Digital Commons Network^™

Factors Contributing To Diminished Long-Term Outcomes Of Secondary Infections, Alia Tayara

Honors Theses

It is widely known that patients suffer diminished long-term outcomes in the years following secondary infections, infectious diseases that occur during or after treatment of a primary infection such as influenza or COVID-19. One common secondary infection is pneumonia, which has become the most fatal hospital-acquired infection. The bacterium responsible for pneumonia is known as Pseudomonas aeruginosa. The cytotoxic supernatant in these studies was generated from a PA103 strain of Psuedomonas aeruginosa with a type III secretion system that maintains the ability to transfer exoenzymes ExoU and ExoT into target cells during infection. The focus of the following studies was …

Gq-Mediated Ca** Signals In Human Airway Smooth Muscle Cells, Hanna Viktoria Bobinger

Honors Theses

Current asthma therapies include corticosteroids, long acting β2-adrenergic receptor (β2-AR) agonists paired with corticosteroids, or short-acting β2-AR agonists used in rescue inhalers. Chronic use of β-agonists results in diminished effectiveness, and use of long-acting β-agonists can even exacerbate asthma symptoms; this is partly because anti-inflammatory therapy does not directly address the exaggerated airway narrowing due to excessive shortening of airway smooth muscle (ASM), which is the hallmark of asthma. These observations led our collaborators to investigate other potential asthma therapies – bitter taste agonists. 2 Bitter taste agonists, such as chloroquine, activate a subset of Gq-coupled receptors known as bitter …

Heavy Metals Found In Juul's Electronic Cigarettes, Joshua F. Gesselberty

Honors Theses

Electronic cigarettes better known as e-cigarettes have been consistently rising in popularity with new products entering the market daily. E-cigarettes function by vaporizing a liquid composed of propylene glycol, glycerin, benzoic acid, nicotine, and flavor additives with the use of a metallic heating element. This vapor produced is then inhaled by the user. The composition of this liquid is critical to discovering the possible health effects.

This study investigates the presence and concentrations of heavy metals in the e-liquid before and after vaping. An ICP-MS was used because of its ability to scan several metals rapidly and its high sensitivity. …

The Functionally Relevant Role Of Sdrna-19b And Sdrna-24 In Prostate Cancer, Addison A. Barchie

Honors Theses

In recent studies small nucleolar RNAs (snoRNA) have been shown to be processed into smaller microRNA-like fragments known as sno-derived RNA (sdRNA). We recently identified 9 snoRNAs that contribute to prostate malignancy using The Cancer Genome Atlas (TCGA) patient prostate tumor next-generation sequencing datasets. These snoRNA were found to be processed into sdRNAs, heavily misexpressed in prostate cancer cell types 8140 and 8550, and shown to function by binding Ago proteins in order to impact mRNA translation. SdRNA-19b and sdRNA-24 in particular stood out as having significant differential expression in prostate cancer vs. control tissue. Interestingly, the targets for sdRNA-19b …

The Role Of Inflammasome In Vascular Remodeling Following Injury, Ted Amadi

Honors Theses

The purpose of the project presented in this thesis is to assess the contribution of inflammasome activation in mediating vascular wall remodeling that occurs following carotid artery injury due to decreased blood flow. To examine this, we used a mouse model of carotid artery ligation in mice lacking the expression of a key mediator of the inflammasome signaling pathway. Following ligation, we completed a histological assessment to compare the degree of the neointima formation and expression of inflammasome related proteins in both injured and the non-injured contralateral carotid artery in both wild-type (WT) and Caspase 1 knockout mice (Cas1 -/-).

Determination Of Pollutant Load Reductions To Three Mile Creek As A Result Of The Implementation Of Storm Water Bio-Infiltration Basins On The Usa Campus, Jordan E. Blackmon

Honors Theses

Three Mile Creek has been identified as an impaired urban stream and is now a priority for cleanup for both the City of Mobile and the Alabama Department of Environmental Management. Methods to better manage storm water runoff on the USA campus have begun, with a goal to reduce sediment and nutrient inputs to Three Mile Creek. Both sediment and nutrient inputs to Three Mile Creek disrupt habitat and lower dissolved oxygen concentrations, which are detrimental to overall stream health. Low Impact Development strategies are an innovative way to use nature-like, green-infrastructures to minimize storm water runoff quantity and improve …

Caregiver Knowledge, Perceived Self-Efficacy, And Level Of Confidence In Limiting Bedtime Screen Use In Preschoolers, Emily Hollingsworth

