Synthesis And Pharmacology Of Illudalic Acid And Analogous Chemical Structures, Robert Gaston Jr

Graduate Theses, Dissertations, and Problem Reports (ETD)

Natural products are the foundation of modern medicine and an inspiration for chemical innovation. Developing new synthetic strategies to complex natural products drives synthetic innovation and promotes pharmacological exploration. As bioactive secondary metabolites of fungi, illudalic acid and associated analogs have unrealized medicinal potential due to synthetic limitations. Illudalic acid is notably the first selective covalent inhibitor of the LAR-PTPs, a class of enzymes linked to many human illnesses, including stimulant addiction. The chemistry herein focuses on optimizing synthetic routes to illudalic acid and associated analogs toward exploring their pharmaceutical potential. We report a second-generation synthesis of illudinine (55% overall …

Clinical And Economic Burden Of Inflammatory Chronic Conditions Among Adults In The United States: Evidence From Three Nationally Representative Surveys, Mohammad Ikram

Graduate Theses, Dissertations, and Problem Reports (ETD)

A significant proportion of adults in the United States (US) suffer from various inflammatory chronic conditions (ICCs). They include a wide range of diseases such as diabetes, rheumatoid arthritis, asthma, and chronic obstructive pulmonary diseases. ICCs are not curable, and their management typically involves medications such as NSAIDs and corticosteroids. Recently, a whole health approach that places patients’ well-being at the center is increasingly being used for better management of ICCs. The whole health approach uses an integrated approach that includes multimodal management with complementary and alternative medicines (CAM) and prescription drugs. However, the use of CAM and prescription drugs …

Sexual Orientation, Age, And Race: An Intersectional Approach To Health Disparities, Laura E. Bernstein

Graduate Theses, Dissertations, and Problem Reports (ETD)

Sexual orientation, age, and race are all identity-based variables that can contribute to health disparities (Dannefer, 2020; Meyer, 2003; Forde et al., 2019). The minority diminished returns (MDR) theory states that marginalized identities (i.e. race and sexual orientation) dampen the positive impact education has on physical and mental health (Assari, 2018). Some evidence suggests that health disparities narrow in older sexual minority adults (Nelson & Andel, 2020a) but this question has not been asked with nationally representative data, and research with older sexual minorities is limited. The present study explored whether 1) age dampens or exacerbates disparities in self-rated health …

Computational Mechanisms Of Face Perception, Jinge Wang

Graduate Theses, Dissertations, and Problem Reports (ETD)

The intertwined history of artificial intelligence and neuroscience has significantly impacted their development, with AI arising from and evolving alongside neuroscience. The remarkable performance of deep learning has inspired neuroscientists to investigate and utilize artificial neural networks as computational models to address biological issues. Studying the brain and its operational mechanisms can greatly enhance our understanding of neural networks, which has crucial implications for developing efficient AI algorithms. Many of the advanced perceptual and cognitive skills of biological systems are now possible to achieve through artificial intelligence systems, which is transforming our knowledge of brain function. Thus, the need for …

Optimizing Sample Collection And Data Interpretation For Effective Wastewater-Based Epidemiology In Combined Sewer Systems, Christopher Allen Anderson

Graduate Theses, Dissertations, and Problem Reports (ETD)

COVID-19 has spurred growth in the science surrounding wastewater-based epidemiology (WBE) pertaining to the detection of severe acute respiratory virus 2 (SARS-CoV-2) in waste streams as an early warning signal for public health. However, the highly variable wastewater environment has made it difficult to standardize an approach for sampling and analysis, especially in locations using combined sewer infrastructure. This study addresses knowledge gaps of WBE via three specific aims: (1) to compare diurnal fluctuations of SARS-CoV-2 and the human fecal indicator, pepper mild mottle virus (PMMoV) in wastewater treatment plant (WWTP) influent samples collected during dry versus wet weather conditions; …

Drought Effects On Biofuel Feedstock Production By Populus Trichocarpa, Marvin Jacob Wright

Graduate Theses, Dissertations, and Problem Reports (ETD)

As the world population continues to increase, so does the need for sustainable sources of fuel. Biofuels are of particular interest and could be an economically feasible fuel source given the right conditions. Populus trichocarpa, is a rapidly growing plantation species that, in addition to having a fully sequenced genome available for study, displays a wide range of phenotypic traits among genotypes. By analyzing these differences in both plantation and more controlled greenhouse settings, we aimed to discover which genotypes performed the best under drought conditions, and which physiological mechanisms granted them that high performance. In the field, differences in …

