Digital Commons Network^™

Synthesis Of Novel Temozolomide Amides As Potential Anti-Glioblastoma Agents, Sion Kim

Honors Theses

Glioblastoma is treated with Temozolomide (TMZ), a lipophilic alkylating drug that can cross the brain-blood barrier. To confront drug resistance, this research aimed to synthesize novel TMZ amide hybrids by using the acid chloride method, replacing an amino group with a primary amine. These novel hybrids were tested on U87-MG cells to determine if the primary amines with greater anticancer properties and lipophilicity have enhanced the drug's anticancer activity and bioavailability. The calculated lethal concentration 50 (LC50) of the hybrids ranged from 0.005 mg/mL to 0.2258 mg/mL, with some demonstrating greater anticancer effects than TMZ itself.

An Ethnography Of Permaculture In Southwest Michigan, Lily Burke

Honors Theses

Permaculture is a holistic design system for meeting human and environmental needs in a sustainable way, using local conditions and circumstances to shape land use and food production practices. My project questions what it means to practice permaculture in southwest Michigan, and how environmental ideological commitments can translate into action and practice. Ethnographically investigating these questions through semi-structured interviews and participant observation with individuals in the permaculture community, along with extensive reading of permaculture materials, my study adds to research on applications and adoptions of permaculture in suburban contexts, and sheds light on how ecological ideological commitments can translate into …

Bone Marrow Donor Recruitment Drive And Registry, Elizabeth R. Dovich

Honors Theses

Bone marrow transplants are vital for those with blood cancers and disorders, but not every ethnic group has an equal chance of finding a match. Some of the human leukocyte antigen (HLA) cell markers used to match donors and recipients are unique to certain ethnic groups, making it harder for members of those groups to find a match. This project worked to address this inequality by organizing a bone marrow registry recruitment drive on the campus of Andrews University in partnership with the NMDP registry. It encompassed the planning, promotion, and execution of the drive which took place March 5-7, …

Musical Figures In Mythology And Their Effect On Ancient Greek And Roman Culture, Nathaniel Weeldreyer

Honors Theses

This thesis combines anthropology and music to approach the topic of how ancient society was affected by mythological stories focusing on musical heroes and the role of music in general. The essay begins with providing introductions to important divine figures such as the Muses, Apollo and others. These figures appear throughout the research and analysis further in the thesis, and it is important to understand their relation between each other and to the world as a whole before going any further. The prevalence of festivals and contests is another point discussed as they provided much more than just entertainment to …

The French Divorcee And Her Evolution, Mackenzie Bialzik

Honors Theses

This thesis serves to explore the greater questions concerning patterns of divorce in France and how women, through divorce, experienced greater liberties within the law. The evidence used in this paper stems mainly from demographic data, opinion pieces on divorce, and legal journals. While I had hoped to access specific divorce hearings, privacy laws in France and the language barrier prevented me from this type of research. Through my research I have found that divorce did not follow typical trends in feminist movements as expected in France. Instead, divorce was reactionary of the social perceptions of marriage and gender. Additionally, …

Sipping Success: A Complete Digital Marketing And Customer Journey Makeover For Local Business Mi Boba Using Principles Of Change Management, In-Store Experience Enhancements, And Website Redesign., Joanna Holecko

Honors Theses

Sipping Success captures the journey of customer experience and marketing strategies for a small, woman-owned business in Kalamazoo, Michigan: Mi Boba. Beginning with an in-depth analysis of existing in-store experience using reviews and interviews, this thesis uses insights to guide the creation of a customer service blueprint catered to creating the perfect Mi Boba interaction. From that blueprint, new signage and menus were created to improve the customer experience. Next, the website was completely redesigned to address issues of navigation, visual representation of products, and search engine optimization (SEO). These enhancements improved user experience, resulting in significant increases in website …

Happy Horn Business Plan, Joseph Schwarz

Honors Theses

As a current Starting Gate member and entrepreneurship major at WMU, I am always surrounded by business ideas and the thought of building and growing my own business. This is the main reason I have made a business plan for my business idea, the Happy Horn.

