Mathematical Contributions To The Study Of Chemotaxis And Cell Signaling, Hajr Zam

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation presents results from two mathematical projects concerned with the biology of cells. Chapter 1 provides biological background and places the two mathematical problems in the context of cell signaling. The larger project, with Prof. H. Hattori on a chemotaxis model is presented in Chapters 3 and 4. Work with Prof. \'{A}. Hal\'{a}sz on a chemical reaction network system with linear multimers and two types of labels is presented in Chapter 2. The chemotaxis system describes the one-dimensional dynamics of a species of cells with two chemical species, a chemo-attractant and chemo-repellent. The goal is to analyze the behavior …

Feasibility Of A Motor Skill Intervention For Adults With Intellectual Disabilities, Candace Brink

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract Feasibility of a Motor Skill Intervention for Adults with Intellectual Disabilities Candace Brink Adults with intellectual disabilities experience significantly lower levels of physical activity and a higher prevalence of obesity-related health conditions compared to neurotypical adults. Furthermore, motor competency has been identified as a barrier to physical activity participation amongst this population. Purpose: The purpose of this feasibility study was to evaluate the viability of implementing an adapted version of an evidence-based physical activity program originally developed for senior citizens, Silver Sneakers. This adapted program, Kicking Off Purple Sneakers, was designed to enhance motor competency and promote engagement in …

The Origin And Properties Of Ionized Gas In The Inner Milky Way Disk, Dylan J. Linville

Graduate Theses, Dissertations, and Problem Reports (ETD)

The interstellar medium (ISM) plays a crucial role in the evolution of the Milky Way and other spiral galaxies, but numerous gaps remain in our collective understanding of its properties. The now-complete Green Bank Telescope (GBT) Diffuse Ionized Gas Survey (GDIGS) and the ongoing extension, the GBT Diffuse Ionized Gas Survey at Low Frequencies (GDIGS-Low), offer the opportunity to study the ionized component of the ISM at unmatched sensitivity and resolution. In this dissertation I will utilize GDIGS and GDIGS-Low data to improve our understanding of discrete regions of ionized gas. I first use GDIGS to provide improved measurements of …

Late Ordovician Evolution Of Sea Scorpions: Eurypterids Of The Big Hill Lagerstätte, Joseph Donaldson Bingham Jr.

Graduate Theses, Dissertations, and Problem Reports (ETD)

Eurypterids are a group of diverse chelicerates that first appeared during the Middle Ordovician (467.3 Ma) and went extinct at the end of the Permian (251.9 Ma). The fossil record of eurypterids during the Ordovician is relatively sparce, comprising only 12 species representing the Megalograptidae, a ‘waeringopterid’ clade, Rhenopteridae, Onychopterellidae, Adelophthalmoidea, and Eurypteroidea clades. This study describes early eurypterids from the Katian aged (~452 Ma) Big Hill Lagerstätte of Michigan. The described material represents two new species, herein named Machipterus margaritae sp. nov. (based on 21 specimens preserving the ventral prosoma and prosomal appendages, and opisthosoma) and Dikranopterus lysinae sp. …

Impact Of Whey And Soy Protein Supplementation On Resistance Training In Young Adults: A Systematic Literature Review And Meta-Analysis, Brandon Eric Davis

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Whey protein is a popular supplement in sports nutrition. Soy protein is an alternative to whey protein, often marketed to individuals following a plant-based diet. Evaluating whey and soy protein supplementation's role in resistance exercise is essential for providing evidence-based nutrition guidance.

Objective: The study aim was to conduct a systematic literature review and meta-analysis on randomized control trials (RCTs) on the effectiveness of whey and soy protein supplementation on outcomes of lean body mass (LBM), squat, bench press, and plasma essential plasma amino acid (EAA) levels in young adult men and women.

Methods: The databases …

Do Demographics And Social Determinants Of Health Relate To Current And Anticipated Caregiving Roles?, Sarah Alison Bolling

Graduate Theses, Dissertations, and Problem Reports (ETD)

In 2021-22, approximately 37.1 million Americans provided care to family or friends who had an illness or disability (U.S. Bureau of Labor, 2024). These informal caregivers experience poorer mental health (Dahlrup et al., 2015) and physical health (Pinquart & Sorensen, 2003) influencing their overall well-being. Experiences in caregiving may differ across age, gender, race (Young et al., 2019). Given the effects of Social Determinants of Health (SDOH), such as financial stability, health care, and food resources (Duran & Perez-Stable, 2019), some adults may experience additional threats to health and quality of life before entering into the caregiver role. Little is …

