Digital Commons Network^™

Sport-Related Head Injury And Performance Anxiety, Haley V. Popp

Honors Theses

Head injury in sport is a highly individualized experience; the symptoms and persistence tend to differ widely between athletes. Neurocognitive deficits in head injury may be worsened by the emotional reaction of the athlete to the injury. Athletes that are removed from play due to musculoskeletal injuries tend to be anxious about becoming reinjured are more likely to be depressed and may have low attention and reaction time. Emotions that result from removal from play can have emotional, psychosocial, and career implications for the athletes. Despite this, there is a lack of literature directly examining the impact of head injury …

The Uptake And Incorporation Of Exogenous Fatty Acids Confer Phenotypic Advantages To Acinetobacter Baumannii, Saba A. Munir

Honors Theses

AIM: Acinetobacter baumannii is a ubiquitous gram-negative bacterium found on a variety of surfaces that include skin, hair, and soil. Some gram-negative bacteria like A. baumannii have the ability to acquire and incorporate fatty acids into their phospholipid membranes. Known as ‘Iraqibacter,’ A. baumannii has emerged as a significant cause of nosocomial infections in the United States and abroad. This study was designed to determine whether structural alterations occur in A. baumannii upon exposure to a wide range of polyunsaturated fatty acids (PUFAs) as well as the significance of this phenomenon in terms of survival and resistance to stress. Thin …

Family Planning, Pregnancy, And Birth In Guatemala: Maya Women And Modern Healthcare, Kelsay Payton

Honors Theses

Within Maya populations in rural Guatemala, childbearing is considered a sacred and spiritual experience, in addition to a physical one. This country is home to some of the highest rates of maternal and infant mortality in Latin America, along with the largest disparities in health care, primarily between the indigenous Maya and ladino women (Schooley 2009). The use of biomedical reproductive services remains surprisingly low among the Maya, while it is continually rising in the ladino populations. To increase the overall reproductive health care in these indigenous communities, attention must be given to the understanding of Maya’s beliefs, therefore enabling …

Access To Healthcare: Understanding Disparities Among Lgbt & Black Communities, Taylor Jones

Honors Theses

This paper aims to explain and improve the disparities that intersect the Black and LGBT communities of Berrien County as it relates to access to healthcare, specifically those at risk for HIV. This paper identifies the various resources used to highlight these including the Kalamazoo Community AIDS Resource Education Services (CARES). There are many factors that put these populations at risk. The LGBT and Black communities are at risk due to factors such as STIs, multiple sex partners, unprotected sex, use of drugs during sex, low socioeconomic status, inadequate data on race, ethnicity, and language lowers the likelihood of effective …

The Insights Of Hannah Arendt And Virtue Ethics On Education, Benjamin Bellinger

Honors Theses

This paper attempts to find the purpose of education and resolve if critical thinking can be taught in education. To answer this question the paper uses Hannah Arendt’s seminal piece The Human Condition, her political essays Between Past and Future, and her journalistic controversy Eichmann in Jerusalem to formulate Arendt’s view on education. Julia Annas’ book Intelligent Virtue gives this work a framework for how one learns a virtue. Alasdair MacIntyre’s After Virtue provides the theory for how one grounds the virtues by continuing a version of Aristolean virtue ethics. While this work does not directly use Nicomachean …

Gay Marriage Laws In Europe Compared To The United States, Megan Stamm

Honors Theses

The issue of same-sex marriage has been the hot social issue of the decade, even of the generation. This social issue has been debated to and fro in countries around the world. Each country has differing policies towards same-sex marriage. Certain countries in the Middle East hold same-sex relationships as crimes punishable by death. Some countries in Europe hold same-sex marriage as completely equal to heterosexual marriage. Each country is different. Each country is made up of different cultures and this plays a huge role in the debate. This thesis will compare and contrast European countries with the United States …

Influence Of Road Salt Deicers On Anaerobic Respiration And Metal Speciation In Soils, Danielle Dupuis

Honors Theses

Road salt deicers, especially NaCl and CaCl₂, are used throughout the world on paved areas during the winter. Previous studies suggest that road salt deicers can alter the biogeochemistry of sediment located near roadways and influence the mobility of heavy metals. The goal of this study is to investigate the influence of CaCl₂ on wetland soil biogeochemistry, especially trace metal speciation. Sediment cores were collected in the fall from a freshwater wetland near an urban kettle lake (Asylum Lake, Kalamazoo, MI) and incubated for 100 days in deionized water (control), 5 g/L of CaCl₂, or …

The Effects Of Adderall On Maternal And Fetal Health, Alyson Brady

Honors Theses

Information available for woman prescribed Adderall to treat ADHD and the effects that it may have on her fetus is limited. However, Adderall and methamphetamine have similar pharmacological and addictive qualities. This paper is concerned with whether there is an adequate approach to treatment that balances the needs of the mother and the fetus. With Adderall use becoming more prevalent, it is essential that society is aware of the physiology and pharmacology of this drug, as well as, the need for more research on this subject to be produced.