Structural Health Monitoring Using Machine Learning And Synthetic Data, Michail Tzimas

Graduate Theses, Dissertations, and Problem Reports (ETD)

Structural health monitoring spans many decades of research across multiple engineering fields. However, typical monitoring processes for damage detection of complex structures usually prohibit real-time or fast detection of debilitating damage to the structure. One of the major issues of real-time detection of damage is the enormity of data that needs to be processed, which is worsened by the relative inability of fast relaying of data to structural engineers. With the rapid advancement of Machine Learning, both issues can be overcome, and detection of failure is achieved with non-invasive techniques. This dissertation explores the applicability of Machine Learning as a …

Nobody’S Perfect! The Effect Of Manipulating Perfectionism On Social Anxiety Symptoms, Anishka Jean

Graduate Theses, Dissertations, and Problem Reports (ETD)

Social anxiety is a common experience that ranges from mild, temporary distress to excessive, persistent, and impairing fear. The current study tested whether perfectionism is causally related to social anxiety symptoms and post-event processing using a contract-based manipulation to shift perfectionism. Participants (N = 67) completed measures of social anxiety and perfectionism prior to delivering a speech. Next, participants were randomly assigned to 1 of 3 contract conditions: High Personal Standards (High PS), High Personal Standards with Evaluative Concerns (High PS+EC), and Low Personal Standards (Low PS). The following day, participants completed the measures of social anxiety and perfectionism again, …

Understanding The Impact Of Scientific Testimony On Potential Jury Members: Independent And Interactive Effects Of Expert Characteristics And Jury Member’S Social Location, Ellory R. Dabbs

Graduate Theses, Dissertations, and Problem Reports (ETD)

As science and technology evolve, they impact society at different levels. With these changes, it is important to understand how members of society will be affected. One area where there has been a rise in the use of scientific information is in jury trials. Those who are on trial for a criminal offense are more often relying on forensic evidence, and forensic experts, to aid in their defense, and those who are prosecuting a criminal case are also relying on forensic evidence and forensic experts. However, forensic evidence is not consistent in type or interpretation – what one person may …

Longitudinal Sport Science Implementation In American Collegiate Men’S Basketball, Jason Stone

Graduate Theses, Dissertations, and Problem Reports (ETD)

The expanding opportunities to implement sport science frameworks in elite-level basketball environments coincide with the sport’s increasing global prominence. Concomitant to these opportunities is the continual growth of the sport technology market (e.g., wearables, force plates) and computational power (e.g., data management tools, coding capabilities), which yields solutions and challenges for both athletes and practitioners. Due to the rapid influx of new sport technologies in high performance environments, particularly American Collegiate Men’s Basketball, more formal and ecologically valid research on how to effectively utilize data derived from them, particularly over long periods of time (i.e., multiple seasons) is needed. To …

Conservative Anabaptists Descriptions Of Delay, Comfort In Connectedness, And Ease In Cultural Tension When Seeking And Responding To Healthcare, Matthew Donald Hottle

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

Conservative Anabaptists description of delay in health seeking behaviors, comfort in connectedness, and ease in cultural tension when seeking and responding to healthcare

Background: Conservative Anabaptists are a large ethnic religious population that continues to grow in the United States. This includes groups of Amish, Mennonites, Hutterites, and Brethren populations residing in rural areas. These groups are known to experience adverse health related outcomes such as community acquired infections, advanced cancer diagnosis, and undiagnosed chronic conditions such as hypertension, diabetes, and heart disease. Therefore, the concept transcending health values has been developed to better understand how conservative anabaptists describe …

Effects Of Ethanol And Nicotine Co-Administration On Risky Choice In Rats, Erin E. Wylie

Graduate Theses, Dissertations, and Problem Reports (ETD)

Individuals often engage in the comorbid use of alcohol (ethanol) and nicotine, leading to further-escalated health consequences than the use of either drug in isolation. Given the poor health outcomes resulting from the combined administration of ethanol and nicotine, some of which may be due to increased risky choice, more basic research is needed to better characterize drug/dose interactions on risky choice. Probability-discounting procedures involve a series of discrete choices between a smaller, certain reinforcer (i.e., a safer choice) and a larger, increasingly uncertain reinforcer (i.e., a riskier choice). Probability-discounting procedures allow for the assessment of …

