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Effects Of Broccoli And Carrots On Fecal Microrna Expression In Infants: A Short-Term Feeding Study, Kaleigh E. Beane
Effects Of Broccoli And Carrots On Fecal Microrna Expression In Infants: A Short-Term Feeding Study, Kaleigh E. Beane
Graduate Theses and Dissertations
Diets, through multiple mechanisms, cause significant impact on human health and disease etiology; proposed modes of action include modulation of non-coding RNAs and influences on the gut microbiome. Specifically, phytochemicals change human miRNA expression thereby impacting gut microbiome and/or increasing host immune functions. Apiaceous and cruciferous vegetables have been linked to decreased chronic inflammation, which is closely related with the host immune system, yet it is not investigated how these two classes of vegetables influence the colonic miRNA profile. In this study, therefore we aimed to determine the effects of short-term feeding of broccoli and carrot to infants on fecal …
Who Is Riding The Bus And How Does It Impact Student Sleep, Attendance, Discipline, Mental Health, And Achievement?, Curtis Neil Hicks
Who Is Riding The Bus And How Does It Impact Student Sleep, Attendance, Discipline, Mental Health, And Achievement?, Curtis Neil Hicks
Graduate Theses and Dissertations
The purpose of this research study was to determine the relationship between morning transportation mode choice, sleep, and factors that impact achievement for students in grades 9-12 at Sleepy Valley High School. The study also examined the relationship between race and/or socioeconomic status and morning transportation mode choice to determine to what extent, if any, students from low socioeconomic backgrounds and minority populations are disproportionally affected by the district’s pupil transportation system.
Data related to morning transportation mode choice, factors that impact mode choice, student sleep, and mental health were collected through a 12 question Student Transportation Survey. Each survey …
Teen Stress And The High School Experience: Fostering The Adaptive Abilities To Survive And Advance, William P. Dewitt
Teen Stress And The High School Experience: Fostering The Adaptive Abilities To Survive And Advance, William P. Dewitt
Graduate Theses and Dissertations
The purpose if this study is to examine the stress experience of teenagers during their high school years. The study uses existing research to identify causes of stress and stress- management techniques and then gathers students’ perceptions through surveys and a group interview to provide student voice on the issue of stress.
Recent nation-wide efforts have been made in schools to provide more supports for the social and emotional well-being of students, but despite these efforts, stress levels of high school students remain elevated. Understanding the ways in which students identify stress and the adaptive abilities they use to manage …
Midseason Nitrogen Sufficiency Guidelines For Corn Production In Arkansas Based On Tissue Analysis And Remote Sensing, Caio Luiz Dos Santos
Midseason Nitrogen Sufficiency Guidelines For Corn Production In Arkansas Based On Tissue Analysis And Remote Sensing, Caio Luiz Dos Santos
Graduate Theses and Dissertations
There are a lack of tools to assess midseason nitrogen (N) status in corn (Zea mays L.) production systems and identify the need for additional N fertilization. This study was conducted to determine the ability of leaf N concentration (LN) and the Dark Green Color Index (DGCI) at the 10th collared leaf stage (V10), the 12th collared leaf stage (V12), and tasseling (VT) to predict if midseason N is required to maximize corn grain yield. From 2017 to 2019, eight field studies with 11 N treatments ranging from 0 to 258 kg N ha-1 were conducted on silt loam soils …
Determination Of Critical Y-Leaf Potassium Concentrations Across Reproductive Growth Stages For Direct-Seeded Delay-Flooded Rice, Chandler Edwin Gruener
Determination Of Critical Y-Leaf Potassium Concentrations Across Reproductive Growth Stages For Direct-Seeded Delay-Flooded Rice, Chandler Edwin Gruener
Graduate Theses and Dissertations
Rice (Oryza sativa L.) grain yield can be limited by potassium (K) deficiency on soils low in exchangeable K. Visually diagnosing K deficiency during early reproductive growth is not easily done and the interpretation of traditional tissue analysis is limited to select growth-stages. Our primary focus was to define continuous critical Y-leaf-K concentrations during reproductive growth for the production of maximal grain yield. A secondary objective was to examine Y-leaf sap-K concentration, measured using a handheld device, as a rapid in-field method of monitoring rice plant K nutrition. The Y-leaf is defined as the uppermost fully extended leaf with a …
