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In Vitro Metabolism Of The Synthetic Cannabinoids Px-1, Px-2, Px-3 And A Comparison Of Their Clearance Rates In Human Liver Microsomes, Travon Cooman

Graduate Theses, Dissertations, and Problem Reports (ETD)

Detection of SCs in body fluids continue to be a challenge because of limited metabolism data, lack of standards and reference mass spectrometry data. In vivo and in vitro experiments help elucidate metabolite markers for novel psychoactive substances and can prompt synthesis of standards to verify proposed metabolites. In this study, metabolism of three SCs N-(1-amino-1-oxo-3-phenylpropan-2-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamine (PX-1), N-(1-amino-1-oxo-3-phenylpropan-2-yl)-1-(5-fluropentyl)-1H-indazole-3-carboxamide (PX-2), and N-(1-amino-1-oxo-3-phenylpropan-2-yl)-1-(cyclohexylmethyl)-1H-indazole-3-carboxamide (PX-3) were investigated using human liver microsomes. Previous studies showed PX-3 as the most potent CB1 and CB2 receptor agonist.

Half-life and clearance data were acquired using liquid chromatography- tandem mass spectrometry. Metabolite elucidation was performed using liquid chromatography …

Impacts Of Climate Change On Water Balance Components In The Central Appalachian Mountains, Usa, Brandi Anne Gaertner

Graduate Theses, Dissertations, and Problem Reports (ETD)

This research investigated the impact of climate and land cover on water balance components including evapotranspiration and runoff in the mountainous central Appalachian region of the United States. The first studyanalyzed trends in climatologic, hydrologic, and growing season length variables, identified the important variables effecting growing season length changes, and evaluated the influence of a lengthened growing season on increasing evapotranspiration trends. The results showed that growing season length has increased, on average, by ~22 days and evapotranspiration has increased ~12 mm. The second study quantified long-term historical and future climate trends, evaluated water balance sensitivity to change, and quantified …

Automatic Kinship Verification In Unconstrained Faces Using Deep Learning, Naman Kohli

Graduate Theses, Dissertations, and Problem Reports (ETD)

Kinship verification has a number of applications such as organizing large collections of images and recognizing resemblances among humans. Identifying kinship relations has also garnered interest due to several potential applications in security and surveillance and organizing and tagging the enormous number of videos being uploaded on the Internet. This dissertation has a five-fold contribution where first, a study is conducted to gain insight into the kinship verification process used by humans. Besides this, two separate deep learning based methods are proposed to solve kinship verification in images and videos. Other contributions of this research include interlinking face verification with …

On Matching Faces With Temporal Variations Using Representation Learning, Daksha Yadav

Graduate Theses, Dissertations, and Problem Reports (ETD)

Developing automatic face recognition algorithms which are robust to intra-subject variations is a challenging research problem in the computer vision research community. Apart from the well-studied covariates such as pose and expression, temporal variations in the facial appearance also lead to a decline in the performance of face recognition systems. This research focuses on analyzing the temporal variations in facial features due to facial aging, facial plastic surgeries, and prolonged illicit drug abuse. The contributions of this dissertation are fivefold: (i) behavioral and neuroimaging studies are conducted to understand the human perception of faces affected by temporal variations, specifically facial …

On Generative Adversarial Network Based Synthetic Iris Presentation Attack And Its Detection, Naman Kohli

Graduate Theses, Dissertations, and Problem Reports (ETD)

Human iris is considered a reliable and accurate modality for biometric recognition due to its unique texture information. Reliability and accuracy of iris biometric modality have prompted its large-scale deployment for critical applications such as border control and national identification projects. The extensive growth of iris recognition systems has raised apprehensions about the susceptibility of these systems to various presentation attacks.