Neurobiological Variables Mediating The Relationship Between Breast Cancer And Sleep Disruption, Brittany Domenique Elliott

Graduate Theses, Dissertations, and Problem Reports (ETD)

Neurobiological Variables Mediating the Relationship between

Breast Cancer and Sleep Disruption

Brittany D. Elliott, MS

Breast cancer is the most commonly diagnosed malignancy in women, with more than two million new cases diagnosed world-wide each year. Improvements in screening technology and diagnostics have increased survival rates, but cancer-associated sleep disruptions persist for the majority of breast cancer survivors well beyond the treatment period. In addition to reducing quality of life, reduced sleep quality is associated with greater incidences of affective dysfunction, reduced treatment efficiency, aggressive cancer progression, increased symptom severity, and increased mortality by all causes. Thus, identifying the variables …

Behavioral Effects Of Prenatal Ecig Aerosol Exposure On Sprague-Dawley Rats, Erin Elizabeth Wylie

Graduate Theses, Dissertations, and Problem Reports (ETD)

Maternal electronic cigarette (ECIG) use during pregnancy raises concerns about potential risks to offspring, yet its behavioral effects remain unclear. The present studies were designed to investigate how prenatal exposure to ECIG aerosols, with and without nicotine, influences the behavior of Sprague-Dawley rat offspring. Dams were exposed to aerosols containing base liquid alone, aerosols containing base liquid with 18 mg/ml nicotine, or filtered air (control) throughout gestation. Following postnatal day 65, male offspring from 17 litters completed lever-press acquisition (Experiment 1), sustained-attending (Experiment 2), and nicotine self-administration (Experiment 3) tasks. One-way analyses of variance (ANOVAs) were used to compare task …

Tobacco And Trouble: Exploring The Health Consequences Of Electronic Cigarette Use In Adolescents, Noor Ibrahim Abdulhay

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Tobacco use remains one of the leading causes of preventable disease and death in the United States (U.S.). Although conventional cigarette use among youth has declined, the use of electronic cigarettes (e-cigarettes) has become highly prevalent and poses emerging public health concerns. Adolescence represents a critical developmental period for both oral and mental health, making it essential to understand the consequences of tobacco and nicotine exposure during this stage. The goal of this dissertation is to examine the health impacts of tobacco use in adolescents across multiple domains. Specifically, this research (1) synthesizes existing evidence on the relationship between …

Reclaiming Revolutionary Relics: How Nineteenth-Century Americans Used George Washington’S Objects To Understand The Civil War, Abbi E. Smithmyer

Graduate Theses, Dissertations, and Problem Reports (ETD)

By combining cultural, memory, and material culture studies, this dissertation examines the ways objects associated with George Washington became instruments within the proxy war over whether the United States or the Confederacy best represented the American Revolutionary era’s principal values of liberty and equality. Exploring monuments, statues, historic homes, relics, and mementoes, as well as antebellum speeches and schoolbooks, letters, diaries, military orders, newspapers, and memoirs, this work demonstrates how the relics linked to Washington and the nation’s founding shaped how the Civil War generation thought about America’s past.

The 250th anniversary of the founding of the United States has …

An Analysis Of Usopc National Governing Body Policies Related To Body Pressures, Body Image Concerns, And Eating Pathology, Sarah Margaret Sadler

Graduate Theses, Dissertations, and Problem Reports (ETD)

Athletes are often exposed to body pressures in sport environments (Voelker & Reel, 2020), which can contribute to body image concerns and eating pathology (Petrie & Greenleaf, 2007, 2012) with lasting consequences for performance and well-being. Although research has highlighted the harmful impacts of these concerns, and has called for a broader investigation into the sources of athletes’ experiences of these concerns (Voelker et al., 2022), little is known about the role of sport organizations in influencing athletes’ body pressures, body image concerns, and eating pathology. Using a descriptive qualitative research design within a post-positivist paradigmatic approach, the current study …

An Edna Assessment Of The Diamond Darter (Crystallaria Cincotta) In Its Current And Historic Distribution Range, Cameron Moore Layne

Graduate Theses, Dissertations, and Problem Reports (ETD)

Environmental DNA (eDNA) can serve as a useful monitoring tool for cryptic and imperiled freshwater stream fishes. eDNA can fill knowledge gaps regarding species’ distribution, site abundance, and habitat usage. The last known stronghold of the Diamond Darter (Crystallaria cincotta) in the Elk River of West Virginia provides an excellent test case to examine the utility of this non-invasive method of surveying rare species. Diamond Darters are one of the most newly recognized freshwater fishes in North America and are among the most imperiled U.S. fishes, having been federally listed as endangered in 2013. The cryptic behavior and limitations of …

