Digital Commons Network^™

In-Vitro Assessment Of Cb1/Cb2 Receptor Binding And Function, Joey M. Davis

Honors Theses

Cannabinoid receptors CB1 and CB2 are G protein-coupled receptors that have a variety of physiological effects on the human body. Many natural product agonists and antagonists are presumed to interact with the cannabinoid receptors and are therefore heavily studied in drug discovery. Assays are used to study the binding of compounds to these receptors. However, a limited number of these assays are efficient in determining the functional activity of ligands associated with CB1 and CB2. Of those, many use radioactivity which is both expensive and potentially dangerous to the researcher. In this study, we first validated the assays already found …

An Outside Gaze On The Relationship Between Indigenous Groups And The Media, Nicole Daoust

Honors Theses

Indigenous groups around the world faced similar challenges. Many of these issues stem from stereotypes, one-sided stories, and overall lack of representation in the media. Without a voice or ally, they are often treated as second class citizens. For my research, I analyzed how the media affected public perception of indigenous people. I specifically focus on four groups: The Aboriginals of Canada, the Māori, Native Americans, and the uncontacted tribes of the Amazon.

Smoke And Mirrors: Policy Solutions For Deterring Adolescent Use Of Nicotine Electronic Cigarettes, Austin Davis Fiala

Honors Theses

In recent years, there has been a dramatic spike in the number of adolescents that regularly use nicotine electronic cigarettes. As recently as 2019, a large outbreak of e- cigarette, or vaping, product use-associated lung injuries was observed in adolescents, leading many to question the safety of these devices, particularly when use by adolescents. By way of a literature review, this thesis will examine the history of nicotine and electronic cigarettes in the United States, as well as existing data on the nature of nicotine electronic cigarettes and the ways in which they are marketed.

From these findings, it is …

Parks And People: Connection To Nature And Wellbeing Among U.S. National Park Seasonal Workers, Maureen Maher

Honors Theses

In the midst of our evolving world, cultivating positive and reciprocal relations between humans and the natural world is essential for our wellbeing and our future. This study on national park seasonal workers (n = 203) was designed using mixed methods to further our understanding of the overlapping relationships humans and communities share with nature and the effects these have with our overall wellbeing. We hypothesized that nature contact, nature connection, sense of community, and intrinsic motivation would predict overall wellbeing, as defined by satisfaction with life, harmony in life, civic action, and diversity attitudes. Each outcome was examined separately …

Sunset Piracy: The Ends Of Atlantic Piratical Careers In The Age Of Sail, Cory Henderson

Honors Theses

This thesis concerns the careers of pirates in the latest stage of that career, as pirates prepared to end their roving of the seas in order to “settle down.” Though pirates are idolized in modern fiction, their ends are often overshadowed by the highlights of their careers. Here, the goal is to find what motivated pirates to engage in a life as outlaws and then at some point choose to cast that life aside. Conclusions on this are drawn from both primary and secondary sources where pirates gave information pertaining to their view of the world and retirement in it, …

When Worlds Collide: Charlie Hebdo And Islam In The 21st Century, Mildred Morse

Honors Theses

Caricatures are entrenched in French socio-political identity. That identity has shifted due to internal and external forces, but the most important event for the socio-political identity of France in the 21st century is the attacks at Charlie Hebdo in January 2015. The event and the responses to it reignited the ideas of incompatibility of France and Islam, furthering the schism between French society and the integration of Islam. The nature of the memory of Charlie Hebdoand its effect on the perception of Islam before January 2015 and after necessitates the question, “How does Charlie Hebdo reveal contradictory ideas of …

Characterization Of A Plasmid-Based Dna Vaccine For Simian Immunodeficiency Virus, Priya Sanipara

