPER group) were exposed to cues followed by a positive reward at random times, fostering anticipation of three different positive experiences. Along with the UPER rats, there was a group of rats that received positive rewards without anticipation (ENR group) and a group that received no positive reward or anticipation (CTRL group). After 7 weeks of behavioral… training, we examined how training impacted the animal’s cognition, emotional resilience, and neurobiological …


(Re)Constructing Race: How Essentialist Beliefs Shape Social Justice Support, Abbey Alvarado Jan 2024

(Re)Constructing Race: How Essentialist Beliefs Shape Social Justice Support, Abbey Alvarado

Honors Theses

The political climate and social discourse around social justice has grown increasingly tense and hostile in recent years. The current study investigated potential predictors of the opposition to support for racial equity and social justice reforms. Research illustrates that a biological conceptualization of race (“essentialism”) has powerful implications on information processing and social-psychological outcomes regarding issues of race and racism. In the current study, we conducted a survey of 164 University of Richmond undergraduate students. The survey examined the interplay of essentialism and beliefs about systemic racism and white privilege on social justice support. The results showed that essentialist beliefs …


Structural Phylogenetics Of A Family Dna Polymerases, Yagmur Bingul Jan 2024

Structural Phylogenetics Of A Family Dna Polymerases, Yagmur Bingul

Honors Theses

The transition from the RNA to the DNA world stands as an important event, demanding the emergence of enzymatic activities for DNA precursor synthesis, retro-transcription of RNA templates, and replication of single and double-stranded DNA molecules. The distribution of protein families associated with these activities across the three domains of life—Archaea, Eukarya, and Bacteria—adds layers of complexity to the narrative. While Archaea and Eukarya often share similar protein structures, structural biology shows homologous, but distinct, structures in Bacteria. On the other hand, viral polymerases emerge as a crucial part of genome replication and transcription. Their versatility, including RNA-dependent RNA polymerase, …


Departure From Magical Realism: Female Agency In Latin American Post-Boom Literature, Nicole Darian Llacza Morazzani Jan 2024

Departure From Magical Realism: Female Agency In Latin American Post-Boom Literature, Nicole Darian Llacza Morazzani

Honors Theses

his thesis explores depictions of female agency in post-colonial Latin American literature. I highlight three primary texts: Gabriel García Márquez's (1927-2014) 1967 One Hundred Years of Solitude, a canonical magical realist novel; Isabel Allende's (1942-present) 1982 The House of Spirits, her debut novel and a multi-generational story similar to Márquez's, and Isabel Allende's 2022 Violeta, a historical novel offering an autodiegetic narrative of a woman's 100 years of life in an unnamed South American country, to analyze how female characters evolve in response to changing sociopolitical landscapes and literary movements in Latin America. My central focus is Allende's most recent …


The Effect Of Housing Burden And Access To Affordable Housing On Abortion Rates, Isabelle Huggard Jan 2024

The Effect Of Housing Burden And Access To Affordable Housing On Abortion Rates, Isabelle Huggard

Honors Theses

In the United States a household’s highest expenditure is housing. Low-income households feel this more acutely and have higher rates of housing burden. Past research documents a link between financial constraints and abortion. Three studies published in 1988, 2004, 2014 sought to understand the reasons women get abortions, and found that finances are a prominent reason given. If housing is a large share of household finances and finances play a large role in abortion demand, how might housing affect abortions? This study looks at the effect of three housing mechanisms on abortion rates: rent to income rate, mortgage to income …


Taylor, Genealogy, History, Peter Hawes Jan 2024

Taylor, Genealogy, History, Peter Hawes

Honors Theses

In this paper I compare two different genealogies of the idea of the ‘self’: Charles Taylor’s and Michel Foucault’s. I begin by arguing that Taylor’s focus on combating what he calls “subtraction stories” places him in the genealogical tradition with Foucault. I then engage with Foucault's genealogy of the self, which illuminates how the notion of the ‘self’ was constructed as a means of control, which leads him to say we should do away with trying to understand it outside of relations of power. This call for the rejection of the self, I suggest, presents a problem for us, who …