Development And Applications Of Capillary Vibrating Sharp-Edge Spray Ionization Coupled With Atmospheric Pressure Chemical Ionization (Cvssi-Apci), Madison Elizabeth Pursell

Graduate Theses, Dissertations, and Problem Reports (ETD)

Mass spectrometry (MS) is a technique that is used in fields in which both complex and non-complex mixtures are analyzed. The state-of-the-art ion sources that are utilized for MS are being demonstrated to be functional for direct infusion of samples as well as for use with online separations. However, ion sources, such as electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) can encounter problems such as ion suppression and an inability to ionize based on size and/or polarity, respectively. Further these sources are bulky and require gas flow, heat sources, and additional high voltage power supplies for optimal performance. …

Neural Network-Based Image Compression, Atefeh Khoshkhahtinat

Graduate Theses, Dissertations, and Problem Reports (ETD)

The rapid advancement of information technology and the exponential growth of digital communication have significantly increased the demand for efficient data compression techniques that reduce storage requirements, minimize bandwidth consumption, and accelerate data transmission—without substantially compromising data quality. This dissertation addresses these challenges by investigating and developing advanced learned image compression (LIC) methods, with a particular focus on lossy compression for both natural images and scientific imagery obtained from NASA’s Solar Dynamics Observatory (SDO) mission. Traditional image compression standards—such as JPEG, JPEG2000, BPG, and HEVC—rely on manually engineered transforms and heuristic rules, which often lack the adaptability required to accommodate …

Assessing And Predicting The Impact Of A Retrofitted Methane Mitigator On Non-Road Large Natural Gas Engines Using Artificial Neural Networks, Augustine Thomas Ojo

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

ASSESSING AND PREDICTING THE IMPACT OF A RETROFITTED METHANE MITIGATOR ON NON-ROAD LARGE NATURAL GAS ENGINES USING ARTIFICIAL NEURAL NETWORKS

Augustine Thomas Ojo

Methane emissions from the oil and gas sector present a pressing environmental and economic challenge, given methane’s high global warming potential and the considerable volumes of unutilized gas lost from industrial processes. This study investigates the impact of a retrofitted methane mitigation system, the Methane Mitigator (M²), on fuel consumption and engine-out emissions in non-road, four-stroke natural gas-powered, lean-burn engines and develops predictive Artificial Neural Network (ANN) models to estimate the resulting engine-out emissions and fuel …

Toward A University-Led Community Indicator Project For West Virginia, Daniel Carson Eades

Graduate Theses, Dissertations, and Problem Reports (ETD)

Rural communities across the United States are experiencing profound social and economic transitions that demand innovative, asset-based approaches to community development (CD). This study responds to calls from West Virginia (WV) community development practitioners, funders, and university leaders for a standardized, contextually relevant framework to assess and track community well-being. The objective of this study was to develop a university-led community indicator project in West Virginia (WV CIP) that incorporates best practices recognized by the literature as critical to successful community-based indicator projects, specifically, the identification of scientifically and normatively grounded indicators rooted in a conceptual framework (the Community Capital …

Soccer Sheikhs: Qatar, Football, And The Quest For Self-Confidence And Global Prominence, Ali Ahsan

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation examines Qatar’s strategic use of football as a mechanism for securing ontological security within the international system. Moving beyond standard International Relations explanations of state behavior, the study draws on ontological security theory which emphasizes the need of states to sustain a coherent sense of self through routines, narratives, and recognition. By framing football as such a practice, the dissertation advances the study of sport as a growing area of interest in the political sciences. Through a qualitative methodology employing Reflexive Thematic Analysis of expert interviews, the research analyzes Qatar’s football policies, including hosting the 2022 FIFA World …

Dynamic Force Feedback Controller Improves Metrics Of Stepping In A Biomimetic Robot Leg, Isabella Mae Kudyba

Graduate Theses, Dissertations, and Problem Reports (ETD)

Force feedback is a type of robotic control where forces are measured, fed back into the control system, and actuation is adjusted to compensate for environmental forces, with the goal of quick and precise limb positioning in walking. Robots of today use single force sensors (e.g. pressure sensitive pads, load cells) per leg which are often bulky, expensive, and susceptible to crosstalk. Walking robots often employ model predictive controllers or policy controllers trained through reinforcement learning (RL) to actuate their limbs, but these methods are time and energy consuming. Biomimetic robots offer an alternative approach, investigating biological theories with the …

Modeling And Simulation Of A Process For Upcycling Of Low-Density Polyethylene Plastic Waste To Ethylene, Xiaoyan Wang

Graduate Theses, Dissertations, and Problem Reports (ETD)

Ethylene is one of the most widely produced petrochemicals, with an estimated global output of 180 million metric tons in 2022. Approximately 82 million metric tons of ethylene are used annually for plastic production, primarily for polyethylene (PE), as well as polypropylene (PP) and polyvinyl chloride (PVC). The CO₂ emissions associated with PE production were approximately 14 million metric tons in 2022. Globally, an estimated 70 million metric tons of PE are produced and consumed each year, with the majority (~79%) ending up in landfills or the environment.

