Enhancing Negative-Ion Native Mass Spectrometry With Field-Assisted Capillary Vibrating Sharp-Edge Spray Ionization (Cvssi), Kushani Udeshika Attanayake

Graduate Theses, Dissertations, and Problem Reports (ETD)

Although the birth of native mass spectrometry (native MS) occurred only several years after the development of electrospray ionization (ESI), it is yet considered an emerging technique for MS-based studies. This stems in part from challenges associated with efficient ionization of biopolymers. Although steady gains in ion production for native structure characterization have been secured primarily with the use of nanoelectrospray ionization (nESI), under negative polarity, the ionization efficiency can be extensively reduced due to an effect called “corona discharge”. The corona discharge occurs at the tip of ESI emitters because of free electron acceleration in the high-field region produced …

Investigation Of Foundation Failures, Ali Buabbas

Graduate Theses, Dissertations, and Problem Reports (ETD)

ABSTRACT

Investigation of Foundation Failures

Ali Buabbas

Foundations form a very critical component of any structure. The integrity and lifespan of the structure are dependent on the strength and durability of the foundation. Under ideal conditions, immediately after the structure is constructed, the foundation meets all the requirements of the structure. However, after a while, due to the action of many other factors, the structure’s foundation may no longer satisfy the needs of the structure.

Some of the factors contributing to the failure of the foundation can be due to natural events. Construction engineers should anticipate these factors to minimize …

Light Non-Aqueous Phase Liquid Migration In Ground Subsurface, Hanadi Al-Hammad

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

Light Non-Aqueous Phase Liquid Migration in Ground Subsurface

Hanadi Al-Hammad

Groundwater aquifers are vital source for water supplies. Such water supplies are under serious potential threats of pollution due to various contaminants. One of the categories of contaminants that pollute groundwater aquifers is non-aqueous phase liquid (NAPL). NAPLs are immiscible organic compounds. NAPLs comprise two categories based on comparison of its density with density of water. The NAPLs that have density less that density of water are known as light non-aqueous phase liquid (LNAPL) such as Diesel, Toluene, and mineral oil. NAPLs with density higher than the density of …

Jurors' Perceptions Of False Confessions, Madison G. Gallimore

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study examined the effect of mock jurors’ perceptions of a defendant’s false confession vs. no confession (false confession presence), coercive interrogation techniques vs. panic-escape (false confession reason), and expert witness testimony vs. defendant explanation vs. expert witness testimony plus defendant explanation for his false confession (source). The four hypotheses and one research question pertained to main effects and interaction effects of false confession presence, false confession reason, and source (separately) and expert witness conditions combined on five outcome variables. Outcome variables were defendant’s guilt, trustworthiness, suggestibility, susceptibility to external influences, and juror’s likelihood of changing their verdict. Using Amazon …

Evaluation Of A Telenutrition Weight Loss Intervention Among Middle-Aged And Older Men In Appalachia, Afnan Majed Alamoudi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Obesity rates among middle-aged and older men in WV are among the highest in the nation. Understanding baseline and intervention factors contributing to losing clinically significant weight are essential to developing effective interventions in target groups. Thus, the purpose of this study is to determine factors associated with losing ≥ 5% of baseline weight among participants of a 12-week pilot randomized controlled telenutrition trial for middle-aged and older men in WV. The study analyzed data from 56 participants who completed the trial. Participants were classified as losing ≥ 5 % or < 5 % of baseline body weight. Diet quality was assessed using 4-day diet records and the Healthy Eating Index (HEI)-2015. Baseline factors and behavioral strategies (i.e., self-monitoring, self-efficacy, and social support) were assessed via survey. Inverse prediction analysis demonstrated that participants who lost ≥ 3.5% of baseline weight at 6 weeks were at least 75% likely to lose ≥ 5% weight at 12 weeks. Predictive models were developed using stepwise logistic regression to assess multiple predictors of losing ≥ 5% of baseline weight at 12 weeks and ≥ 3.5% of baseline at 6 weeks. Weight loss at 6 weeks was a strong predictor of weight loss at 12 weeks, in addition to previous weight loss attempts and weekly self-weight-monitoring (p

Development Of Synthetic Coal Char Simulant For Microwave Conversion Studies: A Computationally-Driven Approach, Kevin A. Hager

Graduate Theses, Dissertations, and Problem Reports (ETD)

Recent experimental demonstration of new reaction windows for coal char/methane reactions that are less energy-intensive, provides innovation for modular reactors. However, the correlation of the exact mechanism for the enhancement of these reaction windows is not certain. This study investigates the simplification of these experimental studies by developing a well-characterized coal char simulant. The approach involves using a computational approach to screen macroscopic composition to replicate the dielectric and compositional response of actual char. This study is focused on PRB coal char. A discrete element method (DEM) technique was used to simulate the packing of coal chars to give the …