Honors Theses

Described as one of the world’s worst pandemics, HIV (Human Immunodeficiency Virus) infects millions of people each year and is the cause for AIDS (Acquired Immunodeficiency Syndrome). Despite the development of vaccines for numerous infectious diseases such as polio, small pox, and influenza, a vaccine for HIV remains elusive due to the virus’s high mutation rate and ability to evade the immune system. HIV causes depletion of CD4+ lymphocytes, resulting in a weakened immune system. However, the development of a plasmid-based DNA vaccine approach may help revolutionize vaccine development for HIV due to its ability to confer cellular and humoral …

Art Of Darkness, Sarah Roper

Honors Theses

This paper describes the process, production, and explanation of Art of Darkness, an artistic expression of the struggle with anxiety. All of the work is inspired by literature and art from the English Romantic and Victorian eras, and focuses on quotes about the mind, emotions, and other thought processes. As each piece highlights a different aspect of anxiety, it also portrays the struggles of anxiety through color palette, printing process, and symbolism. These printed pieces consist of letter-press printed materials, with ink-wiped backgrounds and hand-stitched details. Also included are large-scale prints with silkscreened foregrounds, a selection of bookmarks, a …

Through The Screen: Examining Peer Relationships, Social Anxiety, Loneliness, And Social Media In Undergraduates, Lindsay Sappington

Honors Theses

Interpersonal connections are a fundamental human need, and as technology becomes more ubiquitous, these connections have shifted to frequently occur online through social media platforms. Two factors that independently influence peer relations are loneliness and social anxiety. However, no study to date has concurrently examined the relation of these psychological factors, social media use, and peer relationships. As such, the aims of the current study were to 1) examine the associations between peer relationships, social media use, loneliness, and social anxiety; 2) investigate the moderating role of quality of peer relationships in the relation of social anxiety and loneliness; and …

The Raphe-Hippocampal Tract And Its Age Differences: Diffusion Tensor Imaging And Probabilistic Tractography Study, Ashley Sekul

Honors Theses

The raphe-hippocampal tract links the raphe nuclei to the hippocampus and is responsible for the production of the neurotransmitter serotonin. The hippocampus is key in regulating emotional and stress responses. This study utilized diffusion tensor imaging which uses Functional Magnetic Resonance Imaging to provide scans of the brain for analyzing differences in the raphe-hippocampal tract as one ages. In this specific study, 491 samples were visually analyzed to gather data about the fractional anisotropy of the raphe nuclei in both male and female brains ranging from 6 to 85 years old. Through the ranking of images, some were discarded, and …

A Comprehensive Business Plan For Launching The New Edtech Company Dais Social Group Llc Dba Daisnotes, Nicholas Neilson-Slabach

Honors Theses

This thesis proposes that an online student-to-student academic social networking platform designed to enhance academic achievement and student satisfaction would be feasible and profitable. Ample evidence exists that student-to-student interaction in university courses increases academic achievement and student satisfaction. Student-to-student interaction is difficult to achieve in large classes common at universities. DaisNotes is a startup company developed to deliver this academic social networking experience.

Part I of this thesis will discuss the results of original empirical research into student attitudes on current studying methods and connection interfaces to explore the problems college students face academically. The marketing research study tests …

Agglomeration Economies: How “Y’Allywood” Became The New Hollywood, Joseph Dugan Walker

Honors Theses

Agglomeration economies have gained special attention in recent decades. With the increasing connectivity of our world, specialized regional economies are stronger now than ever before. A specific agglomeration economy that has developed in recent years is the Georgia Film Industry. This region surpassed Hollywood as the premier filming location for the first time since the early 1900s when New York was number one. This thesis analyzes the reasons why Georgia was so successful in attracting the film industry and encouraging its development by comparing infrastructure, film tax incentives, population, and labor development to that of competing states like New York, …

Ensuring Brand Activism In Integrated Marketing Communications Campaigns Resonates With Millennial Consumers, Anna Hermann

