Role Of Β4b-Tubulin (Tubb4b) In The Sensory System And Spermatogenesis, Urikhan Sanzhaeva

Graduate Theses, Dissertations, and Problem Reports (ETD)

Microtubules are ubiquitous cytoskeletal filaments essential in the function of eukaryotic cells. These polymers, comprised of αβ-tubulin heterodimers, are critical for cell division, intracellular transport, and formation of the axonemes of cilia and flagella. This functional diversity of microtubules is attributed to the incorporation of various α- and β-tubulin isotypes encoded by different genes. Indeed, mutations in human tubulin genes have been linked to various tissue-specific diseases, suggesting a unique function for each tubulin isotype. Mutations in the β4B-tubulin gene (TUBB4B) are associated with sensorineural hearing loss, Leber Congenital Amaurosis (LCA), a severe childhood blindness, and primary ciliary dyskinesia …

History Of Federal International Education Policy (1900-2024): A Four-Dimensional View In Action, Winda Wastu Melati

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation examines the history of the evolution of United States international education policy from 1900 to 2024, employing document analysis methodology to explore key themes that have shaped its trajectory. The study utilizes Cooper et al.'s (2004) Four-Dimensional View of Policy theory (normative, structural, constituentive, and technical) to analyze the complex interplay between diplomatic objectives, economic considerations, national security concerns, immigration, internationalization of higher education, and international students in the United States. The research traces major policy shifts from early initiatives like the Boxer Indemnity Scholarship Program to post-9/11 security measures and recent administrative changes by examining primary sources …

Pilot Quality Improvement Project To Update Surgeon Preference Cards Of A Community Hospital's Orthopedic Service, Jessica R. Mitchell

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

Implementation of a Pilot Quality Improvement Project to Update Surgeon Preference Cards

of a Community Hospital’s Orthopedic Service

Jessica R. Mitchell

Problem Statement: Over time, surgeons change preferences for surgical equipment, and their preference cards need updating. Failure to update preference cards leads to impaired staff communication, opening of unnecessary equipment, excess waste, increased cost to patients and facilities, and potential threats to patient safety.

Background: Members of the orthopedic surgical team in a community hospital in suburban West Virginia wanted to establish a process to regularly update outdated surgeon preference cards (SPC) for several common orthopedic procedures. The …

Life Cycle Impacts Of Hardwood Forest Resources For Sustainable Bioenergy And Bioproducts In The Eastern United States, Jinghan Zhao

Graduate Theses, Dissertations, and Problem Reports (ETD)

A life-cycle impact assessment of hardwood resources across the eastern United States was conducted based on the life-cycle inventory data for hardwood forest resource management and was integrated with the Forest Vegetation Simulator (FVS). This integration allowed for the analysis of forest carbon dynamics in the four subregions: northeast (NE), mid-Atlantic (MA), southeast (SE), and northcentral (NC). The system boundary was selected to be consistent with the A1 module (extraction and upstream production) required by an Environmental Product Declaration (EPD) for wood products. The results indicated that uneven-aged management (UA) yielded higher carbon stocks than even-aged management (EA) across all …

Demonstrating The Need For Intergenerational Trauma-Specific Substance Use Treatment For Mothers Receiving Substance Use Treatment And Their Children, Brittany Ti-Esha Smith

Graduate Theses, Dissertations, and Problem Reports (ETD)

For decades the United States has faced substance use epidemics that have devastating public health consequences, with the most recent epidemic being the opioid epidemic. While the substance that is the center of the epidemic’s changes over time, one factor that has been found to be positively related to substance use has remained consistent, that preventable risk factor is adverse childhood experiences (ACEs). Those who experience ACEs are at elevated risk for developing SUD. If the trauma that is a result of experiencing ACE is not treated it can complicate recovery and impact the individuals’ families. The children of individuals …

"Where Did Your Christ Come From?", Kamara V. Townes

Graduate Theses, Dissertations, and Problem Reports (ETD)

This written document is the accompanying thesis for my Master of Fine Arts Exhibition, “WHERE DID YOUR CHRIST COME FROM?”, shown at Gallery 937 in downtown Pittsburgh, Pennsylvania (displayed April 5th-June 9th, 2024). Through painting, sculpture, and installation, I rely on an intuitive artmaking practice to create work that makes commentary on race, gender and identity. This thesis documents my research on contemporary influences, experimentation with materials and my point of view in conversation with intersectional feminism while navigating institutional racism.