The Happy Horn is an add on horn attachment for every type of bike, E-bike, and E-scooter. This horn quickly and easily attaches to the handle bars and features 4 buttons. The first button being a normal horn sound. However, the other three buttons are linked to different tones. These tones are selected and …

Energy-Absorbing Helmet For Safer Football, Aidan Laudeman

Honors Theses

Football-related injuries are a common occurrence and are often detrimental to the player’s health. Force impacts frequently occur at the front, back, and sides of a player’s helmet, resulting in head injuries like concussions. The goal of this project is to reduce recurrent head injuries by designing a solution involving the use of energy-absorbing metallic materials that are inserted into a football helmet. These energy-absorbing materials are configured in target zones inside the helmet to reduce the acceleration of the head based on impact locations. The chosen materials are nitinol and spring steel, which display energy-absorbing properties. Various energy-absorbing material …

Production Of Mrna Vaccine For Influenza, Christina Miller

Honors Theses

The objective of this project is to design a process to produce an mRNA influenza vaccine that serves as an alternative to conventional influenza vaccines, replacing current options with innovative mRNA technologies. Given that older populations are most likely to follow up on immunizations consistently, and the increasing average age worldwide, the market for this project appears to be expanding in the next 80 years. Additionally, experts predict more frequent mutations and outbreaks of viral disease from a variety of factors including globalization and global temperature trends. Rapid response to these viral outbreaks will continue to be as, or even …

How Does Childhood Exposure To Toys And Video Games Relate To Young Adult’S View On Gun Control?, Shelby Wilmot

Honors Theses

The present study investigated the factors influencing support for gun control and attitudes toward gun control restrictions on individuals, specifically violent video games and toys. From the 119 total responses collected, 78 (65.5%) of the participants identified as female, 34 (28.6%) of the participants identified as male, and 7 (5.9%) of the participants identified as nonbinary. Regression analyses were conducted to examine the relationships between various independent variables and the dependent variables representing these attitudes. For the dependent variable measuring support for gun control, the model summary revealed a moderate correlation

(r = .610), with approximately 37.2% of the variability …

The Dark Triad, Creativity And Morality, Erin Beers

Honors Theses

The Dark Triad of personality is the combination of narcissism, Machiavellianism, and psychopathy. The associative theory of creativity involves the default mode network of the brain, which is responsible for memory tasks, imagination, and thoughts of self. Since the Dark Triad traits involve inhibitory control and imagination, there is a high likelihood that observed alterations in these processes may be used to predict dark creativity patterns. Malevolent creativity involves using new ideas to complete tasks that will harm others. With creativity not being limited to positive outcomes, aspects of morality are also part of the creative decision-making processes. Morality is …

Evaluation Of Seizure Recognition And First Aid Training Course And Improving Self-Efficacy Related To Medical Emergencies In Mississippi, Anna Katherine Herrington, Collin Earl Wayne Crawson, Daniel Robert Zuckerman

Honors Theses

Within recent years, there has been increased attention to the growing physician shortage across the United States. This shortage has placed substantial strain upon regions of lower healthcare access, particularly those of rural regions such as much of the state of Mississippi. As rural healthcare providers are placed under more strenuous conditions, they encounter issues of increased patient volume, lack of a trauma team, or adequate transportation to higher-level care facilities. These issues may exacerbate the present inequities in cost of living, access to adequate healthcare, and the distress caused by these concerns. Individuals with epilepsy are one cohort with …

Examining Confidence In Scientific Literacy Amongst General Biology And General Chemistry Students, Amy Sullivan

Honors Theses

Scientific literacy is a term used to describe a person’s ability to understand scientific concepts, read and write those concepts, and link those concepts to situations outside of the classroom in order to make informed decisions in their daily lives. This research paper details a study observing how scientific literacy confidence varies among general biology and chemistry students at the University of Mississippi. The goal of this research is to determine if students in general biology and chemistry classes will have similar self-reported confidence in their science literacy. This research took place at the University of Mississippi amongst Biology 160/161 …

Impact Of Snap On Food Insecurity: A Michigan And Indiana Case Study, Cecelia Chapleau

Honors Theses

Food insecurity is one of the most pervasive and concerning problems in the United States. Approximately 1 in every 13 households within the United States was food insecure at some point during 2022 (Rabbitt et al., 2023) Food insecurity occurs when households have a limited ability to access nutritious foods, there is a limited supply of safe, healthy foods, or they are unable to obtain food in socially acceptable ways (Anderson, 1990). Low food security is associated with adverse health outcomes like type 2 diabetes, cardiovascular disease, and poor mental health, which contributes to the severity of the problem (Thomas …

Princess Proportions & Perceptions: Disney’S Deterioration Of Young Girls’ Self-Esteem, Marah Krick