Examination Of Language Skills In Children Who Attend Head Start Programs, Madilyn Littlefield
Examination Of Language Skills In Children Who Attend Head Start Programs, Madilyn Littlefield
Graduate Theses and Dissertations
Socioeconomic status and poverty can greatly affect child development and have lasting impacts throughout life. Children who are raised in a low socioeconomic status homes may experience limited parent sensitivity, limited parental engagement, and limited access to stimulating materials. These factors may also limit opportunities to experience rich language and literacy experiences which can negatively impact development of emergent literacy skills and later educational growth. To reduce the effects of poverty on school readiness, income-based childcare programs allow families access to affordable early school readiness opportunities that are developmentally appropriate. Head Start programs are designed to facilitate child development, provide …
Techniques To Enhance The Attributes Of Wines Produced From Grapes Grown In Arkansas, Sarah Mayfield
Techniques To Enhance The Attributes Of Wines Produced From Grapes Grown In Arkansas, Sarah Mayfield
Graduate Theses and Dissertations
Grapevines (Vitis spp.) are one of the most widely-planted horticultural crops, and the United States plays a major role in grape and wine production. Arkansas has a long history of grape and wine production with grapes grown in Arkansas including mostly native species, such as muscadines, and hybrids (crosses of Vitis spp.), such as Chambourcin. In addition, the University of Arkansas System Division of Agriculture (UA System) grape breeding program has cultivars and selections that have shown potential for wine production. The objectives of this research were to: evaluate effects of specific inactivated yeast application to Chambourcin grapevines on attributes …
Effects Of Light, Nutrients, And Salts On Microbial Biofilm Productivity And Detrital Processing In Aquatic Mesocosms, Bethanie Brooke Howard-Parker
Effects Of Light, Nutrients, And Salts On Microbial Biofilm Productivity And Detrital Processing In Aquatic Mesocosms, Bethanie Brooke Howard-Parker
Graduate Theses and Dissertations
Anthropogenic activities associated with urbanization, agriculture, and resource extraction continue to increase to support increasing needs of the growing population. These activities increase the amounts of pollutants entering freshwater streams and put aquatic ecosystems at structural and functional risk. Aquatic microbes play an important role in detrital processing in streams as a key linkage in moving carbon from detrital stocks into aquatic food webs. My research investigates the effects of light, nutrients, and salts on detrital microbes and decomposition in freshwaters using a mesocosm approach. In chapter one, I modified a current priming effect (PE) hypothesis model to include light …
The Effects Of Auditory And Olfactory Cues On Visual Attention Toward Food Images Under Acute Stress, Reza Moltaji
The Effects Of Auditory And Olfactory Cues On Visual Attention Toward Food Images Under Acute Stress, Reza Moltaji
Graduate Theses and Dissertations
Psychological stress has been shown to increase preference for high calorie foods containing high levels of sugar and fat. Since excessive intake of high calorie foods may increase potential risk of obesity and other relevant health issues, relieving psychological stress may help in maintaining a balanced diet and good health status. Although a variety of strategies for relieving psychological stress has been suggested, little attention has been paid to regarding whether such strategies can result in balanced diets. Since music therapy and aromatherapy have proven popular approaches to relieving psychological stress, this thesis aimed at determining whether listening to music …
Chefs' Perceptions Of Zero Waste Cooking In Restaurants, Josephine Reardon
Chefs' Perceptions Of Zero Waste Cooking In Restaurants, Josephine Reardon
Graduate Theses and Dissertations
The purpose of this study is to examine chefs’ perceptions and practices relative to current and potentially future efforts to decrease food waste. Through qualitative inquiry, this research aims to identify food waste reduction practices in Northwest Arkansas restaurants; chef’s perceptions of these practices and zero waste cooking; the impact these practices have on successfully implementing sustainability; and the biggest challenges in reducing food waste in restaurants. The results of this study will assist chefs and restaurant owners by providing guidance on practices easily utilized in restaurants currently.