In this thesis, a novel iris presentation attack using deep learning based synthetically generated iris images is presented. Utilizing the generative capability of deep convolutional generative adversarial networks and iris quality metrics, a new framework, named as iDCGAN is …

Analysis Of User Preference With N95 And Powered Air-Purifying Respirators In A Healthcare Work Environment, Brittany Renee Carver

Graduate Theses, Dissertations, and Problem Reports (ETD)

For those working in the healthcare field, personal protective equipment is vital. Healthcare workers are often first responders when it comes to dealing with patients who are infected or when a disease outbreak occurs. The Occupational Safety and Health Administration (OSHA) requires all healthcare operations to provide employee protection against blood borne pathogens. With the increase of life-threatening disease outbreaks, such as SARS in 2003 and Ebola in 2014, it is of the upmost importance to make sure respirators are best suited for users and acceptable for long term use. It has been shown through previous studies that due to …

Numerical Modeling Of Hydraulic Fracture Propagation And Comparison With Microseismic Data At A Field Site, Carter Lawrence Hulcher

Graduate Theses, Dissertations, and Problem Reports (ETD)

A hydraulic fracturing site in Morgantown, West Virginia, USA was selected to be a research site for the Marcellus Shale Energy and Environment Laboratory (MSEEL) project which was funded by the U.S. Department of Energy (DOE). The overall objective of the MSEEL research project is to evaluate and improve technologies to enhance shale gas recovery with minimal impacts on the environment. The field site has two previously drilled wells and two newly drilled wells for extracting natural gas. A separate exploratory well (or “science well”) was also drilled and includes a geophone array to extract important seismic/microseismic event information, which …

Characterization Of Major Flavonols In Ramps (Allium Tricoccum), Wijdan M. Dabeek

Graduate Theses, Dissertations, and Problem Reports (ETD)

Ramps (Allium tricoccum) is a traditional plant in the eastern Appalachian Mountains. Ramps have been used in Appalachian folk medicine for its health promoting roles in lowering blood pressure and cholesterol. Information on the chemical composition of bioactive components responsible for the potential health benefits are scarce. Analysis of the chemical composition in similar Alliumplants showed that flavonols, induced similar health benefits. Therefore, the aim of this work is to characterize major flavonol conjugates in ramps. The secondary aim is to develop a preliminary quantification protocol. Flavonol glycosides were extracted in 50% methanol and 3% acetic acid. …

A Framework For Energy Optimization Of Small, Two-Stroke, Natural Gas Engines For Combined Heat And Power Applications, Mahdi Darzi

Graduate Theses, Dissertations, and Problem Reports (ETD)

This research was focused on the development of a framework for the energy optimization a natural gas engine for small combined heat and power (CHP) applications operating with low-pressure natural gas (NG) available at homes. The required targets of the ARPA-E GENSETS program for 1 kW electric power generation and previous GENSETS simulation at West Virginia University, suggested a design space for the engine which is currently dominated by simple two-stroke designs. Hence this research focused on screening, modeling, and experimentally evaluation of cost-effective technologies to achieve a system design that maximized thermal efficiency and utilization factor, while reducing emissions. …

Development Of Ni-Based Oxide Dispersion Strengthened (Ods) Powder Particles For Metal Additive Manufacturing (Am) Applications, Markova Dion Mcpherson

Graduate Theses, Dissertations, and Problem Reports (ETD)

The capabilities of Additive Manufacturing (AM) techniques has grown rapidly in recent years, however, current available metal powders for AM processes, such as Powder Bed Fusion and Directed Energy Deposition, are limited and primarily fabricated through atomization processes; the atomization process is capable of producing metal powders 15 µm to 150 µm in size, uniform size distribution, and spherical shape. Despite the advantages of atomization process, iron or nickel-based Oxide Dispersion Strengthened (ODS) powders, with nanocrystalline microstructure, cannot be produced with the atomization process because of the high temperature of yttrium (III) oxide (Y₂O₃, 2425 °C) …

Computer-Assisted Instruction Compared To Traditional Instruction On Letter Recognition For Preschoolers With Special Needs, Jamie Nicole Harvey

Graduate Theses, Dissertations, and Problem Reports (ETD)

The need to reach learners with disabilities in inclusive early childhood classrooms has grown with increasing legislative mandates. An essential area of focus is in early literacy and alphabet letter recognition. One such way to bridge the gap includes computer assisted instruction as an instructional method. A concurrent treatment single case design was used to compare the rate of letter acquisition in young children with disabilities (n=6) between computer assisted instruction program, Teach Town Basics™, and traditional teaching of concepts in early childhood inclusive classrooms. Participants received each treatment in random order and data were graphed daily on …

The Role Of Communication Accommodation In Mother-In-Law/Daughter-In-Law Relationships, Erin Claire Shelton

Graduate Theses, Dissertations, and Problem Reports (ETD)

