Digital Commons Network^™

Evaluation Of Ultra Fine Cigarette Smoke Particles Penetration On 3m 6200 Half Mask Respirators With P-100 Filters, Selcuk Elhan

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study was aimed to investigate the effectiveness of half mask respirator with double P-100 filters by determining the penetration of cigarette smoke particles. In this study, faceseal leakage of a breathing manikin donned a 3M 6200 half mask elastomeric respirator with double P-100 filters was determined at various test conditions. A full factorial test conditions of 4 sealing conditions (Non-sealed, only nose sealed, nose and chin sealed, and fully sealed), 2 inspiratory breathing types (Constant, cyclic), 4 flowing rates (15, 30, 50, 85 L/min for cyclic; 15, 30, 50, 80 L/min for constant) were employed and each test condition …

Promoting Sense Of Belonging And Interest In Geosciences Among Undergraduate Women Through Mentoring, Wenyi Du

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this study is to investigate whether students’ university sense of belonging mediates the relationship between mentor network diversity and students’ interest development among undergraduate women in STEM majors. The sample for this study was consisted of 277 undergraduate women majoring in a STEM discipline with initial interests in geosciences across nine universities within the United States. A regression-based mediation analysis was performed using the Hayes’ (2013) macro to test the indirect effect of mentor support on interest through university sense of belonging. Consistent with our hypothesis, the analysis revealed a statistically significant and positive indirect effect of …

Adult Atlantic Sturgeon Population Dynamics In The York River, Virginia, Jason E. Kahn

Graduate Theses, Dissertations, and Problem Reports (ETD)

Sturgeon first appear in the fossil record in the Triassic Period just over 200 million years ago and are among the most primitive of the bony fishes. Despite their large size and historic presence along the East Coast, Atlantic sturgeon were not targeted for their meat and caviar as a commercial fishery until 1880. By 1905 they had declined to less than one percent of their pre-fishing abundance but the fishery continued. Prior to 1980, there had been very little research on Atlantic sturgeon, primarily limited to documenting landing location and poundage, maximum longevity, or weight of eggs per fish. …

Influence Of Climate Change And Prescribed Fire On Habitat Suitability And Abundance Of The High-Elevation Endemic Cow Knob Salamander (Plethodon Punctatus), Carl David Jacobsen

Graduate Theses, Dissertations, and Problem Reports (ETD)

Amphibians are facing global declines due to climate change, loss and degradation of habitat, invasive species, and disease. The Appalachian region of the eastern USA is a global biodiversity hotspot for salamanders, which are considered keystone species that influence nutrient dynamics in terrestrial and aquatic food webs. There are high rates of salamander endemism in the Appalachian region, with many species restricted to isolated, high elevation areas. The Cow Knob Salamander (Plethodon punctatus) is one such species. It is only found at elevations >675 m (most populations are above 900 m) on Shenandoah Mountain, North Mountain, and Nathaniel …

Health Literacy And Family Factors In The Transition To Adult Care In Adolescents With Type I Diabetes, Ellen M. Manegold

Graduate Theses, Dissertations, and Problem Reports (ETD)

Successful management of type 1 diabetes (T1DM) in adolescence involves multiple daily tasks, developmental changes, and the expectation of transition to an adult provider. Health literacy is one variable to consider in the context of transition, as studies have demonstrated the correlation of parental health literacy with health behaviors and outcomes, yet not studied adolescent health literacy in T1DM. Family factors (e.g., management responsibility, diabetes-specific family conflict, parental support) also are important to behavior and health outcomes in adolescents with T1DM. Study aims were to: 1) examine the association of adolescent health literacy to transition readiness and health outcome in …

Development Of Improved Acellular Pertussis Vaccines Through Inclusion Of The Rtx Antigen Or Induction Of Mucosal Immunity, Dylan Tyler Boehm

Graduate Theses, Dissertations, and Problem Reports (ETD)

Pertussis is a human respiratory disease, primarily caused by the Gram-negative pathogen Bordetella pertussis. The infection is most severe and can be life-threatening in young children and infants where it manifests as a series of paroxysmal coughs. The disease is more commonly known as whooping cough, due to the whoop omitted during a massive inspiratory effort to bring air back into the lungs. Pertussis is a toxin-mediated disease that persists due to an early release of toxins that allow that bacteria to evade the cells of the innate immune response. The inhibition of the host response continues as toxin activity …

Description Of Motor Control Using Inverse Models, Anton Sobinov

Graduate Theses, Dissertations, and Problem Reports (ETD)