Three Essays On Political Economy, Colin Michael Steitz

Graduate Theses, Dissertations, and Problem Reports (ETD)

The first chapter studies the impact of conventions and multi-day events on
hotel demand in the Indianapolis metro area. Using hand-collected data on
sporting events and conventions, we study the impact on hotel metrics: ADR,
Occupancy, Daily Rate, and Revenue. We show that traditional sporting
events generate little impact when compared to multi-day conventions. We
show that mega-events such as major championship games generate significant
increases in hotel demand. We find large and statistically significant effects for
multi-day conventions on hotel demand with very little evidence of crowding
out. A single day of a multi-day convention brings in approximately $928,000 …

Evaluating The Effects Of Modifying Mixing And Pelleting Parameters On Feed Quality, Pellet Production Rate, And Broiler Performance, Lucas E. Knarr

Graduate Theses, Dissertations, and Problem Reports (ETD)

In Chapter 2, an experiment was conducted to evaluate the effect of different mixer types (MTY) and mix times (MTI) on mix uniformity (MU). A 2 (mix time) x 3 (mixer type) factorial was utilized in this experiment to create six treatments, each mixed in three randomized complete blocks. Mix times were designated adequate or inadequate, were based on the manufacturers’ recommendation, and varied based on the mixer utilized. The mixer types utilized included a vertical mixer, horizontal mixer, and transfer mixing system. The transfer mixing system can be described as a batch-to-mix system …

Fast Raising: Digital Fundraising As Interaction Rituals, Matthew P. Hartwell

Graduate Theses, Dissertations, and Problem Reports (ETD)

Twice a year, GamesDoneQuick hosts events that showcase the Speed Running Community, a sub-set of the Video Game Community. Since its inception in 2014 through 2021 GDQ has raised $25.7 million that has been distributed to the Prevent Cancer Foundation and Médecins Sans Frontiers (Doctors without Borders). This collection of studies analyzes the Awesome Games Done Quick 2020 event utilizing the Interaction Ritual Theory framework of Randall Collins to understand how ritualistic social action of this community has been leveraged by event organizers to promote successful crowd funding efforts that benefits organizations outside of the community. Further it expands on …

The Diversity And Synaptic Connectivity Of Somatostatin-Containing Inhibitory Interneurons In The Somatosensory (Barrel) Cortex, Rachel Elaine Hostetler

Graduate Theses, Dissertations, and Problem Reports (ETD)

The neocortex is the most evolutionarily advanced part of the mammalian brain and is responsible for a multitude of important tasks, such as sensory processing, movement, memory and learning and, in humans, cognition, and language. Within the neocortex, there are intricate circuits of neurons that are responsible for these tasks. These circuits are comprised of a delicate balance of excitatory and inhibitory neurons. Inhibitory interneurons have the crucial role of constraining and controlling the amount of excitation in the brain; disruptions in this balance can lead to a number of neuropsychiatric diseases and disorders. Our studies focused on the subpopulation …

Solid State Nmr Analysis Of Insect Wing Membranes, Samuel Eddy

Graduate Theses, Dissertations, and Problem Reports (ETD)

Solid State NMR is a powerful tool for analyzing the chemical composition of insects. Previous studies have used Solid State NMR to investigate the chemical composition and investigate the sclerotization (tanning) process of insect exoskeletons. Acquiring sufficient exoskeleton sample for analysis has been relatively simple. This is however not the case for other components of an insect’s physiology, particularly the wing membrane material. The wings of an insect only compose a small percentage of their overall body mass, and many hundreds to thousands of insects must be processed in order to achieve a few milligrams of wing membrane sample. The …

Comparative Analysis Of Artificial Intelligence And Numerical Reservoir Simulation In Marcellus Shale Wells, Arya Maher Sattari

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation addresses the limitations of conventional numerical reservoir simulation techniques in the context of unconventional shale plays and proposes the use of data-driven artificial intelligence (AI) models as a promising alternative. Traditional methods, while providing valuable insights, often rely on simplifying assumptions and are constrained by time, resources, and data quality. The research leverages AI models to handle the complexities of shale behavior more effectively, facilitating accurate predictions and optimizations with less resource expenditure.