Honors Theses

The purpose of this thesis is to determine how consumers, specifically in the millennial generation, perceive brand activism. Additionally, the study will give recommendations to marketing and public relations professionals creating activist-minded marketing campaigns. As brand activism can be incredibly divisive and controversial, this research is essential in order to understand how best to resonate with, instead of alienate, millennial consumers. The aim of the thesis is to answer the following research questions: (1) How do millennial consumers perceive brands that engage in brand activism and (2) How can marketing and public relations professionals ensure brand activism resonates with millennial …

Basements Below The Sanctuary: A Story Of The Church School, Rachel Winstead

Honors Theses

This is the story of belief in a southern Mississippi town and how that belief mirrors the national conservative counterrevolution that took shape at the same time. Hattiesburg’s segregation academy and church school were founded in the context of broader social movements. As the political power of the Citizen’s Council faltered and white moderates’ voices became louder, practical solutions to retain segregation within the boundaries of law grew to be the new focus of white communities. The conservative counterrevolution exploded in the South as Christian morality and “family values” became the rallying cry of former staunch segregationists and white moderates …

Examining The Possibilities Of Telehealth In Tallahatchie County, Taran Carrasco

Honors Theses

This thesis aims to analyze Tallahatchie County and determine the feasibility of establishing a telehealth program in the county. Telehealth is an evolving aspect in the medical field that incorporates technology with healthcare. This thesis used sociotechnical theory to explain how the feasibility of telehealth could be made more likely as the technology is used over time.Through interviewing UMMC telehealth directors, Tallahatchie Wellness center workers, and citizens of Charleston, this study aims to gauge professional and personal opinions on how feasible it would be to implement telehealth into the Charleston community, as well as how positively telehealth would be accepted …

Financial Accounting Through Case Studies, Erik Landry

Honors Theses

This thesis is a compilation of twelve case studies designed to promote an understanding of Generally Accepted Accounting Principles. Given the dynamic nature of accounting as a profession, it is imperative that students and professionals have a firm grasp of the foundational principles set forth by the Financial Accounting Standards Board. Each case provides insight related to the aforementioned standards and many corollary topics relevant to accounting professionals. The cases rely on both real and fictitious companies and their associated financial statements. The completion of these cases was of great benefit inasmuch as it provided the opportunity to examine essential …

The Data Revolution: An Examination Of The Use Of Scouting And Analytics In Major League Baseball Front Offices, Eleanor Weller

Honors Theses

The area of study for this thesis is the use and optimization of the sub-departments within the larger baseball operations department in Major League Baseball front offices. The research is divided into the history of the two major units—scouting and analytics. This background is followed by an investigation of the balance between them. Information for this analysis was obtained through secondary research, primarily articles for online journals and previously conducted interviews with front office personnel. I have also included some of my own work, which was completed during the summer of 2019. The findings of the analysis are that the …

Al Qaeda, Boko Haram, And Isis: A Study On The Life Cycle Of Terrorist Organizations, Taylor Dedic

Honors Theses

This paper discusses the internal activities of terrorist organizations during their different periods of high and low activity. The research in this paper focuses on the case studies of three organizations, al Qaeda, Boko Haram, and ISIS, and analyzes the shifts in their activities throughout their life cycles. By focusing on terrorist organizations rooted in Salafi-Jihadism, this paper aims to point out the importance of analyzing these organizations through the context of their own ideology. Due to their ideology, these groups view their fight to be centuries-long, thus they do not view a period of reduced activity as their defeat. …

An Analysis Of Accounting Concepts Through A Comprehensive Series Of Case Studies, Colin Baker

Honors Theses

This thesis is a compilation of 10 case studies completed under the direction of Dr. Victoria Dickinson during the ACCY 420 course over two semesters to satisfy the requirements of the Sally McDonnell Barksdale Honors College. Each case guides the study of different accounting standards. These include topics such as contingent liabilities, retirement obligations, non-GAAP financial reporting, financial statement analysis, and more. The case topics often coincided with subjects that were being covered in intermediate, audit, and tax accounting. These cases provided an opportunity to learn how to do independent accounting research in FASB codification. Each case exposed me to …