Humans can perform complicated movements like writing or running without giving them much thought. The scientific understanding of principles guiding the generation of these movements is incomplete. How the nervous system ensures stability or compensates for injury and constraints – are among the unanswered questions today. Furthermore, only through movement can a human impose their will and interact with the world around them. Damage to a part of the motor control system can lower a person’s quality of life. Understanding how the central nervous system (CNS) forms control signals and executes them helps with the construction of devices and rehabilitation …

Role Of Sox9 In Cancer Stem Cell Regulation In Lung Cancer Chemoresistance And Particle-Induced Carcinogenesis, Maria Voronkova

Graduate Theses, Dissertations, and Problem Reports (ETD)

Lung cancer is a leading cause of cancer-related death worldwide. Every year it claims more lives than other common malignancies, breast, prostate, and colorectal cancers, combined. And despite recent improvements in disease diagnostics and treatment, drug resistance and tumor relapse remain major contributors to low patient survival. Both issues have been largely attributed to the existence of cancer stem-like cells (CSCs) or tumor initiating cells (TICs). CSCs are a small cell population within heterogeneous tumors that is inherently resistant to apoptosis, chemo- and radiation therapy. Thus, it is critical to elucidate CSC-specific signaling pathways and identify early biomarkers for therapeutic …

Internalized Heterosexism, Outness, Athletic Identity, And Perceived Stress Among Queer Female Athletes, Olivia C. Scott

Graduate Theses, Dissertations, and Problem Reports (ETD)

The historical presence of heterosexism in sport has been discussed in numerous publications, with unique considerations for female athletes (Anderson, Magrath, & Bullingham, 2016; Cahn, 1993; Griffin, 1998; Rankin, 1998). Unfortunately, few studies have examined the impact of this climate on female athletes with minoritized sexual identities. Most research pertaining to this population has been qualitative and largely focused on lesbian athletes (Fynes & Fisher, 2016; Stoelting, 2011). Consequently, more generalizable conclusions about queer female athlete experiences has been limited. The present study was an attempt to address this research gap, by assessing the internalized heterosexism, outness, athletic identity, and …

The Effect Of Bovine Galectin-1, A Conceptus Secretory Protein, On The Endometrial Transcriptome, Lindsay Faye Grose

Graduate Theses, Dissertations, and Problem Reports (ETD)

Early embryonic loss in cattle is detrimental to reproduction thus, the profitability of both the beef and dairy industries. Therefore, an important aspect of study is to find techniques that beef or dairy producers could use to decrease early embryonic loss Galectin-1, the protein that was investigated in this research is important in modulating the maternal immune system in rodent and human early pregnancies by promoting fetomaternal immune tolerance. The role of galectin-1 within the reproductive tissues has not been thoroughly investigated in cattle. Galectin-1 is located in the caruncular and intercaruncular regions of the bovine endometrium, specifically the maternal …

Evaluating Post-Fire Plantation Restoration In A Mixed Conifer Forest In The Sierra Nevada, Iris C. Allen

Graduate Theses, Dissertations, and Problem Reports (ETD)

Forests in the western United States have experienced a shift from historical disturbance regimes in the past century. Many of these changes were induced by European settlers logging the forests and suppressing fires. In the past, the dry mixed conifer forests of California’s Sierra Nevada mountains experience frequent, low to mixed severity fires. This fire regime helped maintain a heterogeneous landscape comprised of groups of trees and openings. However, due to fire suppression and high grading logging, forest structure has changed; there are less openings and more small, fire-intolerant trees that can carry a fire into the forests crown. The …

The Parent-Child Interaction Therapy Family Experiences And Feedback Study: A Follow-Up Examination Of Attrition In An Evidence-Based Treatment In Community Settings Statewide, Brittany K. Liebsack

Graduate Theses, Dissertations, and Problem Reports (ETD)

Attrition is a significant problem in child psychotherapy (De Haan, Boon, De Jong, Hoeve, & Vermeiren, 2013) and has serious implications (Barrett et al., 2008). Predictors of attrition include those at the client, therapist, and treatment levels. The current study investigated variables associated with attrition in Parent-Child Interaction Therapy (PCIT), an evidence-based parent training program for families with young children (ages 2.5- to 7-years-old) with disruptive behavior disorders. The sample of 67 caregivers were treated by 25 therapists from 19 different licensed psychiatric outpatient clinics across one state and were part of a larger study (RO1 MH09750; A Statewide Trial …

An Investigation Of The Relation Between Mindfulness And Self-Esteem Stability, Cameron Grant Ford

Graduate Theses, Dissertations, and Problem Reports (ETD)