An interview protocol, with five sections, was conducted with ten chefs at …
Evaluation Of Microbiome On Chicken Necrotic Enteritis And Growth Performance, Mussie Abraha
Evaluation Of Microbiome On Chicken Necrotic Enteritis And Growth Performance, Mussie Abraha
Graduate Theses and Dissertations
Necrotic enteritis (NE) has re-emerged following restriction of antimicrobial usage and costs $6 billion every year worldwide. The primary objective of the studies was to evaluate prevention and treatment of NE using a microbiota metabolic product, secondary bile acid deoxycholic acid (DCA), in drinking water. Day-old birds were tagged and placed in floor pens. In experiments 1 and 2, the birds were infected with Eimeria maxima (Em) at d 18 and C. perfringens at d 23 and 24 and the birds were euthanized at d 26. In experiment 3, birds were infected with Eimeria at d 20 and C. perfringens …
Understanding One’S Own Teaching Experiences: New Family And Consumer Sciences Teachers Reflect On Their First-Year Of Teaching Through Video-Recorded Classroom Observations And Interviews, Sheila K. Cook
Graduate Theses and Dissertations
The purpose of this study was to examine the experiences of new Family and Consumer Sciences (FCS) teachers and to describe their perceptions of classroom teaching readiness. The researcher completed a series of three classroom observations and three interviews of five first-year FCS teachers. The Danielson’s Framework for Teaching instrument was used for all observations and two sections of interviews used Interview Questions for Family and Consumer Sciences Educators instrument, which was taken in part, with permission, by Horizon Research, incorporated. All observations and interviews were completed over a time span of two to three weeks and examined essential teaching …
The Role Of Protein Degradation In Cancer Cachexia In Female Tumor Bearing Mice, Noah Thomas
The Role Of Protein Degradation In Cancer Cachexia In Female Tumor Bearing Mice, Noah Thomas
Graduate Theses and Dissertations
Background: Cancer is a leading cause of death in the world in which half of the people affected by this disease die from its effects. Cancer-cachexia is a syndrome associated with the significant loss of skeletal muscle mass and function, which cannot be fully reversed by nutritional intervention alone and in turn, impairs the host. Cancer-cachexia affects 50-80% of cancer patients and is a primary cause of death accounting for 20-40% of cancer related deaths. Efforts to reverse the effects of cancer-related cachexia have been largely unsuccessful and have primarily focused on the late stages of CC. Methods: Lewis Lung …
Barriers To Integrated Primary Care And Specialty Mental Health Services: Perspectives From Latinx And Non-Latinx White Primary Care Patients, Elizabeth A. Anastasia
Barriers To Integrated Primary Care And Specialty Mental Health Services: Perspectives From Latinx And Non-Latinx White Primary Care Patients, Elizabeth A. Anastasia
Graduate Theses and Dissertations
High need, low access, and rising health care costs reveal the inadequacies of the current mental health system in the U.S. Racial/ethnic minorities, including Latinxs, face substantial disparities in accessing mental health treatment compared with non-Latinx Whites. Integrated primary care (IPC) offers an alternate model for meeting mental health needs by providing care in a way that is accessible to the general population. Though it has been suggested that IPC may reduce health disparities by decreasing barriers to mental health treatment, empirical data relevant to this question are limited. A series of three studies were conducted using a mixed methodology …
Preliminary Study: Leucine Supplementation Exacerbates Muscle Wasting Independent Of The Ubiquitin-Proteasome System, Katarina Bejarano
Preliminary Study: Leucine Supplementation Exacerbates Muscle Wasting Independent Of The Ubiquitin-Proteasome System, Katarina Bejarano
Graduate Theses and Dissertations
Cancer cachexia is the rapid, drastic loss of muscle mass associated with cancer and is not reversible by conventional nutritional means (Brown et al., 2018; Brown et al., 2017). It occurs in ~80% of cancer patients and is responsible for 20-40% of cancer-related deaths (Brown et al., 2018; Brown et al., 2017). This condition leaves patients with fatigue, functional impairment, reduced quality of life, and a decrease in survival rates. Cachexia occurs through an imbalance between protein degradation and protein synthesis (Brown et al., 2018), which is associated with inflammation and altered metabolic processes.