Conceptually the work of my thesis is deeply influenced by womanism and Black culture, which informs my exploration …

Developing And Adapting An Art Therapy Mask Creation (Atmc) Intervention For Individuals With Traumatic Brain Injury (Tbi) Across Select Clinical And Non-Clinical Settings, Stephen John Heck

Graduate Theses, Dissertations, and Problem Reports (ETD)

The study aimed to explore the feasibility and adaptation of the Art Therapy Mask Creation (ATMC) technique in select clinical and non-clinical settings for individuals with traumatic brain injuries (TBIs). Utilizing the Consolidated Framework for Implementation Research (CFIR), qualitative interviews were conducted to assess barriers, facilitators, and feasibility of implementing the ATMC. Major findings included the ATMC’s adaptability across diverse settings, the flexibility and accessibility of art therapy as an intervention, and the significance of addressing emotional and psychological needs in individuals with TBIs. These insights contributed to understanding evolving healthcare practices, the role of technology, the importance of human …

Bystander Interventions For Sexual Assault Prevention Among Students In Greek Life, Caterina Defazio

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Bystander-based sexual violence (SV) prevention programs are critical on college campuses to meet federal Title IX requirements and have proven effective in reducing violence. Greek-affiliated students (members of fraternities and sororities) are at a higher risk for sexual assault than their peers, yet current training programs often do not address their specific needs. This dissertation comprises three interconnected studies that collectively aim to improve bystander intervention strategies for this high-risk group. Aim 1 - Scoping Review: A scoping review was conducted to identify and describe bystander intervention programs delivered to Greek-affiliated students in the US and Canada. An eight-database …

Power Safety Plan Checklist As An Intervention In The Operating Room, Scott John Fankhauser

Graduate Theses, Dissertations, and Problem Reports (ETD)

ABSTRACT

Power Safety Plan Checklist as an Intervention in the Operating Room

Scott J. Fankhauser

Background: Intraoperative power failures (IOPF) force anesthesia providers to quickly make decisions to prevent patient harm when equipment does not operate as designed. Familiarity with alternative methods is critical during this decision process to deliver high-quality care during IOPF events. Purpose: The purpose of this project was to assess the impact of a checklist on anesthesia providers’ perceptions regarding continuation of care during an IOPF. Interventions: Pre- and post-intervention surveys were conducted during a simulation and education setting for annual competencies. Methods: The study …

Relationships Among The Concepts Of Organizational Theory And Nurse Burnout Before And After Covid-19, Bridget M. Webb

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Nurse burnout is a global health priority that has been compounded by Coronavirus 2019 (COVID-19). Organizational theory states that nurse burnout is directly impacted by operant mechanisms (nurse characteristics, nurse specialization) and hospital-wide models. The purpose of this study is to determine the relationship between hospital wide models (evidence-based care, team-based care, discharge planning, care coordination), operant mechanisms (nurse characteristics, nurse specialization), and outcomes (nurse burnout) before and after COVID-19.

Research Question: The specific aim of this study is to determine the relationship between hospital wide models (evidence-based care, team-based care, discharge planning, care coordination) and operant mechanisms (nurse …

Synaptic Zinc Transporters Support Normal Synapse Structure And Function In Mouse Auditory Cortex, Abbey Manning

Graduate Theses, Dissertations, and Problem Reports (ETD)

Many regions of the brain are highly enriched with free zinc inside glutamatergic vesicles at presynaptic terminals. At these synapses, zinc transporter 3 (ZnT3) moves zinc into vesicles where it is co-released with glutamate. Alterations in ZnT3 are implicated in multiple neurodevelopmental disorders, and ZnT3 knock-out (KO) mice – which lack synaptic zinc – show behavioral deficits associated with autism spectrum disorder and schizophrenia. Shank3 is a synaptic scaffolding protein that assists in tethering and organizing structural proteins and glutamatergic receptors in the postsynaptic density of excitatory synapses. The localization of Shank3 at excitatory synapses and the formation of stable …

Implementation Of A Targeted “Micro-Learning” Inpatient Diabetes Education Program In A Rural Hospital Setting, Melissa Lynn Fannon-Wisner

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction/Background: Diabetes affects a large portion of Americans and West Virginians annually. Inpatient hospitalization provides an opportunity to provide evidence-based diabetes education to patients. A lack of access to diabetes education at rural hospitals across the United States exists, creating a need for patients who require education while hospitalized. An intervention needs to be explored to bridge the gap for patients that need education when the diabetes educator is not available.