Honors Theses

Screen time usage is a major factor leading to negative behavioral and health consequences in young children. Screen time also affects sleep, with prior research showing a significant association between screen time, particularly at bedtime, and reduced sleep duration and increased sleep problems. The initial aim of this research was to measure and attempt to increase, through an educational intervention, the knowledge, perceived self-efficacy, and confidence of study participants/primary caregivers with regard to limiting the bedtime screen use of their preschoolers with the goal of health promotion. It was intended to be a quantitative, quasi-experimental, multi-site, pre- post-intervention case study. …

Iot-Enabled Environmental Monitoring Technologies, Clayton Suell

Honors Theses

Environmental monitoring is essential to protect human life and the environment due to issues such as global warming, pollution, and weather phenomena like hurricanes. To this end this thesis presents a prototype IoT (Internet of Things)-enabled environmental monitoring network. The network will include the ability to collect data from various locations that will be uploaded to a cloud so that the data can be accessed from any device with a network connection allowing for greater environmental awareness and a database that can be used for environmental analysis. The network will be flexible enough that every data collection point will either …

Ogt Glycosylation Of Histones In T Cells May Participate In Systemic Lupus Erythematosus, Jared Luke Ridgeway

Honors Theses

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that primarily affects women. The etiology is not known yet, but genetics and environmental factors trigger the disease. These epigenetic changes modify gene expression and contribute to the development of the disease. It is known that T cells from patients with lupus overexpress genes that may contribute to the onset and progression of the disease. Dr. Gorelik has shown that OGT (O-linked N-acetyl-Glucosamine Transferase), which is an X-linked gene, is overexpressed in women with SLE. OGT adds b-N-acetylglucosamine (O-GlcNAc) to serine and threonine residues of proteins. …

Characterization Of Bpa Sensitive Strains In C. Elegans, Giulianna I. Escobar

Honors Theses

Bisphenol A (BPA) has been present in our environment since 1891 when it was first synthesized by Aleksandr Dianin. BPA has since been a topic of interest due to the possibility of diseases associated in human consumption of the chemical. Interestingly, Caenorhabditiselegans, commonly known as C.eleganshave shown to be able to tolerate the chemical. Thisorganism is an advantageous model organism for research since they are simple organisms to study, cheap, produce a large brood size, and have a short life cycle. Previously a forward genetic screen was done to isolate 2000 healthy strains in order to determine which strains showed …

Rights For The “Non-Conforming” Woman: The Intersectionality Of The Fight For Women’S Rights And Lgbtq+ Rights In Argentina, Talia C. Housman

Honors Theses

Argentina has faced many challenges throughout its history of activism as the people have pushed for an equal society. Different movements have sprung up over the years, but they have begun to twist together in recent times due to the need for support during repressive regimes. This brings into question the concept of intersectionality, which spans feminist, queer, and legal theory in its attempt to explain the need for overlap, modeling the natural development of personal identities and groups like family. The feminist movement and the LGBTQ+ movements have woven together in many rallies, especially during El Encuentro Nacional de …

Food Insecurity At Bucknell University: A Look At Student Experiences And Contributing Factors, Emma Curtin

Honors Theses

This thesis explores the prevalence of food insecurity at Bucknell and examines the contributing factors. Two research questions frame the present study: 1) What factors contribute to food insecurity on Bucknell’s campus? And 2) How do students at Bucknell experience food insecurity? Additionally, the impact of the COVID-19 pandemic on college student food insecurity is explored. The theoretical framework used in this thesis is Bourdieu’s theory of social reproduction. This framework coupled with a phenomenological approach to analyzing the data are the most appropriate for the present study because food insecurity is a systemic phenomenon, maintained by institutions but lived …

Arab Media's Representation Of Arab-Israeli Normalization Agreements, Rylan L. Forester

Honors Theses

When, on August 13, 2020, the United Arab Emirates (UAE) announced it was normalizing relations with the state of Israel, few could have predicted the effects it would have. However, since the Emirati decision, three other Arab countries - Bahrain, Sudan, and Morocco - have reached agreements with Tel Aviv to normalize relations. Such events are a sharp divergence from the status quo and thus, this thesis examines, through the application of Critical Discourse Analysis (CDA) and analyzed through a constructivist framework, how three Arab media sources - Al-Jazeera, Al-Arabiya, and Al-Mayadeen - discuss and represent these normalization agreements. By …

Korean Fusion: Consuming A Globalized Korea Through Food And Music, Ashley Hong

Honors Theses

In Koreatown, Los Angeles, one of the largest centers of Korean immigrants in the Western hemisphere, restaurant owners are constantly creating new forms of Korean cuisine that both challenge and preserve traditional methods of Korean culinary methods. Based on participant observation and semi-structured interviews conducted in Koreatown, Los Angeles in December 2020, I examine how Korean restaurant owners are navigating the current food scene while also maintaining their ethnic identity in a globalized landscape such as Los Angeles. I conceptualize the idea of a “twist” which can be understood as components of fusion food that allow Korean restaurant owners to …