This project proposes a novel process in which waste low-density polyethylene (LDPE) …

Fundamental And Applied Investigation Of Ammonia Combustion: Characteristics And Emissions At Relevant Ic Engine Conditions, Luis Fernando Alvarez Correa

Graduate Theses, Dissertations, and Problem Reports (ETD)

Ammonia (NH3) is regarded as a promising fuel for future carbon-free power and propulsion systems due to its high hydrogen content, ease of storage, and existing infrastructure. Despite these advantages, NH3 exhibits inherently poor combustion characteristics, including low laminar burning velocity, high ignition energy, narrow flammability limits, and sluggish chemical kinetics. These limitations were solved in prior research by blending NH3 with hydrogen (H2) or hydrocarbons, which improved reactivity but introduced trade-offs such as increased complexity, safety concerns, or carbon emissions. Consequently, there remains a significant lack of fundamental and applied research on neat NH3 combustion, particularly under engine-relevant conditions …

Synergetic Effect Of Cellulose And Chitosan Polymers In Cancer Treatment, Grace Peterson

Graduate Theses, Dissertations, and Problem Reports (ETD)

This research explores the development of a biocompatible, natural drug delivery system designed for targeted cancer therapy. Lung cancer cells are used in these particular tests, but further research indicates treatment could be used for various cancer types. Traditional cancer treatments like chemotherapy are often limited by poor selectivity for tumor cells, causing significant damage to healthy tissues. The study proposes a dual-layered delivery system, utilizing Carboxymethyl Cellulose (CMC) as the core material and a charge-reversible chitosan shell to encapsulate and target cancer drugs. CMC, with its water solubility and ability to form stable gels, serves as a stable drug …

Characterization Of Properties And Defects Of Alternative Matrix Materials For 3d Printed Continuous Carbon Fiber Reinforced Composites, Noah Darren Osborne

Graduate Theses, Dissertations, and Problem Reports (ETD)

Additive manufacturing, commonly known as 3D printing, has the potential to transform the production of end-use parts by facilitating the creation of complex shaped, low-volume components that are expensive to manufacture using traditional methods. However, thermoplastic polymer matrices currently utilized in 3D printing of carbon fiber composites, often lack the mechanical properties needed for aerospace applications. To address this issue, researchers have developed fiber-reinforced 3D-printed composites using an innovative two-step process which involves printing 3D preforms using fused deposition modeling, followed by compression molding. However, most previous work involves the use of nylon-based polymer matrices while there are a number …

Rational Design Of Small Molecules Targeting Mitochondrial Redox Proteins, Matheus Barbosa Belchior

Graduate Theses, Dissertations, and Problem Reports (ETD)

Reactive oxygen species play a crucial role in many cellular processes. Despite being a natural byproduct of cellular metabolism, overexpression of these species causes damage to the cell, leading to cell dysfunction. Central to the regulation of these highly reactive molecule is the mitochondria. Impairment in its function has been associated with oxidative stress within the cell. Herein, a ligand-based and structure-based approach to design new small molecules to inhibit mitochondrial redox proteins associated with oxidative stress and reactive oxygen species. In the first project two molecules were synthesized and characterized as potential monoamine oxidase B inhibitors. Results showed two …

Pancreatic Cancer In Appalachia: An Examination Of Detection, Associated Factors, And Provider Experiences With A Focus On West Virginia, Melissa Mae Elder

Graduate Theses, Dissertations, and Problem Reports (ETD)

ABSTRACT

Pancreatic Cancer in Appalachia: An Examination of Detection, Associated Factors, and Provider Experiences with a Focus on West Virginia

Melissa M. Elder

Introduction: The Appalachian population accounts for a substantial proportion of the United States and are uniquely susceptible to health care disparities. The Appalachian Regional Commission has reported on the inequities found within the Appalachian region as part of its formal establishment in 1965. When compared to the Non-Appalachian U.S., Appalachia experiences a higher incidence of chronic disease such as diabetes, cancer, lung, and liver disease; mortality from diseases of despair constituting prescription drug, alcohol, illegal drug use, …