La Perception Et La Représentation Du Corps Des Femmes Africaines Par Rapport À La Colonisation Française, Mofiyinfoluwa Tunji-Ekundayo Jan 2024

La Perception Et La Représentation Du Corps Des Femmes Africaines Par Rapport À La Colonisation Française, Mofiyinfoluwa Tunji-Ekundayo

Honors Theses

The thesis proposes an analysis of the perception that the French colonizers had towards the bodies of black women in France, women from northern Africa, and women from western Africa. Then, the work evaluates how this perception manifests in current French and francophone media. Furthermore, it traces how much influence these perceptions have on the depiction and representation of African female bodies. This influence could manifest as a reinforcement or an opposition to colonial perceptions.


The Impact Of U.S. News And World Report College Rankings On Prospective Students’ Decisions And Enrollment Outcomes, Camilla Schneider Jan 2024

The Impact Of U.S. News And World Report College Rankings On Prospective Students’ Decisions And Enrollment Outcomes, Camilla Schneider

Honors Theses

The following paper further expands on previous research using more recent data which is important given changes in the last decade. This paper will answer the question: How do U.S. News and World Report college rankings impact college application and enrollment decisions for prospective students within American public and private colleges and universities? Application decisions refer to the choice to apply to a school while enrollment decisions refer to the choice to attend a school after being accepted. This paper analyzes Integrated Postsecondary Education Data System (IPEDs) admissions/applicant, fall enrollment, and financial data alongside historical USNWR rankings lists to investigate …


Assessing Evolution Of Reproduction Traits Along Seasonal Transitions And Latitudinal Gradients In An Invasive Species Of Fruit Fly, Zaprionus Indianus, Ansleigh Gunter Jan 2024

Assessing Evolution Of Reproduction Traits Along Seasonal Transitions And Latitudinal Gradients In An Invasive Species Of Fruit Fly, Zaprionus Indianus, Ansleigh Gunter

Honors Theses

This thesis examines the reproductive traits of Zaprionus indianus, an invasive species to the United States, to assess the possibility of rapid evolution. Significant differences in fecundity and diapause incidence have been seen in other Drosophilid fly species across the seasonal transition, from early to late season, and across the latitudinal gradient, from north to south. For this reason, fecundity, the reproductive ability of a female fly, and diapause incidence, a stress-induced reproductive arrest, were selected as variables of choice. Field collections and experiments revealed unexpected patterns in fecundity and diapause incidence, challenging initial hypotheses. While no significant differences in …


Shifting Grounds: Movement And Continuity In Mustang, Nepal, Lauren Carter Jan 2024

Shifting Grounds: Movement And Continuity In Mustang, Nepal, Lauren Carter

Honors Theses

This thesis explores the socio-cultural and economic transformations in the Mustang region of Nepal. Drawing from fieldwork conducted over a month, this study examines how traditional economic activities, particularly yak herding, are being replaced by tourism and agriculture due to shifting socio-economic conditions and global influences. The concept of 'adaptive traditionality' is introduced to describe how the community in Mustang actively engages with both internal pressures and external changes to reshape their socio-cultural landscape. This adaptability is evident in the transition from nomadic pastoralism to more sedentary agricultural practices and tourism, which not only reflects a survival tactic but also …


Heterocycles As Peptide-Based Cleavable Linkers, John Blobe Jan 2024

Heterocycles As Peptide-Based Cleavable Linkers, John Blobe

Honors Theses

As cancer cases continue to rise, the need for advancing the treatment options for cancer is ever increasing. Current cancer therapeutics, while effective at treating localized cancers and a fraction of advanced cancers, generally lack the specificity needed to target more advanced cancers. Recent advancements in cancer treatments have leveraged antibodies to target certain cancers. A class of drugs that utilize antibodies to deliver anti-cancer therapy preferentially to cancer cells, termed antibody-drug conjugates (ADCs), have been quite effective in treating certain advanced forms of certain cancers. These ADCs could be more effective if they could allow for the facile release …


The Effect Of Factors And Constraints On Sporting Attendance, Joshua D. Whitlow Dec 2023