The Comparison Of Treadmill And Overground Running With The Use Of Inertial Measurement Units (Imus), Griffin R. Moon

Graduate Theses, Dissertations, and Problem Reports (ETD)

Treadmill running has historically been utilized in the laboratory to mimic outdoor running. Recent developments in portable technology, such as Inertial Measurement Units (IMUs) allow researchers to assess runners in their natural environment. PURPOSE: The primary purpose of the study was to compare peak tibial acceleration, stance time, stride frequency, and rearfoot eversion velocity between treadmill and overground running (asphalt, track, and grass). The secondary purpose was to test the reliability of IMU-based estimations of maximum rearfoot eversion velocity during treadmill running. METHODS: Twenty subjects (Age: 22.1 ± 2.0 yrs, Mass: 70.8 ± 11.9 kg, Height: 174.5 ± 10.0 cm, …

Analyzing And Measuring Petrophysical Properties Of Marcellus Shale, Yahia Mustafa Yassin Mustafa

Graduate Theses, Dissertations, and Problem Reports (ETD)

Unconventional oil and natural gas play a key role in our nation's future. The U.S. has vast reserves of such resources that are commercially viable as a result of advances in horizontal drilling and hydraulic fracturing technology. These technologies enable greater access to oil and natural gas in shale formations. Responsible development of America's shale gas resources offers important economic, energy security, and environmental benefits. Hydraulic fracturing and horizontal drilling apply the latest technologies and make it commercially viable to recover shale gas and oil.

In order to estimate the original gas-in-place, predict the production rates, and optimize the hydraulic …

The Impact Of Driver Reaction In Cooperative Vehicle Safety Systems, Elwarfalli Ibrahim

Graduate Theses, Dissertations, and Problem Reports (ETD)

Cooperative Vehicular Safety (CVS) has recently been widely studied in the field of automated vehicular systems. CVS systems help decrease the rates of accidents. However, implementing and testing CVS applications in real world is very costly and risky. Hence, most of the related research studies on CVS applications have relied mainly on simulations. In simulated CVS systems, it is important to consider all critical aspects of used models, and how these models affect one another.

The movement model is a key component in the simulation study of CVS systems, which controls the mobility of vehicles (nodes) and responses to the …

Feeling Depleted? If English Is Not Your First Language, You Might Be Experiencing Stereotype Threat, Mingang K. Geiger

Graduate Theses, Dissertations, and Problem Reports (ETD)

An estimated 67.3 million people are nonnative English speakers in the U.S. Research has shown that nonnative English speakers are often perceived to be less competent in communication, less intelligent, and less reliable in English-speaking environments, regardless of their actual capability. Given that English is a common tool for business communication, the nonnative English speaker stigma is likely to be particularly salient in the workplace. For example, empirical research evidence has shown that nonnative English speakers are less likely to be hired or promoted to managerial positions and are more likely to fail to receive funding for their business due …

The Ethics Of Aerial Bombardment In International Conflicts: From Douhet To Drones, Rauan Zhaksybergen

Graduate Theses, Dissertations, and Problem Reports (ETD)

In this thesis, I demonstrate how the question of ethics in aerial bombardment has been evolving and transforming since its inception at the beginning of the twentieth century to contemporary targeted killings/assassinations by drones. I interact with early airpower theories from Douhet, Trenchard, Mitchell, and contemporary air tactics in order to establish a crucial sequence between these early theories and practices of aerial violence and modern ones conducted by armed drones. I show how the evolution of aerial bombardment challenged, influenced, and transformed essentials of conventional warfare, as well as dispersed boundaries between combatants and non-combatants. Contemporary legally uncontrolled targeted …

Application Of Project Management Strategies And Tools For An Efficient And Successful Competition-Based Engineering Senior Capstone Design Project, Benton Duane Morris

Graduate Theses, Dissertations, and Problem Reports (ETD)

The industry-level engineering workforce for a project in modern times requires a clear plan and management process to execute the goals of the consumer and the producer. The engineers of tomorrow need the ability to be competitive and successful upon entry into the industry, where there have already been established management tactics for the execution of the company's goals. The mentality within the industry is adaptable to senior collegiate-level competition-based capstone projects. Therefore the West Virginia University EcoCAR Mobility Challenge team has adapted, altered, or adjusted industry-level practices in order to have an overall functioning and effective team that follows …