Purpose: The purpose of this Doctor of Nursing Practice (DNP) project is to create and implement a video micro-learning diabetic education series that can be utilized for diabetes self-management …

Advancing Gfrp Column Design: Strength, Effective Lengths, And Failure Modes, Jack Alan Wykle

Graduate Theses, Dissertations, and Problem Reports (ETD)

Glass fiber reinforced polymer (GFRP) composites have become an increasingly popular choice in construction industry due to their higher strength-to-weight ratio, ease of manufacture including lower Embodied Carbon Factor, and better durability in harsh environmental conditions than conventional structural construction materials. Currently, GFRP composite column design lacks well-established design standards due to the material's unique properties such as lower bending and shear stiffness than steel, differing compressive and tensile moduli, which leads to complexities in computing buckling capacities under local effects such as flange or web buckling and even torsional buckling under off-centered compression loading. Therefore, GFRP columns will behave …

Ung: A Diagnostic Standard C Library, Jakob Knute Kaivo

Graduate Theses, Dissertations, and Problem Reports (ETD)

Undefined behavior in C programs is a major source of unreliable software. Many of the most common exploitable software vulnerabilities can be traced directly to undefined behavior. In the increasingly connected world, a successful attack can cost the victim millions of dollars to recover from. While static program analysis aids in identifying undefined behavior, testing indicates that even the best static analysis tools correctly identifies about 35% of these defects. This dissertation introduces UNG’s Not GNU (UNG), a standard C library designed to mitigate undefined behavior. Where others have seen opportunities for optimization, UNG makes every effort to identify undefined …

Embedded State Estimation For Optimization Of Cislunar Space Domain Awareness Constellation Design, Thomas Henry Clareson

Graduate Theses, Dissertations, and Problem Reports (ETD)

The traffic in cislunar space is expected to increase over the coming years, leading to a higher likelihood of conjunction events among active satellites, orbital debris, and non-cooperative satellites. This increase necessitates enhanced space domain awareness (SDA) capabilities that include state estimation for targets of interest. Both Earth surface-based and space-based observation platforms in geosynchronous orbit or below face challenges such as range, exclusion, and occlusion that hinder observation. Motivated by the need to place space-based observers in the cislunar space regime to overcome these challenges, this paper proposes a cislunar SDA constellation design and analysis framework that integrates state …

Diet And Population Genomics Of River Otters (Lontra Canadensis) In West Virginia, Eden Grace Nitza

Graduate Theses, Dissertations, and Problem Reports (ETD)

North American river otters (Lontra canadensis), hereafter, otters, are apex predators in aquatic ecosystems across Appalachia, and thus have important impacts on their ecosystems such as food web regulation, nutrient cycling, and reducing the impacts of invasive species. Otters were extirpated from most of Appalachia, including all of West Virginia, by the mid-1900’s due to habitat destruction and overharvest. The West Virginia Division of Natural Resources (WVDNR) began an otter reintroduction program in 1984 which translocated approximately 250 otters into the state by 1997. This reintroduction program was largely considered successful, and a regulated harvest season was opened …

Development Of Probabilistic Dynamic Model Building And Bayesian Machine Learning Approaches, Samuel Oladayo Adeyemo

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

Development of Probabilistic Dynamic Model Building and Bayesian Machine Learning Approaches

Samuel Adeyemo

The recent years have seen a tremendous increase in the use of artificial intelligence (AI) and machine learning (ML) for the development of data-driven mathematical models needed for performing real-time optimization, model-based control, performance optimization, dynamic data reconciliation, and process performance monitoring. However, the development of data-driven models is faced with some challenges including lack of model interpretability, sensitivity of algorithm to noise in training data, limited extrapolation capabilities and violation of conservation laws. Drawing motivation from these existing gaps, this work aims to develop robust …

Spatial Degradation And Livelihood Diversification In The Ever-Changing Landscape Of Pastoralist Kajiado, Kenya, John A. Paine

Graduate Theses, Dissertations, and Problem Reports (ETD)

The study centers on both internal and external pressures on Maasai communities, such as environmental changes and socio-economic shifts, all of which are rapidly changing. It further examines the historical colonial context in Kajiado that has led to spatial degradations - a decline in an objective geographic area's function, usage, or ecological health. Such degradation has taken on different forms based on varying cultural, environmental, and livelihood-centered understandings and motivations. Understanding this is particularly important to investigation of how the cultural identity of the Maasai shapes realities and informs decisions about livelihoods. This idea is especially relevant when, out of …

The Effects Of Feed Manufacture On Exogenous Enzymes, Starch Gelatinization, And Antinutritional Factors Associated With Soybeans, Kristina M. Bowen

Graduate Theses, Dissertations, and Problem Reports (ETD)

This doctorate dissertation consists of four individual studies with the overarching theme of the effect of feed manufacture on exogenous enzymes and antinutrients found in soybeans.