A Comparative Analysis Of Chinese And American Cinematic Depictions Of The Female Adolescent Life Transition, Lily Li

Honors Theses

The thesis examines the representation through film of the ways social systems in Western and Eastern societies impact female adolescents’ growth. My study focuses on the transition from childhood to adolescence, from a relatively "naive" state to a reflective state of mind, filled with uncertainty about oneself and the future. In this process, there are emotions of confusion, insecurity, struggle, anxiety, and intergenerational conflicts. Some crucial factors such as friendships, family relationships, and societal pressures are influential in adolescents' formation of their personalities. This transformational process is universal across all cultures, as every adolescent experiences the transition from youth to …

Biking At Bucknell: The Evaluation Of The Built Environment, Societal Environment, And Individual Behavior And Attitudes In Relation To Biking At Bucknell University, Makenna Cerney

Honors Theses

A biking market in this thesis is defined by three major contributors: (a) the built environment such as the engineering and construction of bike lanes, parking corrals, and other aspects of the physical infrastructure for biking, (b) the societal environment which includes the norms and communal acceptance of biking, and (c) individual beliefs, behaviors and attitudes toward biking. These three areas form the foundation of the factors that stimulate the demand for biking in the biking market, which in turn drives the supply of biking and biking services. This thesis intends to conduct research on the built environment, societal environment, …

Determination Of Hydrogel Degradation By Passive Mechanical Testing, Avery Rosh-Gorsky

Honors Theses

This paper details a new technique to measure the mechanical properties of ETTMP PEGDA hydrogels using Hertz Contact Theory and simultaneously analyze both the model drug release and gel erosion in situ. This method involves curing a drug loaded hydrogel in a standard cuvette and placing a glass bead and phosphate buffer solution (PBS). Over time, the cross-linked network of the hydrogel breaks down, and, as a result, the ball sinks into the hydrogel. This method provides a macroscopic and inexpensive way to continuously and passively measure properties of the hydrogel as the hydrogel degrades. By plotting both the …

To Believe Or Not To Believe: Voters’ Responses To Sexual Assault Allegations In Politics, Emily Brandes

Honors Theses

Since the viral 2017 #MeToo movement, public opinion on cases of sexual misconduct has been shaped by the mainstream media coverage of high-profile stories. A shift in public attitude towards these issues has encouraged more victims to come forward and share their stories, many detailing harrowing events perpetrated by successful businessmen and politicians. Credible accusations continue to come forward, and while some end in legal action, many do not, and perpetrators face little to no consequences. I examined how individuals respond to issues of sexual misconduct and assault in politics, and based on the severity of the accusation, how they …

Development Of An Eci5 Group Iib Intron Mutagenesis System For Use In Chlamydia Trachomatis, Cassidy Evelyn Lounsbury

Honors Theses

No abstract provided.

Health Insurance And The Undocumented Immigrant, Anja Diercks

Honors Theses

The purpose of this thesis is to perform a comparative analysis on how seven different countries (USA, South Africa, Germany, England, Canada, France and Singapore) organize their healthcare system to cope with the issue of undocumented immigrants and whether or not these systems in place were “fair.” The thesis will also explore the possible ways the United States could change to be more inclusive and fairer in the world of healthcare and health insurance for the undocumented immigrant. A study on what fairness means both in ethical and economical terms is done to suggest a new basis of a fair …

Soft Power And Human Development In Central Asia, Cheryl White

Honors Theses

Due to the wealth of natural resources and the strategic geographic location of Kazakhstan and Kyrgyzstan, these two countries have attracted a significant amount of soft power investments, including foreign direct investment, non-government organizations, and infrastructure development. This paper compares the fluctuations in the soft power measurements to the levels of human development in Kazakhstan and Kyrgyzstan. The findings show highly similar changes in the amount soft power investments to the level of human development indicators, suggesting a strong correlation between the two measures. A methodological analysis and further data sets would be necessary to determine the connection though.