The Effect Of Factors And Constraints On Sporting Attendance, Joshua D. Whitlow

Honors Theses

21,625 fans packed the confines of Brooks stadium on September 3, 2022, for a clash between the Army Black Knights football team and the Coastal Carolina Chanticleers football team. This was a new record at Brooks stadium, and was followed with just 12,261 the next week vs. Gardner Webb. Meanwhile, a 2022 Coastal Carolina Women’s Soccer game draws in less than 200 spectators. On the surface level, the disparity of these numbers appears confusing and unconnected to one another, however there are a multitude of factors that go into the number of people who show up to a particular sporting …


Clearing The Hurdles: Examining The Development Of High-Speed Rail Systems In The United States Of America, Shanice Tan Dec 2023

Clearing The Hurdles: Examining The Development Of High-Speed Rail Systems In The United States Of America, Shanice Tan

Honors Theses

In today’s world where globalization is rapidly growing, the role of an effective transportation system is crucial for societal and economic advancement. Among the various modes of travel, high-speed rail has emerged as a transformative force, reshaping the landscape of intercity connectivity, economic progress, and environmental sustainability. You would expect that the United States, as one of the most developed countries in the world, would have huge advancements in their high-speed rail systems for better travel choices and improved mobility for their citizens. However, it is found that the United States only has two high-speed rails currently operating and two …


Investigation Of Zinc And Iron In Wildflower Honey, Savannah Simpson Dec 2023

Investigation Of Zinc And Iron In Wildflower Honey, Savannah Simpson

Honors Theses

Honey acts as a valuable food source for both animals and humans. When found in contaminated environments, there is an increased likelihood that honey samples will have high metal concentrations. It has been discovered that honey concentrations in metals can be different based on location. This experiment aims to determine the amount of two valuable metals, zinc, and iron, in various honey sources. These metals can be important to the human body because they help boost immunity and allow the body to carry out the functions required for survival. However, if these elements are present in copious quantities, then it …


College Student Attitudes Toward Student-Athlete's Ability To Profit From Name, Image, And Likeness (Nil), Daniel G. Panzano Dec 2023

College Student Attitudes Toward Student-Athlete's Ability To Profit From Name, Image, And Likeness (Nil), Daniel G. Panzano

Honors Theses

Since the recent passing of legislation allowing student-athletes to profit from their own personal brands and sponsorships (Name, Image, and Likeness; NIL), there has been very little research. The purpose of this study was to measure the attitudes and support students have towards the financial compensation of their student-athlete counterparts. The researchers surveyed 67 Coastal Carolina University students. Using a quantitative study, data was gathered pertaining to the opinions toward NIL, feelings of team affiliation, and demographic information. Statistically significant differences were found toward some elements of NIL and gender, major, and academic year. A statistically significant correlation was also …


The Religious Landscape Of Uruguay In The Third Millennium: Present Piety As A Product Of The Past?, Brandon Kriplean Dec 2023

The Religious Landscape Of Uruguay In The Third Millennium: Present Piety As A Product Of The Past?, Brandon Kriplean

Honors Theses

Of all Latin American countries, Uruguay enjoys both the lowest percentage of Catholics and the highest percentage of religiously unaffiliated. The central aim of this thesis is to explore the extent to which historical secularization processes and laicidad are responsible for the low number of Catholics and the large number of religiously unaffiliated. With regards to the former, the historical evidence suggests that the small Catholic population is not a result of laicidad but is instead a product of internal issues within the Uruguayan Catholic Church. Part 1 of this thesis will explore the factors that have weakened the Uruguayan …


Cannabis-Induced Psychotic Disorder And Schizophrenia Diagnostic Comparison, Tyanna Brodhagen Dec 2023

Cannabis-Induced Psychotic Disorder And Schizophrenia Diagnostic Comparison, Tyanna Brodhagen

Honors Theses

Recent changes in cannabis legalization will have broad societal impacts for decades to come, not the least of which are the unknown consequences to neuropsychiatric health, particularly for adolescents and young adults. Cannabis-induced psychotic disorder (CIPD) is a controversial and poorly understood neuropsychiatric condition characterized by a psychotic experience brought on by excessive cannabis intoxication and/or withdrawal. Although CIPD is currently an uncommon diagnosis, the overlapping symptomology and comorbidity with schizophrenia indicates CIPD may be underdiagnosed. Some authors suggest the under diagnosis of CIPD may be correlated to physician diagnostic practices. This honors thesis constitutes a scholarly literature review and …