Study 1. Including exogenous enzymes in poultry diets can liberate nutrients that are typically inaccessible to monogastric animals. Phytase feeding research has traditionally been conducted by rearing broilers in raised wire cages, whereas commercially grown broilers are reared on built-up litter. Therefore, cage-based studies may not accurately represent commercial bird performance response to phytase. Birds with access to litter consume it, possibly increasing phosphorus intake leading to suggestions that lower phytase concentrations are required. …

Modeling And Techno-Economic Optimization Of Microwave Assisted Ammonia Synthesis Processes, Opeyemi Aduragbemi Ogunniyan

Graduate Theses, Dissertations, and Problem Reports (ETD)

Ammonia, which plays a crucial role in agriculture, chemical production, and energy storage applications, has traditionally been produced using the Haber-Bosch (HB) process. However, this well-established technology has significant drawbacks. The HB process requires extremely high pressures (up to 300 bar) and temperatures (400-500°C), making it feasible only for large-scale operations with substantial capital investment. Additionally, the high energy consumption of the HB process contributes significantly to greenhouse gas emissions, raising concerns about its environmental sustainability. This dissertation extensively explores a new low-pressure microwave-assisted process for synthesizing ammonia, demonstrating its economic viability and potential cost-effectiveness compared to the traditional method, …

Development Of Dynamic Mass-Energy-Thermodynamics Constrained Hybrid Neural Network Models For Process Systems Applications, Angan Mukherjee

Graduate Theses, Dissertations, and Problem Reports (ETD)

First-principles models can provide very good predictions even for cases when there are no data at all, or data are limited in certain range of operating conditions, or for cases where data collection is infeasible. However, the development of accurate first-principles models for complex nonlinear dynamic systems can be time consuming, computationally expensive, and may be infeasible for certain systems due to lack of sufficient knowledge (information). It is also challenging to adapt first-principles models for time-varying systems. Furthermore, it can be difficult, if not impossible, to develop accurate models for some complex phenomena that are poorly understood. On the …

Application Of The Expert Algorithm For Substance Identification (Easi) To Predict Astm E1618-19 Ignitable Liquid Classes From Gas Chromatography-Mass Spectrometry Data Of Ignitable Liquid Residues, Hannah L. Mcmillen

Graduate Theses, Dissertations, and Problem Reports (ETD)

Arson investigators require reliable and objective methods to interrogate fire debris for the presence of ignitable liquid residues. Although standard methods like ASTM E1618-19 exist for such procedures, these methods typically do not rely on quantitative measures but instead rely on the subjective judgment of fire debris analysts. To provide a more objective means to interpret fire debris evidence, we examined the ability of the Expert Algorithm for Substance Identification (EASI) to identify ignitable liquid classes from the total ion spectrum (TIS) of gas chromatography-mass spectrometry (GC-MS) data files. TISs have been promoted by others to help remove variability caused …

How Does Locality Impact The Sales And Purchases Of Textiles And Apparel? Exploring Retailers' And Consumers' Perspectives In The U.S., Md Rokibul Hasan

Graduate Theses, Dissertations, and Problem Reports (ETD)

The revival of U.S. textile and apparel (T&A) manufacturing is largely attributed to rising consumer interest in locally-produced goods, the pursuit of economic sustainability, and the need to mitigate environmental impacts. This study aims to fill a critical research gap by examining the perceptions and behaviors of both U.S. retailers and consumers regarding locally-made T&A products. Utilizing the theory of planned behavior (TPB) as a theoretical framework, the research explores the constructs of attitudes, subjective norms, and perceived behavioral control to elucidate the factors affecting local T&A sales and purchases. The study employs semi-structured interviews with nine U.S. retailers and …

State Estimation And Economic Analysis For Electrochemical Sensor-Based Corrosion Monitoring, Chandra Sekhar Somayajula

Graduate Theses, Dissertations, and Problem Reports (ETD)

Coal is currently the third-largest source of electricity production in the U.S. However, renewables are projected to be the primary source of electricity production in the future. Though coal-fired power plants (CFPPs) are rapidly retiring in the U.S., many CFPPs worldwide are expected to stay operational for a while due to factors like easy and cheap access to comparatively inexpensive coal. Therefore, non-renewable sources like coal are still expected to be prevalent and be used to ensure the stability of the electric grid in the foreseeable future. The existing coal-fired power plants generally designed to operate at base-loaded conditions are …

An Approach For Robotic Pollination That Utilizes Imitation Learning, Ronald Michael Butts Ii

Graduate Theses, Dissertations, and Problem Reports (ETD)

The global decline in pollinator populations poses a significant threat to agriculture, motivating the development of robotic pollination systems. Previous works demonstrated successful robotic pollination of bramble flowers using visual servoing; however, pollination was limited to specific flower orientations. As such, the objective of this work is to develop a robotic pollination system that is capable of pollinating a wider range of orientations.