An Analysis Of Free-Will, Matthew Campbell

Honors Theses

The following paper is a broad analysis of the concept of free-will. Free-will can be defined as having the ability to act outside of necessity, such that one can be the ultimate author and initiator of their actions and decisions. Stated differently, possessing free-will allows an individual to be held accountable for their behaviors, because those behaviors are the result of something controllable within the individual, rather than something external to the individual and beyond their control.

A belief in free-will is widely assumed, for we hold individuals both legally and morally accountable for their actions. Nevertheless, it remains a …

Habitat Suitability Study Of Parcel In Gourdneck State Game Area For Downy Woodpeckers, Emma Fojtik

Honors Theses

This study examines the habitat suitability for Downy woodpecker for a parcel of land in Gourdneck State Game Area, Portage, Michigan. Land within the State Game Area has undergone habitat restoration from forest and shrub to savanna and prairie, intentionally excluding two parcels directly north of the restoration. This study took place on one of the excluded parcels. Using the Habitat Suitability Index Model produced by the Fish and Wildlife Service, basal area and number of snags within the study site were measured to determine suitability of the study site for Downy woodpeckers. Ten-1/10th acre sample plots were randomly chosen …

Cyclin-Dependent Kinase 5 Mediates Metastatic Melanoma Cell Invasion Into A Brain Micro-Environment, Nicholas C. Borkey

Honors Theses

While survival rates for localized melanoma are above 98%, metastatic melanoma proves to be an extraordinarily dreadful disease because of its notoriously poor prognosis resulting in less than 15% survival within 5 years. This is due to the fact that the disease is highly resistant to standard cancer therapies. With approximately 40% of melanoma patients progressing to brain metastasis, a greater understanding of the pathways mediating melanoma cell invasion into the brain must be achieved. In this study, a potentially key target often deregulated in melanoma and other cancers, Cyclin- Dependent Kinase 5 (CDK5), will be interrogated for its implications …

Exploration Of Protein-Protein Interactions Involving Deinococcus Radiodurans Pria, Dnab And Ssb, Christopher S. Morrow

Honors Theses

Deinococcus radiodurans is a species of bacteria that has sparked a lot of interest since its discovery due to its incredible resistance to ionizing radiation. When exposed to ionizing radiation the genome of D. radiodurans will sustain over one hundred double stranded breaks. D. radiodurans demonstrates the ability to repair its genome and restart replication after sustaining, typically lethal, DNA damage. This project examined the mechanism of replication restart in D. radiodurans by investigating primosome protein PriA interacting with replicative helicase DnaB and single stranded binding protein. Many different types of gel electrophoresis were employed to investigate potential protein complex …

Investigation Of The Genetic Interactions Between Hippo Signaling Pathway And Drosophila C-Terminal Src Kinase (Dcsk), Hailey Jimin Kwon

Honors Theses

The focus of my research revolved around the intersection between the Hippo tumor suppressor pathway and the Src oncogenic pathway. Both pathways control tissue and organ size during development by regulating cell proliferation, cell death, cell migration, and cell adhesion. Aberrant functions in either pathway are often detected in human cancers and correlate with poor prognosis. The Drosophila C-terminal Src kinase (dCsk) is a genetic modifier of warts (wts), a tumor-suppressor gene in the Hippo pathway, and interacts with the Src oncogene. Reduction in dCsk expression and the consequent activation of Src are reported in hepatocellular and colorectal tumors. …

Coding Dna Into Music: An Alternate Way Of Analysis, Samuel Fesenmeier

Honors Theses

In the study, we are analyzing the human genome in order to determine patterns that may tell something about how DNA functions. Patterns require an explanation: it is highly improbable that they are random occurrence. These patterns may hint to something about how DNA functions. There are known patterns already discovered in DNA. For example, in the coding portion, three base pairs translate to a specific amino acid. In the non coding portion, however, specific patterns are not as simple.