Perceptions Of Judicial Bias In The Mississippi Judiciary, Allyson Avant

Honors Theses

The purpose of this study is to explore Mississippians’ opinions towards the Mississippi state judiciary and further examine any differences in such opinions across race, gender, knowledge, and education levels. In doing so, it is possible to gain further understanding of the ways that historical context and knowledge influence perceptions of the state judiciary. Data collected from an anonymous survey of approximately 500 individuals shed some light on the perceptions Mississippians have towards the state judiciary. While many of the results were generalizable across various demographics, African Americans consistently held more negative views of their state judiciary than their White …

Sobremesa: The Time Spent Savoring Food And Friendship, Rosa V. Salas Gonzalez

Honors Theses

Sobremesa is the culmination of five different ceramic sets handcrafted and uniquely made as a way to enhance the experience of eating and sharing food. This work honors the Latino and Hispanic tradition of Sobremesa, which is the time we spend sharing special moments with friends and family after eating. I explore the relevance of sharing meals as a member of a Venezuelan family and how these memories of my childhood before moving away to another country relates to the way in which I approach the creation of my functional vessel’s aesthetic and conceptual background.

The pieces that make up …

Glucose Metabolism Of Breast Cancer Sub-Clones That Preferentially Metastasize To The Lungs And Bone, Anna G. Skubiz

Honors Theses

Malignant breast cancers exhibit preferential metastasis to bone and lung (1). While changes in gene expression in lung-specific (LM) and bone-specific metastasis (BoM) lines derived from the MDA-MB-231 breast cancer line have been identified, few metabolic genes are differentially expressed; thus it is unknown if tissue-specific metabolic reprogramming occurs. Two hallmarks of cancer cells are an altered metabolic phenotype characterized by enhanced conversion of glucose to lactate in spite of adequate oxygen availability for complete mitochondrial oxidation of this substrate (referred to as aerobic glycolysis or the Warburg effect) and a greater dependence on glutamine. These changes in primary tumor …

Assessment Of Antebrachial And Carpal Muscle Activity During Smartphone Use: Is “Selfie Wrist” A Real Phenomenon?, Monica Stacy

Honors Theses

Reports in the media by celebrities have sparked an interest in a phenomenon being called “selfie-wrist,” in which smartphone users develop symptoms traditionally associated with carpal tunnel syndrome (CTS). There has been no research to date which investigates the claims of “selfie wrist.” The primary aim of this study was to address the validity of “selfie wrist” claims. The secondary aim of this study was to further investigate the effects of texting on musculoskeletal health, taking into account the differences between texting one-handed versus two-handed, and the effect of using a grip device while texting.

The experiment consisted of an …

Does It Get Any Worse Than Acne? It Does, Actually. An In-Depth Review Of Accutane’S Regulatory History., Bridget A. Betts

Honors Theses

Isotretinoin, most often recognized by the brand name Accutane®, is regarded by many patients and prescribers as the miracle cure for acne. Its unsurpassed efficacy is paired with serious risk of adverse events and birth defects, which poses ethical questions regarding its safety and necessity. Its regulatory history established precedent in Food and Drug Administration Risk Evaluation and Mitigation Strategies and brought awareness to the sharp dangers of teratogenic drug use.