Several studies have investigated the effects …
Efficacy Of Multivitaim-Mineral Supplementation On Health-Related Quality Of Life And Physical Activity In Young Adults, Sarah Pendergraft
Efficacy Of Multivitaim-Mineral Supplementation On Health-Related Quality Of Life And Physical Activity In Young Adults, Sarah Pendergraft
Graduate Theses and Dissertations
Micronutrients are essential for both physical and mental health. There is a correlation between poor health and mood and micronutrient deficiencies. Young adults age 18-24 are an at-risk, understudied population likely to benefit from multivitamin mineral supplementation. Multivitamin mineral supplementation is a potential way to bridge gaps in micronutrient levels, thus influencing health-related outcomes. Here, we provide the first attempt at influencing health-related quality of life and physical activity with a multivitamin mineral supplement in young adults. Using a supplement formulated without herbal extracts and caffeine, this double-blind study examined the efficacy of a daily multivitamin mineral supplement for 30 …
The Effect Of Breakfast Macronutrient Composition In Children Ages 7-17 Years Old As A Potential Method To Combat Childhood Obesity, Angela M. Tacinelli
The Effect Of Breakfast Macronutrient Composition In Children Ages 7-17 Years Old As A Potential Method To Combat Childhood Obesity, Angela M. Tacinelli
Graduate Theses and Dissertations
The prevalence of childhood overweight and obesity is an ongoing concern. Currently, approximately 20% of children in the United States are obese. While obesity was once regarded merely as excessive adiposity within the body, it is has emerged as a major risk factor for chronic diseases such as metabolic syndrome, type 2 diabetes, and cardiovascular disease. Obesity is multifactorial in nature. Weight gain can result from an energy imbalance in the body due to excess energy intake (calories in) and decreased energy expenditure (calories out). Identifying methods to combat obesity is essential. Nutritional intervention may be a strategy to help …
Evaluation Of Anthelmintic Therapies In A Fall Calving Beef Cowherd, Laine Zammit
Evaluation Of Anthelmintic Therapies In A Fall Calving Beef Cowherd, Laine Zammit
Graduate Theses and Dissertations
Internal parasitism inevitability prompts economic loss in beef cattle production by decreasing growth performance and reproductive traits. Today, the most widely used class of anthelmintic used to treat parasitism, is the macrocyclic lactone. Many studies have conflicting results on the efficacy of macrocyclic lactones (ML) efficacy against internal parasitism. The objective of this study was to evaluate the effectiveness of moxidectin and eprinomectin, two of the MLs, on cow performance. Multiparous fall calving, crossbred beef cows (n = 106) were allocated randomly to 1 of 3 anthelmintic treatments: 1) Negative control (CON), in which cows did not receive an anthelmintic, …
Liver Transcriptomic Analysis After Short- And Long-Term Feeding Of Soy Protein Isolate And Its Ability To Reduce Liver Steatosis In Obese Zucker Rats, Melisa Kozaczek
Liver Transcriptomic Analysis After Short- And Long-Term Feeding Of Soy Protein Isolate And Its Ability To Reduce Liver Steatosis In Obese Zucker Rats, Melisa Kozaczek
Graduate Theses and Dissertations
According to the Centers for Disease Control and Prevention (CDC) the prevalence of obesity in adults in the United States during 2017-2018 was a 42.4%, a high number considering all the risks factors associated with this disorder, such as cardiovascular disease, insulin resistance, diabetes type 2, and fatty liver disease, among others. Fatty liver disease is the accumulation of lipids in the liver that can account for more than 5 to 10% of the liver’s weight. There are two types of fatty liver disease, alcoholic fatty liver disease (AFLD), and non-alcoholic fatty liver disease (NAFLD). AFLD is the detrimental accumulation …
Microbiota Characterization Of Poultry Processing Systems And Associated Microbiological Sampling Materials Collected At Commercial Processing Facilities, Jennifer A. Wages
Microbiota Characterization Of Poultry Processing Systems And Associated Microbiological Sampling Materials Collected At Commercial Processing Facilities, Jennifer A. Wages
Graduate Theses and Dissertations
The poultry industry and associated regulatory bodies use whole bird carcass (WBC) rinsates to evaluate different stages of broiler processing systems for the prevalence of food-borne pathogens, including Salmonella spp. and Campylobacter spp. Within industry and research groups, the same sample collections are enumerated to determine E. coli, Enterobacteriaceae (EB), and Aerobic Plate Count (APC) microorganisms. Analysis of these indicator microorganisms provides numerical data that can be used to demonstrate the effects of specific process control steps where low occurrences of target pathogens hinder the exclusive use of prevalence data. With the utilization of next generation sequencing (NGS), including analysis …
Development Of Arkansas Net Energy Equation, Katie Hilton
Development Of Arkansas Net Energy Equation, Katie Hilton
Graduate Theses and Dissertations
The modern broiler is growing at a rapid rate generating tremendous amounts of heat. A sensitive Net Energy (NE) system is needed to measure body heat production (HP) generated primarily by daily maintenance and synthesis and degradation of myofibrillar and sarcoplasmic protein. The first two chapters present evaluation of the classic way to calculate NE versus a new methodology; the Arkansas NE (Ark NE) system, with birds from two genetic lines fed diets with different AA content or different ME content in two different environmental temperatures.