We will search for patterns by applying a coding system that turns DNA into music. Music may serve as a …

Chitinozoan Biodiversity In The Ordovician Of Gondwana: An Interval-Free Approach Using The Quantitative Stratigraphic Correlation Program Conop9, Rachel Sales

Honors Theses

The purpose of this study is to examine the biodiversity patterns of a group of fossil organisms called chitinozoans. Chitinozoans are organic-walled, planktonic microfossils that first appear in the Early Ordovician Period (488 million years ago) and diversify rapidly through the Paleozoic Era. The Ordovician Period was a time of great global climate change, and by studying this group of fossil plankton, we hope to better understand how modern plankton, which are the base of the marine food chain, might respond to climate change. We used a method called constrained optimization (CONOP9) to construct a composite range chart of 152 …

Genre Controversy: Human Universality Or Plagiarism In The Dystopian Genre?, Taylor V. Kingston

Honors Theses

In a fusion of behavioral psychology, evolutionary psychology, and literary analysis, this thesis considers the possibility that human nature dictates the types of rhetoric utilized in any given genre. Operant conditioning emerged as the governing device in a case study of the dystopian genre since readers must be made to associate fear or hope with particular government structures. Implicitly then, literature is molded into its genres by the human desires addressed by that genre’s reigning themes. This “mold” seems to have created a strain of novels within the dystopian genre that are so similar there have been accusations of plagiarism. …

Removing Aflatoxin M1 From Milk Using Activated Carbon And Its Effects On Protein Concentration, Kaylin Chaney

Honors Theses

No abstract provided.

Kinetic Characterization Of B-Carotene In N-Hexane At Various Oxygen Concentrations, Katelyn Mary Arnold

Honors Theses

We have characterized the photo – degradation of ẞC in oxygenated and deoxygenated n–hexane solvent and in the solid phase using broadband (BB; λ ≥ 200 nm) and 313 nm filtered output of a 100 W Hg Arc lamp. Oxygen concentrations of 0, 10, 20, and 100% were used in the solution phase studies. ẞC(s) did not photo – degrade upon exposure to BB light under air atmospheres; the mass and appearance of the samples, TLC chromatograms, and the absorption spectra were all identical pre- and post-irradiation. In the solution phase, the order of the photo – degradation with respect …

Suspension Electrospinning Carbon Nanotube Doped Poly (Vinyl Alcohol) Nanowires, Ryan Hensleigh

Honors Theses

The synthesis, characterization and application of carbon nanotubes (CNTs) have received substantial attention in recent years, particularly in the field of polymer nanomaterial composites (PNCs). CNTs possess impressive thermal, electrical and mechanical properties, and PNCs incorporating them have shown multitude increases in these same properties with relatively low percolation thresholds [1]. Electrospinning is an effective and tunable materials synthesis platform for the manufacture of micro and nanofibers that has shown particular promise in the fields of carbon nanotube PNC processing due to the favorable isotropic alignment CNTs undergo due to the electrospinning process [2]. CNT alignment has been shown to …

The Effect Of Exercise Training On Skeletal Muscle Gdnf Content And Neuromuscular Physiology In A Mouse Model Of Amyotrophic Lateral Sclerosis., Nicole Carpp

Honors Theses

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease accompanied by the loss of motor neurons, leading to paralysis and death. Glial cell line-derived neurotrophic factor (GDNF) promotes neuron health and function and has been proposed as a therapeutic treatment for ALS. GDNF protein expression in skeletal muscle is regulated by physical activity. The aim of this study was to determine if low intensity exercise would increase GDNF expression in skeletal muscle and slow degeneration of motor neurons in a mouse model of ALS. Following the first sign of disease onset, transgenic ALS mice were randomly assigned to one of three …

Horses: How Saddle Style Defines A Culture And The Skeletal System, Brandy Morgan

Honors Theses

This paper examines the way in which various parameters affect injury type and prevalence in horse eventing. The human-horse relationship has a long history that has continued to evolve, and their relationship is still strong today, especially in the role of sports and entertainment. In equestrian sports, horseback riding has been found to be extremely dangerous in terms of prevalence and severity of injury. This paper evaluates how saddle style, the sex of the rider, rider experience, and nature of event impacts injury patterns specifically within horse eventing which utilizes an English styled saddle.

Horses: How Saddle Style Defines A Culture And The Skeletal System, Elizabeth Brandon

Honors Theses

Throughout history different cultures have been greatly impacted by horses and their uses. Today horseback riding is still a very popular sport, and though it is more dangerous than other forms of transportation, such as motorcycle riding, horseback riding is still used in entertainment, occupational, and leisure activities. Saddles have long been an important piece of equipment for riding. As the horse became a mode of transportation, many cultures had their own saddle style, but today there are two prominent saddle styles, the western and english styles. The western saddle style is used more for leisure, occupational, and rodeo riding. …

Investigations On The Involvement Of Dopamine In The Gustatory Responses Of The Fruit Fly, Drosophila Melanogaster, Emily Anne Ousterhout

Honors Theses

No abstract provided.