Social Media Dependency And College Student Adjustment, Kylee Defrese

Honors Theses

While previous studies have looked at the effects of social media dependency on disordered eating symptoms, body image concerns, and anxiety and depression symptoms, few have looked at these effects on exclusively college students. The current study utilized a survey to examine the associations between social media dependency, disordered eating symptoms, body image concerns, and anxiety and depression symptoms. Ninety-seven college students (M_age = 18.8 years, SD = 1.51; 82.5% young women; 17.5% young males ; 75.3% White; 91.8% non-Hispanic/non-Latinx) completed established measures, and reported on their social media dependency (Xanidis & Brignell, 2016), body image concerns (Schaefer, …

Providing A Safe Space For Children Who Have Experienced Trauma, Alexis Garcia

Honors Theses

Health care professionals are continuing to learn about childhood trauma and the implications on health and development. With time, there has become a better understanding of how to determine and provide the resources needed for families and children who have experienced childhood trauma. Additionally, information about childhood trauma is slowly being understood throughout public school districts. This allows teachers to better understand children and accommodate their needs. This honors thesis will discuss childhood trauma and the development of a resource that can be used to provide elementary school-aged students with a place to go when they need assistance with regulation. …

“Space For All?”: An Analysis Of Race, Gender, And Society In The Cult Classic Doctor Who., Liron Sussman

Honors Theses

Much like the Doctor, people are constantly growing and evolving, and it is out of a desire for human connection that people strive, always, to improve and as a long-running television program, Doctor Who reflects that desire for connection. This analysis explores race, gender, and society as portrayed in the modern series of Doctor Who (2005-).

Wmu Essential Studies Program: Creating Awareness For The New Required Curriculum, Catherine Lemus

Honors Theses

In the Fall semester of 2020, the WMU Essential Studies (WES) Program officially launched. This new program replaces the previous WMU General Education curriculum which was over 30 years old with curriculum concepts over 100 years old. While the WES program was not allocated any financial or human resources by Western Michigan University as its inception, it required assistance in creating messaging and content to help educate multiple audiences including current and prospective students, WMU faculty, WMU staff, and local community members. Catherine Lemus stepped in the role of WES Strategy and Marketing Assistant with the guidance of Prof. Greg …

Westbound, Genevieve Nicolow

Honors Theses

Westbound is a twenty-five chapter novella that aims to demonstrate ways in which creative writers can use climate fiction to overcome psychological barriers to act on climate change. The narrative follows Cassie, a character loosely based on a relative of its author, living in a future version of the United States that has been ravaged by climate change and its indirect consequences.

In the novella, Cassie and her mother Nia set out on a cross-country road trip as a climate disaster looms. The narrative explores their relationship and that with Cassie’s estranged father, the implications of projected ecological changes under …

Housing Pre-Fabrication And Resource Optimization, Emma Dubensky

Honors Theses

Enclosure during construction is often time-consuming, expensive, and at the mercy of the weather. By introducing methods for manufacturing prefabricated enclosure components such as wall panels and roof sections, the impact of the three major variables is reduced. Designs for trusses, roof sections, wall sections, and foundations were developed and selected using civil engineering principles; and manufacturing and logistical processes were optimized using engineering and project management skill sets. These multi-disciplinary efforts were combined to create an accessible and versatile set of designs and instructions that can improve the effectiveness of both a skilled and non-skilled volunteer workforce. By creating …

The Textile Industry: A Deep Look Into The Environmental Impacts Of Fast Fashion, Jordan Miller

Honors Theses

The purpose of this research was to understand the detrimental effects the textile industry has had on global environments and ecosystems across the globe. The textile industry for many years has continued to disregard the current acceleration of global warming and other environmental crises, and it is time the fashion industry holds itself accountable for these actions and takes a change in a new, more sustainable future. With proper education of the environmental pollution the textile industry has made, young consumers will be able to make the change necessary for businesses to develop more sustainable habits for the future production. …

Housing Prefabrication And Resource Optimization, Megan Scherpereel

Honors Theses

Enclosure during construction is often time-consuming, expensive, and at the mercy of the weather. By introducing methods for manufacturing prefabricated enclosure components such as wall panels and roof sections, the impact of the three major variables is reduced. Designs for trusses, roof sections, wall sections, and foundations were developed and selected using civil engineering principles; and manufacturing and logistical processes were optimized using engineering and project management skill sets. These multi-disciplinary efforts were combined to create an accessible and versatile set of designs and instructions that can improve the effectiveness of both a skilled and non-skilled volunteer workforce. By creating …

"Foreign" Language: Examining Systemic Attitudes, Xenophobia, And Foreign Language Anxiety, Olivia Jennings

Honors Theses

With the focus on the systemic attitudes, this study examines previous background in foreign language, attitudes about language in general, and the relation of language to identity. This study stresses the defining process in the making of American as a national and cultural identity, and how it has changed over the years. It examines the role of xenophobia and xenoglossophobia in the context of American identity, and through its evolution in past and current sociopolitical believes impacting an overall disinterest in foreign language. The disinterest in foreign language is investigated to discover the reasons why foreign language programs are being …