Two specific methodologies are investigated for this purpose: traditional numerical reservoir simulations using Computer Modelling Group's GEM reservoir simulation software, and an AI-based Shale Analytics …

Cue Reactivity In Electronic Cigarette Users With Sign-Tracking Or Goal-Tracking Behaviors, Polina Krom

Graduate Theses, Dissertations, and Problem Reports (ETD)

Polina Krom

Cue reactivity is an important predictor of addiction course and relapse. However, cue reactivity is only observed after an addiction develops. As such, it is unclear to what degree cue reactivity represents a state stemming from the addiction process versus a trait-like propensity towards developing cue-reward associations. Work in animal models has pointed to important individual differences in trait-like inclination to attribute incentive salience to reward-predictive cues that is associated with addiction-relevant behavioral and neurobiological features. These individual differences manifest as sign-tracking (ST) and goal-tracking (GT) behaviors during Pavlovian conditioning. Little research has attempted to translate ST and …

Applications Of Digital Filters In Radio Astronomy, Joseph William Kania

Graduate Theses, Dissertations, and Problem Reports (ETD)

The radio sky spans tens of orders of magnitude in length, density, and time.
In this thesis, using novel filtering techniques and two different telescopes,
we investigate two tracers of cosmic structure: Baryon Acoustic Oscillations
(BAOs) and Fast Radio Bursts (FRBs). BAOs formed as the universe cooled
after the Big Bang. BAOs provide a fiducial length scale of the universe
throughout cosmic time and thus can be used to understand how the universe
is evolving. FRBs are very bright, short timescale, bursts of as-yet unknown
origin which occur uniformly on the sky at a rate of a few thousand per …

American Art Songs In The 21st Century: A Catalogue Of Selected Works, Islei Mariano Correa Hammer

Graduate Theses, Dissertations, and Problem Reports (ETD)

This research explores American art songs of the 21st century. The paper provides a listing of 54 composers based in the United States and the art songs they composed from 2000 to 2023 which are available either through publishers or the composers’ websites. The research is divided into three categories: art songs with piano, chamber works with voice, and works for solo voice and large ensemble. The paper also includes biographies of each composer. This research provides singers, voice teachers, and collaborative pianists a useful resource to gain familiarity with the American art-song repertoire of the current century.

“I’Ll Tell You No Lies”: An Exploration Of Trauma, Memory, And Violence Against Women In North Carolina Murder Ballads, Madison Ava Helman

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation explores trauma, memory and violence against women in Western North Carolina murder ballads “Tom Dooley,” “Poor Omie Wise,” “Poor Ellen Smith,” “The Ballad of the Lawson Family,” and “Frankie Silver.” I posit that these ballads were influenced by prescriptive societal conceptions of femininity, which in turn influenced societal ideations of violence against women. Using folklore performance theory, I analyze the text and context of these ballads and their subsequent histories, eventually arriving at a template for polyvocality that incorporates multiple ballad variants and encourages diverse performances.

Probabilistic Short Term Solar Driver Forecasting With Neural Network Ensembles, Joshua Daniell

Graduate Theses, Dissertations, and Problem Reports (ETD)

Commonly utilized space weather indices and proxies drive predictive models for thermosphere density, directly impacting objects in low-Earth orbit (LEO) by influencing atmospheric drag forces. A set of solar proxies and indices (drivers), F_10.7, S_10.7, M_10.7, and Y_10.7, are created from a mixture of ground based radio observations and satellite instrument data. These solar drivers represent heating in various levels of the thermosphere and are used as inputs by the JB2008 empirical thermosphere density model. The United States Air Force (USAF) operational High Accuracy Satellite Drag Model (HASDM) relies on JB2008, and …

Evaluation Of Changes In Cellular Behavior Upon Exposure To Selected Analytes Used In Synthetic Applications, Olivia L. Rose

Graduate Theses, Dissertations, and Problem Reports (ETD)

Metal-organic frameworks (MOFs) are organic crystalline hybrids that have been used for a variety of applications from catalysis to gas storage and drug delivery. Studies have shown that generally, while such frameworks are more biocompatible than similar aspect ratio nanostructures, they are also more prone to transformation and disintegration due to their flexible and fragile nature as resulted from the structure assembly and implemented structure-function relationships. With extensive previous literature showing that materials with nano dimensions such as carbon nanotubes, quantum dots and other nanomaterials have unique physicochemical properties that lead to increased biosystems’ reactivity. With increasing concerns regarding adverse …

One Voice Training To Enable Nurses And Anesthesia Providers To Mitigate Pediatric Presurgical Anxiety, Sarah E. Hinnant

Graduate Theses, Dissertations, and Problem Reports (ETD)