Isolation Of Microbial Nrps And Pks Gene Clusters For Natural Product Isolation, Danielle N. O'Hara

Honors Theses

Greater than 99% of microbes living in the environment are uncultivable due to their complex nutrient and temperature requirements for growth. These microorganisms present a potential source of natural products that could be developed for biotechnological and pharmaceutical uses. Microorganisms with phosphopantetheinyl transferase (PPTase) activity are of high interest due to the role PPTase plays in activating non-ribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) gene clusters. These gene clusters produce multi-enzymatic, multi-domain megasynthases that produce complex natural products utilized by the host organism for selective advantages. This study isolated genomic DNA from soil samples collected from the University of …

An Investigation Of Bag3 Knockdown And Its Effects On The Cytotoxicity Of Laromustine, Colin Sheehan

Honors Theses

Laromustine is a sulfonylhydrazine anticancer prodrug whose main cytotoxic arises from its ability to interfere with DNA replication of dividing cells. Multiple studies have suggested that Laromustine induces a form of cell death known as apoptosis. In a previous study investigating the mechanism of apoptosis, bcl2-associated athanogene 3 (BAG3) demonstrated significant upregulation in the presence of Laromustine. Given its anticancer ability, we selected BAG3 as a target for further investigation. BAG3 knockdown through transient shRNA transfections was performed in U138 glioblastoma multiforme cells and verified using qRT-PCR analysis. Finally, cell death assays were used to assess Laromustine’s cytotoxic effect on …

Acl Injuries In Female Athletes: Are Prevention Programs The Answer?, Brooke Chandor

Honors Theses

Around 400,000 people tear their anterior cruciate ligaments (ACLs) every year in the United States. The majority of these injuries occur during athletics, and most commonly to females. Their neuromuscular abilities, anatomies, and hormones put female athletes at a much higher risk of ACL injury than male athletes. The current gold standard of treatment, ACL reconstruction, is an imperfect technique at best. It leaves patients with much higher risk of both ACL reinjury and early onset of osteoarthritis. Prevention programs, aimed at reducing the neuromuscular risk factors in female athletes, have proved to effectively reduce the number of noncontact ACL …

School Gardens: Cultivating A Child’S Nutritional Habits, Environmental Knowledge, And Sustainability Practices, Jeffrey Meltzer

Honors Theses

School gardens have existed since the late nineteenth century and today are becoming increasingly popular in many parts of the world, including where I studied in Maine and Australia (AUS). Multiple organizations support school gardens in Maine, including the Maine School Garden Network, which has over 125 registered school gardens. In AUS, the Stephanie Alexander Kitchen Garden Foundation primarily supports the school garden movement and has over 800 registered school gardens. While many researchers have studied school gardens, few have compared two countries, focused on environmental sustainability, or investigated Maine in particular. This thesis combines information from literature reviews, and …

Mathematical Modeling Of Emiliania Huxleyi And A Host-Specific Virus, Julia Middleton

Honors Theses

The world’s oceans provide the basis for life on the planet. One microscopic algae, the coccolithophores, and Emiliania huxleyi in particular, is a major source of carbon drawdown in the context of the global carbon cycle and account for a significant amount of the primary production in oceanic ecosystems. We know that the oceans are packed with marine viruses and they have an important role in the rise and fall of plankton populations but current mathematical models do not accurately account for virus-host interactions when predicting plankton blooms. Therefore I am using model optimization and comparison techniques to evaluate current …

The Growing Crisis In Maine: Neonatal Abstinence Syndrome, Olivia Avidan

Honors Theses

Neonatal Abstinence Syndrome (NAS) is a Maine epidemic. In addition to having medical repercussions, NAS is intrinsically linked to social, political and economic factors. NAS is a conglomeration of symptoms, short-term and long-term, that affect a child that has been exposed to opioids in utero. These factors that impact NAS are interdependent. The past decade is characterized by a dramatic rise in NAS cases in Maine. This paper explores the social, political and economic landscape surrounding NAS in an effort to describe fully the syndrome’s effect on both individuals and the community as a whole.

A Constellation Of Caring: The Dynamic And Fluctuating Nature Of Pediatric Cancer Care, Anne Friedrich

Honors Theses

This honors thesis explores the fluctuating and dynamic nature of pediatric cancer care. I discuss the ways in which pediatric medical providers make meaningful interactions both for themselves and for their patients by enacting a caring liminality that allows them to fight disease while also creating a more personal, relational, and social moment of care. Providers care and work in shifting landscapes of care, what I call carescapes. The carescapes of the built environment, of value, and of physical movement all make the provider’s liminality visible. Ultimately, I argue that care is a way of being in the world, …