Self-esteem stability is the magnitude of the short-term fluctuations in one’s immediate feelings of self-worth (Kernis, 2005). Stable self-esteem is associated with several psychological benefits, such as lower depression (Kernis et al., 1998). However, it is unknown what factors lead to self-esteem stability. Because mindfulness promotes a nonjudgmental orientation whereby thoughts, feelings, and reactions are viewed as transient events that do not necessarily represent objective reality, mindfulness might be associated with more stable self-esteem. Thus, the present research examined the relation between mindfulness and self-esteem stability. Undergraduates (N = 190) were randomly assigned to one of three conditions: mindfulness …

Behavioral And Anti-Inflammatory Effects Of Magl Inhibition In A Mouse Model Of Inflammatory Arthritis, Floyd Franklin Steele Iii

Graduate Theses, Dissertations, and Problem Reports (ETD)

Cannabinoids have analgesic and anti-inflammatory properties. For example, in preclinical models of acute inflammatory pain, cannabinoid receptor subtype 2 (i.e., CB_2, Table 1) agonists decrease paw inflammation and resulting pain. Yet, the anti-inflammatory properties of cannabinoid receptor manipulation in chronic inflammatory pain states are unknown. Monoacylglycerol lipase (MAGL) is the primary catabolic enzyme of the endocannabinoid (i.e., endogenous cannabinoid ligand) 2-arachidonoyl glycerol (i.e., 2-AG). Compounds that inhibit MAGL indirectly increase tissue levels of 2-AG by preventing its catabolism. MAGL inhibitors demonstrate efficacy in acute models of inflammatory/rheumatic disease. Thus, in this study, the MAGL inhibitor JZL184 was tested …

Novel Computational Methods For Catalytic Applications, Gihan Uthpala Panapitiya

Graduate Theses, Dissertations, and Problem Reports (ETD)

Thiolate protected nanoclusters gold nanoparticles are gaining interest of many researchers due to their promising applications in a variety of fields the development of synthesizing techniques capable of producing atomically precise nanoclusters with high purity. Au₂₅(SR)₁₈ is one of the widely studied nanoclsuters due its remarkable stability. In this first part of this study, we explore the structural, electronic and catalytic properties of bimetallic Au_25−xAg_x(SR)₁₈ (for x = 6, 7, 8). Due to the combinatorial enormity of the total number of possible alloyed isomers, we choose a randomly selected subset corresponding to …

A Study Of Gastrointestinal Pathophysiology, Emily Minor

Graduate Theses, Dissertations, and Problem Reports (ETD)

Though the duodenum is the primary site of iron absorption, the colon also contains iron transporters and participates in iron absorption. The purpose of this study was to characterize colonic iron absorption in control patients and those with ulcerative colitis (UC), a disease that frequently results in iron deficiency. Using RT-qPCR and western blot analysis, we found that colonic expression of the apical iron importer, divalent metal transporter 1 (DMT1), is equal to duodenal expression. However, colonic expression of ferroportin 1 (FPN1), an iron exporter, is only about one-quarter that of the duodenum. Patients with active ulcerative colitis were found …

Glial Cell Expansion And Intercellular Signaling In The Developing Medial Nucleus Of The Trapezoid Body (Mntb), Ashley N. Brandebura

Graduate Theses, Dissertations, and Problem Reports (ETD)

Neural circuit formation is a complex process involving coordinated communication between neurons, glia and vascular-associated cells (VACs). Each cell type is responsible for a unique transcriptional and translational contribution to tissue maturation. Deciphering the intercellular signaling patterns which guide neural circuit formation during normal development is thus an essential step in understanding which components of neural circuit formation go awry in neurodevelopmental disorders. The medial nucleus of the trapezoid body (MNTB), located in the auditory brainstem, was used as a model system to study the dynamics of neural circuit formation because it contains a mostly homogeneous population of postsynaptic neurons …

Object-Based Supervised Machine Learning Regional-Scale Land-Cover Classification Using High Resolution Remotely Sensed Data, Christopher A. Ramezan

Graduate Theses, Dissertations, and Problem Reports (ETD)

High spatial resolution (HR) (1m – 5m) remotely sensed data in conjunction with supervised machine learning classification are commonly used to construct land-cover classifications. Despite the increasing availability of HR data, most studies investigating HR remotely sensed data and associated classification methods employ relatively small study areas. This work therefore drew on a 2,609 km2, regional-scale study in northeastern West Virginia, USA, to investigates a number of core aspects of HR land-cover supervised classification using machine learning. Issues explored include training sample selection, cross-validation parameter tuning, the choice of machine learning algorithm, training sample set size, and feature selection. A …

Sediment Provenance Study Of The Lower Hamilton Group: An Analysis Of The Organic-Rich Facies And Its Depositional History, Luke Patrick Fritz