Utilizing together the Net Energy maintenance (NEm), determined from indirect calorimetry, and Net Energy …
An Evaluation Of Unmanned Aircraft Systems' Ability To Assess Stripe Rust In Large Wheat Breeding Nursies, Jamison T. Murry
An Evaluation Of Unmanned Aircraft Systems' Ability To Assess Stripe Rust In Large Wheat Breeding Nursies, Jamison T. Murry
Graduate Theses and Dissertations
Stripe Rust (Puccinia striiformis f. sp. tritici) is a foliar disease that significantly impacts global wheat production, and resistant cultivars provide the most efficient method of control. High-throughput phenotyping using unmanned aircraft systems (UAS) offers a potentially more efficient method for field-based phenotyping compared to visual assessment. Here we tested the ability of remote sensing to predict stripe rust severity in a diverse population of 594 soft red winter wheat lines, planted in single-rows, and evaluated them by visually rating stripe rust intensity and remotely using the dark green color index (DGCI), normalized difference vegetation index (NDVI) and blue NDVI. …
Food Safety Risk In An Indoor Microgreen Cultivation System, Gina Marie Misra
Food Safety Risk In An Indoor Microgreen Cultivation System, Gina Marie Misra
Graduate Theses and Dissertations
Microgreens are immature sprouts of edible plants, sharing some similarities with sprouted seeds and petite leafy greens. Since they are most often grown in containers in buildings or greenhouses, they present a new area for food safety research at the intersection of the built environment and produce farming. Contamination by human pathogens has been extensively studied in other types of produce typically eaten raw, including sprouted seeds, which have been implicated in numerous outbreaks of salmonellosis over the last several decades. There is a paucity of knowledge about the microgreen sector of the fresh-cut industry; thus, it was determined that …
A Putative Cystathionine Beta-Synthase Homolog Of Mycolicibacterium Smegmatis Is Involved In De Novo Cysteine Biosynthesis, Saroj Kumar Mahato
A Putative Cystathionine Beta-Synthase Homolog Of Mycolicibacterium Smegmatis Is Involved In De Novo Cysteine Biosynthesis, Saroj Kumar Mahato
Graduate Theses and Dissertations
Mycobacteria include serious pathogens of humans and animals. Mycolicibacterium smegmatis is a non-pathogenic model that is widely used to study core mycobacterial metabolism. This thesis explores mycobacterial pathways of cysteine biosynthesis by generating and study of genetic mutants of M. smegmatis. Published in vitro biochemical studies had revealed three independent routes to cysteine synthesis in mycobacteria involving separate homologs of cysteine synthase, namely CysK1, CysK2, and CysM. However, in vivo data were lacking. The M. smegmatis genome encodes only a CysM homolog and lacks orthologs for CysK1 or CysK2. The gene that codes for CysM is a part of an …
Asymmetric Exchange Rate Pass-Through In Southeast Asian Rice Trade, Taylor Wiseman
Asymmetric Exchange Rate Pass-Through In Southeast Asian Rice Trade, Taylor Wiseman
Graduate Theses and Dissertations
Asian countries consume approximately 90% of the world’s rice supply. Between 2007 and 2014, Thailand, Vietnam, and India accounted for 60% of the world’s exports of rice. This paper estimates the impact of exchange rate fluctuations on bilateral trade flows in Southeast Asia. Because most Southeast Asian countries have state trading enterprises or agencies controlling rice trade, this analysis will provide insight as to whether these agencies respond to exchange rate fluctuations in a manner consistent with economic theory. Behavior inconsistent with economic theory could provide evidence of stabilizing domestic prices, market power, or export expansion policies. The analysis focuses …
Hydroponic And Soilless Culture Systems And Transplant Practices Influence Production Of Basil (Omicum Basilicum L.), Samuel Warren Edward Doty
Hydroponic And Soilless Culture Systems And Transplant Practices Influence Production Of Basil (Omicum Basilicum L.), Samuel Warren Edward Doty
Graduate Theses and Dissertations