Artificial Engineering Intelligence Proxy Modelling For Numerical Reservoir Simulation Of Co2 Injection, Mohammad Altahow

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

Artificial Engineering Intelligence Proxy Modelling for Numerical Reservoir Simulation of CO2 Injection

Mohammad Altahow

This study uses Artificial Intelligence (AI) and Machine Learning (ML) to improve the speed and efficiency of reservoir simulations for CO₂ storage applications. Numerical reservoir simulators, such as CMG, provide accurate predictions but demand extensive computational time and resources, making them impractical for rapid scenario analyses. To tackle this challenge, I developed a Smart Proxy Model using Artificial Neural Networks (ANNs) within the Improve software platform to replicate the results of numerical reservoir simulations conducted with CMG.

The framework predicts key reservoir performance indicators, including …

Evaluation Of Small Unmanned Tailsitter Hybrid Air Vehicles Via Full Flight Simulation, Andrew Spencer Winters

Graduate Theses, Dissertations, and Problem Reports (ETD)

Small Unmanned Aerial Vehicles have exploded in popularity in the past 15 years among researchers and for industrial uses such as agriculture, search and rescue, and infrastructure inspection. Fixed wing and multirotor designs present two major paths that can be taken with these technologies. Fixed wing platforms have superior aerodynamic efficiency but require large areas for takeoff/landing and cannot hold a constant position in space, limiting their use. Multirotor configurations offer a more versatile platform that can maneuver in 3 dimensions independently but lack the endurance of fixed wing vehicles. This thesis analyses a quadrotor biplane and a variable wingspan …

Applications Of Deep Learning For Optimizing Fingerphoto And Latent Fingerprint Biometrics, Amol Sanjay Joshi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Fingerprint-based biometric recognition remains one of the most dependable and widely adopted approaches for identity verification due to its permanence and distinctiveness. Recent advancements in mobile and contactless imaging have extended fingerprint acquisition beyond controlled environments into unconstrained, real-world conditions through fingerphotos, contactless fingerprint images captured by digital or smartphone cameras. While this paradigm shift enhances accessibility and user convenience, it introduces significant technical challenges. Variations in illumination, focus, and motion blur often degrade ridge patterns, making accurate feature extraction and matching more difficult. Similarly, in forensic applications, latent fingerprints, incomplete or smudged prints lifted from surfaces, pose unique challenges …

The Effects Of Operatic Voice Type On Singer Identity, Adelaide J. Mcdonald

Graduate Theses, Dissertations, and Problem Reports (ETD)

Within Western art music, voices are typically classified using the Fach system, which is based upon vocal characteristics and separates singers into the categories of soprano, mezzo soprano, contralto, counter tenor, tenor, bass, and baritone. Over time, these categories have become embedded with social and cultural meaning within the operatic world, leading to the development of stereotypes and expectations surrounding singers, as well as social categories and identities, referred to in this study as “sociocultural vocal categories” and “sociocultural vocal identity,” respectively. Currently, there are limited explorations of the sociocultural vocal categories and their associated stereotypes, with research on singer …

Recovery Of Iron And Aluminum From Acid Mine Drainage For Beneficial Uses, Katelyn Renee Pepe

Graduate Theses, Dissertations, and Problem Reports (ETD)

Acid mine drainage (AMD) is a widespread issue across the globe, in which some of the most critical cases are created by the mining industry. Researchers have investigated ways to derive benefits from AMD, such as precipitating rare earth elements (REEs) to generate potential revenue from AMD treatment and supplement market demand. However, the bulk of precipitated sludge is composed of iron and aluminum, which also have market value but are discarded in current practice.

Using the Omega site in West Virginia (WV) as a representative AMD source, the objectives of this study are (1) to determine a replicable precipitation …

Survival And Spatial Ecology Of North American River Otters (Lontra Canadensis) In West Virginia, Laurel Marie Glover

Graduate Theses, Dissertations, and Problem Reports (ETD)

Wildlife reintroductions function to regain wildlife populations in areas where they have been extirpated or greatly diminished. One such species that has been reintroduced to several states is the North American river otter (Lontra canadensis). The West Virginia Division of Natural Resources (WVDNR) conducted a river otter reintroduction effort between 1984-1997, releasing 245 individuals into the state. The reintroduction was deemed a success with the WVDNR opening a regulated trapping season for river otters in 2011, allowing trappers to take one river otter per season. As the population has reestablished in West Virginia, several management challenges have arisen …