Graduate Theses, Dissertations, and Problem Reports (ETD)

Currently, insufficient geological models exist to explain the variability and distribution of TOC in the Marcellus Shale, within the Hamilton Group. TOC is one of the several limiting factors for natural gas production within the Marcellus Shale basin. One possible explanation for the low TOC regions is that detrital dilution was variable across the basin, with different sediment sources contributing detritus to low TOC areas, compared to surrounding regions with higher TOC. This hypothesis is tested by analyzing the source composition of inorganic detritus, using elemental and mineralogical proxies, with two cores in the Hamilton Group. The Armstrong #1 core …

Bacterial Contamination Study Of Loose-Fitting Power Air Purifying Respirators (Papr) Compared To N-95 Ffr And Surgical Mask, In A Simulated Sterile Environment, Tyler J. Church

Graduate Theses, Dissertations, and Problem Reports (ETD)

Powered air purifying respirators (PAPRs) are commonly used in a health care setting, providing a higher level of protection than traditional surgical masks or N-95’s. However, little can be found in literature about their use in a sterile environment, such as an operating room. Thus, this study aims to compare bacterial contamination of three different models of PAPRs (3M^TM Versaflo^TM TR-600-ECK, 3M^TM Air-Mate^TM, and MAXAIR CAPR 710) to a N-95, surgical N-95 and surgical mask. The experiments were conducted in a small room with no ventilation, under two conditions, door open and door closed. Each …

Predictors Of Perceived Multicultural Competence Among Neuropsychological Trainees, Hannah K. Greenbaum

Graduate Theses, Dissertations, and Problem Reports (ETD)

Multicultural competence is necessary to provide psychological services to an increasingly diverse population (Sue, 2001). It is established that multicultural competence is important for training in psychology (Bodin et al., 2014; Diaz-Santos & Hill, 2016). Despite increased interest in recent years, multicultural competence in neuropsychology has not progressed in parallel with the focus of multiculturalism in psychology broadly (Rivera Mindt, Byrd, Saez, & Manly, 2010). Little is known about multicultural assessment, and it is not yet known what factors in training contribute to perceived multicultural competence in neuropsychological trainees (Elbulok-Charape, Rabin, Spadaccini, & Barr, 2014). The primary purpose of this …

Bridging The Gap: Utilizing Socratic Inquiry Facilitation In Cross-Cultural Communication And Conflict Exploration, Mikaela G. Zimmerman

Graduate Theses, Dissertations, and Problem Reports (ETD)

The objective of this research is to explore the possibilities for improving governmental relations (local, national, and international) using microcosms of cross-cultural dialogues facilitated with Socratic Inquiry methodology and their potential to project situational similarities into more formal political conversation. Using twenty-five recorded dialogues from The Pennsylvania State University’s Center for Public Diplomacy (World in Conversation), I have broadly observed the role of Socratic Inquiry facilitation in cross-cultural dialogues whose content varies across a span of contentious social topics. By generally accounting for a range of relevant social factors such as gender, body language, conversational tools, and proxies for empathy, …

Compound-Specific Isotope Analysis Of Amino Acids In Biological Tissues: Applications In Forensic Entomology, Food Authentication And Soft-Biometrics In Humans, Mayara Patricia Viana De Matos

Graduate Theses, Dissertations, and Problem Reports (ETD)

In this work we demonstrate the power of compound-specific isotope analysis (CSIA) to analyze proteinaceous biological materials in three distinct forensic applications, including: 1) linking necrophagous blow flies in different life stages to their primary carrion diet; 2) identifying the harvesting area of oysters for food authentication purposes; and 3) the ability to predict biometric traits about humans from their hair.

In the first application, we measured the amino-acid-level fractionation that occurs at each major life stage of Calliphora vicina (Robineau-Desvoidy) (Diptera: Calliphoridae) blow flies. Adult blow flies oviposited on raw pork muscle, beef muscle, or chicken liver. Larvae, pupae …

Soil Microbial Succession Following Surface Mining Is Governed Primarily By Deterministic Factors, Jennifer Lynne Kane

Graduate Theses, Dissertations, and Problem Reports (ETD)

Understanding the successional dynamics governing soil microbial community assembly is a promising way to advance development of remediation strategies for lands disturbed by anthropogenic activities. The environmental and ecological influences shaping these communities following soil disturbance remain only partially understood. One example of a physical anthropogenic disturbance is extraction of minerals such as coal by surface mining. Surface mining removes natural soils and these soils may be replaced immediately on adjacent reclaimed areas or they may be stored in piles for later use. During reclamation, the soil is replaced on the landscape and the site is re-vegetated with grasses and …