ABSTRACT

ONE VOICE Training to Enable Nurses and Anesthesia Providers to Mitigate Pediatric Presurgical Anxiety

Sarah E. Hinnant

Background: Children in the preoperative area experience presurgical anxiety at rates of up to seventy-five percent. Increased pediatric anxiety is directly linked to increased anesthetic requirements, increased risk for development of emergence delirium, and increased time spent in the post anesthesia care unit. Numerous high-quality studies show that intervention by a certified child life specialist mitigates preoperative pediatric anxiety. Often child life specialists are not available to meet with all children prior to surgery. Registered nurses (RNs) and certified registered nurse anesthesiologists …

Leveraging Data Science To Promote Sustainable Resource Recovery From Organic Waste Streams In Rural Regions, Mohammed Tamim Zaki

Graduate Theses, Dissertations, and Problem Reports (ETD)

Conventional organic waste management practices such as landfilling contribute to global warming and degrade environmental and human health. Alternatively, organic waste can be treated to recover energy, nutrients, and carbon through resource recovery technologies. Data science could benefit such technologies by improving their efficiency through data-driven process modeling along with reducing environmental and economic burdens via life cycle assessment (LCA) and techno-economic analysis (TEA), respectively.

A critical review of 616 peer-reviewed articles published during 2002–2022 was conducted on the use of data science methods in resource recovery from organic waste. Although applications of machine learning (ML) methods have drastically increased …

Conditioned Reinforcement By Stimuli Correlated And Uncorrelated With A Schedule Of Food Reinforcement, Lillian L. Skiba-Thayer

Graduate Theses, Dissertations, and Problem Reports (ETD)

A conditioned reinforcer derives its function from a relation to an established reinforcer. Respondent views suggest that a stimulus acquires reinforcing properties because it is positively correlated with an established reinforcer. Alternatively, the information hypothesis suggests that a stimulus acquires reinforcing properties because it reduces uncertainty about the likelihood of an established reinforcer. Observing response procedures have been used to evaluate the function of stimuli positively correlated (S+), negatively correlated (S-), and uncorrelated (S1, S2) with established reinforcers such as food (with animals) or money (with humans). Verbal instructions have been shown to alter the extent to which correlated and …

Rebuilding The Appalachian Economy From The Ground Up: Towards A Holistic Organizational Framework For Community And Economic Development In Rural Extractive Areas, Brandon M. Dennison

Graduate Theses, Dissertations, and Problem Reports (ETD)

Central Appalachia specifically and rural extractive areas more generally face some of the most challenging socio-economic realities in North America. Community-based organizations (CBOs) are an important tool for addressing these challenges. As governments intensify efforts to mitigate climate change, and as fossil-fuel industries contract, extracted communities are experiencing economic, cultural, and environmental upheaval. Many leaders call for a “just transition” away from fossil-fuels, which would make local extraction communities whole. However, achieving a truly just transition away from fossil fuels is extraordinarily challenging, and many extracted communities were never whole to begin with. I argue CBOs are the crucial vehicle …

Microwave-Assisted Ammonia Synthesis Over Cs-Ru/Ceo2 Catalyst, Alazar Kesete Araia

Graduate Theses, Dissertations, and Problem Reports (ETD)

Ammonia synthesis is one of the greatest innovations of the 20^th century with extensive applications from fertilizers to intermediates for nitrogen-containing chemicals and pharmaceuticals. Annually, more than 242 million tons of ammonia is produced globally, supporting approximately 27% of the world’s population. One of the fast-growing applications for ammonia is as H₂ energy carrier due to its high energy storage capacity, considered to be a decarbonized energy source. The low volumetric energy density and incompressibility makes Hydrogen a non-preferable energy carrier; an alternative carrier becomes a requirement. Ammonia possesses unique property as an energy-dense carrier to store and …

Dispositional Optimism And Autonomic Reactivity During Passive-Coping And Active-Coping Stress Tasks, Emma R. Pino

Graduate Theses, Dissertations, and Problem Reports (ETD)

Optimism is a positive psychological factor that has been associated with improved mental and physical health outcomes. To better understand the mechanism through which optimism results in improved health, researchers have examined whether autonomic reactivity to stress moderates this relation. While many studies have examined the relation between optimism and autonomic reactivity to stress, findings are mixed. Although some studies have found optimism to be associated with reductions in heart rate and blood pressure responses to acute stress presentations, many studies exploring this relation have found optimism to be associated with greater blood pressure responses to stress. However, most of …