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Graduate Theses, Dissertations, and Problem Reports (ETD)

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Machine Learning For Environmental Sustainability, Syeda Nyma Ferdous Jan 2024

Machine Learning For Environmental Sustainability, Syeda Nyma Ferdous

Graduate Theses, Dissertations, and Problem Reports (ETD)

This research proposes a comprehensive approach to address pressing challenges in environmental sustainability, agricultural residue management, using machine learning based approaches. Machine learning (ML) techniques have emerged as powerful tools for addressing environmental sustainability challenges by facilitating the analysis and prediction of ecological phenomena, and optimization of resource management strategies. The study explores the synergies between environmental sustainability and machine learning to develop a framework that leverages artificial intelligence techniques covering a wide range of tasks including crop residue management, soil CO2 flux prediction, and forest carbon system prediction for sustainable development. The study analyze various ML models, such as, …


Quantifying Chemical Erosion In The Lithologically-Heterogenous Appalachian Valley And Ridge, Amelia Jayne Zanoni Jan 2024

Quantifying Chemical Erosion In The Lithologically-Heterogenous Appalachian Valley And Ridge, Amelia Jayne Zanoni

Graduate Theses, Dissertations, and Problem Reports (ETD)

Quantifying chemical erosion in the lithologically-heterogenous Appalachian Valley and Ridge

Amelia J. Zanoni

The interplay between physical and chemical erosion is well understood in landscapes underlain by a uniform rock type, but many regions are underlain by a mixture of rock types with varying erosion resistance and solubility. We used measurements of stream-water chemistry to estimate chemical erosion rates in the Appalachian Valley and Ridge, a region where the mechanisms of lithologic control over topography are poorly understood. Newly acquired stream water samples were collected from 51 locations across the research area during the Fall of 2023. The sampled waters …


Zoo Communication: A Study Of Stewardship With Animal Conservation In Zoos Across The United States, Abby Rachelle Lester Jan 2024

Zoo Communication: A Study Of Stewardship With Animal Conservation In Zoos Across The United States, Abby Rachelle Lester

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis investigates the communication strategies employed by zoo professionals to promote engagement and advanec animal conservation education. Through in-depth interviews with zoo experts, the stidy explores the intricate connections between communication practices and stewardship princliples within zoo facilities. Findings from this study contribute to the understanding of effective communication in the realm of animal conservation, with implications for both zoo practitioners and conservation educators. The study delves into the effective strategies for identifying and fostering relationships with environmental stewards, alongside encouraging their involvement in zoo-based animal conservation initiatives. The theoretical implications highlight gaps in existing models, emphasizing the need …


Strategies For Process Systems Mapping And Control Based On Operability Analysis, Victor Manuel Cunha Alves Jan 2024

Strategies For Process Systems Mapping And Control Based On Operability Analysis, Victor Manuel Cunha Alves

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation aims to develop strategies for process systems engineering (PSE) mapping using models, emerging tools and algorithms motivated by process operability analysis research. Such strategies will be employed to ensure simultaneous design and control of large-scale industrial systems. The emerging tools and techniques in this research include supervised machine learning-based (ML-based) operability mapping, automatic differentiation (AD) for implicit mapping, and the development of a systematic mapping approach for control structure selection using operability analysis. Thus far, the developed operability algorithms either recur to nonlinear programming (NLP) solutions which are computationally expensive or to linearizing the underlying modeling task at …


Estradiol’S Role In Timely Puberty Onset In The Ewe, Eliana Gerardine Aerts Jan 2024

Estradiol’S Role In Timely Puberty Onset In The Ewe, Eliana Gerardine Aerts

Graduate Theses, Dissertations, and Problem Reports (ETD)

In female sheep, the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus triggers luteinizing hormone (LH) to be released from the pituitary. Luteinizing hormone, in turn, acts on the ovaries to elicit estradiol (E2) release. E2 acts in a negative feedback manner to control the amount of LH released. The increase in LH release that drives puberty onset results from a decrease in sensitivity to E2 as the animal ages. However, the neural mechanisms mediating this change in sensitivity are not known, as is where in the hypothalamus E2-negative feedback occurs. In the arcuate …


The Impact Of Occupational Therapy In Lactation Services, Sarah Adrienne Mcaninch Jan 2024

The Impact Of Occupational Therapy In Lactation Services, Sarah Adrienne Mcaninch