Two controlled-environment greenhouse experiments evaluated (1) plant growth and morphology of basil (Omicum basilicum L.) grown in three different hydroponic and soilless substrate systems and (2) seedling tray cell-count and transplant date into hydroponic culture effects on basil growth and yield at harvest. For the first experiment, four basil cultivars (‘Genovese’, ‘Mrs. Burns Lemon’, ‘Sweet Thai’, and ‘Cinnamon’) were grown in deep flow technique (DFT) hydroponics, nutrient film technique (NFT) hydroponics, and a novel shallow aggregate ebb-and-flood (SAEF) soilless substrate system and were harvested after 21 d. Plant yield and morphological characteristics measured at harvest included shoot fresh mass, shoot …
Reactions To Gulf War I And Gulf War Ii In American And Iraqi Cinema And Theatre: The Quest For A Global Utopia, Tajaddin Salahaddin Noori
Reactions To Gulf War I And Gulf War Ii In American And Iraqi Cinema And Theatre: The Quest For A Global Utopia, Tajaddin Salahaddin Noori
Graduate Theses and Dissertations
Many American and Iraqi cultural reactions to Gulf War I and Gulf War II, including the texts selected for this story, expressed the dystopian consequences of these wars. However, this study focuses on exploring the utopian dimensions of the selected texts and investigates how these texts attempt to reconcile both sides of the conflict and produce visions toward a global utopia. Significantly, this study represents the visions toward a global utopia as a series of visions toward oneness. That is, oneness of human beings over otherness, oneness of different nation states under one global community, and oneness of cultural productions’ …
Evaluation Of The Arkansas Double Up Food Bucks Program, Colton G. Henderson
Evaluation Of The Arkansas Double Up Food Bucks Program, Colton G. Henderson
Graduate Theses and Dissertations
Fruit and vegetable consumption is particularly low in Arkansas with only a small percentage of residents meeting daily recommendations. Arkansas also has one of the highest percentages of food insecurity and obesity in the United States. Low-income households, such as Supplemental Nutrition Assistance Program (SNAP) recipients, are at a higher risk of these issues. Financial assistance programs have been implemented to help in aiding these problems. The Double Up Food Bucks program (DUFB) is one of these programs. DUFB provides matching financial vouchers for SNAP benefits recipients spend on fresh local produce at participating grocery stores and farmers’ markets. The …
Determining Cluster Thinning And Storage Effects On Fruit Quality And Marketability Attributes Of Arkansas Table Grapes Grown Under High Tunnel Systems., Virginia Beasley
Determining Cluster Thinning And Storage Effects On Fruit Quality And Marketability Attributes Of Arkansas Table Grapes Grown Under High Tunnel Systems., Virginia Beasley
Graduate Theses and Dissertations
Table Grapes (Vitus vinifera) are highly valued horticulture crops world-wide. Often, table grape production in the southern United States is restricted due to climate and pest issues. Viticulture production could be expanded to this region by the use of controlled environment growing systems, such as high tunnels (HT). The objective of this project was to evaluate the effectiveness of HT systems for grape cultivation and compare the effects of different cluster thinning treatments on vines. In this two-year study, the cultivars Faith, Gratitude, Hope, and Jupiter were grown in HT systems and assessed for postharvest qualities at harvest and during …
Nutritional Supplementation And Skeletal Muscle Health In Chronic Diseases, Hexirui Wu
Nutritional Supplementation And Skeletal Muscle Health In Chronic Diseases, Hexirui Wu
Graduate Theses and Dissertations
Prevalence of chronic diseases in the United States keeps increasing in recent years. There are approximately four in ten adults having chronic diseases in America. Chronic diseases include obesity, aging, heart diseases, cancer and many others. This thesis mainly focuses on obesity and aging. Skeletal muscle performance is impaired in obesity and aging conditions. One common reason causing this could be higher fat mass and lower muscle mass. However, there is no study showing what pathways are involved in the imbalance of body composition. Therefore, the first objective of the thesis is to determine gene expression of selected pathways in …