The goal of this thesis was to further the literature on mother-in-law/daughter-in-law relationships by directly employing Communication Accommodation Theory (CAT) to examine relationships between categories of accommodation and relational quality in these relationships. Daughters-in-law (N= 677) were solicited via private Facebook groups to complete an online survey regarding accommodation (their own and their mothers-in-law’s), their feelings of shared family identity, and their relationship satisfaction in their relationship with their mothers-in-law. Results demonstrated relationships between mothers-in-law’s accommodation, overaccommodation, and underaccommodation of their daughters-in-law and daughters-in-law’s feelings of shared family identify and relationship satisfaction. Additionally, relationships were present between daughters-in-law’s …

In Situ Measurement Of Fatigue Induced Crack Growth In Inconel 718 Using Direct Current Potential Drop Method, Joel C. Lindsay

Graduate Theses, Dissertations, and Problem Reports (ETD)

With recent advances in air breathable engines comes more extreme temperature environments that engine components must tolerate. During the design of these engines, it is necessary to understand how material fatigue failures occur at these new, higher operating temperatures. In providing understanding, the following fundamental study focuses on the statistical nature of crack jumps (changes in crack length over time) during fatigue in a polycrystalline nickel-based superalloy, Inconel 718 (IN718). In situ measurement of the crack length at several loading conditions were conducted using a direct current potential drop (DCPD) measurement method. Experimental data was collected at six different fatigue …

A Critical Assessment On The Resources And Extraction Of Rare Earth Elements From Acid Mine Drainage, Christopher R. Vass

Graduate Theses, Dissertations, and Problem Reports (ETD)

Rare earth elements (REEs) are crucial to many modern products used in both civilian and defense applications. Currently, a reliable supply of these elements is uncertain with the clear majority of REE production and refining occurring predominately in China. Furthermore, domestic ore deposits with commercially attractive concentrations of REEs are uncommon in the United States. As a result, the identification of a domestic supply of these technology metals is essential not only for manufacturing consumer merchandise but also for national security. Recently, one promising source of REEs has been identified: coal and coal-byproducts. One of those is acid mine drainage …

The Relationship Between Social Skills And Problem Behaviors In Adolescent Males With Autism Spectrum Disorders, Amanda Armstrong Randall

Graduate Theses, Dissertations, and Problem Reports (ETD)

Adolescent males with autism spectrum disorder commonly display an increased prevalence of problem behaviors and persistent deficits in social skills when compared to their typically developing peers. The present study deployed a single subject, multiple-baseline design to investigate the use of the social skills training program Super Skills: A Social Skills Group Program for Children with Asperger Syndrome, High-Functioning Autism and Related Challengesto promote enhanced social skills and minimize problem behaviors. Two groups of adolescent males with autism (N = 6) participated in weekly social skills training groups also containing typically developing peers (N = 3) once …

Chemical Analysis Of Firearm Discharge Residues Using Laser Induced Breakdown Spectroscopy, Courtney Helen Vander Pyl

Graduate Theses, Dissertations, and Problem Reports (ETD)

According to the Gun Violence Archive, in 2017, firearms were involved in 57,134 criminal incidents in the United States. The detection of firearm discharge residues (FDR), including inorganic and organic gunshot residues, can provide essential information in such investigations. For instance, when the question of suicide or murder arises, estimating the barrel to victim distance plays a critical role in the outcome of the case. In addition, clothing, wounds and other target materials are often inspected to determine if a bullet has produced an entry or exit orifice. Currently, the most common method for distance determination and identification of bullet …

Carbon Deposition On Ni/Ysz Anode Sofc For Direct Methane Steam Reforming, Haiyang Li

Graduate Theses, Dissertations, and Problem Reports (ETD)

Solid Oxide Fuel Cells (SOFCs) are electrochemical devices that produce electricity directly from oxidizing fuels. Compared to direct combustion of hydrogen to generate power, it has a big advantage in aspects from efficiency and safety when using hydrogen as the fuel of SOFCs. Hydrocarbon reforming is one of the conventional methods to convert natural gas into hydrogen. While considering the difficulty in storage and transportation of hydrogen, we can utilize the supporting materials on the anode side of SOFCs as catalyst to generate hydrogen via hydrocarbon reforming process and pour the hydrogen as fuel into the SOFC system. Ni/YSZ is …