Exploring The Effect Of Resilience Training On The Effectiveness Of Psychological Body Armor Among College Students, Devaney Ross Dec 2023

Exploring The Effect Of Resilience Training On The Effectiveness Of Psychological Body Armor Among College Students, Devaney Ross

Honors Theses

Using Everly’s proposal of a unique form of human resilience known as Psychological Body ArmorTM (PBA), this study aimed to investigate the effectiveness of Psychological Body Armor training in improving the resilience capacity amongst college students. In this study, data was collected from 194 (N = 108 for the 2022 Fall Semester and N = 86 for the 2023 Spring Semester) participants enrolled in a Wellness class at Andrews University. Participants were asked to complete a 20-item PBA questionnaire developed by Tan et al. (2022) to measure resilience based on two previous PBA studies (Burnett et al., 2019; Burnett et …


Honoring Neurodiversity As An Occupational Therapist, Haley Munson Dec 2023

Honoring Neurodiversity As An Occupational Therapist, Haley Munson

Honors Theses

The purpose of this study is to discover if and how current occupational therapists use neurodiversity affirming practices through their work with clients that identify as neurodivergent. Neurodiversity refers to variations in cognitive functioning that are considered normal since no two brains function the same. Occupational Therapists (OTs) frequently work with clients that identify as neurodiverse, including with individuals with diagnoses such as autism, ADHD, dyslexia, and sensory processing disorder. This study uses a qualitative approach with a semi-structured interviews to gain insight into OT’s integration of ND affirming principles into practice. Learning how OT’s implement ND affirming practices will …


Acid Attack: How Escherichia Coli Strains Resist Acid Stress, Lindsey Miller Dec 2023

Acid Attack: How Escherichia Coli Strains Resist Acid Stress, Lindsey Miller

Honors Theses

The systems used by Escherichia coli to combat heightened levels of acidity within their environment are varied and complex. Four distinct systems used by E. coli to resist acid-induced stress were identified in 2004 by Foster (1), though six now are known today. These systems include the glucose-repressed, glutamate-dependent, arginine-dependent, lysine-dependent, ornithine-dependent, and serine-dependent acid resistance systems. Each system is also known by its corresponding abbreviation, AR1-AR6. What is known about each system varies due to identification date, complexity of the pathway, and amount of research completed. Within this paper, each system will be identified and the pathway defined, combining …


Biophysical Study Of The Von Willebrand Factor Via Optical Tweezers—Investigating The Collagen Binding Force Profile To Distinguish Types Of Von Willebrand Disease, Leigh Hardin Dec 2023

Biophysical Study Of The Von Willebrand Factor Via Optical Tweezers—Investigating The Collagen Binding Force Profile To Distinguish Types Of Von Willebrand Disease, Leigh Hardin

Honors Theses

von Willebrand disease (vWD) is a genetic disorder due to quantitative or qualitative abnormalities of the von Willebrand factor (vWF). There are three main types of vWD in addition to acquired von Willebrand syndrome. Type 1 is due to a deficiency of vWF, while Type 3 is due to a complete absence of vWF. Type 2 is due to malformed factors and broken into four subtypes: 2A, 2B, 2M, and 2N. Each subtype corresponds to different abnormalities of the protein that affect its binding to other proteins such as collagen, Factor VIII, platelets, etc. Therefore, determining a patient’s type and …


Privacy Within Autonomous Vehicle Cameras, Joshua Montgomery Dec 2023

Privacy Within Autonomous Vehicle Cameras, Joshua Montgomery

Honors Theses

In recent years, cameras have become ubiquitous in daily life, constantly surveilling, and taking in information. This leads to a potential security risk of the invasion in one’s privacy without their knowledge or any ability to prevent the privacy threat. While cameras alone are an issue, they are often only in locations where a user has some expectation of a loss of privacy, such as public locations with security systems. However, systems that rely on cameras to operate correctly, including autonomous vehicles, are becoming a more prominently used technology while often appearing in places where an average person has some …