Honors Theses

Animated children’s media is becoming increasingly thinner, particularly as society demands continually smaller waists in the ideal female body size. The present study is focused on analyzing the origin and effects of abnormally small waist-to-hip ratios in animated Disney Princesses on a younger, primarily female audience. Exposure to these unrealistic body standards may result in internalization that leads to body dissatisfaction, as well as a drive for impossible thinness that results in disordered eating, mental health concerns, and suicide ideation. Adolescents and preadolescents are particularly at risk, due to daily entertainment screen time nearly tripling since 1999. While the risks …

Resilience Building In Appalachian College Students: The Intersection Of Motivation And Identity, Ashton B. Burchfield

Honors Theses

Appalachian students are underrepresented in existing literature regarding higher education. Central Appalachia also has some of the lowest median household incomes and college attrition rates in the country. Appalachian culture is unique with its collectivistic culture which prioritizes familial bonds. This has previously been found to have an academic impact for Appalachian students. For this study, Appalachian college students at Eastern Kentucky University were recruited to investigate if social versus personal identity had an impact on academic achievement as measured by grade-point average. Resilience levels were also measured to investigate an effect from resilience of students on personal versus social …

The Effects Of A Mindfulness Intervention On Ameliorating Premenstrual Hedonic Eating Patterns In College-Aged Females, Nicole R. Palmieri

Honors Theses

Background: Young women in college are susceptible to weight gain from a myriad of factors to include environmental and hormonal influences.

Objective: The aim of this study was to determine the impact of a mindfulness intervention on food craving behaviors in women in the luteal and follicular phases of the menstrual cycle.

Methods: This was a quasi-experimental study using repeated samples one-way ANOVA and qualitative data to examine pre-intervention and post-intervention changes in cravings and mindfulness.

Results: 23 participants completed the intervention and study-related requirements pre-intervention and post-intervention. There was a trend of mean decrease in FCQ-T scores (124.83 ± …

Exploration Of Cytotoxicity Of _Rabidosa Rabida_ Venom On Invertebrate And Vertebrate Cell Cultures, Martina Gooden

Honors Theses

Venom has been observed in thousands of species across different taxa. It can be adapted for different purposes, including prey capture or predator defense. Venom is found almost universally in spiders, but there has been little exploration of spiders that are not medically significant. Rabidosa rabida, the rabid wolf spider, is a common species whose venom has not been adequately investigated. Previous studies indicate that they do not require venom to apprehend easy prey in a laboratory setting, raising a question as to what their venom is adapted to do. To evaluate its effect on mammalian cells, L929 murine fibroblasts …

Exploring Narrative Strengths In Animated Storytelling, Amelia Kretzer

Honors Theses

This thesis explores tactics for effective narrative development for animation through the analyses of key works of strong animated films synthesized with literature discussing narrative frameworks. This research resulted in a shortlist of animated storytelling best practices—six principles to reflect on in the creation of effective stories for animation. Additionally, an original 2D animated short film was created utilizing the principles on the shortlist in its development as an outpouring of this research.

The Diverse Musical Traditions Of Appalachian Folk Music, Brooks M. Kidd

Honors Theses

Appalachian folk music has a rich heritage, although society has the misconception that Appalachian music is uncultured and closed off. To the contrary, the folk music of Appalachia has been directly linked to the music traditions of Ireland, Scotland, England, Africa, Germany, Spain, and Italy. The migration of people from other countries to Appalachia has been attributed to significant historical events such as the signing of the Treaty of Paris and the African Slave Trade. These migrants brought with them their musical traditions, which influenced the music of people living in the Appalachian region. These musical influences come in different …

The Ultimate How-To Guide: Addressing Sustainability In Fashion, Corinne R. Campbell

Honors Theses

Every year, the pollution in our world increases but few people have addressed this issue. Between the culture of consumerism, little to no recycling, and lack of education, it can feel difficult as a regular person to make a difference. However, it is not impossible. As the consumer, the general public has the ability to enact change. While sustainability in the fashion industry may seem unattainable, making progressive changes in the manufacturing and buying process of clothing will make fashion more eco-friendly over time. With the proper education and guidance, anyone can make more sustainable fashion choices without going outside …

The Core Collapse Of The Rising Sun, Elisabeth J. Craft

Honors Theses

There are many different types of literature in the world so it is no surprise that some gets overlooked in the sheer volume. This is more so seen in Western literature overpowering Eastern literature’s importance. One such place overlooked is Japan. There is plenty to unpack in Japanese literature, but one such area is the changes it has due to cultural events. Using well known events can make Japanese literature more accessible for other audiences. One of these events is WWII because of Japan’s incredibly active role in it. WWII changed Japanese literature from Romanticism and Naturalism to a more …