This medication came as a breakthrough solution to patients that suffered years of unsuccessful regimens for the treatment of acne vulgaris. Some question the risk-benefit evaluation of such a …

Can Cities Be Feminist? A Cross-National Analysis Of Factors Affecting Local Female Representation In Latin America, Katie Davis

Honors Theses

Women are underrepresented in mayor’s offices and on city councils across Latin America. In this paper, I examine gender-based differences in individual opinions toward running for office in Argentina and Uruguay, as well as conduct a twenty-six country analysis on factors related to female representation in municipal government. Based on these analyses, I make three main conclusions about female local representation in Latin America. The first conclusion is that women in Latin America are significantly less likely to want to run or feel qualified to run for office. The second conclusion is that cross-national variation in the percentage of female …

Detection And Characterization Of Delta-9-Tetrahydrocannabinol And Novel Synthetic Cannabinoid Metabolites Using Human Liver Microsomes, Seema Murugan

Honors Theses

Marijuana and synthetic cannabinoids are the most commonly used and trafficked illicit drug. ∆⁹-tetrahydrocannabinol (THC) is the primary active compound in marijuana. Synthetic cannabinoids were created as a method to study the effects of cannabinoids on the endocannabinoid system, which consists of endogenous cannabinoids, cannabinoid receptors, and the synthetic and degrading enzymes responsible for the synthesis and degradation of endocannabinoids. Cannabinoids activate the same receptors as endocannabinoids. Synthetic cannabinoids gained popularity as recreational drugs due to their ability to avoid detection. Synthetic cannabinoids have been found to have a greater binding affinity to the cannabinoid CB₁ receptor …

Crystallization Efforts For An Engineered Nickel-Binding Protein, Gold-Bovine Serum Albumin Nanoclusters, And An Artificial De Novo Tetramer Hydrogenase Mimic, Skyler Crane

Honors Theses

Protein crystallization is fundamental to modern research efforts given its ability to determine a protein’s structure as well as the interactions that structure allows and relies upon. This process, though lacking direct application, provides necessary information for subsequent research efforts for which applicationsmay be explored. As such, efforts were taken to crystallize nickel-binding protein (NBP) reengineered from Copper Storage Protein 1 (Csp1) in its apo and metal bound form, Bovine Serum Albumin (BSA) in its apo and gold bound form (Au-BSA), and an artificial de novo tetramer hydrogenase mimic peptide to better inform future research actions for these respective molecules. …

The Differences In Talk About Violence And Terrorism: A Case Study Of Northern Ireland And The Basque Country, Mcclellan Davis

Honors Theses

The Northern Irish and Basque conflicts have been studied throughout the years, as both serve as examples of conflicts involving ethnonationalist terrorist groups and successful disarmaments. While there are similarities, there are also distinctions between the two conflicts. The Irish Republican Army (IRA) and Euskadi Ta Askatasuna (ETA) both fought for independence from a larger government, inflicted horrific pain on populations where they considered themselves members, but ultimately both ended without accomplishing their goal of separatism. This thesis seeks to understand the differences within these conflicts and their subsequent peace processes/disarmaments, which I believe contribute to the differences in ‘talk’ …

The Red Swimsuit: Essays, Jacqueline Knirnschild

Honors Theses

This thesis is a collection of creative non-fiction essays that offers a collage of ethnography, reportage and memoir. The Red Swimsuit blurs the lines between what is considered social science, journalism and art. These essays will become part of a book- length work of creative non-fiction that will explore what it’s like to grow up as a woman in a globalized world wrought with social media, hookup culture and cross-cultural interactions. The Red Swimsuit provides first-hand experience, reflexive narration, and reflection on life as a member of Generation Z, also known as iGen.

Evaluation Of The Bax-Vdac Interaction And Their Influence On Apoptosis In Drosophila Melanogaster, Frances Marie Gatlin

Honors Theses

Apoptosis, also known as programmed cell death, is a cellular process used for development or for when cells undergo injury or stress. The Bcl2 family of proteins includes both pro-apoptotic and anti-apoptotic proteins that control the intrinsic pathway of apoptosis. Understanding the mechanisms and influence these proteins have on apoptosis is an important area of research focused on in Dr. Jones’s lab. Evidence shows a homology amongst the Bcl2 family of proteins at the BH3 domain. Dr. Jekabsons' lab has found a potential homology amongst VDAC 1-3 and the Bcl2 family at the BH3 domain.

Specifically, our lab is using …