Rania: A Framework For A Modular, Voice Enabled, Gerontechnology-Centric, Smart-Home System, Emily Francis

Graduate Theses, Dissertations, and Problem Reports (ETD)

In the United States, the proportion of senior citizens is expected to rise significantly over the next few decades. This increasing number of senior citizens combined with the increasing demand for at home healthcare workers is putting a strain on the elderly healthcare system. Smart-home healthcare technology { such as smart medication dispensers, fall detection systems, smart pantry systems, etc. { has the potential to alleviate this strain on the elderly healthcare system. Smart devices can give an individual more autonomized and personalized surveillance of their health and well-being. While these devices are beneficial as standalone devices, they would be …

Fostering Music Performers In The 21st Century: A Contemporary Professional Perspective Toward A New Curricular Agenda For Graduate Study In Music, Andre Januario

Graduate Theses, Dissertations, and Problem Reports (ETD)

What if the core curriculum for graduate students in music performance were designed to prepare students to succeed in the world of the Fourth Industrial Revolution?

This dissertation offers a hypothetical answer: a structured and systematic academic curricular framework for music graduate students of performance of concert music (especially those in terminal degrees, such as doctoral students), along with music instructors, professional music performers, school administrators, and college professors, seeking to prepare such students for achieving and maintaining a music career more in keeping with the current work environment, especially those skills demanded by the Fourth Industrial Revolution and the …

A Deep Learning Approach To Lncrna Subcellular Localization Using Inexact Q-Mer, Weijun Yi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Long non coding Ribonucleic Acids (lncRNAs) can be localized to different cellular components, such as the nucleus, exosome, cytoplasm, ribosome, etc. Their biological functions can be influenced by the region of the cell they are located. Many of these lncRNAs are associated with different challenging diseases. Thus, it is crucial to study their subcellular localization. However, compared to the vast number of lncRNAs, only relatively few have annotations in terms of their subcellular localization. Conventional computational methods use q-mer profiles from lncRNA sequences and then train machine learning models, such as support vector machines and logistic regression with the profiles. …

Implementation Of Fuzzy Logic Control Into An Equivalent Minimization Strategy For Adaptive Energy Management Of A Parallel Hybrid Electric Vehicle, Jared Alexander Diethorn

Graduate Theses, Dissertations, and Problem Reports (ETD)

As government agencies continue to tighten emissions regulations due to the continued increase in greenhouse gas production, automotive industries are seeking to produce increasingly efficient vehicle technology. Electric vehicles have been introduced by the industry, showing promising signs of reducing emissions production in the automotive sector. However, many consumers may be hesitant to purchase fully electric vehicles due to several uncertainty variables including available charging stations. Hybrid electric vehicles (HEVs) have been introduced to reduce problems while improving fuel economy. HEVs have led to the demand of creating more advanced controls software to consider multiple components for propulsive power in …

Aerosol Sampling Strategy: Effect Of Particle Transfer To Sampler Covers And Estimation Of Conversion Factors Between The United States And German Methods For Quartz Sampling, Godwin Akpevwe Erekaife

Graduate Theses, Dissertations, and Problem Reports (ETD)

ABSTRACT

AEROSOL SAMPLING STRATEGY: Effect of Particle Transfer to Sampler Covers and Estimation of Conversion Factors between the United States and German Methods for Quartz sampling

GODWIN A. EREKAIFE

In many countries, communities of experts, including industrial hygienists, have developed unique sampling strategies to determine workers’ exposure to aerosolized particles (e.g., metals, wood dust etc.). However, using different sampling and analytical methods for the same chemical often results in different exposure levels for a similar exposure group (SEG). The exposure discrepancies among different countries that are caused by using different measurement strategies are not always systematically defined. Therefore, this study …

Dry Reforming Of Methane Using Microwave Irradiated Metal Oxide/Coal Char Catalysts, Anthony Carter

Graduate Theses, Dissertations, and Problem Reports (ETD)

This research focuses on the synthesis of both shaped and amorphous powder materials, the combination of these materials with dried Powder River Basin (PRB) coal char, and their reactionary properties with methane and carbon dioxide gasses with conventional and microwave (MW) heating. The first goal of this project was to synthesize shaped micro and nano sized particles with ideal dielectric properties for converting electromagnetic energy into heat and proven capabilities of activating methane. These particles were synthesized via solvothermal, hydrothermal, and co-preceptory treatments alone and onto the surface of dried PRB coal char. PRB is a sub-bituminous, low-ranking coal (LRC) …

Comparative Analysis Of Different Classes Of On-Line State Estimators For Aerodynamics Angles And True Airspeed Sensors For Applications To The Sensor Failure Problem, Alexandra Anne Augsberger