Graduate Theses, Dissertations, and Problem Reports (ETD)

Many benefits to breastfeeding exist for both mothers and infants, yet exclusive breastfeeding rates remain low across the nation. These benefits include decreased chance of infections for infants, low infant mortality, and decreased chances of breast and ovarian cancers for mothers (Binns et al., 2016; CDC, 2023). Education strategies have recently become imperative for health organizations to help mothers sustain their ability to breastfeed within the recommended six-month timeframe. Current literature on education supports that women who receive education at some point in their lactation journey are more likely to reach the six-month period and have more confidence in their …


Finding “A Good Thing”: Embodying The Traumatic Sustainably, Erika Kuhn Jan 2024

Finding “A Good Thing”: Embodying The Traumatic Sustainably, Erika Kuhn

Graduate Theses, Dissertations, and Problem Reports (ETD)

Contemporary dramatic work such as the play Anatomy of a Suicide by Alice Birch demands a significant toll on the actors embodying the characters. Western pedagogies that emphasize a need for the utmost authenticity must be merged with the modern practice of self-care and trauma informed boundaries. This document outlines the merging of traditional acting techniques of characterization with solutions for self preservation such as preparation, mental and physical upkeep, a personalized set of character de-rolement practices, and social rituals. Through an analysis of the text itself, its context, author, and the lens of one actor’s experience portraying the character …


Resource Affluence And Sustainable Consumer Behavior, Liguo Liu Jan 2024

Resource Affluence And Sustainable Consumer Behavior, Liguo Liu

Graduate Theses, Dissertations, and Problem Reports (ETD)

While resource affluence is desired by most individuals, it may not always be advantageous for a collective group. Recent research documents some “dark side” effects associated with resource affluence, such as reducing people’s willingness to help others or leading to unethical behaviors (e.g., Piff et al. 2012; Vohs et al. 2016). Building on this body of work and advances in sustainability research, this study investigates the impact of financial affluence on sustainable consumer behavior. Using a multi-method approach (archival data and experiments), this study demonstrates that financial affluence leads to less sustainable consumer behaviors compared to a control group, across …


Contracture Management For Acute Burn Injury Patients, Brianna Paige Pestrosky Jan 2024

Contracture Management For Acute Burn Injury Patients, Brianna Paige Pestrosky

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: The Occupational Therapists working within the burn unit at West Penn Hospital assess and treat patients utilizing the biomechanical approach FOR, as well as the support from MOHO and PEOP. The patients seen within the burn unit encompass a variety of injuries and occupational deficits that require an individualized and holistic approach to care.

Purpose: The purpose of the contracture management project is to provide an interdisciplinary approach to improve carryover and patient care within and out of the hospital.

Theoretical framework: The contracture management project is guided using the biomechanical frame of reference as well as supporting constructs …


Global Experiences: How Locality And Space Shape Pedagogical Practices And Experiences Between Western Institutions And Ghanaian Musical Centers, Andrew Patrick Simonette Jan 2024

Global Experiences: How Locality And Space Shape Pedagogical Practices And Experiences Between Western Institutions And Ghanaian Musical Centers, Andrew Patrick Simonette

Graduate Theses, Dissertations, and Problem Reports (ETD)

Pedagogical research on African music and dance practices have conventionally focused on ways in which styles and traditions are taught including, but not limited to, modes of transmission, curriculum structure, and cultural responsiveness. These investigations, and subsequent applications, have contributed towards a deeper understanding of pedagogical structures as related to cultural context and effective modes of teaching and learning African music. At the same time, the impact that space and locality play within African music and dance instruction, particularly as related to learning experiences have been largely overlooked. Locality and space involve several factors that range from elements attributed to …


Examining Invalid Brief Child Abuse Potential Inventory Profiles Within A Randomized Controlled Trial For Toddler-Aged Children And Their Parents, Lindsay Rebecca Druskin Jan 2024

Examining Invalid Brief Child Abuse Potential Inventory Profiles Within A Randomized Controlled Trial For Toddler-Aged Children And Their Parents, Lindsay Rebecca Druskin

Graduate Theses, Dissertations, and Problem Reports (ETD)