Demographic, Spatial, And Epigenetic Response Of The Louisiana Waterthrush (Parkesia Motacilla) To Shale Gas Development, Mack W. Frantz

Graduate Theses, Dissertations, and Problem Reports (ETD)

My study centered on a bioindicator songbird, the Louisiana Waterthrush (Parkesia motacilla), hereafter waterthrush, an organism that co-occurs in both forested and aquatic habitat across the aquatic-terrestrial interface. This enabled the opportunity to quantify demographic, spatial, and epigenetic (i.e., DNA methylation) responses in a highly forested watershed of the Central Appalachians, the areas that have undergone the most rapid transformations over the last decade from unconventional shale gas development and activities. I organized my dissertation into 4 parts (Part 1: Introduction, Part 2: Louisiana Waterthrush Demography, Part 3: Spatial Assessment of Louisiana Waterthrush Foraging, Part 4: Louisiana Waterthrush …

Non-Target Analyses Of Novel Psychoactive Substances; Inherent Variation In Gcms Relative Abundances And Gas Phase Hydrogen Deuterium Exchange Isomer Discrimination, Kristin Michelle Kelly

Graduate Theses, Dissertations, and Problem Reports (ETD)

Novel psychoactive substances (NPSs) are synthetically derived compounds designed to mimic the effects of other illicit drugs. An endless cycle of NPSs continually reach the drug market due to limitations in drug legislation creating two problems: (1) non-availability of standards and (2) multiple isobars indistinguishable even to high resolution mass spectrometry. Gas chromatography-mass spectrometry (GCMS) is the most common instrument used for compound identification in non-targeted seized drug analysis. Compound identification using this technique relies on mass spectra where the percent relative abundances (%RAs) of all m/z values are compared manually or searched against a library database. Lacking standards, laboratories …

Regulation Of The Long Non-Coding Rna Fam83h-As1 By Human Papillomavirus In Cervical Cancer, Jamie Ann Barr Ph.D.

Graduate Theses, Dissertations, and Problem Reports (ETD)

Non-coding RNAs (NcRNAs), such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), have been found to be involved in a variety of critical biological processes, and dysregulation of ncRNAs have been involved with several human diseases including cancer.

High-risk human papillomavirus (HPV) infection is one of the first events in the process of carcinogenesis in cervical and a subset of head and neck cancers. The expression of the viral oncoproteins E6 and E7 is essential in this process by inactivating the tumor suppressor proteins p53 and Rb, respectively, in addition to their interactions with other host proteins and regulation of …

Evaluation Of Ufp Number Concentrations Near A Natural Gas Transmissions Station, John M. Thornsbury

Graduate Theses, Dissertations, and Problem Reports (ETD)

Identifying UFP number concentrations near a natural gas compressor station is key to understanding ambient exposures associated with the transmission station. Developing an atmospheric survey to characterize these concentrations was key in understanding ambient exposures. The aims of this study are to compare and contrast number concentrations taken in a hollow, near the transmission station to those of the background. From this, it would be possible to identify whether or not the compressor station was a contributing factor to peaks and spikes in number concentrations.

This study begins with a review of what UFPs are, how they react in different …

Impacts Of Climate Change On Water Balance Components In The Central Appalachian Mountains, Usa, Brandi Anne Gaertner

Graduate Theses, Dissertations, and Problem Reports (ETD)

This research investigated the impact of climate and land cover on water balance components including evapotranspiration and runoff in the mountainous central Appalachian region of the United States. The first studyanalyzed trends in climatologic, hydrologic, and growing season length variables, identified the important variables effecting growing season length changes, and evaluated the influence of a lengthened growing season on increasing evapotranspiration trends. The results showed that growing season length has increased, on average, by ~22 days and evapotranspiration has increased ~12 mm. The second study quantified long-term historical and future climate trends, evaluated water balance sensitivity to change, and quantified …

Material Disease: Agency And Illness In Early American Literature, Mariah Crilley

Graduate Theses, Dissertations, and Problem Reports (ETD)

Material Disease: Agency and Illness in Early American Literature argues that diseases shaped bodies of literature. Drawing on new materialism, disability studies, and the medical humanities, this dissertation argues that diseases were material and literary agents that transformed not only individual bodies and lives but also cultures, history, and even literature. In each chapter, I explore how one disease impacted a particular genre or paradigm: syphilis and the natural history, smallpox and the body politic, yellow fever and the novel, dysentery and sensibility, and malaria and narratives of Western expansion. By emphasizing disease’s material and literary agency, by conjoining the …