Graduate Theses, Dissertations, and Problem Reports (ETD)

Throughout aviation history, there have been numerous incidents due to sensor failure that have caused a range of issues from loss of control of the aircraft to crashes resulting in loss of human life. Although there are many hardware-based solutions to this problem, the threat of control hardware failure still exists. This work investigates the efficacy of implementing neural networks (NN) and Kalman filters (KF) to solve the accommodation portion of the sensor failure detection, identification, and accommodation (SFDIA) problem through on-line real-time estimation of specific aircraft dynamic parameters. The implementation of on-line estimation architectures into the aircraft flight control …

Design And Synthesis Of Targeted Immunotherapeutic Agents, Md Shohel Rana

Graduate Theses, Dissertations, and Problem Reports (ETD)

The therapeutic monoclonal antibodies are very important tools to fight against the diseases especially in the field of cancer immunotherapy. Many immunotherapeutic antibodies are being used to treat cancer that target multiple different components of the cancer microenvironment. Cells with extracellular juxtacrine ligands [JL-cells] and extracellular juxtacrine receptors [JR-cells] form JL-cell-JR-cell interfaces that produce juxtacrine signals inside JR-cells. [76] Juxtacrine signaling unlike endocrine or paracrine signaling requires no release or cellular uptake of ligands. [76] Immune checkpoint inhibitors are soluble IgG antibodies that block juxtacrine ligand engagements with juxtacrine receptors on tumor or other immune cells. [77] Rapid Nobel Prize …

Unique Biological Applications Of Charge Transfer Dissociation Mass Spectrometry, Halle M. Edwards

Graduate Theses, Dissertations, and Problem Reports (ETD)

The ever-changing landscape of mass spectrometry is driven by gaps in knowledge, and one of the biggest driving forces is the desire to understand the structure and dynamics of biomolecules in living organisms. New and better methods of tandem mass spectrometry are often at the heart of technological developments. Some fragmentation methods are limited to expensive FTICR instruments, some techniques are limited multiply charged precursors, and others are limited to breaking only the weakest bonds in precursor ions; all of which support the pursuit of new activation methods. Charge transfer dissociation (CTD) addresses some of these concerns by providing structurally …

Mitigating Insider Threats In A Cooperative Adaptive Cruise Control System Using Local Intra-Vehicle Data, Alexander Francis Colon

Graduate Theses, Dissertations, and Problem Reports (ETD)

With the rise of Connected-and-Automated-Vehicle (CAV) technologies on roadways, transportation networks have become increasingly connected through Vehicle-to-Everything (V2X) systems. With access to the additional data from V2X, modern cruise control systems like Adaptive Cruise Control (ACC) are further improved upon to develop systems like Cooperative ACC (CACC) which reduces traffic congestion and increases driver safety and energy efficiency. With that increased connectivity, previously closed vehicle systems are now vulnerable to new security threats which pose new technical challenges. Significant research has been done to strengthen the network against external threats such as denial-of-service attacks (DoS) or passive eavesdropping attacks using …

A Selected Analytical Bibliography Of Works For Saxophone By Composers Associated With The Darmstadt International Summer Courses For New Music: 1946-2021, Christopher Mark Delouis

Graduate Theses, Dissertations, and Problem Reports (ETD)

Although the saxophone is one of the most recently invented concert instruments, countless pieces of music have been written for it. This document aims to contribute to the established scholarship that examines and highlights existing saxophone repertoire, by looking specifically at composers associated with the Darmstadt International Summer Courses. Bruce Ronkin’s Londeix Guide to the Saxophone Repertoire 1844-2012 is a standard resource for the 21st century saxophonist to have. It includes some, but not all, compositions for saxophone written before 2012. By looking at this specific set of composers, with many who are alive today, this document is able to …

Evaluation Of Lidar Systems For Rock Mass Discontinuity Identification In Underground Stone Mines From 3d Point Cloud Data, Mario Alejandro Bendezu De La Cruz

Graduate Theses, Dissertations, and Problem Reports (ETD)

The goal of this thesis is to compare the accuracy and precision of the discontinuity identification results obtained by three active remote sensing technologies along with a point cloud processing program, and the results obtained by conventional methods. For this research, the active remote sensing devices were terrestrial LIDAR, mobile LiDAR with Simultaneous localization, and mapping (SLAM), and LIDAR/Camera on an autonomous UAV. The open-source point cloud data processing programs Discontinuity Set Extractor (DSE) and the Cloud Compare were used to process point cloud data.