Genet-Cnv: Boolean Implication Networks For Modeling Genome-Wide Co-Occurrence Of Dna Copy Number Variations, Salvi Singh

Graduate Theses, Dissertations, and Problem Reports (ETD)

Lung cancer is the leading cause of cancer-related death in the world. Lung cancer can be categorized as non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). NSCLC makes up about 80% to 85% of lung cancer cases diagnosed, whereas SCLC is responsible for 10% to 15% of the cases. It remains a challenge for physicians to identify patients who shall benefit from chemotherapy. In such a scenario, identifying genes that can facilitate therapeutic target discoveries and better understanding disease mechanisms and their regulation in different stages of lung cancer, remains an important topic of research.

In this …

Optimizing The Production And Injection Wells Flow Rates In Geothermal Field Using Artificial Intelligence, Muhammet Salih Ariturk

Graduate Theses, Dissertations, and Problem Reports (ETD)

In a geothermal field, power plants are designed for long-term electricity generation. Therefore, it is crucial to predict the future production and injection flow rates of the wells to determine the capacity of a power plant. In the designing of such power plants, calculations and estimations are based on the current future production, and injection flow rates and pressures in the geothermal field. Prediction of future production and injection flow rates also assist in building surface facilities with cost-efficient power plants. The most common problem in a power plant in geothermal fields is the inability to accurately estimate future expected …

Short Beam Shear Strength Evaluations Of Gfrp Composites: Correlations Through Accelerated And Natural Aging, William Todd Barker

Graduate Theses, Dissertations, and Problem Reports (ETD)

Fiber Reinforced Polymers (FRP) composites have been materials of interest in replacing or reinforcing steel, wood, and concrete, but lack of understanding of degradation under physical and chemical aging is a main concern. Through many years of research, the understanding of aging or durability of GFRPs has improved. To be able to evaluate aging related degradation rates, an accelerated aging methodology under varying environments is introduced. Accelerated aging is a concept used to age composites in a lab controlled environment under varying pH conditions (2 to 13) and temperatures (~ -20° to +160°F). Once acceleratedly aged testing is completed, Arrhenius …

Evaluating The Approach Of Using Nox Control Performance Tracking For On-Board Diagnostics Of Heavy-Duty Diesel Vehicles, Renata Castiglioni

Graduate Theses, Dissertations, and Problem Reports (ETD)

egulatory agencies have taken several measures to ensure proper regulation of engine exhaust in response to a yearly rise in urban pollution levels. This is due in no small part to vehicular traffic and resulting air pollution from exhaust.

This study evaluates the NOx Control Performance Tracking (NCPT) Onboard Diagnostic (OBD) parameter proposed by the California Air Resources Board (CARB) as a tool to assess in-use heavy-duty vehicle performance. It also assesses the various criteria prescribed in the NCPT approach for applicability to real-world vehicle data.

In order to analyze the data, the study also investigated the effect of various …

A Timeless Ritual, Luke Thomas Doyle

Graduate Theses, Dissertations, and Problem Reports (ETD)

This written thesis is the supporting documentation for A Timeless Ritual, my Master of Fine Arts thesis exhibition. The exhibition seeks to define my expression of aesthetics through utilitarian vessels to create a sense of nostalgia with the user my mimicking industrial objects.

The research pertaining to my thesis explores the interactions between object and user. A patina layered over time evokes a sense of age, weathered memories of a time once lived. I look for these subtle nuances in form. Borrowing an aesthetic from manufactured products and reviving it in a domestic space is where my pots takes life. …

Coaches' Preparedness For Sudden Death Conditions In Secondary School Athletics In West Virginia, Jillian Mary Sarm

Graduate Theses, Dissertations, and Problem Reports (ETD)

Context: Coaches in the secondary school setting may encounter and be expected to provide emergency medical care for student athletes in the absence of a healthcare professional such as athletic trainers. The National Athletic Trainers’ Association (NATA) categorized ten sudden death conditions which are common in athletics and may warrant a medical emergency. Since the coaches may not be cognizant of these common sudden death conditions, they may not be prepared to handle a medical emergency which threatens the life of student athletes. Objective: Determine if West Virginia Secondary School Activities Commission (WVSSAC) coaches are aware and prepared to provide …