Child abuse is a significant public health concern that impacts children worldwide. Efforts to connect at-risk parents with prevention and intervention programs require the use of high-quality measures that evaluate child abuse potential. Researchers frequently use the Child Abuse Potential Inventory (Milner, 1986) and the Brief Child Abuse Potential Inventory (BCAP; Ondersma et al., 2005) which contain Validity indices that evaluate response patterns such as social desirability responding. The measure developers recommended that abuse risk scores from invalid profiles be disregarded in clinical and research settings; however, little is known about factors that may relate to invalid responses and whether …


The Line Between Man And Monster: A Theatrical Costume Design Of Caryl Churchill's The Skriker, Katrina Anne Lundquist Jan 2024

The Line Between Man And Monster: A Theatrical Costume Design Of Caryl Churchill's The Skriker, Katrina Anne Lundquist

Graduate Theses, Dissertations, and Problem Reports (ETD)

Produced at West Virginia University, this is a record of the costume design process for The Skriker by Caryl Churchill. As a play about vicious folkloric faerie creatures in modern day England, there was a heavy emphasis on showcasing the difference between the human and fae characters. With such a fantastical script, there is a potential to take the design down any number of creative paths. Finding a way to cohesively costume the cast while not losing the intricacies of their individual stories became a personal priority. After coming to an agreement with the director and the rest of the …


Its Just A Ride, Pat Loricco Jan 2024

Its Just A Ride, Pat Loricco

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis presents a detailed exploration of the Technical Director's role in a theatrical production through the experience of the production of Ride the Cyclone at West Virginia University. The author covers every stage of the process from budgeting, drafting, and the build, to load-in, technical rehearsals, and strike. Each chapter offers valuable insights into the challenges faced by Technical Directors, from coordinating personnel to managing resources effectively. The narrative is enriched by personal reflections, highlighting the author's growth and lessons learned throughout the production journey. Additionally, this document serves as a comprehensive resource for aspiring Technical Directors, providing guidance …


“Population, Proximity, And Promise: A Study Of College Choice And The Competition For Students In Higher Education”, Donielle Maust Jan 2024

“Population, Proximity, And Promise: A Study Of College Choice And The Competition For Students In Higher Education”, Donielle Maust

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation is an empirical investigation of the relationship between institution and state characteristics and college choice for students enrolling out-of-state, as well as the relationship between Promise programs and college choice. The theoretical framework used in this study draws on both an economic model of human capital investment and sociological concepts of habitus, cultural, and social capital, and organizational context and assumes that an individual’s college choice is shaped by four contextual layers: the individual’s habitus, school and community context, the higher education context, and broader social, economic, and policy context. Public data from the Integrated Postsecondary Education Data …


Synthetic Elaboration Of Β-Carbonyl Alkylboronic Esters, Mason D. Hamilton Ph.D. Jan 2024

Synthetic Elaboration Of Β-Carbonyl Alkylboronic Esters, Mason D. Hamilton Ph.D.

Graduate Theses, Dissertations, and Problem Reports (ETD)

Organoboron compounds are some of the most synthetically versatile compounds in organic chemistry due to the many valuable transformations of the C-B bond. This synthetic versatility combined with the pharmacophoric nature of carboxylic acids has led to an increased interest in the one-pot difunctionalization of vinyl arenes using CO2 and pinacol boranes. Recently, much progress has been made to improve the scope and versatility of boracarboxylation reactions to now include electron-deficient and α-methyl substituted vinyl arenes. However, the potential transformations of boracarboxylated products have remained unexplored. Here, methodologies to transform the β-aryl alkylboronic ester into new C-C, C-N, and …


Transition Readiness, Coping, And Psychological Risk And Protective Factors In Adolescents With Type 1 Diabetes, Jennifer Kelleher Jan 2024

Transition Readiness, Coping, And Psychological Risk And Protective Factors In Adolescents With Type 1 Diabetes, Jennifer Kelleher

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Many adolescents with type 1 diabetes (T1D) find the transition from pediatric to adult healthcare stressful, reporting high levels of diabetes distress and burnout. Although promoting positive coping strategies (primary control, secondary control), and inhibiting negative coping (disengagement) improves health outcomes in youth of transition age, little research has examined how different types of coping relate to transition readiness in T1D. Additionally, it remains unknown what psychological factors predict disengagement coping in adolescents with T1D. Therefore, this study aimed to (1) examine which coping styles predict transition readiness in adolescents with T1D, (2) determine whether diabetes distress mediates …