The results of this research found that it is possible to identify certain geological structures …

Dynamic Modeling Of A Coal Mill For Simultaneous Dynamic Data Reconciliation And Parameter Estimation, Vinayak Dwivedy

Graduate Theses, Dissertations, and Problem Reports (ETD)

In comparison with other gaseous and liquid fossil fuels used in power production, a coal fired power plants requires additional equipment for fuel preparation. A medium speed mill is usually a preferred equipment which serves in grinding and drying of the raw feed coal. Due to the high recycle of coal particles within a medium speed coal mill, the mill performance is sensitive to the efficiency of grinding and classification operations within mill. The goal of this research is to study the performance of the milling system and develop a method to estimate some of the unmeasured variables, which include …

Dynamic Data-Driven Smart Proxy Modeling For Numerical Reservoir Simulation, Maher Jasim Alabboodi

Graduate Theses, Dissertations, and Problem Reports (ETD)

A successful Geologic Carbon Dioxide (CO₂) Storage (GCS) operation requires the ability to make quick and reliable subsurface modeling decisions; such decisions must be made based on an accurate and realistic modeling of the reservoir. Numerical reservoir simulation is the most common tool used for predicting fluid flow behavior and analyzing uncertainties in the subsurface reservoirs.

In general, a numerical reservoir simulation model has tens of millions of grid blocks and requires intensive computations to be performed at each time-step of the simulation, therefore, they are computationally expensive and time-consuming. As a result, studies (such as uncertainty analysis …

Estimation And Mitigation Of Stresses In Mass Concrete Structures Containing Ground Granulated Blast Furnaceslag And Fly Ash, Guadalupe Leon

Graduate Theses, Dissertations, and Problem Reports (ETD)

In large concrete structures, due to concrete’s low thermal conductivity, the interior temperature rise can approach the concrete’s adiabatic temperature rise. As the concrete’s surface losses heat to the environment and cools rapidly, the interior of the concrete attempts to expand while the exterior provides an internal restraint. The phenomenon causes thermal stresses at the concrete’s surface. If the thermal stresses exceed the concrete’s tensile strength, there is a high probability of cracking. The cracks usually appear during the first few days after construction while the concrete’s tensile strength is low. These early-age cracks can reduce the service life of …

Can Stable Isotopes From Tree Rings Improve Our Understanding Of Past Variability In The Southern Annular Mode?, Zachary Grzywacz

Graduate Theses, Dissertations, and Problem Reports (ETD)

Few annually dated stable isotope records exist across Oceania. In mid- to high-latitude locations in South America, tree-ring stable isotopes provide information about past climate dynamics such as the Southern Annular Mode (SAM). The SAM drives latitudinal shifts in Southern Hemisphere westerly winds, influencing temperature and moisture delivery across the mid- to high-latitudes, including Tasmania. Combinations of paleoclimate proxies from across the Southern Ocean might provide insight into dynamic processes like the SAM that are difficult to measure with a single proxy. Measuring stable carbon and oxygen isotope ratios from tree rings in Tasmania could provide complementary data to contribute …

Online Ultra-High Performance Liquid Chromatography-Charge Transfer Dissociation-Mass Spectrometry (Uhplc-Ctd-Ms) Of Complex Mixtures Of Oligosaccharides, Praneeth M. Mendis

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

Online Ultra-High Performance Liquid Chromatography-Charge Transfer Dissociation-Mass Spectrometry (UHPLC-CTD-MS) of Complex Mixtures of Oligosaccharides

Praneeth M. Mendis

Complex carbohydrates make up more than half the biomass on earth, and they are crucial to a wide range of processes in living organisms. When polysaccharides and glycans are enzymatically digested into manageable units called oligosaccharides, they typically consist of 2-20 linear or branched sugar units. The detailed structural analysis of oligosaccharides assists in the identification of structural and chemical properties of the polymers from which they derive. Tandem mass spectrometry (MS/MS) is a key technique used in oligosaccharides structural characterization. Within …

Terrestrial Salamander And Ant Community Responses To Imidacloprid Application In Central Appalachian Eastern Hemlock Forests, Lenza E. Paul

Graduate Theses, Dissertations, and Problem Reports (ETD)

Imidacloprid is the most widely used insecticide in the world and has been found to impact non-target taxa in systems in which it is applied. It is used as the primary treatment method in the protection of eastern hemlocks (Tsuga canadensis) from impacts of hemlock woolly adelgid (HWA; Adelges tsugae), an invasive insect in the U.S. that is causing widespread mortality of hemlock trees. In this study, we investigated whether imidacloprid applied in eastern hemlock forests is impacting woodland salamander and ant communities.

In Chapter 1, I provide an overview of the ecological importance of eastern hemlocks …