This research introduces an imitation learning-based framework for robotic pollination that positions the manipulator to view chosen flowers in specific orientations. The developed model leverages object detection (YOLOv8) to identify individual flowers and a convolutional neural network …

Autonomous Object Search Planning In Large-Scale Environments, Matthew A. Collins

Graduate Theses, Dissertations, and Problem Reports (ETD)

The advancement of autonomous search holds significant promise for applications ranging from emergency response to planetary exploration. This thesis investigates strategies to enhance autonomous search performance in large-scale environments. The main contribution of this work is its practical application in real-world scenarios, where efficient search methods are essential for managing vast amounts of data, particularly in large environments. Effective search planning requires navigating complexities such as limited prior information and managing large state spaces, necessitating advanced strategies to plan with this limited information. Additionally, balancing exploration and exploitation is crucial for optimizing the search process, as it ensures thorough coverage …

Spiral Wave Teleportation And Multiplex Network Synchronization In Light Sensitive Belousov-Zhabotinsky Systems, Shannyn Alicia Tyler

Graduate Theses, Dissertations, and Problem Reports (ETD)

We experimentally and computationally investigate dynamical behaviors in excitable and oscillatory media using light sensitive Belousov-Zhabotinsky (BZ) systems. These systems are not in a state of thermodynamic equilibrium, and have been proven to show various interesting phenomena including spatiotemporal patterns, self-organization, and chaos. We utilize the BZ reaction, a nonlinear chemical reaction, known for its relaxation-type oscillations, to explore the dynamics of these systems.

We examine spiral wave teleportation in an excitable media as an effective alternate defibrillation method. Spiral waves have emerged as a key phenomenon associated with the initiation and persistence of cardiac arrhythmias. Using a light sensitive …

Making Something Out Of Nothing: Immobility As An Operant, KaʻAla K. Bajo

Graduate Theses, Dissertations, and Problem Reports (ETD)

The tradition of research in the experimental analysis of behavior generally emphasizes the analysis of overt, discrete responses such as lever presses or key pecks. Reflecting this emphasis, definitions of behavior involve the observable action or movement of an organism through space. Although continuous responses involving little to no movement, such as “holding still” or “immobility”, fall outside these definitions, immobility is a form of continuous, operant responding that can be learned and experimentally controlled. Three experiments were conducted to investigate parameters surrounding immobility as an operant. In Experiment 1, immobility in the form of platform-standing bouts was shaped and …

Cellular Level Changes Induced In Cancer Cells Due To Microgravity, Sai Deepika Reddy Yaram

Graduate Theses, Dissertations, and Problem Reports (ETD)

The increase in human activity in space has revealed several kinds of physiological challenges brought on by the absence of Earth's gravitational pull. NASA observed that during spaceflight, astronauts experience a 1-1.5% monthly loss in the mineral density of weight-bearing bones, with rehabilitation efforts on Earth often proving ineffective. This issue extends to muscles, the neuro vestibular system, the cardiovascular system, and vision. Cancer has emerged as a significant cause of mortality among astronauts, with studies up to 2017 showing that 41.3% of natural cause deaths among U.S. astronauts were due to cancer, primarily due to space radiation exposure. Cancer …

Policy Dynamics In Young Democracies: Attention, Electoral Change, And Responsiveness In Ghana And South Africa, Christiana Bugri

Graduate Theses, Dissertations, and Problem Reports (ETD)

My dissertation is a collection of three essays that assess the nature of government attention in young democracies. Theories of the policy process focus on policy dynamics in Western democracies with little application to non-Western democracies. This dissertation bridges this gap by studying policy dynamics in the neopatrimonial democracies of Ghana and South Africa. The dissertation sheds light on how the unique features of young democracies (centralization, clientelism, and powerful executives) shape government attention, responsiveness to public opinion, and the importance of elections in policy change. The first essay examines the dynamics of government attention and how the neopatrimonial nature …