Evaluating The Impact Of Ergonomic Interventions On Reducing Knee Musculoskeletal Disorder Risks During Residential Roof Shingle Installation: A Phase-Level Analysis, Nazia Zerin Jan 2024

Evaluating The Impact Of Ergonomic Interventions On Reducing Knee Musculoskeletal Disorder Risks During Residential Roof Shingle Installation: A Phase-Level Analysis, Nazia Zerin

Graduate Theses, Dissertations, and Problem Reports (ETD)

The prevalence of knee musculoskeletal disorders (MSDs) among roofers due to awkward kneeling postures during shingle installation is a well-recognized concern. While knee-saving interventions like knee savers (KSs) and knee pads (KPs) have shown the potential to reduce MSD risks, their effectiveness across different phases of shingle installation remains unknown. The objective of this study is to assess how interventions of KSs and KPs alleviate the risks of MSDs in the knees during various phases of shingle installation. These phases include (1) reaching for shingles, (2) placing shingles, (3) grabbing a nail gun, (4) moving to the first nailing position, …


Machine Learning-Driven Quantification Of Co₂ Plume Dynamics At Ibdp Sites Using Microseismic Data, Ikponmwosa Bright Iyegbekedo Jan 2024

Machine Learning-Driven Quantification Of Co₂ Plume Dynamics At Ibdp Sites Using Microseismic Data, Ikponmwosa Bright Iyegbekedo

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis delves into the utilization of machine learning methodologies to quantify the spatial extent of CO₂ plumes by leveraging microseismic data obtained from the Illinois Basin Decatur Project (IBDP) site spanning November 2011 to June 2018. This initiative, focused on the geological sequestration of carbon dioxide, furnishes a unique and comprehensive dataset comprising well logs, microseismic activity records, and CO₂ injection metrics, all crucial for quantifying the subsurface CO₂ saturation plume dynamics. The primary objective is to forecast the temporal evolution of CO₂ saturation plumes in the subsurface, a critical undertaking for ensuring both the environmental integrity and operational …


Sex, Drugs, And Tbi: The Effects Of Sex Hormones And Trkb Activation On Alcohol-Related Behavior Following A Traumatic Brain Injury, Robin B. Oliverio Jan 2024

Sex, Drugs, And Tbi: The Effects Of Sex Hormones And Trkb Activation On Alcohol-Related Behavior Following A Traumatic Brain Injury, Robin B. Oliverio

Graduate Theses, Dissertations, and Problem Reports (ETD)

Traumatic brain injury (TBI) and alcohol use disorder (AUD) exhibit a bidirectional relationship: AUD increases the risk of incurring a TBI and, inversely, a history of TBI increases the risk of future AUD. The second portion of this relationship has not been as thoroughly investigated. Our lab previously demonstrated that a juvenile TBI significantly increases alcohol self-administration in females compared to uninjured females and the injured females developed a conditioned place preference (CPP) for ethanol. Given this stark sex difference, this dissertation will examine the mechanism through which this occurred by investigating how manipulations of sex steroids might affect this …


A Structured Diabetes Continuous Glucose Monitor Education Program To Improve Patient Knowledge And Self-Efficacy, Krystal Abucevicz-Swick Jan 2024

A Structured Diabetes Continuous Glucose Monitor Education Program To Improve Patient Knowledge And Self-Efficacy, Krystal Abucevicz-Swick

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction/background: Continuous glucose monitor (CGM) is a recommended method of glucose monitoring for patients living with diabetes who are on insulin or experience documented hypoglycemia. CGM is a tool that can improve patient management of diabetes but works best when paired with education to achieve the maximum therapeutic benefits.

Purpose: The purpose of this project was (1) to develop an evidence-based structured CGM education program toolkit for people with diabetes who are ordered CGM, (2) to implement the CGM education toolkit into the Diabetes Self-Management and Education Services (DSMES) program at the project site, (3) to improve patient knowledge about …


Implementing A Nurse-Driven Clostridium Difficile Screening Protocol, Sandrela Magnuson Jan 2024

Implementing A Nurse-Driven Clostridium Difficile Screening Protocol, Sandrela Magnuson

Graduate Theses, Dissertations, and Problem Reports (ETD)

ABSTRACT

Background: Clostridium difficile infection (CDI) is a prevalent infection often contracted in hospitals. CDI is also increasingly originating from community settings. In addition to the health risks associated with CDI, diagnosis of a hospital-acquired CDI can have a significant financial impact on hospital systems. When hospital acquired, hospital systems are no longer reimbursed by payers. Secondary to the increasing prevalence of community-acquired CDI, mechanisms for early detection and isolation are warranted.