The Influence Of Race: College Students’ Sense Of Belonging At Their Predominantly White University, Jaelyn Barker

Honors Theses

Racism, underrepresentation, and anti-Diversity, Equity, and Inclusivity (DEI) movements are current, ongoing battles on college campuses across the nation, specifically at predominantly white institutions (PWIs) and universities. This study will examine the influence of race and other relevant factors on undergraduate students’ sense of belonging on their college campuses by understanding how students define and use race to shape and change their lives. The researcher created and distributed an original survey to undergraduate students at Eastern Kentucky University (EKU), collecting a total of 466 responses. The study found that race, divided by white and nonwhite categorizations, did not have a …

Play Like A Girl! A Then And Now Comparative Analysis Of Title Ix In Collegiate Athletics: An Oral History Collection, Gretta Gunn

Honors Theses

Title IX in collegiate athletics aims to provide female athletes with the same opportunities as their male counterparts, through equal resources, financial scholarships, viewership, etc by prohibiting discrimination on the basis of gender. This is accomplished through certain compliance standards and a Three Prong Test. However, the results of a literature review show that Black female athletes, female coaches and administrators, and male athletes whose sport has been cut still don’t receive fully equal opportunities. Through the creation of an oral history project with the William Berge Center and Special Archives at Eastern Kentucky University, personal stories and experiences related …

Death And Drugs: Exploring Grief And Addiction Among College Students, Alexis B. Kelly

Honors Theses

Grief and addiction are typically associated with death and drugs. However, there are many types of non-death losses and behavioral addictions that are overlooked in research and daily living. The experiences of grief and addiction affect everyone, often at many points in their lifetime. College students are at particular risk for these factors, as many changes are occurring in their environment during these years. This research aims to explore the impact and relationship of grief and addiction on college students. The main hypothesis is that grief and addiction are positively correlated with one another. To study this, a survey was …

What Are The Barriers? An Examination Of College Students' Perspectives On Mental Health Care Utilization, Isabella Robbins

Honors Theses

This study delves into the perceptions and experiences of college students regarding the utilization of mental health services at a university in the central Appalachian region of the United States. Focusing on understanding barriers to help-seeking, perceived stressors, and preferences for mental health resources, the research aims to inform strategies for enhancing mental health support on campus. A total of 91 undergraduate students completed an electronic survey at Eastern Kentucky University, providing insights into their attitudes towards seeking professional help, perceived stressors, and factors influencing help-seeking behavior. Contrary to expectations, demographic factors showed no significant correlation with willingness to seek …

In Search Of Empire's Monsters: Horror And American Imperialism, 1890-1910, Cj Seals

Honors Theses

Horror is a commonly recognized concept that is closely associated with notions of fear and disturbance. However, horror can also serve as a valuable historical tool to learn about the people of the past through what they feared most. As such, this project adopts this historical approach to horror in investigating an often overlooked period of American history: American imperialism in the late nineteenth century to the early twentieth century. Namely, this project examines the connection between horror and American imperialism to understand how horror shaped and informed imperialism. Performing this examination through the analysis of historical sources that employed …

Recent Snap Participation In Farmers Markets: Market Representatives’ Perspectives, Laura Fincher

Honors Theses

As the 2023 farmers market season is the first in three years without Supplemental Nutrition Assistance Program (SNAP) Emergency Allotments, SNAP participation in farmers markets is likely to decrease, which could have negative impacts for farmers market earnings and community relations. The purpose of this study was to examine farmers market SNAP participation and the impacts of the expiration of SNAP Emergency Allotments from the perspective of market representatives. Farmers market representatives from Central Arkansas and East Texas were interviewed in field testing, then representatives from North Texas were interviewed in target data collection. Observations of farmers market sites and …

Navigating Social Commerce: Analyzing The Economic Impact And Practical Strategies For Small E-Commerce Ventures Utilizing Social Networks For Sales And Brand Loyalty, Zachary Redmon

Honors Theses

No abstract provided.

Personality Linked To Tv Genres, Kinsey P. Skinner

Honors Theses

The goal of this study was to consider the relationship between people’s personalities and their television preferences. One model for this study was the work of Samuel Gosling from UT- Austin. Gosling has explored connections to personality from the mundane, such as music. To do this research in relation to television, students at Texas A&M University-Commerce completed the Big Five personality inventory as well as rating their interest in different genres of television, reporting on their favorite shows, and providing basic demographic variables. From this, correlations were found between certain personality traits and what television shows they are associated with. …