Essays On Environmental, Energy And Land Economics In China, Yiming He

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation consists of three essays involving environmental pollution, electricity consumption, and farmland leasing in China. These economic analyses are linked by their inclusion of institutional changes which have occurred in China over the past half-century. The first essay examines the effects of environmental pollution and institutional abatement targets on real average housing prices in China. The Spatial Difference-In-Difference model shows that the overall effect of 2006 SO₂ institutional abatement targets is to increase real average housing prices across provinces. The changes in both emissions of sulfur dioxide and industrial wastewater discharges have negative impacts on the change of …

Ferritin: An Iron Deficiency Biomarker In Collegiate Female Distance Runners, Ty Bigelow

Graduate Theses, Dissertations, and Problem Reports (ETD)

Context: Iron deficiency is a concern in distance runners due to the implications that hemoglobin production becomes impaired limiting oxygen uptake and tissue oxidation in the body. Ferritin is a biomarker used to diagnose iron deficiency. The related signs and symptoms of iron deficiency are associated with decreased performance and prolonged recovery. Objective: The purpose of this study was to investigate whether the change in ferritin levels affect measures of performance, measures of recovery, and rate of perceived exertion in female endurance runners. Design: The study was a descriptive longitudinal study. Setting: The study was conducted at a Mid-Atlantic Division …

The Role Of Sirt1 In Skeletal Muscle Function And Repair Of Older Mice, Matthew John Myers

Graduate Theses, Dissertations, and Problem Reports (ETD)

Human skeletal muscle is a highly metabolic tissue necessary for mobility and coordination. Responsible for approximately one-fifth of the resting human metabolism, skeletal muscle is also an important regulator of metabolites like glucose and contributes to the regulation of body temperature. Although there is a gradual decline in muscle mass associated with aging, a certain percentage of the population suffer from severe muscle mass and strength deterioration, classified as sarcopenia (5-13% for people aged 60-70 years old, 11-50% for those 80 or older). Sarcopenia is linked to increased morbidity and mortality rates in the elderly population, while annual healthcare costs …

Living Tangent, Cornelius Alexander Hugo

Graduate Theses, Dissertations, and Problem Reports (ETD)

A living tangent is how I am known by many and how I have lived my life for some time. I think in tangents and my life and art seem to evolve through them. Everything I make is connected by multiple thoughts or tangent lines that run from something as simple as the color red, to the idea that I believe communism has invaded my family’s homeland. This then leads to the recollection of childhood games, taught to me by my family in Venezuela and the importance these games played in my psychological development and in my presence as an …

Making Armenian Politically Exposed Persons’ Money Public: A Data-Driven Journalism Project That Aims To Create A Database Of Armenian Mps’ Assets, Ani Hovhannisyan

Graduate Theses, Dissertations, and Problem Reports (ETD)

This data-driven journalism project tackles an age-old problem that seems common in virtually every government around the world: governmental officials hiding assets. By applying the theory of social responsibility, this paper uses data-journalism methods to trace the full financial assets of Armenian members of parliament and eventually making those assets and income declarations available via an interactive website to the Armenian public as well as other journalists throughout the country and region.

Longitudinal Associations Between Functional Disability, Depression, And Suicide In Middle-Aged And Older Adults, Julie Ann Lutz

Graduate Theses, Dissertations, and Problem Reports (ETD)

Suicide is a significant public health problem among older adults in the United States and around the world. There has been little research to date on longitudinal change in functional disability and depressive symptoms, both of which have been posited to be associated with suicide risk among middle-aged and older adults, and their association with death by suicide. The aims of this study were to 1) characterize longitudinal change in functional disability and depressive symptoms separately; 2) characterize the directional associations between functional disability and depressive symptoms in bivariate models; and 3) determine how different patterns of change among these …

Resurgence Of Academic Responses, Catherine Louise Stephens

Graduate Theses, Dissertations, and Problem Reports (ETD)

Resurgence is the recurrence of a previously reinforced response after a more recently reinforced response is placed on extinction. Resurgence may explain the recurrence of socially appropriate behavior, including academic responding, but this had not yet been empirically demonstrated. The aim of this study was to determine if resurgence would occur when a participant solved quadratic equations using multiple methods. Each participant was taught two methods of solving quadratic equations across experimental phases, followed by a phase in which neither method resulted in the correct solution. In the first phase, only simple factoring was reinforced. In the second phase, only …