Local Problem: J.W. Ruby Memorial Hospital has an integrated Clostridium difficile (C. difficile) electronic health record (EHR) screening questionnaire that requires updating to align with current guidelines.

Purpose: …


The Impact Stress On The Fracture Conductivity And The Productivity Of The Marcellus Shale Horizontal Well, Simon Hanna Menhem Jan 2024

The Impact Stress On The Fracture Conductivity And The Productivity Of The Marcellus Shale Horizontal Well, Simon Hanna Menhem

Graduate Theses, Dissertations, and Problem Reports (ETD)

The increase in effective stress during depletion adversely impacts the productivity of the multi-stage fractured Marcellus shale horizontal well. The geomechanical properties and proppant size influence the degree of shale compaction, the fracture conductivity, and the well productivity. This study seeks to assess the impact of net stress increase during depletion on the productivity of multi-stage fractured Marcellus shale horizontal wells. To investigate the impact of the net stress increase, a model for Bogges-5H well was developed based on the petrophysical and geomechanical properties of the shale obtained from the core plugs and well logs measurements from the pilot (Bogges …


Standardizing Nasogastric Tube Securement: A Quality Improvement Initiative, Shannon Lee Thompkins Jan 2024

Standardizing Nasogastric Tube Securement: A Quality Improvement Initiative, Shannon Lee Thompkins

Graduate Theses, Dissertations, and Problem Reports (ETD)

Problem: At a large academic medical center located in the northeastern United States, nasogastric tubes (NGT) were traditionally secured with tape. The institutional policy was nonspecific with no written procedure. The inconsistent use of nasal bridle securement devices (NBSD) and predominant use of tape has the potential to lead to a high rate of NGT dislodgement.

Background: NGT complication and dislodgement rates range from 2%-36% (Gimenes et al., 2019). Stabler et al. (2018) report 29%-63% NGT dislodgement rates in critically ill patients. Patients with intracranial hemorrhage dislodge NGTs in 25% of patients (Rahman et al., 2022)

Available Knowledge: Based on …


Real-Time Cyber-Power Testbed Enhancement And Synchrophasor Data Generation For Anomaly Detection Using Physics-Informed Machine Learning, Vasavi Sivaramakrishnan Jan 2024

Real-Time Cyber-Power Testbed Enhancement And Synchrophasor Data Generation For Anomaly Detection Using Physics-Informed Machine Learning, Vasavi Sivaramakrishnan

Graduate Theses, Dissertations, and Problem Reports (ETD)

Advanced sensing and automation are essential to managing the evolving electric power system with tight coupling of information and power system layer. However, this increasing number of cyber-physical devices brings vulnerabilities from cyber threats and extreme weather events can endanger the power system on a physical level as well. Advanced monitoring and control algorithms with human operators in the loop are needed to enable power system resiliency despite these increasing threats. These advanced algorithms require validation using a realistic test system that mimics real-world scenarios.

This work focuses on a) developing a realistic real-time cyber-power testbed with hardware-in-the-loop to generate …


An Examination Of Coping Resources And Strategies Among Appalachian Transgender And Gender Nonconforming Adults And Youth, Zachary Ramsey Jan 2024

An Examination Of Coping Resources And Strategies Among Appalachian Transgender And Gender Nonconforming Adults And Youth, Zachary Ramsey

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background. The body of literature shows that TGNC adults and youth face a multitude of health disparities (e.g., depression, anxiety, suicidal ideation, eating disorders, body dysmorphia) due to their marginalization. Neither Meyer’s Minority Stress Model nor Testa’s Gender Minority Stress and Resilience Model sufficiently examines coping and the ways it interacts with other concepts within the model. Aims. The objective of this dissertation was to examine the coping resources and strategies of Appalachian transgender and gender nonconforming individuals. The three aims of this study were to: 1) evaluate the relationship of coping resources and strategies between TGNC Youth and cisgender …


A Hyperbolic Relaxation Solver For Numerical Relativity, Thiago Assumpcao Jan 2024

A Hyperbolic Relaxation Solver For Numerical Relativity, Thiago Assumpcao

Graduate Theses, Dissertations, and Problem Reports (ETD)

Numerical relativity (NR) simulations are essential for self-consistently modeling compact binary mergers, whose observations form the heart of gravitational-wave science. Stable NR simulations are the result of mathematical and computational breakthroughs spanning several decades: early attempts to numerically solve the two-body problem in General Relativity (GR) date back to the 1960s, while the first successful black-hole binary merger simulations were performed in 2005 with the generalized harmonic coordinates, and in 2006 using the moving-puncture gauge.

Today, NR continues to drive progress in gravity research, with ongoing efforts focused on increasing physical realism in simulations containing matter, exploring alternative theories of …


X-Ray Absorption And Related Studies In Superconducting Devices And Magnetic Thin Films, Ghadendra Bahadur Bhandari Jan 2024

X-Ray Absorption And Related Studies In Superconducting Devices And Magnetic Thin Films, Ghadendra Bahadur Bhandari

Graduate Theses, Dissertations, and Problem Reports (ETD)

Superconducting and magnetic thin films are commonly used in sensors for analytical detectors, especially those that operate at very low temperatures, often below 1 Kelvin. These highly sensitive detectors, capable of functioning across a broad range of wavelengths, have garnered significant interest in scientific research. The focus of this thesis is to address a material challenge associated with an emerging technology known as microwave kinetic inductance detectors (MKIDs). The research involves the study of Al/Si and Al-Mn/Si-based thin films, as well as an investigation into the magnetic properties of LaMnO₃ thin films. LaMnO₃, a perovskite thin film that plays a …


A Floquet Solver For Time Periodic Open Quantum Systems, Fenton Ross Clawson Jan 2024

A Floquet Solver For Time Periodic Open Quantum Systems, Fenton Ross Clawson

Graduate Theses, Dissertations, and Problem Reports (ETD)

Computational physics has been a backbone of experimental and theoretical physics since the 1940’s, when the first nuclear bomb and ballistic simulations were per- formed at Los Alamos Laboratory. Nowadays, however, simulation of open quan- tum systems has been formalized into coding packages and user-friendly functions, such as QuTiP or Qiskit, which allow users to simulate these systems without hav- ing the in-depth knowledge required to build the computational backbone from the ground-up. With the shift in modern quantum physics towards the realization of quantum computation, a strong computational background is still necessary to lend validity to theoretical results and …


Novel Membrane Materials For Nutrient Recovery From Nutrient-Rich Resources, Km Prottoy Shariar Piash Jan 2024

Novel Membrane Materials For Nutrient Recovery From Nutrient-Rich Resources, Km Prottoy Shariar Piash

Graduate Theses, Dissertations, and Problem Reports (ETD)

Global demand for fertilizer production is expanding substantially to meet the food demand of an increasing world population. Anaerobic digestate (AD) of various centralized wastewater facilities contains substantial amounts of ammonium (NH4+) (300-800 mg/L), potassium (K+) (13-120 mg/L), and phosphorus (P) (30-100 mg/L)- based nutrients. In addition to reducing energy costs and CO2 emissions compared to conventional fertilizing raw material manufacturing, recovering nutrients from these waste streams could help mitigate problems such as eutrophication, which otherwise incurs billions of dollars losses to US economy annually. Apart from nutrients, wastewater streams also contain organic pollutants …


Cell-Type-Specific Effects Of Synaptic Zinc In Mouse Auditory Cortex, Mason Mccollum Jan 2024

Cell-Type-Specific Effects Of Synaptic Zinc In Mouse Auditory Cortex, Mason Mccollum

Graduate Theses, Dissertations, and Problem Reports (ETD)

Synaptic zinc signaling modulates synaptic activity and is present in specific populations of cortical neurons, suggesting that synaptic zinc contributes to the diversity of intracortical synaptic microcircuits and their auditory tuning properties. Stimulus-specific adaptation is a hallmark of sensory processing in which a repeated stimulus results in diminished successive neuronal responses, but a deviant stimulus will still elicit robust responses from the same neurons. Recent work has established that synaptically released zinc is an endogenous mechanism that shapes neuronal responses to sounds in the auditory cortex. Here, to understand the role of zinc signaling in the auditory cortex and the …